Fertilin β and other ADAMs as integrin ligands: insights into cell adhesion and fertilization

Integrins: Versatility, modulation, and signaling in cell adhesion

1992 • 9,986 citations

Cell Migration: A Physically Integrated Molecular Process

1996 • 3,909 citations

COLLAGENS: Molecular Biology, Diseases, and Potentials for Therapy

1995 • 1,599 citations

Form and function: The laminin family of heterotrimers

2000 • 1,226 citations

Structural Basis of Collagen Recognition by Integrin α2β1

2000 • 945 citations

The tetraspanin superfamily: molecular facilitators

1997 • 938 citations

Binding of the integrin Mac-1 (CD11b/CD18) to the third immunoglobulin-like domain of ICAM-1 (CD54) and its regulation by glycosylation

1991 • 796 citations

A potential fusion peptide and an integrin ligand domain in a protein active in sperm–egg fusion

1992 • 680 citations

Laminin receptor on platelets is the integrin VLA-6

1988 • 679 citations

Requirement of CD9 on the Egg Plasma Membrane for Fertilization

2000 • 658 citations

The Collagen-binding A-domains of Integrins α1β1 and α2β1Recognize the Same Specific Amino Acid Sequence, GFOGER, in Native (Triple-helical) Collagens

2000 • 636 citations

Severely Reduced Female Fertility in CD9-Deficient Mice

2000 • 622 citations

2.0 Å Crystal Structure of a Four-Domain Segment of Human Fibronectin Encompassing the RGD Loop and Synergy Region

1996 • 621 citations

Disintegrins: A Family of Integrin Inhibitory Proteins from Viper Venoms

1990 • 497 citations

Fertilization Defects in Sperm from Mice Lacking Fertilin β

1998 • 497 citations

The Evolution of Cell Adhesion

2000 • 478 citations

The gamete fusion process is defective in eggs of Cd9-deficient mice

2000 • 476 citations

Mouse egg integrin α6β1functions as a sperm receptor

1995 • 472 citations

Folding of the N-terminal, ligand-binding region of integrin α-subunits into a β-propeller domain

1997 • 414 citations

Angiotensin-converting enzyme and male fertility

1998 • 321 citations

The Integrin α9β1 Binds to a Novel Recognition Sequence (SVVYGLR) in the Thrombin-cleaved Amino-terminal Fragment of Osteopontin

1999 • 299 citations

The putative chaperone calmegin is required for sperm fertility

1997 • 277 citations

Alpha 2 beta 1 integrins from different cell types show different binding specificities.

1990 • 274 citations

[27] Arginine-glycine-aspartic acid adhesion receptors

1987 • 263 citations

The Cysteine-Rich Domain of Human Adam 12 Supports Cell Adhesion through Syndecans and Triggers Signaling Events That Lead to β1 Integrin–Dependent Cell Spreading

2000 • 246 citations

A Role for the Disintegrin Domain of Cyritestin, a Sperm Surface Protein Belonging to the ADAM Family, in Mouse Sperm–Egg Plasma Membrane Adhesion and Fusion

1997 • 235 citations

Male Mice Deficient for Germ-Cell Cyritestin Are Infertile1

1999 • 226 citations

Role of the integrin-associated protein CD9 in binding between sperm ADAM 2 and the egg integrin α6β1: Implications for murine fertilization

1999 • 223 citations

The c-ros tyrosine kinase receptor controls regionalization and differentiation of epithelial cells in the epididymis.

1996 • 218 citations

Specific Interaction of the Recombinant Disintegrin-like Domain of MDC-15 (Metargidin, ADAM-15) with Integrin αvβ3

1998 • 214 citations

RGD-independent Binding of Integrin α9β1 to the ADAM-12 and -15 Disintegrin Domains Mediates Cell-Cell Interaction

2000 • 211 citations

Interaction of metargidin (ADAM-15) with αvβ3 and α5β1 integrins on different haemopoietic cells

1999 • 193 citations

Meltrin γ (ADAM-9) mediates cellular adhesion through α6β1 integrin, leading to a marked induction of fibroblast cell motility

2000 • 190 citations

Viper Venom Disintegrins and Related Molecules

1998 • 189 citations

Snake venom metalloproteinases: Structure, function and relationship to the ADAMs family of proteins

1996 • 184 citations

Normal Fertilization Occurs with Eggs Lacking the Integrin α6β1 and Is Cd9-Dependent

2000 • 178 citations

Sperm-egg fusion is the prelude to the initial Ca2+ increase at fertilization in the mouse

1997 • 172 citations

Cell adhesion, spreading and neurite stimulation by laminin fragment E8 depends on maintenance of secondary and tertiary structure in its rod and globular domain

1990 • 163 citations

The regulation of integrin function by Ca2+

2000 • 155 citations

Mammalian sperm-egg fusion: The rat egg has complementary sites for a sperm protein that mediates gamete fusion

1992 • 154 citations

Characterization of the Binding of Recombinant Mouse Sperm Fertilin β Subunit to Mouse Eggs: Evidence for Adhesive Activity via an Egg β1Integrin-Mediated Interaction

1997 • 153 citations

Identification of the Ligand Binding Site for the Integrin α9β1 in the Third Fibronectin Type III Repeat of Tenascin-C

1998 • 151 citations

Molecular Phenotype of the Human Oocyte by PCR–SAGE

2000 • 143 citations

Arrangement of domains, and amino acid residues required for binding of vascular cell adhesion molecule-1 to its counter-receptor VLA-4 (alpha 4 beta 1)

1994 • 142 citations

Function of Disintegrin-like/Cysteine-rich Domains of Atrolysin A

1997 • 141 citations

Cell adhesion in vascular biology. New insights into integrin-ligand interaction.

1997 • 139 citations

Expression of β1 integrin complexes on the surface of unfertilized mouse oocyte

1993 • 127 citations

ADAM 23/MDC3, a Human Disintegrin That Promotes Cell Adhesion via Interaction with the αvβ3 Integrin through an RGD-independent Mechanism

2000 • 115 citations

Mediation of sperm-egg fusion: evidence that mouse egg α6β1 integrin is the receptor for sperm fertilinβ

1999 • 108 citations

Integrins: alternative splicing as a mechanism to regulate ligand binding and integrin signaling events

1999 • 108 citations

Sequence-specific Interaction between the Disintegrin Domain of Mouse ADAM 2 (Fertilin β) and Murine Eggs

2000 • 100 citations

Identification and localization of integrin subunits in oocytes and eggs of the mouse

1995 • 99 citations

Analysis of Mouse Fertilin in Wild-Type and Fertilin β−/− Sperm: Evidence for C-terminal Modification, α/β Dimerization, and Lack of Essential Role of Fertilin α in Sperm–Egg Fusion

2000 • 98 citations

Mammalian oocytes exhibit specific recognition of the RGD (ARG‐Gly‐Asp) tripeptide and express oolemmal integrins

1993 • 97 citations

Evidence that Distinct States of the Integrin α6β1 Interact with Laminin and an ADAM

1999 • 96 citations

Getting integrins into shape: recent insights into how integrin activity is regulated by conformational changes

1996 • 94 citations

α4 Integrin Binding Interfaces on VCAM-1 and MAdCAM-1

1997 • 93 citations

Sequence and Biological Activity of Catrocollastatin-C: A Disintegrin-Like/Cysteine-Rich Two-Domain Protein fromCrotalus atroxVenom

1997 • 90 citations

Activation of Xenopus Eggs by RGD-Containing Peptides Accompanied by Intracellular Ca 2+ Release

1996 • 90 citations

The human fertilin α gene is non-functional: implications for its proposed role in fertilization

1997 • 89 citations

Different Ca2+-releasing abilities of sperm extracts compared with tissue extracts and phospholipase C isoforms in sea urchin egg homogenate and mouse eggs

2000 • 89 citations

Sperm disintegrins, egg integrins, and other cell adhesion molecules of mammalian gamete plasma membrane interactions

1999 • 88 citations

Integrin Modulation by Lateral Association

2000 • 84 citations

MDC-9 (ADAM-9/Meltrin γ) Functions as an Adhesion Molecule by Binding the αvβ5 Integrin

2001 • 84 citations

Identification of Key Functional Amino Acids of the Mouse Fertilin β (ADAM2) Disintegrin Loop for Cell-Cell Adhesion during Fertilization

2000 • 80 citations

Mammalian Oocyte Activation by the Synergistic Action of Discrete Sperm Head Components: Induction of Calcium Transients and Involvement of Proteolysis

2000 • 76 citations

Treatment of Mouse Oocytes with PI-PLC Releases 70-kDa (pI 5) and 35- to 45-kDa (pI 5.5) Protein Clusters from the Egg Surface and Inhibits Sperm–Oolemma Binding and Fusion

1999 • 72 citations

Inhibitory Effects of MLDG-containing Heterodimeric Disintegrins Reveal Distinct Structural Requirements for Interaction of the Integrin α9β1 with VCAM-1, Tenascin-C, and Osteopontin

2000 • 71 citations

Ability of Integrins to Mediate Fertilization, Intracellular Calcium Release, and Parthenogenetic Development in Bovine Oocytes1

2000 • 71 citations

Roles of the Disintegrin Domains of Mouse Fertilins α and β in Fertilization1

1998 • 70 citations

Isolation of Two Novel Metalloproteinase-Disintegrin (ADAM) cDNAs That Show Testis-Specific Gene Expression

1999 • 65 citations

Partial Characterization of the Calcium-Releasing Activity of Porcine Sperm Cytosolic Extracts

1998 • 63 citations

Voltage-Dependent Activation of Frog Eggs by a Sperm Surface Disintegrin Peptide

1998 • 63 citations

Adhesive interactions in the immune system

1997 • 60 citations

Receptor-mediated binding of IgE-sensitized rat basophilic leukemia cells to antigen-coated substrates under hydrodynamic flow

1994 • 60 citations

Molecular Basis for Leukocyte Integrin αEβ7 Adhesion to Epithelial (E)-Cadherin

2000 • 57 citations

Decreased in vitro fertilization efficiencies in the presence of specific cyritestin peptides

1997 • 54 citations

Sequence analysis of a variety of primate fertilin α genes: Evidence for non-functional genes in the gorilla and man

1998 • 53 citations

Potential role of alphav and beta1 integrins as oocyte adhesion molecules during fertilization in pigs

2000 • 46 citations

The gene for the human tMDC I sperm surface protein is non-functional: implications for its proposed role in mammalian sperm–egg recognition

1998 • 44 citations

Novel Peptide Ligands for Integrin 6 1 Selected from a Phage Display Library

1996 • 41 citations

The identification of seven metalloproteinase-disintegrin (ADAM) genes from genomic libraries

1999 • 39 citations

Making a Little Affinity Go a Long Way: A Topological View of LFA-1 Regulation

1998 • 38 citations

Defining Extracellular Integrin α-Chain Sites That Affect Cell Adhesion and Adhesion Strengthening without Altering Soluble Ligand Binding

1997 • 37 citations

The disulfide bond pattern of catrocollastatin C, a disintegrin‐like/cysteine‐rich protein isolated from Crotalus atrox venom

2000 • 36 citations

Characterisation and role of integrins during gametic interaction and egg activation

1996 • 36 citations

Different Ca2+-releasing abilities of sperm extracts compared with tissue extracts and phospholipase C isoforms in sea urchin egg homogenate and mouse eggs

2000 • 33 citations

ECD peptides inhibit in vitro fertilization in mice

1997 • 29 citations

Analysis of the role of egg integrins in sperm-egg binding and fusion

2000 • 23 citations

Characterization of fertilinβ-disintegrin binding specificity in sperm–egg adhesion

2000 • 23 citations

Molecular Cloning, Chromosomal Localization, and Expression Analysis ofCYRN1andCYRN2, Two Human Genes Coding for Cyritestin, a Sperm Protein Involved in Gamete Interaction

1998 • 20 citations

Transcripts encoding the sperm surface protein tMDC II are non-functional in the human

1999 • 15 citations

Expression of TAPA-1 in preimplantation mouse embryos

1992 • 12 citations

Transcripts encoding the sperm surface protein tMDC II are non-functional in the human

1999 • 3 citations