Crystal Structure of the Catalytic Domains of Adenylyl Cyclase in a Complex with G _sα ·GTPγS

PROCHECK: a program to check the stereochemical quality of protein structures

1993 • 23,689 citations

Improved methods for building protein models in electron density maps and the location of errors in these models

1991 • 12,831 citations

The interpretation of protein structures: Estimation of static accessibility

1971 • 5,771 citations

AMoRe: an automated package for molecular replacement

1994 • 4,990 citations

Free R value: a novel statistical quantity for assessing the accuracy of crystal structures

1992 • 3,863 citations

X-PLOR Version 3.1: A System for X-ray Crystallography and NMR

1992 • 3,488 citations

The 2.0 Å crystal structure of a heterotrimeric G protein

1996 • 1,118 citations

Complexity and Diversity of Mammalian Adenylyl Cyclases

1996 • 857 citations

Structures of active conformations of Gi alpha 1 and the mechanism of GTP hydrolysis

1994 • 823 citations

Adenylyl Cyclase Amino Acid Sequence: Possible Channel- or Transporter-Like Structure

1989 • 745 citations

GTPase mechanism of Gproteins from the 1.7-Å crystal structure of transducin α - GDP AIF−4

1994 • 564 citations

Loops in Globular Proteins: A Novel Category of Secondary Structure

1986 • 533 citations

Structure of the adenylyl cyclase catalytic core

1997 • 388 citations

Distinct patterns of bidirectional regulation of mammalian adenylyl cyclases.

1994 • 351 citations

Crystal Structure of the Adenylyl Cyclase Activator G _{s α}

1997 • 310 citations

Molecular and functional diversity of mammalian G _s ‐stimulated adenylyl cyclases

1993 • 295 citations

Molecular cloning and characterization of a Ca2+/calmodulin-insensitive adenylyl cyclase from rat brain.

1991 • 286 citations

A Region of Adenylyl Cyclase 2 Critical for Regulation by G Protein βγ Subunits

1995 • 276 citations

Substrate-assisted catalysis as a mechanism for GTP hydrolysis of p21ras and other GTP-binding proteins

1995 • 273 citations

Isolation and characterization of a novel cardiac adenylylcyclase cDNA.

1992 • 263 citations

Molecular cloning and expression of cDNAs coding for soluble guanylate cyclase from rat lung.

1990 • 220 citations

SIGNAL TRANSDUCTION BY GUANYLYL CYCLASES

1991 • 217 citations

Construction of a Soluble Adenylyl Cyclase Activated by G _s α and Forskolin

1995 • 188 citations

Structural basis for transfer RNA aminoacylation by Escherichia coli glutaminyl-tRNA synthetase

1993 • 186 citations

Evolutionarily conserved Galphabetagamma binding surfaces support a model of the G protein-receptor complex.

1996 • 181 citations

Identification of effector-activating residues of Gsα

1992 • 180 citations

Interaction of Gsα with the Cytosolic Domains of Mammalian Adenylyl Cyclase

1997 • 178 citations

Calmodulin-regulated adenylyl cyclases and neuromodulation

1997 • 138 citations

The Catalytic Mechanism of Mammalian Adenylyl Cyclase

1997 • 134 citations

Two Cytoplasmic Domains of Mammalian Adenylyl Cyclase Form a GSα- and Forskolin-activated Enzyme in Vitro

1996 • 129 citations

Interaction of the two cytosolic domains of mammalian adenylyl cyclase.

1996 • 129 citations

Truncation and Alanine-Scanning Mutants of Type I Adenylyl Cyclase

1995 • 127 citations

Expression of cDNAs for G proteins in Escherichia coli. Two forms of Gs alpha stimulate adenylate cyclase.

1987 • 111 citations

Purification and Characterization of a Soluble Form of Mammalian Adenylyl Cyclase

1996 • 92 citations

Expression and analysis of Gs alpha mutants with decreased ability to activate adenylylcyclase

1991 • 79 citations

Stereochemical course of the reaction catalyzed by guanylate cyclase from bovine retinal rod outer segments.

1990 • 70 citations

Stereochemistry of the mammalian adenylate cyclase reaction.

1981 • 58 citations

A surface on the G protein β-subunit involved in interactions with adenylyl cyclases

1997 • 53 citations

Mechanism of the adenylate cyclase reaction. Stereochemistry of the reaction catalyzed by the enzyme from Brevibacterium liquefaciens.

1980 • 53 citations

Three Discrete Regions of Mammalian Adenylyl Cyclase Form a Site for Gsα Activation

1997 • 51 citations

The stereochemical course of the reaction catalyzed by soluble bovine lung guanylate cyclase.

1983 • 41 citations

Characterization and crystallization of a minimal catalytic core domain from mammalian type II adenylyl cyclase

1997 • 24 citations