The state of the union: the cell biology of fertilization

The Physiology of Reproduction

1988 • 7,765 citations

Soluble Adenylyl Cyclase as an Evolutionarily Conserved Bicarbonate Sensor

2000 • 831 citations

Mammalian sperm-egg interaction: Identification of a glycoprotein in mouse egg zonae pellucidae possessing receptor activity for sperm

1980 • 704 citations

Repetitive calcium transients and the role of calcium in exocytosis and cell cycle activation in the mouse egg

1992 • 693 citations

Comparative Biology of Calcium Signaling during Fertilization and Egg Activation in Animals

1999 • 692 citations

A potential fusion peptide and an integrin ligand domain in a protein active in sperm–egg fusion

1992 • 680 citations

Requirement of CD9 on the Egg Plasma Membrane for Fertilization

2000 • 658 citations

TRPC1, a human homolog of a Drosophila store-operated channel.

1995 • 623 citations

Severely Reduced Female Fertility in CD9-Deficient Mice

2000 • 622 citations

O-linked oligosaccharides of mouse egg ZP3 account for its sperm receptor activity

1985 • 587 citations

The ADAM gene family: surface proteins with adhesion and protease activity

2000 • 582 citations

TRP Channel Proteins and Signal Transduction

2002 • 571 citations

Fertilization Defects in Sperm from Mice Lacking Fertilin β

1998 • 497 citations

The gamete fusion process is defective in eggs of Cd9-deficient mice

2000 • 476 citations

Mouse egg integrin α6β1functions as a sperm receptor

1995 • 472 citations

A profile of fertilization in mammals

2001 • 387 citations

Calcium oscillations in mammalian eggs triggered by a soluble sperm protein

1996 • 385 citations

Specific tetraspanin functions

2001 • 380 citations

Egg Activation at Fertilization: Where It All Begins

2002 • 361 citations

Evolution of Gamete Recognition Proteins

1998 • 355 citations

Novel signaling pathways involved in sperm acquisition of fertilizing capacity

2002 • 345 citations

The Family of Guanylyl Cyclase Receptors and Their Ligands

1994 • 335 citations

Exocytosis in spermatozoa in response to progesterone and zona pellucida

1994 • 328 citations

Hyperactivation of mammalian spermatozoa: function and regulation

2001 • 321 citations

Trp2 regulates entry of Ca2+ into mouse sperm triggered by egg ZP3

2001 • 313 citations

Cholesterol Efflux-Mediated Signal Transduction in Mammalian Sperm: Cholesterol Release Signals an Increase in Protein Tyrosine Phosphorylation during Mouse Sperm Capacitation

1999 • 297 citations

Fertilization and Development of Mouse Oocytes Injected with Isolated Sperm Heads1

1996 • 279 citations

Mouse trp2, the homologue of the human trpc2 pseudogene, encodes mTrp2, a store depletion-activated capacitative Ca ²⁺ entry channel

1999 • 278 citations

2 Molecular Basis of Mammalian Egg Activation

1995 • 276 citations

Autoradiographic visualization of the mouse egg's sperm receptor bound to sperm.

1986 • 276 citations

Inositol 1,4,5-trisphosphate receptors selectively localized to the acrosomes of mammalian sperm.

1995 • 272 citations

The Molecular Basis of Sperm Capacitation

1998 • 267 citations

Analysis of Loss of Adhesive Function in Sperm Lacking Cyritestin or Fertilin β

2001 • 258 citations

The Molecules of Mammalian Fertilization

1996 • 239 citations

An adhesion-associated agonist from the zona pellucida activates G protein-promoted elevations of internal Ca2+ and pH that mediate mammalian sperm acrosomal exocytosis

1989 • 238 citations

Activation of mouse sperm T-type Ca ²⁺ channels by adhesion to the egg zona pellucida

1996 • 228 citations

Male Mice Deficient for Germ-Cell Cyritestin Are Infertile1

1999 • 226 citations

Role of the integrin-associated protein CD9 in binding between sperm ADAM 2 and the egg integrin α6β1: Implications for murine fertilization

1999 • 223 citations

Control of the low voltage-activated calcium channel of mouse sperm by egg ZP3 and by membrane hyperpolarization during capacitation

1999 • 223 citations

Analysis of Mouse Oocyte Activation Suggests the Involvement of Sperm Perinuclear Material1

1998 • 216 citations

Requirement of Phospholipase Cδ4 for the Zona Pellucida-Induced Acrosome Reaction

2001 • 202 citations

Sequential Focal and Global Elevations of Sperm Intracellular Ca2+ Are Initiated by the Zona Pellucida during Acrosomal Exocytosis

1994 • 200 citations

Cyclic Nucleotide-gated Channels on the Flagellum Control Ca2+ Entry into Sperm

1998 • 186 citations

Normal Fertilization Occurs with Eggs Lacking the Integrin α6β1 and Is Cd9-Dependent

2000 • 178 citations

Repetitive sperm-induced Ca2+ transients in mouse oocytes are cell cycle dependent

1995 • 177 citations

Identification of mouse trp homologs and lipid rafts from spermatogenic cells and sperm

2001 • 174 citations

A Sperm Membrane Protein That Binds in a Species-specific Manner to the Egg Extracellular Matrix Is Homologous to von Willebrand Factor

1995 • 173 citations

NO is necessary and sufficient for egg activation at fertilization

2000 • 172 citations

Why did the Sperm Cross the Cumulus? To Get to the Oocyte. Functions of the Sperm Surface Proteins PH-20 and Fertilin in Arriving at, and Fusing With, the Egg1

1997 • 171 citations

Functional Classification of ADAMs Based on a Conserved Motif for Binding to Integrin α9β1

2002 • 159 citations

Activation of a G Protein Complex by Aggregation of β-1,4-Galactosyltransferase on the Surface of Sperm

1995 • 154 citations

Fertilin β and other ADAMs as integrin ligands: insights into cell adhesion and fertilization

2001 • 145 citations

ZP3-dependent activation of sperm cation channels regulates acrosomal secretion during mammalian fertilization.

1996 • 140 citations

Calcium Release at Fertilization in Starfish Eggs Is Mediated by Phospholipase Cγ

1997 • 139 citations

SH2 Domain-Mediated Activation of Phospholipase Cγ Is Not Required to Initiate Ca2+Release at Fertilization of Mouse Eggs

1998 • 139 citations

Inactivation of the mouse sperm receptor, mZP3, by site-directed mutagenesis of individual serine residues located at the combining site for sperm

1998 • 136 citations

Development of ability to penetrate the cumulus oophorus by hamster spermatozoa capacitated in vitro, in relation to the timing of the acrosome reaction

1986 • 125 citations

Molecularly cloned mammalian glucosamine-6-phosphate deaminase localizes to transporting epithelium and lacks oscillin activity

1998 • 122 citations

Sequence-Specific Interaction between the Disintegrin Domain of Mouse ADAM 3 and Murine Eggs: Role of β1 Integrin-associated Proteins CD9, CD81, and CD98

2001 • 122 citations

Residues SFQ (173-175) in the large extracellular loop of CD9 are required for gamete fusion

2002 • 120 citations

Involvement of Phospholipase Cγ1 in Mouse Egg Activation Induced by a Truncated Form of the C-kit Tyrosine Kinase Present in Spermatozoa

1998 • 114 citations

Mammalian Sperm Contain a Ca2+-Sensitive Phospholipase C Activity That Can Generate InsP3 from PIP2 Associated with Intracellular Organelles

2000 • 114 citations

Structural Analysis of Murine Zona Pellucida Glycans

2000 • 112 citations

Identification of PLCγ-Dependent and -Independent Events during Fertilization of Sea Urchin Eggs

1999 • 110 citations

Mediation of sperm-egg fusion: evidence that mouse egg α6β1 integrin is the receptor for sperm fertilinβ

1999 • 108 citations

Sperm Factor Induces Intracellular Free Calcium Oscillations by Stimulating the Phosphoinositide Pathway1

2001 • 107 citations

Aggregation of β-1,4-galactosyltransferase on mouse sperm induces the acrosome reaction

1991 • 102 citations

Roles of heterotrimeric and monomeric G proteins in sperm-induced activation of mouse eggs

1994 • 101 citations

Sequence-specific Interaction between the Disintegrin Domain of Mouse ADAM 2 (Fertilin β) and Murine Eggs

2000 • 100 citations

Calcium-triggered acrosomal exocytosis in human spermatozoa requires the coordinated activation of Rab3A and N -ethylmaleimide-sensitive factor

2000 • 94 citations

Requirement of a Src Family Kinase for Initiating Calcium Release at Fertilization in Starfish Eggs

1999 • 94 citations

Sperm extract injection into ascidian eggs signals Ca2+ release by the same pathway as fertilization

2000 • 94 citations

Activation of mouse sperm phosphatidylinositol-4,5 bisphosphate-phospholipase C by zona pellucida is modulated by tyrosine phosphorylation

1996 • 93 citations

Species-specific binding of sperm proteins to the extracellular matrix (zona pellucida) of the egg.

1994 • 91 citations

Activation of Xenopus Eggs by RGD-Containing Peptides Accompanied by Intracellular Ca 2+ Release

1996 • 90 citations

Sperm disintegrins, egg integrins, and other cell adhesion molecules of mammalian gamete plasma membrane interactions

1999 • 88 citations

Structure and mRNA expression of a bovine trp homologue related to mammalian trp2 transcripts

1998 • 86 citations

Evidence that Gq family G proteins do not function in mouse egg activation at fertilization.

1998 • 83 citations

Membrane Fusion Is Induced by a Distinct Peptide Sequence of the Sea Urchin Fertilization Protein Bindin

1998 • 81 citations

Identification of Key Functional Amino Acids of the Mouse Fertilin β (ADAM2) Disintegrin Loop for Cell-Cell Adhesion during Fertilization

2000 • 80 citations

Evidence That Fertilization Activates Starfish Eggs by Sequential Activation of a Src-like Kinase and Phospholipase Cγ

2000 • 75 citations

Analysis of the Roles of RGD-Binding Integrins, α4/α9 Integrins, α6 Integrins, and CD9 in the Interaction of the Fertilin β (ADAM2) Disintegrin Domain with the Mouse Egg Membrane1

2002 • 75 citations

Selective activation of Gi1 and Gi2 in mouse sperm by the zona pellucida, the egg's extracellular matrix.

1994 • 74 citations

Evidence That a Starfish Egg Src Family Tyrosine Kinase Associates with PLC-γ1 SH2 Domains at Fertilization

1999 • 72 citations

Human glucosamine-6-phosphate isomerase, a homologue of hamster oscillin, does not appear to be involved in Ca2+ release in mammalian oocytes

1999 • 71 citations

Ability of Integrins to Mediate Fertilization, Intracellular Calcium Release, and Parthenogenetic Development in Bovine Oocytes1

2000 • 71 citations

Towards the Molecular Basis of Sperm and Egg Interaction during Mammalian Fertilization

2000 • 69 citations

The Exocytosis Regulatory Proteins Syntaxin and VAMP Are Shed from Sea Urchin Sperm during the Acrosome Reaction

1997 • 65 citations

In vitro fertilization by intracytoplasmic sperm injection

1999 • 64 citations

Voltage-Dependent Activation of Frog Eggs by a Sperm Surface Disintegrin Peptide

1998 • 63 citations

Evidence That Phospholipase C from the Sperm Is Not Responsible for Initiating Ca2+ Release at Fertilization in Mouse Eggs

2001 • 60 citations

Role of the Fyn Kinase in Calcium Release during Fertilization of the Sea Urchin Egg

2000 • 56 citations

Structure of the Main Saccharide Chain in the Acrosome Reaction-inducing Substance of the Starfish, Asterias amurensis

1997 • 53 citations

Simultaneous Measurement of Intracellular Nitric Oxide and Free Calcium Levels in Chordate Eggs Demonstrates That Nitric Oxide Has No Role at Fertilization

2001 • 52 citations

High Molecular Mass Egg Fucose Sulfate Polymer Is Required for Opening Both Ca2+ Channels Involved in Triggering the Sea Urchin Sperm Acrosome Reaction

2002 • 45 citations

Synaptotagmin VIII Is Localized to the Mouse Sperm Head and May Function in Acrosomal Exocytosis1

2002 • 45 citations

Analysis of Fertilin α (ADAM1)-mediated Sperm-Egg Cell Adhesion during Fertilization and Identification of an Adhesion-mediating Sequence in the Disintegrin-like Domain

2001 • 43 citations

Molecular Mechanisms Involved in Mammalian Gamete Fusion

2001 • 39 citations

Detection of progesterone receptors in human spermatozoa and their correlation with morphological and functional properties

2001 • 36 citations

The Crystal Structure of a Fusagenic Sperm Protein Reveals Extreme Surface Properties^,

2001 • 25 citations

Activation of mouse oocytes requires multiple sperm factors but not sperm PLCγ1

2000 • 17 citations

An Intimate Biochemistry: Egg-Regulated Acrosome Reactions of Mammalian Sperm

1999 • 14 citations

Maturation-promoting factor in the early days

1995 • 13 citations