A single peripheral CD8⁺T cell can give rise to progeny expressing type 1 and/or type 2 cytokine genes and can retain its multipotentiality through many cell divisions

Functional diversity of helper T lymphocytes

1996 • 4,512 citations

Acquisition of Lymphokine-Producing Phenotype by CD4+ T Cells

1994 • 1,573 citations

Essential role of Stat6 in IL-4 signalling

1996 • 1,563 citations

Lack of IL-4-induced Th2 response and IgE class switching in mice with disrupted State6 gene

1996 • 1,304 citations

Disruption of the murine IL-4 gene blocks Th2 cytokine responses

1993 • 1,197 citations

Cytokine-induced differentiation of precursor mouse CD8+ T cells into cytotoxic CD8+ T cells secreting Th1 or Th2 cytokines

1995 • 686 citations

Generation of polarized antigen-specific CD8 effector populations: reciprocal action of interleukin (IL)-4 and IL-12 in promoting type 2 versus type 1 cytokine profiles.

1994 • 527 citations

Th1 and Th2 subsets: paradigms lost?

1995 • 482 citations

Reversibility of T helper 1 and 2 populations is lost after long-term stimulation.

1996 • 437 citations

Developmental commitment to the Th2 lineage by extinction of IL-12 signaling

1995 • 429 citations

T cell populations primed by hapten sensitization in contact sensitivity are distinguished by polarized patterns of cytokine production: interferon gamma-producing (Tc1) effector CD8+ T cells and interleukin (Il) 4/Il-10-producing (Th2) negative regulatory CD4+ T cells.

1996 • 398 citations

Switch of CD8 T Cells to Noncytolytic CD8 ^- CD4 ^- Cells that Make T _H 2 Cytokines and Help B Cells

1993 • 343 citations

Differentiation and stability of T helper 1 and 2 cells derived from naive human neonatal CD4+ T cells, analyzed at the single-cell level.

1996 • 287 citations

T and B memory cells

1994 • 285 citations

Generation and in vivo persistence of polarized Th1 and Th2 memory cells

1994 • 283 citations

Single IL-2-secreting precursor CD4 T cell can develop into either Th1 or Th2 cytokine secretion phenotype.

1994 • 282 citations

Virus-specific CD8+ cells can switch to interleukin 5 production and induce airway eosinophilia.

1995 • 255 citations

Alloreactive murine CD8+ T cell clones secrete the Th1 pattern of cytokines.

1990 • 240 citations

Disparate differentiation in mouse hemopoietic colonies derived from paired progenitors.

1984 • 233 citations

Analysis of Th1 and Th2 cells in murine gut-associated tissues. Frequencies of CD4+ and CD8+ T cells that secrete IFN-gamma and IL-5.

1990 • 226 citations

CD8+ T cells can be primed in vitro to produce IL-4.

1992 • 214 citations

The Cellular Basis of T-Cell Memory

1989 • 161 citations

Stability of T_h1 and T_h2 populations

1995 • 158 citations

Induction of interleukin 4 (IL-4) expression in T helper (Th) cells is not dependent on IL-4 from non-Th cells.

1994 • 158 citations

A common precursor for CD4+ T cells producing IL-2 or IL-4.

1992 • 153 citations

Activation of cytokine genes in T cells during primary and secondary murine influenza pneumonia.

1993 • 150 citations

Clonal analysis of proliferation and differentiation of paired daughter cells: action of granulocyte-macrophage colony-stimulating factor on granulocyte-macrophage precursors.

1980 • 147 citations

Recently activated naive CD4 T cells can help resting B cells, and can produce sufficient autocrine IL-4 to drive differentiation to secretion of T helper 2-type cytokines.

1995 • 144 citations

FAS is highly expressed in the germinal center but is not required for regulation of the B-cell response to antigen.

1995 • 134 citations

Heterogeneity in Lymphokine Profiles of CD4⁺ and CD8⁺ T Cells and Clones Activated in vivo and in vitro

1991 • 132 citations

Coexpression of granulocyte-macrophage colony-stimulating factor, gamma interferon, and interleukins 3 and 4 is random in murine alloreactive T-lymphocyte clones.

1988 • 106 citations

Human naive CD4 T cells produce interleukin‐4 at priming and acquire a Th2 phenotype upon repetitive stimulations in neutral conditions

1995 • 104 citations

Novel features of the respiratory tract T-cell response to influenza virus infection: lung T cells increase expression of gamma interferon mRNA in vivo and maintain high levels of mRNA expression for interleukin-5 (IL-5) and IL-10

1994 • 99 citations

Evidence for the stochastic acquisition of cytokine profile by CD4⁺ T cells activated in a T helper type 2‐like response in vivo

1995 • 98 citations

Interleukin (IL) 4, in the absence of antigen stimulation, induces an anergy-like state in differentiated CD8+ TC1 cells: loss of IL-2 synthesis and autonomous proliferation but retention of cytotoxicity and synthesis of other cytokines.

1995 • 78 citations

Co-engagement of CD3 with LFA-1 or ICAM-1 adhesion molecules enhances the frequency of activation of single murine CD4⁺ and CD8⁺ T cells and induces synthesis of IL-3 and IFN-γ but not IL-4 or IL-6

1992 • 65 citations

Enumeration of lymphokine mRNA-containing cells in vivo in a murine graft-versus-host reaction using the PCR.

1992 • 59 citations

The role of Th2 type CD4⁺ T cells and Th2 type CD8⁺ T cells in asthma

1996 • 45 citations

Dissociated expression of granulocyte-macrophage CSF and IL-3 in short-term T cell clones from normal mice.

1995 • 27 citations

Limiting dilution analysis reveals the precursors of interleukin-4-producing CD4+ cells induced by protein immunization.

1994 • 16 citations