The Molecules of Mammalian Fertilization

Integrins: Versatility, modulation, and signaling in cell adhesion

1992 • 9,986 citations

The Physiology of Reproduction

1988 • 7,765 citations

Traffic signals for lymphocyte recirculation and leukocyte emigration: The multistep paradigm

1994 • 7,068 citations

Integrins and Signal Transduction Pathways: the Road Taken

1995 • 3,002 citations

Membrane Fusion

1990 • 2,458 citations

Mechanisms of intracellular protein transport

1994 • 2,280 citations

A potential fusion peptide and an integrin ligand domain in a protein active in sperm–egg fusion

1992 • 680 citations

ADAM, a novel family of membrane proteins containing A Disintegrin And Metalloprotease domain: multipotential functions in cell-cell and cell-matrix interactions.

1995 • 507 citations

A metalloprotease-disintegrin participating in myoblast fusion

1995 • 492 citations

Regulation of growth factor activation by proteoglycans: What is the role of the low affinity receptors?

1995 • 478 citations

Mouse egg integrin α6β1functions as a sperm receptor

1995 • 472 citations

Complementarity between sperm surface β-l,4-galactosyl-transferase and egg-coat ZP3 mediates sperm–egg binding

1992 • 439 citations

Oocyte Galα1,3Gal Epitopes Implicated in Sperm Adhesion to the Zona Pellucida Glycoprotein ZP3 Are Not Required for Fertilization in the Mouse

1995 • 399 citations

Calcium oscillations in mammalian eggs triggered by a soluble sperm protein

1996 • 385 citations

Identification and purification of a sperm surface protein with a potential role in sperm-egg membrane fusion.

1987 • 368 citations

95 kd sperm proteins bind ZP3 and serve as tyrosine kinase substrates in response to zona binding

1989 • 341 citations

Identification of a secondary sperm receptor in the mouse egg zona pellucida: Role in maintenance of binding of acrosome-reacted sperm to eggs

1988 • 330 citations

Exocytosis in spermatozoa in response to progesterone and zona pellucida

1994 • 328 citations

Cloning and functional expression of a cyclic-nucleotide-gated channel from mammalian sperm

1994 • 312 citations

Cloning and mRNA expression analysis of a novel human protooncogene, c-mer.

1994 • 305 citations

Characterization of novel complexes on the cell surface between integrins and proteins with 4 transmembrane domains (TM4 proteins).

1996 • 274 citations

Inositol 1,4,5-trisphosphate receptors selectively localized to the acrosomes of mammalian sperm.

1995 • 272 citations

A hyaluronidase activity of the sperm plasma membrane protein PH-20 enables sperm to penetrate the cumulus cell layer surrounding the egg.

1994 • 270 citations

A role for the migrating sperm surface antigen PH-20 in guinea pig sperm binding to the egg zona pellucida.

1985 • 247 citations

Targeted disruption of the mZP3 gene results in production of eggs lacking a zona pellucida and infertility in female mice.

1996 • 246 citations

Molecular Events Mediating Sperm Activation

1993 • 242 citations

Identification of a binding site in the disintegrin domain of fertilin required for sperm-egg fusion.

1994 • 241 citations

Identification of a ZP3-binding protein on acrosome-intact mouse sperm by photoaffinity crosslinking.

1990 • 219 citations

Sequential Focal and Global Elevations of Sperm Intracellular Ca2+ Are Initiated by the Zona Pellucida during Acrosomal Exocytosis

1994 • 200 citations

Sperm attraction to a follicular factor(s) correlates with human egg fertilizability.

1991 • 187 citations

Interaction of the HIV-1 Fusion Peptide with Phospholipid Vesicles: Different Structural Requirements for Fusion and Leakage

1994 • 183 citations

Olfactory receptors are displayed on dog mature sperm cells.

1993 • 179 citations

p95, the major phosphotyrosine-containing protein in mouse spermatozoa, is a hexokinase with unique properties.

1994 • 178 citations

A Sperm Membrane Protein That Binds in a Species-specific Manner to the Egg Extracellular Matrix Is Homologous to von Willebrand Factor

1995 • 173 citations

Sperm-egg recognition in the mouse: characterization of sp56, a sperm protein having specific affinity for ZP3.

1994 • 165 citations

Sea Urchin Egg Receptor for Sperm: Sequence Similarity of Binding Domain and hsp70

1993 • 164 citations

Mouse sperm-egg plasma membrane interactions: analysis of roles of egg integrins and the mouse sperm homologue of PH-30 (fertilin) β

1995 • 157 citations

Regulation of mouse gamete interaction by a sperm tyrosine kinase.

1992 • 156 citations

Activation of a G Protein Complex by Aggregation of β-1,4-Galactosyltransferase on the Surface of Sperm

1995 • 154 citations

Photolabeling Identifies a Putative Fusion Domain in the Envelope Glycoprotein of Rabies and Vesicular Stomatitis Viruses

1995 • 149 citations

Molecular Mechanisms of Sperm-Egg Membrane Binding and Fusion in Mammals

1993 • 139 citations

Egg cortical granule N-acetylglucosaminidase is required for the mouse zona block to polyspermy.

1993 • 137 citations

Extraordinary divergence and positive Darwinian selection in a fusagenic protein coating the acrosomal process of abalone spermatozoa.

1995 • 130 citations

Plasma membrane association, purification, and partial characterization of mouse sperm beta 1,4-galactosyltransferase.

1988 • 111 citations

Biochemical Characterization of a Glycosylphosphatidylinositol-Linked Hyaluronidase on Mouse Sperm

1995 • 102 citations

Membrane Interaction and Conformational Properties of the Putative Fusion Peptide of PH-30, a Protein Active in Sperm-Egg Fusion

1994 • 89 citations

A specific defect in galactosyltransferase regulation on sperm bearing mutant alleles of the T/t locus

1979 • 88 citations

Towards molecular mechanisms for gamete adhesion and fusion during mammalian fertilization

1995 • 87 citations

Overexpressing sperm surface beta 1,4-galactosyltransferase in transgenic mice affects multiple aspects of sperm-egg interactions.

1994 • 84 citations

1 Sperm-Egg Recognition Mechanisms in Mammals

1995 • 84 citations

Selective activation of Gi1 and Gi2 in mouse sperm by the zona pellucida, the egg's extracellular matrix.

1994 • 74 citations

Membrane Fusion: The Influenza Paradigm

1995 • 70 citations

Fus2 localizes near the site of cell fusion and is required for both cell fusion and nuclear alignment during zygote formation.

1995 • 67 citations

Mouse Sperm Adenylyl Cyclase: General Properties and Regulation by the Zona Pellucida1

1995 • 66 citations

Delayed Translation and Posttranslational Processing of Cyritestin, an Integral Transmembrane Protein of the Mouse Acrosome

1995 • 65 citations

Molecular Genetics of Sexuality in Chlamydomonas

1995 • 63 citations

Inhibition of Zona Pellucida Gene Expression by Antisense Oligonucleotides Injected Into Mouse Oocytes

1995 • 50 citations

Properties and localization of a tyrosine phosphorylated form of hexokinase in mouse sperm

1996 • 48 citations

Monoclonal antibodies which recognize equatorial segment epitopes presented de novo following the a23187-induced acrosome reaction of guinea pig sperm

1995 • 46 citations

The Hexokinase Isoenzyme PII of Saccharomyces cerevisiae is a Protein Kinase

1989 • 45 citations

Egg Membranes during Fertilization

1996 • 39 citations

ATP-dependent regulation of flagellar adenylylcyclase in gametes of Chlamydomonas reinhardtii.

1991 • 36 citations

Echistatin, a disintegrin, inhibits sperm-oolemmal adhesion but not oocyte penetration

1995 • 32 citations

Distribution and Dynamics of Mouse Sperm Surface Galactosyltransferase: Implications for Mammalian Fertilization

1995 • 24 citations

LL95 monoclonal antibody mimics functional effects of ZP3 on mouse sperm: Evidence that the antigen recognized is not hexokinase

1995 • 22 citations

Sperm from mice carrying twot haplotypes do not possess a tyrosine phosphorylated form of hexokinase

1996 • 20 citations

Identification of Porcine Oocyte 55 kDa α and β Proteins within the Zona Pellucida Glycoprotein Families Indicates that Oocyte Sperm Receptor Activity is Associated with Different Zona Pellucida Proteins in Different Mammalian Species

1993 • 17 citations

Molecular cloning of a protein kinase whose phosphorylation is regulated by genetic adhesion during Chlamydomonas fertilization.

1996 • 16 citations

Na+Requirements for Capacitation

1994 • 13 citations