Cutting Edge: OX40 Agonists Can Drive Regulatory T Cell Expansion if the Cytokine Milieu Is Right

Conversion of Peripheral CD4+CD25− Naive T Cells to CD4+CD25+ Regulatory T Cells by TGF-β Induction of Transcription Factor Foxp3

2003 • 4,529 citations

TGFβ in the Context of an Inflammatory Cytokine Milieu Supports De Novo Differentiation of IL-17-Producing T Cells

2006 • 3,545 citations

CD4+CD25+ Immunoregulatory T Cells Suppress Polyclonal T Cell Activation In Vitro by Inhibiting Interleukin 2 Production

1998 • 2,658 citations

OX40 Promotes Bcl-xL and Bcl-2 Expression and Is Essential for Long-Term Survival of CD4 T Cells

2001 • 638 citations

Ox-40 Ligand: A Potent Costimulatory Molecule for Sustaining Primary CD4 T Cell Responses

1998 • 515 citations

Triggering of OX40 (CD134) on CD4+CD25+ T cells blocks their inhibitory activity: a novel regulatory role for OX40 and its comparison with GITR

2005 • 406 citations

OX40 costimulation turns off Foxp3+ Tregs

2007 • 398 citations

Expansion and function of Foxp3-expressing T regulatory cells during tuberculosis

2007 • 395 citations

Therapeutic targeting of the effector T-cell co-stimulatory molecule OX40

2004 • 320 citations

Distinct Roles for the OX40-OX40 Ligand Interaction in Regulatory and Nonregulatory T Cells

2004 • 305 citations

Blocking OX-40/OX-40 Ligand Interaction In Vitro and In Vivo Leads to Decreased T Cell Function and Amelioration of Experimental Allergic Encephalomyelitis

1999 • 250 citations

Antagonistic nature of T helper 1/2 developmental programs in opposing peripheral induction of Foxp3 ⁺ regulatory T cells

2007 • 236 citations

Cutting Edge: OX40 Inhibits TGF-β- and Antigen-Driven Conversion of Naive CD4 T Cells into CD25+Foxp3+ T cells

2007 • 202 citations

Complete Freund's adjuvant-induced T cells prevent the development and adoptive transfer of diabetes in nonobese diabetic mice.

1993 • 176 citations

Foxp3+ regulatory T cells in the control of experimental CNS autoimmune disease

2008 • 163 citations

Male SJL mice do not relapse after induction of EAE with PLP 139-151

1996 • 114 citations

Critical Involvement of OX40 Ligand Signals in the T Cell Priming Events During Experimental Autoimmune Encephalomyelitis

2001 • 108 citations

Engagement of OX40 Enhances Antigen-Specific CD4+ T Cell Mobilization/Memory Development and Humoral Immunity: Comparison of αOX-40 with αCTLA-4

2001 • 99 citations

Vaccination with dendritic cells pulsed with apoptotic tumors in combination with anti‐OX40 and anti‐4‐1BB monoclonal antibodies induces T cell–mediated protective immunity in Her‐2/neu transgenic mice

2005 • 93 citations

Antagonism of Airway Tolerance by Endotoxin/Lipopolysaccharide through Promoting OX40L and Suppressing Antigen-Specific Foxp3+ T Regulatory Cells

2008 • 72 citations

IL-12 Is Required for Anti-OX40-Mediated CD4 T Cell Survival

2008 • 69 citations

OX40/OX40L Costimulation Affects Induction of Foxp3+ Regulatory T Cells in Part by Expanding Memory T Cells In Vivo

2008 • 61 citations

OX‐40 antibody enhances for autoantigen specific Vβ8.2⁺ T cells within the spinal cord of lewis rats with autoimmune encephalomyelitis

1996 • 41 citations