Identification of PLCγ-Dependent and -Independent Events during Fertilization of Sea Urchin Eggs

Cleavage of Structural Proteins during the Assembly of the Head of Bacteriophage T4

1970 • 253,849 citations

G proteins

1992 • 871 citations

Regulation of Phosphoinositide-specific Phospholipase C Isozymes

1997 • 866 citations

Binding of SH2 Domains of Phospholipase Cγ1, GAP, and Src to Activated Growth Factor Receptors

1990 • 608 citations

Intracellular pH and activation of sea urchin eggs after fertilisation

1976 • 561 citations

Intracellular calcium release at fertilization in the sea urchin egg

1977 • 523 citations

Block of Ca ²⁺ Wave and Ca ²⁺ Oscillation by Antibody to the Inositol 1,4,5-Trisphosphate Receptor in Fertilized Hamster Eggs

1992 • 493 citations

Activation of Sea-Urchin Eggs by a Calcium Ionophore

1974 • 454 citations

Regulation of purified subtypes of phosphatidylinositol-specific phospholipase C beta by G protein alpha and beta gamma subunits

1993 • 444 citations

Epidermal growth factor receptor-mediated cell motility: phospholipase C activity is required, but mitogen-activated protein kinase activity is not sufficient for induced cell movement.

1994 • 333 citations

Redundant Mechanisms of Calcium-Induced Calcium Release Underlying Calcium Waves During Fertilization of Sea Urchin Eggs

1993 • 313 citations

Sources of calcium in egg activation: A review and hypothesis

1983 • 309 citations

Activation of phospholipase C isozymes by G protein beta gamma subunits.

1993 • 306 citations

Direct measurement of intracellular pH during metabolic derepression of the sea urchin egg

1978 • 300 citations

Calcium Mobilization by Dual Receptors During Fertilization of Sea Urchin Eggs

1993 • 296 citations

THE FINE STRUCTURE OF PRONUCLEAR DEVELOPMENT AND FUSION IN THE SEA URCHIN, ARBACIA PUNCTULATA

1968 • 238 citations

Microinjection of the live spermatozoa into sea urchin eggs

1962 • 228 citations

Tandem SH2 Domains Confer High Specificity in Tyrosine Kinase Signaling

1998 • 226 citations

A dual functional signal mediator showing RhoGAP and phospholipase C-delta stimulating activities.

1995 • 212 citations

Evidence That Phospholipase δ1 Is the Effector in the Gh (Transglutaminase II)-mediated Signaling

1996 • 180 citations

The Sperm-Induced Ca2+ Wave Following Fertilization of the Xenopus Egg Requires the Production of Ins(1,4,5)P3

1993 • 177 citations

Temporal sequence and spatial distribution of early events of fertilization in single sea urchin eggs.

1984 • 177 citations

Chapter 2 Microinjection of Echinoderm Eggs: Apparatus and Procedures

1982 • 174 citations

Actin, microvilli, and the fertilization cone of sea urchin eggs.

1980 • 170 citations

Membrane potential, action potential and activation potential of eggs of the sea urchin, Lytechinus variegatus

1979 • 161 citations

Stimulation of the Na/H exchanger of sea urchin eggs by phorbol ester

1985 • 160 citations

Dual ionic controls for the activation of protein synthesis at fertilization

1980 • 143 citations

Development of calcium release mechanisms during starfish oocyte maturation

1990 • 140 citations

Calcium Release at Fertilization in Starfish Eggs Is Mediated by Phospholipase Cγ

1997 • 139 citations

SH2 Domain-Mediated Activation of Phospholipase Cγ Is Not Required to Initiate Ca2+Release at Fertilization of Mouse Eggs

1998 • 139 citations

Phospholipase C in mouse oocytes: characterization of β and γ isoforms and their possible involvement in sperm-induced Ca2+ spiking

1996 • 138 citations

Requirement of phospholipase C gamma, the tyrosine phosphatase Syp and the adaptor proteins Shc and Nck for PDGF-induced DNA synthesis: evidence for the existence of Ras-dependent and Ras-independent pathways.

1996 • 136 citations

Involvement of inositol 1,4,5-trisphosphate-mediated Ca2+release in early and late events of mouse egg activation

1994 • 134 citations

Cortical localization of a calcium release channel in sea urchin eggs.

1992 • 118 citations

The initiation of development at fertilization (Review)

1990 • 111 citations

Intracellular pH and the sodium requirement at fertilisation

1979 • 107 citations

Sources of Calcium in Sea Urchin Eggs during the Fertilization Response

1993 • 105 citations

Fusion of membranes during fertilization. Increases of the sea urchin egg's membrane capacitance and membrane conductance at the site of contact with the sperm.

1992 • 103 citations

A G protein-gated K channel is activated via beta 2-adrenergic receptors and G beta gamma subunits in Xenopus oocytes.

1995 • 102 citations

Requirement for Phospholipase C-γ1 Enzymatic Activity in Growth Factor-Induced Mitogenesis

1998 • 100 citations

Evidence for Both Tyrosine Kinase and G-Protein-Coupled Pathways Leading to Starfish Egg Activation

1994 • 97 citations

Effects of cytochalasin B on sperm-egg interactions

1978 • 94 citations

Demonstration of calcium uptake and release by sea urchin egg cortical endoplasmic reticulum.

1991 • 92 citations

MAP kinase links the fertilization signal transduction pathway to the G1/S-phase transition in starfish eggs

1997 • 89 citations

Components of the Signaling Pathway Linking the 1-Methyladenine Receptor to MPF Activation and Maturation in Starfish Oocytes

1998 • 88 citations

Complete Mouse Egg Activation in the Absence of Sperm by Stimulation of an Exogenous G Protein-Coupled Receptor

1993 • 87 citations

Anti-tubulin immunofluorescence microscopy of microtubules present during the pronuclear movements of sea urchin fertilization

1981 • 86 citations

The Calcium Transient in Sea Urchin Eggs during Fertilization Requires the Production of Inositol 1,4,5-Trisphosphate

1998 • 74 citations

Presence of Inositol 1,4,5-Trisphosphate Receptor, Calreticulin, and Calsequestrin in Eggs of Sea Urchins and Xenopus laevis

1994 • 74 citations

Internal calcium release and activation of sea urchin eggs by cGMP are independent of the phosphoinositide signaling pathway.

1992 • 73 citations

Newly assembled cyclin B-cdc2 kinase is required to suppress DNA replication between meiosis I and meiosis II in starfish oocytes.

1996 • 73 citations

Effect on Sperm-Induced Activation Current and Increase of Cytosolic Ca2+by Agents That Modify the Mobilization of [Ca2+]i

1995 • 70 citations

An SH3 domain is required for the mitogenic activity of microinjected phospholipase C‐γ1

1995 • 70 citations

A cholera toxin-sensitive G-protein stimulates exocytosis in sea urchin eggs

1987 • 69 citations

In Vitro Development of the Sea Urchin Male Pronucleus

1994 • 67 citations

Mechanisms regulating intracellular pH in sea urchin eggs

1983 • 66 citations

Presence of SH2 domains of phospholipase C gamma 1 enhances substrate phosphorylation by increasing the affinity toward the epidermal growth factor receptor.

1992 • 64 citations

Effects of Protein Tyrosine Kinase Inhibitors on Egg Activation and Fertilization-Dependent Protein Tyrosine Kinase Activity

1995 • 63 citations

2 Transforming Sperm Nuclei into Male Pronuclei in Vivo and in Vitro

1996 • 62 citations

The putative phospholipase C inhibitor U73122 and its negative control, U73343, elicit unexpected effects on the rabbit parietal cell.

1997 • 56 citations

A synthetic peptide of the pseudosubstrate domain of protein kinase C blocks cytoplasmic alkalinization during activation of the sea urchin egg

1990 • 56 citations

Calcium uptake and release by isolated cortices and microsomes from the unfertilized egg of the sea urchin Strongylocentrotus droebachiensis.

1986 • 55 citations

1,2‐diacylglycerols mimic phorbol 12‐myristate 13‐acetate activation of the sea urchin egg

1986 • 49 citations

Tyrosine Kinase Signaling at Fertilization

1997 • 48 citations

Protein tyrosine kinase‐dependent release of intracellular calcium in the sea urchin egg

1999 • 47 citations

Redistribution of cytoplasmic components during germinal vesicle breakdown in starfish oocytes

1994 • 47 citations

Induction of Ca2+ oscillations by selective, U73122-mediated, depletion of inositol-trisphosphate-sensitive Ca2+ stores in rabbit pancreatic acinar cells

1994 • 46 citations

Thimerosal reveals calcium-induced calcium release in unfertilised sea urchin eggs

1993 • 41 citations

Tumor promoters and diacylglycerol activate the Na+H+ antiporter of sea urchin eggs

1986 • 35 citations

Protein Synthesis Increases after Fertilization of Sea Urchin Eggs in the Absence of an Increase in Intracellular pH

1995 • 35 citations

Relation of intracellular pH and pronuclear development in the sea urchin, Arbacia punctulata,

1980 • 34 citations

Nuclear envelope dynamics during male pronuclear development

1997 • 33 citations

Na+H+ antiport during fertilization of the sea urchin egg is blocked by W-7 but is insensitive to K252a and H-7

1989 • 33 citations

Two Steps Required for Male Pronucleus Formation in the Sea Urchin Egg

1993 • 29 citations

The Cyclic GMP-Mediated Calcium Release Pathway in Sea Urchin Eggs Is Not Required for the Rise in Calcium during Fertilization

1996 • 27 citations

Rates of male pronuclear enlargement in sea urchin zygotes

1987 • 26 citations

Protein Tyrosine Kinase Activity Following Fertilization Is Required to Complete Gastrulation, but Not for Initial Differentiation of Endoderm and Mesoderm in the Sea Urchin Embryo

1998 • 26 citations

Construction of an SH2 Domain-binding Site with Mixed Specificity

1995 • 21 citations

Initiation of DNA replication cycle in fertilized eggs of the starfish, Asterina pectinifera

1991 • 19 citations

[34] Biochemical analysis of SH2 domain-mediated protein interactions

1995 • 14 citations

Sea urchin sperm nuclear enlargement and shape transformations are differentially regulated in vitro

1997 • 5 citations

Heterotrimeric Guanine Nucleotide Binding Proteins: Structure and Function

1997 • 2 citations

Deleted Work

1955 • 0 citations