Inositol 1,4,5-trisphosphate receptors selectively localized to the acrosomes of mammalian sperm.

Inositol phosphates and cell signalling

1989 • 4,058 citations

Thapsigargin, a tumor promoter, discharges intracellular Ca2+ stores by specific inhibition of the endoplasmic reticulum Ca2(+)-ATPase.

1990 • 3,250 citations

Capacitative calcium entry revisited

1990 • 1,499 citations

Thapsigargin inhibits the sarcoplasmic or endoplasmic reticulum Ca-ATPase family of calcium pumps.

1991 • 1,282 citations

Na+/H+ exchange and growth factor-induced cytosolic pH changes. Role in cellular proliferation

1989 • 749 citations

Mammalian sperm-egg interaction: Identification of a glycoprotein in mouse egg zonae pellucidae possessing receptor activity for sperm

1980 • 704 citations

Mechanisms of regulation of the Na+/H+ exchanger

1986 • 685 citations

Solubilization, purification, and characterization of an inositol trisphosphate receptor.

1988 • 650 citations

Sperm-egg interactions in the mouse: Sequence of events and induction of the acrosome reaction by a zona pellucida glycoprotein

1983 • 603 citations

Calcium dependence of the acrosome reaction and activation of guinea pig spermatozoa

1974 • 587 citations

The ryanodine receptor/calcium channel genes are widely and differentially expressed in murine brain and peripheral tissues.

1995 • 551 citations

Characterization of inositol trisphosphate receptor binding in brain. Regulation by pH and calcium.

1987 • 551 citations

Purified inositol 1,4,5-trisphosphate receptor mediates calcium flux in reconstituted lipid vesicles

1989 • 512 citations

Block of Ca ²⁺ Wave and Ca ²⁺ Oscillation by Antibody to the Inositol 1,4,5-Trisphosphate Receptor in Fertilized Hamster Eggs

1992 • 493 citations

Ion channels in human neutrophils activated by a rise in free cytosolic calcium concentration

1986 • 489 citations

Progesterone and 17 alpha-hydroxyprogesterone. Novel stimulators of calcium influx in human sperm.

1990 • 485 citations

The pharmacology of intracellular Ca2+-release channels

1994 • 448 citations

Complementarity between sperm surface β-l,4-galactosyl-transferase and egg-coat ZP3 mediates sperm–egg binding

1992 • 439 citations

Differential immunohistochemical localization of inositol 1,4,5- trisphosphate- and ryanodine-sensitive Ca2+ release channels in rat brain

1993 • 435 citations

Steroid induced exocytosis: The human sperm acrosome reaction

1989 • 413 citations

95 kd sperm proteins bind ZP3 and serve as tyrosine kinase substrates in response to zona binding

1989 • 341 citations

Exocytosis in spermatozoa in response to progesterone and zona pellucida

1994 • 328 citations

Phosphatidylinositol 4,5-bisphosphate hydrolysis in human sperm stimulated with follicular fluid or progesterone is dependent upon Ca2+ influx

1989 • 318 citations

Cell surface-binding sites for progesterone mediate calcium uptake in human sperm.

1991 • 291 citations

Members of the Gq alpha subunit gene family activate phospholipase C beta isozymes.

1992 • 277 citations

A role for inositol triphosphate in intracellular Ca2+ mobilization and granule secretion in platelets.

1985 • 263 citations

An adhesion-associated agonist from the zona pellucida activates G protein-promoted elevations of internal Ca2+ and pH that mediate mammalian sperm acrosomal exocytosis

1989 • 238 citations

Activation of voltage-dependent calcium channels of mammalian sperm is required for zona pellucida-induced acrosomal exocytosis

1992 • 224 citations

IP ₃ Receptor: Localization to Plasma Membrane of T Cells and Cocapping with the T Cell Receptor

1992 • 213 citations

Sequential Focal and Global Elevations of Sperm Intracellular Ca2+ Are Initiated by the Zona Pellucida during Acrosomal Exocytosis

1994 • 200 citations

Depletion of the inositol 1,4,5-trisphosphate-sensitive intracellular Ca2+ store in vascular endothelial cells activates the agonist-sensitive Ca2+-influx pathway

1992 • 190 citations

Stereospecific inositol 1,4,5-[32P]trisphosphate binding to isolated rat liver nuclei: evidence for inositol trisphosphate receptor-mediated calcium release from the nucleus.

1990 • 188 citations

Activation of Ca2+ entry into acinar cells by a non-phosphorylatable inositol trisphosphate

1991 • 182 citations

Sperm-egg recognition in the mouse: characterization of sp56, a sperm protein having specific affinity for ZP3.

1994 • 165 citations

Evidence Suggesting Involvement of a Unique Human Sperm Steroid Receptor/Cl- Channel Complex in the Progesterone-Initiated Acrosome Reaction

1993 • 161 citations

Regulation of mouse gamete interaction by a sperm tyrosine kinase.

1992 • 156 citations

Evidence for the role of a guanine nucleotide-binding regulatory protein in the zona pellucida-induced mouse sperm acrosome reaction

1987 • 148 citations

Cloning and expression of a cAMP-activated Na+/H+ exchanger: evidence that the cytoplasmic domain mediates hormonal regulation.

1992 • 142 citations

Involvement of inositol 1,4,5-trisphosphate-mediated Ca2+release in early and late events of mouse egg activation

1994 • 134 citations

Calcium mobilization is required for nuclear vesicle fusion in vitro: Implications for membrane traffic and IP3 receptor function

1993 • 130 citations

Plasma membrane inositol 1,4,5-trisphosphate receptor of lymphocytes: selective enrichment in sialic acid and unique binding specificity.

1992 • 120 citations

Localization of the inositol 1,4,5-trisphosphate receptor in synaptic terminals in the vertebrate retina

1991 • 110 citations

Inositol 1,4,5-trisphosphate-triggered Ca2+ release from bovine adrenal medullary secretory vesicles.

1990 • 110 citations

Odorant Receptors and Desensitization Proteins Colocalize in Mammalian Sperm

1995 • 101 citations

Purification and characterization of the inositol 1,4,5-trisphosphate receptor protein from rat vas deferens

1990 • 92 citations

Inositol trisphosphate and thapsigargin discriminate endoplasmic reticulum stores of calcium in rat brain

1990 • 90 citations

An Endoplasmic Reticulum Protein, Calreticulin, Is Transported into the Acrosome of Rat Sperm

1993 • 90 citations

Comparison between the effects of the microsomal Ca2+-translocase inhibitors thapsigargin and 2,5-di-(t-butyl)-1,4-benzohydroquinone on cellular calcium fluxes

1991 • 89 citations

Localization of inositol trisphosphate receptor subtype 3 to insulin and somatostatin secretory granules and regulation of expression in islets and insulinoma cells.

1994 • 88 citations

Initiation of the human sperm acrosome reaction by thapsigargin

1993 • 88 citations

Differential sensitivity of progesterone‐ and zona pellucida‐induced acrosome reactions to pertussis toxin

1993 • 83 citations

How the Egg Regulates Sperm Function during Gamete Interaction: Facts and Fantasies1

1991 • 81 citations

Embryonal carcinoma cells transfected with ZP3 genes differentially glycosylate similar polypeptides and secrete active mouse sperm receptor.

1991 • 81 citations

Immunocytochemical and biochemical characterization of guanine nucleotide-binding regulatory proteins in mammalian spermatozoa

1991 • 80 citations

The calcium loading of secretory granules. A possible key event in stimulus‐secretion coupling

1992 • 74 citations

Selective activation of Gi1 and Gi2 in mouse sperm by the zona pellucida, the egg's extracellular matrix.

1994 • 74 citations

The fucose-sulfate glycoconjugate that induces an acrosome reaction in spermatozoa stimulates inositol 1,4,5-trisphosphate accumulation.

1988 • 74 citations

Isolation of the outer acrosomal membrane from bull sperm

1975 • 72 citations

Biphasic Ca2+ responses in human basophils. Evidence that the initial transient elevation associated with the mobilization of intracellular calcium is an insufficient signal for degranulation.

1993 • 59 citations

Localization of phosphatase activity on the membranes of the mammalian sperm head

1973 • 58 citations

Calcium pools mobilized by calcium or inositol 1,4,5-trisphosphate are differentially localized in rat heart and brain.

1992 • 56 citations

Na+-requiring mechanisms modulate capacitation and acrosomal exocytosis in mouse spermatozoa

1993 • 54 citations

Endpoint of first stage of zona pellucida‐induced acrosome reaction in mouse spermatozoa characterized by acrosomal H⁺ and Ca²⁺ permeability: Population and single cell kinetics

1989 • 50 citations

A plasma‐membrane progesterone receptor in human sperm is switched on by increasing intracellular free calcium

1993 • 48 citations

Calcium channels play a pivotal role in the sequence of ionic changes involved in initiation of mouse sperm acrosomal exocytosis

1993 • 48 citations

Stimulus–Secretion Coupling In Excitable Cells: A Central Role For Calcium

1993 • 46 citations

Agonist-induced activation of Na+/H+ exchange in rat parotid acinar cells

1989 • 45 citations

Calcium release and internal calcium regulation in acinar cells of exocrine glands

1991 • 45 citations

A transient rise in intracellular Ca²⁺ is a precursor reaction to the zona pellucida‐induced acrosome reaction in mouse sperm and is blocked by the induced acrosome reaction inhibitor 3‐quinuclidinyl benzilate

1992 • 43 citations

Rapid secretagogue-induced activation of Na+H+ exchange in rat parotid acinar cells. Possible interrelationship between volume regulation and stimulus-secretion coupling

1991 • 42 citations

Thapsigargin defines the roles of cellular calcium in secretagogue-stimulated enzyme secretion from pancreatic acini.

1992 • 41 citations

Effects of tannic acid on antigenicity and membrane contrast in ultrastructural immunocytochemistry.

1992 • 37 citations

Identification of phosphatases on the membranes of guinea pig sperm

1978 • 34 citations

Influence of external calcium ions on labelled calcium efflux from pancreatic beta‐cells and insulin granules in mice.

1981 • 29 citations

Diacylglycerol in the exocytosis of the mammalian sperm acrosome

1993 • 28 citations

G-protein Specificity in Signaling Pathways That Mobilize Calcium in Insulin-Secreting β-TC3 Cells

1993 • 22 citations

Rat sperm enzymes during epididymal transit

1982 • 17 citations

Na+Requirements for Capacitation

1994 • 13 citations

Spatial Aspects of Ca2+Signalling in Pancreatic Acinar Cells

1993 • 11 citations

Ontogeny of mitochondrial calcium transport in spontaneously hypertensive (SHR) and WKY rats.

1990 • 6 citations