Evidence That a Starfish Egg Src Family Tyrosine Kinase Associates with PLC-γ1 SH2 Domains at Fertilization

Cleavage of Structural Proteins during the Assembly of the Head of Bacteriophage T4

1970 • 253,849 citations

Electrophoretic transfer of proteins from polyacrylamide gels to nitrocellulose sheets: procedure and some applications.

1979 • 54,907 citations

SH2 domains recognize specific phosphopeptide sequences

1993 • 2,685 citations

Regulation, substrates and functions of src

1996 • 1,173 citations

SH2-Containing Phosphotyrosine Phosphatase as a Target of Protein-Tyrosine Kinases

1993 • 666 citations

Phospholipase C-γ1 and phosphatidylinositol 3 kinase are the downstream mediators of the PDGF receptor's mitogenic signal

1993 • 658 citations

PDGF stimulation of inositol phospholipid hydrolysis requires PLC-γ1 phosphorylation on tyrosine residues 783 and 1254

1991 • 583 citations

Block of Ca ²⁺ Wave and Ca ²⁺ Oscillation by Antibody to the Inositol 1,4,5-Trisphosphate Receptor in Fertilized Hamster Eggs

1992 • 493 citations

A cytosolic sperm factor stimulates repetitive calcium increases and mimics fertilization in hamster eggs

1990 • 456 citations

Point mutation in FGF receptor eliminates phosphatidylinositol hydrolysis without affecting mitogenesis

1992 • 438 citations

Point mutation of an FGF receptor abolishes phosphatidylinositol turnover and Ca2+ flux but not mitogenesis

1992 • 414 citations

Ciliary neurotrophic factor/leukemia inhibitory factor/interleukin 6/oncostatin M family of cytokines induces tyrosine phosphorylation of a common set of proteins overlapping those induced by other cytokines and growth factors

1994 • 359 citations

Lighting the fuse at fertilization

1993 • 328 citations

Inositol 1,4,5-trisphosphate microinjection activates sea urchin eggs

1984 • 316 citations

Phospholipase C-γ1 Interacts with Conserved Phosphotyrosyl Residues in the Linker Region of Syk and Is a Substrate for Syk

1996 • 230 citations

Tandem SH2 Domains Confer High Specificity in Tyrosine Kinase Signaling

1998 • 226 citations

Injection of a soluble sperm fraction into sea-urchin eggs triggers the cortical reaction

1985 • 211 citations

Phosphorylation of synthetic peptides by a tyrosine protein kinase from the particulate fraction of a lymphoma cell line.

1982 • 193 citations

GRB2 and Phospholipase C-7γ1 Associate with a 36- to 38-Kilodalton Phosphotyrosine Protein after T-Cell Receptor Stimulation

1994 • 181 citations

Tyrosine residues in bovine phospholipase C-gamma phosphorylated by the epidermal growth factor receptor in vitro.

1990 • 178 citations

The Role of Calcium Explosions, Waves, and Pulses in Activating Eggs

1985 • 164 citations

A synthetic peptide derived from p34cdc2 is a specific and efficient substrate of src-family tyrosine kinases.

1992 • 151 citations

Two phases of inositol polyphosphate and diacylglycerol production at fertilisation

1986 • 142 citations

SH2 Domain-Mediated Activation of Phospholipase Cγ Is Not Required to Initiate Ca2+Release at Fertilization of Mouse Eggs

1998 • 139 citations

Calcium Release at Fertilization in Starfish Eggs Is Mediated by Phospholipase Cγ

1997 • 139 citations

Requirement of phospholipase C gamma, the tyrosine phosphatase Syp and the adaptor proteins Shc and Nck for PDGF-induced DNA synthesis: evidence for the existence of Ras-dependent and Ras-independent pathways.

1996 • 136 citations

Fertilization Events Induced by Neurotransmitters After Injection of mRNA in Xenopus Eggs

1988 • 129 citations

Association of the tyrosine kinase LCK with phospholipase C-gamma 1 after stimulation of the T cell antigen receptor.

1992 • 125 citations

Identification of PLCγ-Dependent and -Independent Events during Fertilization of Sea Urchin Eggs

1999 • 110 citations

Requirement for Phospholipase C-γ1 Enzymatic Activity in Growth Factor-Induced Mitogenesis

1998 • 100 citations

Evidence for Both Tyrosine Kinase and G-Protein-Coupled Pathways Leading to Starfish Egg Activation

1994 • 97 citations

A rapid change in phosphorylation on tyrosine accompanies fertilization of sea urchin eggs

1991 • 90 citations

Evidence that Gq family G proteins do not function in mouse egg activation at fertilization.

1998 • 83 citations

Role of G proteins in mouse egg activation: Stimulatory effects of acetylcholine on the ZP2 to ZP2f conversion and pronuclear formation in eggs expressing a functional m1 muscarinic receptor

1992 • 81 citations

Ionic Signaling in the Sea Urchin Egg at Fertilization

1985 • 79 citations

Effect on Sperm-Induced Activation Current and Increase of Cytosolic Ca2+by Agents That Modify the Mobilization of [Ca2+]i

1995 • 70 citations

An SH3 domain is required for the mitogenic activity of microinjected phospholipase C‐γ1

1995 • 70 citations

Phosphatidylinositol metabolism during fertilization in the sea urchin egg

1985 • 70 citations

Phospholipase C-gamma 1 associates with viral and cellular src kinases

1993 • 69 citations

Highly Polarized EGF Receptor Tyrosine Kinase Activity Initiates Egg Activation in Xenopus

1994 • 63 citations

Effects of Protein Tyrosine Kinase Inhibitors on Egg Activation and Fertilization-Dependent Protein Tyrosine Kinase Activity

1995 • 63 citations

Identification of an abl-related protein tyrosine kinase in the cortex of the sea urchin egg: Possible role at fertilization

1994 • 55 citations

Association of p72 with the src Homology-2 (SH2) Domains of PLCγ1 in B Lymphocytes

1995 • 55 citations

Biphasic Activation of Fyn Kinase upon Fertilization of the Sea Urchin Egg

1996 • 53 citations

Recepter-mediated signal transduction and egg activation

1993 • 53 citations

Tyrosine Kinase Signaling at Fertilization

1997 • 48 citations

Protein tyrosine phosphorylation in response to fertilization.

1988 • 47 citations

Protein tyrosine kinase‐dependent release of intracellular calcium in the sea urchin egg

1999 • 47 citations

Activation by serotonin of starfish eggs expressing the rat serotonin 1c receptor.

1990 • 46 citations

A protein that is highly related to GTPase-activating protein-associated p62 complexes with phospholipase C gamma.

1994 • 42 citations

Protein tyrosine phosphorylation during sea urchin fertilization: Microtubule dynamics require tyrosine kinase activity

1995 • 40 citations

Egg Membranes during Fertilization

1996 • 39 citations

Protein tyrosine kinase activity of eggs of the sea urchin Strongylocentrotus purpuratus: The regulation of its increase after fertilization

1985 • 33 citations

Regulation of tyrosine-specific kinase activity at fertilization

1984 • 30 citations

The Protein Tyrosine Kinases of the Sea Urchin Anthocidaris crassispina

1997 • 23 citations

Anti‐peptide Antibody Identifies a 57 kDa Protein Tyrosine Kinase in the Sea Urchin Egg Cortex

1993 • 20 citations

Quantitation of a SRC-like tyrosine protein kinase during fertilization of the sea urchin egg

1986 • 19 citations

Fertilization promotes selective association of the Abl [correction of AbI] kinase with the egg cytoskeleton.

1996 • 17 citations

Protein Tyrosine Kinase Activity during Egg Activation Is Important for Morphogenesis at Gastrulation in the Sea Urchin Embryo

1995 • 14 citations

[34] Biochemical analysis of SH2 domain-mediated protein interactions

1995 • 14 citations

A diversity of enzymes involved in the regulation of reversible tyrosine phosphorylation in sea urchin eggs and embryos

1995 • 13 citations

Receptors, G-Proteins, and Egg Activation

1989 • 7 citations