Antigen-independent signalosome of CARMA1, PKCθ, and TNF receptor-associated factor 2 (TRAF2) determines NF-κB signaling in T cells

Shared Principles in NF-κB Signaling

2008 • 4,283 citations

Regulation and Function of NF-κB Transcription Factors in the Immune System

2009 • 2,403 citations

TNF-R1 Signaling: A Beautiful Pathway

2002 • 1,860 citations

Activation of IKK by TNFα Requires Site-Specific Ubiquitination of RIP1 and Polyubiquitin Binding by NEMO

2006 • 956 citations

PKC-θ is required for TCR-induced NF-κB activation in mature but not immature T lymphocytes

2000 • 890 citations

Co-stimulatory members of the TNFR family: keys to effective T-cell immunity?

2003 • 848 citations

The role of TNF superfamily members in T-cell function and diseases

2009 • 846 citations

OX40 Promotes Bcl-xL and Bcl-2 Expression and Is Essential for Long-Term Survival of CD4 T Cells

2001 • 638 citations

Ox-40 Ligand: A Potent Costimulatory Molecule for Sustaining Primary CD4 T Cell Responses

1998 • 515 citations

Control of Immunity by the TNFR-Related Molecule OX40 (CD134)

2010 • 484 citations

Location is Everything: Lipid Rafts and Immune Cell Signaling

2003 • 477 citations

The Distinct Roles of TRAF2 and RIP in IKK Activation by TNF-R1

2000 • 429 citations

The OX40 Costimulatory Receptor Determines the Development of CD4 Memory by Regulating Primary Clonal Expansion

2000 • 395 citations

4-1BB and Ox40 Are Members of a Tumor Necrosis Factor (TNF)-Nerve Growth Factor Receptor Subfamily That Bind TNF Receptor-Associated Factors and Activate Nuclear Factor κB

1998 • 342 citations

CARMA1 is a critical lipid raft–associated regulator of TCR-induced NF-κB activation

2002 • 338 citations

Phosphorylation of the CARMA1 Linker Controls NF-κB Activation

2005 • 333 citations

Ox40-Ligand Has a Critical Costimulatory Role in Dendritic Cell:T Cell Interactions

1999 • 320 citations

Herpesvirus Entry Mediator, a Member of the Tumor Necrosis Factor Receptor (TNFR) Family, Interacts with Members of the TNFR-associated Factor Family and Activates the Transcription Factors NF-κB and AP-1

1997 • 294 citations

A requirement for CARMA1 in TCR-induced NF-κB activation

2002 • 288 citations

Impairment of Antigen-Presenting Cell Function in Mice Lacking Expression of Ox40 Ligand

2000 • 284 citations

Phosphorylation of CARMA1 Plays a Critical Role in T Cell Receptor-Mediated NF-κB Activation

2005 • 282 citations

Function of TRADD in tumor necrosis factor receptor 1 signaling and in TRIF-dependent inflammatory responses

2008 • 268 citations

Requirement for CARMA1 in Antigen Receptor-Induced NF-κB Activation and Lymphocyte Proliferation

2003 • 253 citations

Sustained Survivin Expression from OX40 Costimulatory Signals Drives T Cell Clonal Expansion

2005 • 243 citations

CD27, a Member of the Tumor Necrosis Factor Receptor Superfamily, Activates NF-κB and Stress-activated Protein Kinase/c-Jun N-terminal Kinase via TRAF2, TRAF5, and NF-κB-inducing Kinase

1998 • 239 citations

Costimulation via OX40L Expressed by B Cells Is Sufficient to Determine the Extent of Primary CD4 Cell Expansion and Th2 Cytokine Secretion In Vivo

2003 • 235 citations

CD4+CD3− Accessory Cells Costimulate Primed CD4 T Cells through OX40 and CD30 at Sites Where T Cells Collaborate with B Cells

2003 • 226 citations

The costimulation-regulated duration of PKB activation controls T cell longevity

2004 • 208 citations

The function of TRADD in signaling through tumor necrosis factor receptor 1 and TRIF-dependent Toll-like receptors

2008 • 207 citations

CD4 T cell traffic control:in vivo evidence that ligation of OX40 on CD4 T cells by OX40-ligand expressed on dendritic cells leads to the accumulation of CD4 T cells in B follicles

1999 • 190 citations

Activation of OX40 Signal Transduction Pathways Leads to Tumor Necrosis Factor Receptor-associated Factor (TRAF) 2- and TRAF5-mediated NF-κB Activation

1998 • 181 citations

CD30/TNF receptor-associated factor interaction: NF-kappa B activation and binding specificity.

1996 • 173 citations

The α and β Subunits of IκB Kinase (IKK) Mediate TRAF2-Dependent IKK Recruitment to Tumor Necrosis Factor (TNF) Receptor 1 in Response to TNF

2001 • 149 citations

IL-15-Dependent Induction of 4-1BB Promotes Antigen-Independent CD8 Memory T Cell Survival

2006 • 140 citations

Multifunctional roles for MALT1 in T-cell activation

2008 • 120 citations

Activation of NF-κB1 by OX40 Contributes to Antigen-Driven T Cell Expansion and Survival

2008 • 111 citations

OX40-OX40 Ligand Interaction through T Cell-T Cell Contact Contributes to CD4 T Cell Longevity

2006 • 100 citations

Dynamic regulation of T‐cell costimulation through TCR–CD28 microclusters

2009 • 90 citations

OX40-Mediated Memory T Cell Generation Is TNF Receptor-Associated Factor 2 Dependent

2003 • 76 citations

Cross-Linking of 4-1BB Activates TCR-Signaling Pathways in CD8+ T Lymphocytes

2005 • 64 citations

Differential Requirements for OX40 Signals on Generation of Effector and Central Memory CD4+ T Cells

2007 • 64 citations

Differential requirement of MALT1 for BAFF-induced outcomes in B cell subsets

2009 • 58 citations

Selective regulation by δ-PKC and PI 3-kinase in the assembly of the antiapoptotic TNFR-1 signaling complex in neutrophils

2004 • 56 citations

TRAF4 functions as an intermediate of GITR-induced NF-?B activation

2004 • 54 citations

Activation of NF‐kB1 by OX40 contributes to antigen‐driven T cell expansion and survival

2008 • 50 citations