Intratumor OX40 stimulation inhibits IRF1 expression and IL‐10 production by Treg cells while enhancing CD40L expression by effector memory T cells

Specific recruitment of regulatory T cells in ovarian carcinoma fosters immune privilege and predicts reduced survival

2004 • 4,872 citations

How regulatory T cells work

2008 • 3,048 citations

The regulation of IL-10 production by immune cells

2010 • 2,691 citations

Regulatory T Cell Lineage Specification by the Forkhead Transcription Factor Foxp3

2005 • 2,256 citations

Targeting Tim-3 and PD-1 pathways to reverse T cell exhaustion and restore anti-tumor immunity

2010 • 1,779 citations

Regulatory T Cell-Derived Interleukin-10 Limits Inflammation at Environmental Interfaces

2008 • 1,438 citations

Molecular mechanism and function of CD40/CD40L engagement in the immune system

2009 • 1,330 citations

Cancer despite immunosurveillance: immunoselection and immunosubversion

2006 • 1,263 citations

The transcription factor T-bet controls regulatory T cell homeostasis and function during type 1 inflammation

2009 • 1,171 citations

TSLP-activated dendritic cells induce an inflammatory T helper type 2 cell response through OX40 ligand

2005 • 1,029 citations

Interleukin‐10: new perspectives on an old cytokine

2008 • 1,018 citations

Function of miR-146a in Controlling Treg Cell-Mediated Regulation of Th1 Responses

2010 • 960 citations

IL-10-Secreting Regulatory T Cells Do Not Express Foxp3 but Have Comparable Regulatory Function to Naturally Occurring CD4+CD25+ Regulatory T Cells

2004 • 654 citations

OX40 Promotes Bcl-xL and Bcl-2 Expression and Is Essential for Long-Term Survival of CD4 T Cells

2001 • 638 citations

Regulatory T cells expressing interleukin 10 develop from Foxp3+ and Foxp3− precursor cells in the absence of interleukin 10

2007 • 576 citations

RedirectingIn vivoElicited Tumor Infiltrating Macrophages and Dendritic Cells towards Tumor Rejection

2005 • 525 citations

Foxp3+ regulatory T cells: differentiation, specification, subphenotypes

2009 • 495 citations

Control of Immunity by the TNFR-Related Molecule OX40 (CD134)

2010 • 484 citations

CD40 activation in vivo overcomes peptide-induced peripheral cytotoxic T-lymphocyte tolerance and augments anti-tumor vaccine efficacy

1999 • 463 citations

Characterization of Foxp3+CD4+CD25+ and IL-10-Secreting CD4+CD25+ T Cells during Cure of Colitis

2006 • 448 citations

A Unique Subset of CD4+CD25highFoxp3+ T Cells Secreting Interleukin-10 and Transforming Growth Factor-β1 Mediates Suppression in the Tumor Microenvironment

2007 • 429 citations

CD40 antibody evokes a cytotoxic T-cell response that eradicates lymphoma and bypasses T-cell help

1999 • 423 citations

Conversion of tumor-specific CD4+ T-cell tolerance to T-cell priming through in vivo ligation of CD40

1999 • 409 citations

Triggering of OX40 (CD134) on CD4+CD25+ T cells blocks their inhibitory activity: a novel regulatory role for OX40 and its comparison with GITR

2005 • 406 citations

OX40 costimulation turns off Foxp3+ Tregs

2007 • 398 citations

Engagement of the OX-40 Receptor In Vivo Enhances Antitumor Immunity

2000 • 386 citations

OX40 triggering blocks suppression by regulatory T cells and facilitates tumor rejection

2008 • 383 citations

Heterogeneity of CD4⁺ memory T cells: Functional modules for tailored immunity

2009 • 341 citations

Reversal of Tumor-induced Dendritic Cell Paralysis by CpG Immunostimulatory Oligonucleotide and Anti–Interleukin 10 Receptor Antibody

2002 • 340 citations

Plasticity of CD4+ FoxP3+ T cells

2009 • 301 citations

Nonredundant Roles for B Cell-Derived IL-10 in Immune Counter-Regulation

2009 • 279 citations

Selective Depletion of Foxp3+ Regulatory T Cells Improves Effective Therapeutic Vaccination against Established Melanoma

2010 • 257 citations

IFN-inducible GTPases and immunity to intracellular pathogens

2004 • 222 citations

Genomic definition of multiple ex vivo regulatory T cell subphenotypes

2010 • 208 citations

Dendritic cells require maturation via CD40 to generate protective antitumor immunity.

1998 • 204 citations

Cutting Edge: OX40 Inhibits TGF-β- and Antigen-Driven Conversion of Naive CD4 T Cells into CD25+Foxp3+ T cells

2007 • 202 citations

OX40 ligand shuts down IL-10-producing regulatory T cells

2006 • 193 citations

Dendritic Cells Infiltrating Tumors Cotransduced with Granulocyte/Macrophage Colony-Stimulating Factor (Gm-Csf) and Cd40 Ligand Genes Take up and Present Endogenous Tumor-Associated Antigens, and Prime Naive Mice for a Cytotoxic T Lymphocyte Response

1999 • 184 citations

T-Regulatory Cells Shift from a Protective Anti-Inflammatory to a Cancer-Promoting Proinflammatory Phenotype in Polyposis

2009 • 184 citations

Conditional Regulatory T-Cell Depletion Releases Adaptive Immunity Preventing Carcinogenesis and Suppressing Established Tumor Growth

2010 • 181 citations

Reprogrammed Foxp3+ Regulatory T Cells Provide Essential Help to Support Cross-presentation and CD8+ T Cell Priming in Naive Mice

2010 • 166 citations

OX40 Agonist Therapy Enhances CD8 Infiltration and Decreases Immune Suppression in the Tumor

2008 • 162 citations

Cutting Edge: OX40 Agonists Can Drive Regulatory T Cell Expansion if the Cytokine Milieu Is Right

2009 • 156 citations

Cutting Edge: Dendritic Cells Require Maturation via CD40 to Generate Protective Antitumor Immunity

1998 • 155 citations

OX40 is required for regulatory T cell–mediated control of colitis

2010 • 148 citations

The contribution of transcription factor IRF1 to the interferon-γ–interleukin 12 signaling axis and TH1 versus TH-17 differentiation of CD4+ T cells

2007 • 141 citations

IFN-α Induces the Human IL-10 Gene by Recruiting Both IFN Regulatory Factor 1 and Stat3

2003 • 139 citations

OX40 is differentially expressed on activated rat and mouse T cells and is the sole receptor for the OX40 ligand

1996 • 138 citations

OX40–OX40 Ligand Interaction in T-Cell-Mediated Immunity and Immunopathology

2010 • 134 citations

Cytomegalovirus exploits IL-10–mediated immune regulation in the salivary glands

2007 • 122 citations

IFN Regulatory Factor-1 Bypasses IFN-Mediated Antiviral Effects through Viperin Gene Induction

2010 • 118 citations

Activation of NF-κB1 by OX40 Contributes to Antigen-Driven T Cell Expansion and Survival

2008 • 111 citations

Developmental plasticity of Foxp3+ regulatory T cells

2010 • 74 citations

CD40L+ CD4+ memory T cells migrate in a CD62P-dependent fashion into reactive lymph nodes and license dendritic cells for T cell priming

2008 • 68 citations

OX40 Ligand-Transduced Tumor Cell Vaccine Synergizes with GM-CSF and Requires CD40-Apc Signaling to Boost the Host T Cell Antitumor Response

2003 • 67 citations

Distinct and Overlapping Roles of Interleukin-10 and CD25+ Regulatory T Cells in the Inhibition of Antitumor CD8 T-Cell Responses

2005 • 66 citations

A non‐redundant role for OX40 in the competitive fitness of Treg in response to IL‐2

2010 • 62 citations

OX40/OX40L Costimulation Affects Induction of Foxp3+ Regulatory T Cells in Part by Expanding Memory T Cells In Vivo

2008 • 61 citations

Distinct Inflammatory Signals Have Physiologically Divergent Effects on Epigenetic Regulation of Foxp3 Expression and Treg Function

2011 • 59 citations

Suppression of Mature Dendritic Cell Function by Regulatory T Cells In Vivo Is Abrogated by CD40 Licensing

2008 • 51 citations

A Therapeutic OX40 Agonist Dynamically Alters Dendritic, Endothelial, and T Cell Subsets within the Established Tumor Microenvironment

2010 • 50 citations

Antigen-independent signalosome of CARMA1, PKCθ, and TNF receptor-associated factor 2 (TRAF2) determines NF-κB signaling in T cells

2011 • 49 citations

Differential CD40/CD40L Expression Results in Counteracting Antitumor Immune Responses

2007 • 45 citations

Regulation of Transcriptional Activity of the Murine CD40 Ligand Promoter in Response to Signals Through TCR and the Costimulatory Molecules CD28 and CD2

2001 • 37 citations

Anthrax Lethal Toxin Enhances TNF-Induced Endothelial VCAM-1 Expression via an IFN Regulatory Factor-1-Dependent Mechanism

2008 • 32 citations