Activation of the alpha subunit of Gs in intact cells alters its abundance, rate of degradation, and membrane avidity.

Cleavage of Structural Proteins during the Assembly of the Head of Bacteriophage T4

1970 • 253,849 citations

Short-Term Effects of Nose-Only Cigarette Smoke Exposure on Glutathione Redox Homeostasis, Cytochrome P450 1A1/2 and Respiratory Enzyme Activities in Mice Tissues

2013 • 47,043 citations

A highly sensitive adenylate cyclase assay

1974 • 4,213 citations

General method for the rapid solid-phase synthesis of large numbers of peptides: specificity of antigen-antibody interaction at the level of individual amino acids.

1985 • 1,650 citations

GTPase inhibiting mutations activate the α chain of Gs and stimulate adenylyl cyclase in human pituitary tumours

1989 • 1,405 citations

G Proteins: A Family of Signal Transducers

1986 • 975 citations

Immunogenic structure of the influenza virus hemagglutinin

1982 • 759 citations

Relationship between the beta-adrenergic receptor and adenylate cyclase.

1977 • 497 citations

G Proteins in Signal Transduction

1990 • 479 citations

G proteins control diverse pathways of transmembrane signaling ¹

1989 • 399 citations

Molecular basis for two forms of the G protein that stimulates adenylate cyclase.

1986 • 319 citations

Dynamic fatty acylation of p21N-ras.

1987 • 309 citations

Selection of a Variant Lymphoma Cell Deficient in Adenylate Cyclase

1975 • 276 citations

Expression of Gsα in Escherichia coli

1989 • 262 citations

The purified alpha subunits of Go and Gi from bovine brain require beta gamma for association with phospholipid vesicles.

1986 • 253 citations

Identification of receptor contact site involved in receptor–G protein coupling

1987 • 249 citations

Synthesis in Escherichia coli of GTPase-deficient mutants of Gsα

1989 • 247 citations

Amino acid sequence of retinal transducin at the site ADP-ribosylated by cholera toxin.

1984 • 235 citations

Molecular Cloning of Complementary DNA for the Alpha Subunit of the G Protein that Stimulates Adenylate Cyclase

1985 • 209 citations

Mutations of Gs α Designed to Alter the Reactivity of the Protein with Bacterial Toxins

1989 • 177 citations

A mutation that prevents GTP-dependent activation of the α chain of Gs

1988 • 176 citations

The G226A mutant of Gs alpha highlights the requirement for dissociation of G protein subunits.

1992 • 148 citations

Cross-regulation between G-protein-mediated pathways. Stimulation of adenylyl cyclase increases expression of the inhibitory G-protein, Gi alpha 2.

1990 • 140 citations

Stoichiometry of receptor‐G _s ‐adenylate cyclase interactions

1991 • 139 citations

Stimulation of beta-adrenergic receptors of S49 lymphoma cells redistributes the alpha subunit of the stimulatory G protein between cytosol and membranes.

1989 • 135 citations

Pancreatic beta cells express two autoantigenic forms of glutamic acid decarboxylase, a 65-kDa hydrophilic form and a 64-kDa amphiphilic form which can be both membrane-bound and soluble.

1991 • 118 citations

Cholera Toxin Induces cAMP-independent Degradation of Gs

1989 • 104 citations

Time-dependent decreases in binding affinity of agonists for beta-adrenergic receptors of intact S49 lymphoma cells. A mechanism of desensitization.

1983 • 85 citations

Prostaglandin E1-mediated, cyclic AMP-independent, down-regulation of Gs alpha in neuroblastoma x glioma hybrid cells.

1990 • 81 citations

Quantitation of the guanine nucleotide binding regulatory protein Gs in S49 cell membranes using antipeptide antibodies to alpha s.

1988 • 78 citations

Biogenesis of the avian erythroid membrane skeleton: receptor-mediated assembly and stabilization of ankyrin (goblin) and spectrin.

1984 • 66 citations

Translocation of alpha subunits of stimulatory guanine nucleotide-binding proteins through stimulation of the prostacyclin receptor in mouse mastocytoma cells.

1992 • 44 citations

α‐Subunits of N_s are released from the plasma membrane following cholera toxin activation

1986 • 41 citations

Novel S49 lymphoma variants with aberrant cyclic AMP metabolism.

1981 • 40 citations

Hormone-sensitive adenylate cyclase. Mutant phenotype with normally regulated beta-adrenergic receptors uncoupled with catalytic adenylate cyclase.

1981 • 37 citations