CD154 is a negative regulator of autoaggressive CD8 + T cells in type 1 diabetes

Signaling by intrathymic cytokines, not T cell antigen receptors, specifies CD8 lineage choice and promotes the differentiation of cytotoxic-lineage T cells

2010 • 5,969 citations

T-cell help for cytotoxic T lymphocytes is mediated by CD40–CD40L interactions

1998 • 2,615 citations

Cytotoxic T Lymphocyte–Associated Antigen 4 Plays an Essential Role in the Function of Cd25+Cd4+ Regulatory Cells That Control Intestinal Inflammation

2000 • 2,211 citations

Help for cytotoxic-T-cell responses is mediated by CD40 signalling

1998 • 2,106 citations

B7/CD28 Costimulation Is Essential for the Homeostasis of the CD4+CD25+ Immunoregulatory T Cells that Control Autoimmune Diabetes

2000 • 2,090 citations

An Essential Role for Interleukin 10 in the Function of Regulatory T Cells That Inhibit Intestinal Inflammation

1999 • 1,607 citations

Immunologic self-tolerance maintained by CD25+CD4+ naturally anergic and suppressive T cells: induction of autoimmune disease by breaking their anergic/suppressive state.

1998 • 1,579 citations

CD40 AND CD154 IN CELL-MEDIATED IMMUNITY

1998 • 1,546 citations

CD4+CD25+ Immunoregulatory T Cells

2002 • 1,434 citations

A critical role for transforming growth factor-beta but not interleukin 4 in the suppression of T helper type 1-mediated colitis by CD45RB(low) CD4+ T cells.

1996 • 909 citations

CD4+CD25+ T Cells Inhibit Both the Induction and Effector Function of Autoreactive T Cells and Represent a Unique Lineage of Immunoregulatory Cells

1998 • 893 citations

Mice deficient for the CD40 ligand

1994 • 753 citations

The Nonobese Diabetic Mouse as a Model of Autoimmune Diabetes: Immune Dysregulation Gets the NOD

1997 • 685 citations

Antigen-dependent Proliferation of CD4+ CD25+ Regulatory T Cells In Vivo

2003 • 600 citations

B cells and professional APCs recruit regulatory T cells via CCL4

2001 • 496 citations

CD4 ⁺ CD25 ⁺ T regulatory cells control anti-islet CD8 ⁺ T cells through TGF-β–TGF-β receptor interactions in type 1 diabetes

2003 • 439 citations

Requirement for CD40 Ligand in Costimulation Induction, T Cell Activation, and Experimental Allergic Encephalomyelitis

1996 • 425 citations

TGF-β regulatesin vivoexpansion of Foxp3-expressing CD4⁺CD25⁺regulatory T cells responsible for protection against diabetes

2004 • 425 citations

Long-term survival and function of intrahepatic islet allografts in rhesus monkeys treated with humanized anti-CD154

1999 • 418 citations

Pancreatic Lymph Node-Derived CD4+CD25+ Treg Cells

2002 • 312 citations

CD40 Ligation Releases Immature Dendritic Cells from the Control of Regulatory CD4+CD25+ T Cells

2003 • 292 citations

CD40 ligand-CD40 interactions are necessary for the initiation of insulitis and diabetes in nonobese diabetic mice.

1997 • 244 citations

Local Expression of TNFα in Neonatal NOD Mice Promotes Diabetes by Enhancing Presentation of Islet Antigens

1998 • 195 citations

Viral and Bacterial Infections Interfere with Peripheral Tolerance Induction and Activate CD8+ T Cells to Cause Immunopathology

1998 • 161 citations

CD40L Blockade Prevents Autoimmune Diabetes by Induction of Bitypic NK/DC Regulatory Cells

2002 • 159 citations

Fc-dependent depletion of activated T cells occurs through CD40L-specific antibody rather than costimulation blockade

2003 • 139 citations

Induction of bcl-x by CD40 engagement rescues sIg-induced apoptosis in murine B cells.

1995 • 129 citations

Expression of CD40 identifies a unique pathogenic T cell population in type 1 diabetes

2002 • 117 citations

The Temporal Importance of TNFα Expression in the Development of Diabetes

2000 • 99 citations

THE CD154-CD40 COSTIMULATORY PATHWAY IN TRANSPLANTATION

2002 • 95 citations

Blockade of CD40 Ligand Suppresses Chronic Experimental Myasthenia Gravis by Down-Regulation of Th1 Differentiation and Up-Regulation of CTLA-4

2001 • 88 citations

Pancreatic Infiltration But Not Diabetes Occurs in the Relative Absence of MHC Class II-Restricted CD4 T Cells: Studies Using NOD/CIITA-Deficient Mice

1999 • 71 citations

Neonatal Tumor Necrosis Factor α Promotes Diabetes in Nonobese Diabetic Mice by Cd154-Independent Antigen Presentation to Cd8+ T Cells

2000 • 69 citations

Evidence for a novel function of the CD40 ligand as a signalling molecule in T‐lymphocytes

1997 • 59 citations

Prolonged Survival of Rat Islet and Skin Xenografts in Mice Treated with Donor Splenocytes and Anti-CD154 Monoclonal Antibody

1998 • 47 citations

CD154-Dependent Priming of Diabetogenic CD4+ T Cells Dissociated from Activation of Antigen-Presenting Cells

2002 • 43 citations

The Immunobiology of Inductive Anti-CD40L Therapy in Transplantation: Allograft Acceptance is Not Dependent Upon the Deletion of Graft-Reactive T Cells

2002 • 41 citations

Increased expression of CD40 on thymocytes and peripheral T cells in autoimmunity: a mechanism for acquiring changes in the peripheral T cell receptor repertoire.

1999 • 37 citations

Functional CD40 on B lymphocytes and dendritic cells

1994 • 35 citations

Role of TNF-alpha in the development of autoimmunity and the pathogenesis of insulin-dependent diabetes mellitus in NOD mice.

1994 • 18 citations

Imprint of Thymic Selection on Autoreactive Repertoires

1990 • 12 citations

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