CD4⁺ memory T cells: functional differentiation and homeostasis

Two subsets of memory T lymphocytes with distinct homing potentials and effector functions

1999 • 5,659 citations

Interleukin 17–producing CD4+ effector T cells develop via a lineage distinct from the T helper type 1 and 2 lineages

2005 • 4,573 citations

A distinct lineage of CD4 T cells regulates tissue inflammation by producing interleukin 17

2005 • 4,165 citations

IL-23 drives a pathogenic T cell population that induces autoimmune inflammation

2005 • 3,961 citations

TGFβ in the Context of an Inflammatory Cytokine Milieu Supports De Novo Differentiation of IL-17-Producing T Cells

2006 • 3,545 citations

Interleukin-23 rather than interleukin-12 is the critical cytokine for autoimmune inflammation of the brain

2003 • 2,856 citations

Novel p19 Protein Engages IL-12p40 to Form a Cytokine, IL-23, with Biological Activities Similar as Well as Distinct from IL-12

2000 • 2,755 citations

Interleukin-17 Family Members and Inflammation

2004 • 2,340 citations

Lineage relationship and protective immunity of memory CD8 T cell subsets

2003 • 1,833 citations

Interleukin-23 Promotes a Distinct CD4 T Cell Activation State Characterized by the Production of Interleukin-17

2003 • 1,828 citations

Selective expression of the interleukin 7 receptor identifies effector CD8 T cells that give rise to long-lived memory cells

2003 • 1,790 citations

A function for interleukin 2 in Foxp3-expressing regulatory T cells

2005 • 1,744 citations

Reversible Defects in Natural Killer and Memory Cd8 T Cell Lineages in Interleukin 15–Deficient Mice

2000 • 1,578 citations

IL-15 Receptor Maintains Lymphoid Homeostasis by Supporting Lymphocyte Homing and Proliferation

1998 • 1,293 citations

Memory CD8+ T cell differentiation: initial antigen encounter triggers a developmental program in naïve cells

2001 • 1,277 citations

Potent and Selective Stimulation of Memory-Phenotype CD8+ T Cells In Vivo by IL-15

1998 • 1,262 citations

A well adapted regulatory contrivance: regulatory T cell development and the forkhead family transcription factor Foxp3

2005 • 957 citations

Duration of antiviral immunity after smallpox vaccination

2003 • 901 citations

Similarities and differences in CD4+ and CD8+ effector and memory T cell generation

2003 • 865 citations

HCV Persistence and Immune Evasion in the Absence of Memory T Cell Help

2003 • 811 citations

Interleukin (IL)-15 and IL-7 Jointly Regulate Homeostatic Proliferation of Memory Phenotype CD8+ Cells but Are Not Required for Memory Phenotype CD4+ Cells

2002 • 783 citations

Dynamic Imaging of T Cell-Dendritic Cell Interactions in Lymph Nodes

2002 • 707 citations

Conditional deletion of Gata3 shows its essential function in TH1-TH2 responses

2004 • 625 citations

Developmental Stage, Phenotype, and Migration Distinguish Naive- and Effector/Memory-like CD4+ Regulatory T Cells

2004 • 618 citations

Antigen-dependent Proliferation of CD4+ CD25+ Regulatory T Cells In Vivo

2003 • 600 citations

Differential regulation of antiviral T-cell immunity results in stable CD8+ but declining CD4+ T-cell memory

2001 • 600 citations

Constitutive Cytokine mRNAs Mark Natural Killer (NK) and NK T Cells Poised for Rapid Effector Function

2003 • 598 citations

Progressive differentiation and selection of the fittest in the immune response

2002 • 503 citations

Early Transcription and Silencing of Cytokine Genes Underlie Polarization of T Helper Cell Subsets

2001 • 498 citations

IL-17 production from activated T cells is required for the spontaneous development of destructive arthritis in mice deficient in IL-1 receptor antagonist

2003 • 488 citations

Suppression of IL7Rα Transcription by IL-7 and Other Prosurvival Cytokines

2004 • 472 citations

Unequal Death in T Helper Cell (Th)1 and Th2 Effectors: Th1, but not Th2, Effectors Undergo Rapid Fas/FasL-mediated Apoptosis

1997 • 460 citations

Initial T cell frequency dictates memory CD8+ T cell lineage commitment

2005 • 458 citations

Direct access to CD4+ T cells specific for defined antigens according to CD154 expression

2005 • 457 citations

Interleukin 7 and T cell receptor signals regulate homeostasis of CD4 memory cells

2003 • 454 citations

Interleukin 7 Regulates the Survival and Generation of Memory CD4 Cells

2003 • 449 citations

Reversibility of T helper 1 and 2 populations is lost after long-term stimulation.

1996 • 437 citations

Cloning of a receptor subunit required for signaling by thymic stromal lymphopoietin

2000 • 435 citations

Class II-Independent Generation of CD4 Memory T Cells from Effectors

1999 • 422 citations

Cutting Edge: CD4 and CD8 T Cells Are Intrinsically Different in Their Proliferative Responses

2002 • 402 citations

Salmonella typhimurium aroA- infection in gene-targeted immunodeficient mice: major role of CD4+ TCR-alpha beta cells and IFN-gamma in bacterial clearance independent of intracellular location.

1996 • 397 citations

In vivodynamics of antigen-specific regulatory T cells not predicted from behaviorin vitro

2003 • 384 citations

Dynamics of Blood-Borne CD8 Memory T Cell Migration In Vivo

2004 • 371 citations

Follicular Dendritic Cells as Accessory Cells

1990 • 351 citations

GATA-3 deficiency abrogates the development and maintenance of T helper type 2 cells

2004 • 339 citations

Th2 Lineage Commitment and Efficient IL-4 Production Involves Extended Demethylation of the IL-4 Gene

2002 • 328 citations

CD4 Effector T Cell Subsets in the Response to Influenza

2002 • 328 citations

IL-7 Promotes the Transition of CD4 Effectors to Persistent Memory Cells

2003 • 307 citations

A live-cell assay to detect antigen-specific CD4+ T cells with diverse cytokine profiles

2005 • 306 citations

Overexpression of Interleukin (IL)-7 Leads to IL-15–independent Generation of Memory Phenotype CD8+ T Cells

2002 • 291 citations

Distinct lineages of TH1 cells have differential capacities for memory cell generation in vivo

2002 • 289 citations

Antigen persistence is required throughout the expansion phase of a CD4+ T cell response

2005 • 271 citations

Different Dynamics of CD4+ and CD8+ T Cell Responses During and After Acute Lymphocytic Choriomeningitis Virus Infection

2003 • 269 citations

Depletion of Lymphocytes and Diminished Cytokine Production in Mice Infected with a Highly Virulent Influenza A (H5N1) Virus Isolated from Humans

2000 • 253 citations

Unexpected prolonged presentation of influenza antigens promotes CD4 T cell memory generation

2005 • 249 citations

A Two-Step Process for Cytokine Production Revealed by IL-4 Dual-Reporter Mice

2005 • 241 citations

Induction of antigen-specific immunologic tolerance by in vivo and in vitro antigen-specific expansion of naturally arising Foxp3+CD25+CD4+ regulatory T cells

2004 • 240 citations

How αβ T cells deal with induced TCRα ablation

2001 • 224 citations

Protective long-term antibody memory by antigen-driven and T help-dependent differentiation of long-lived memory B cells to short-lived plasma cells independent of secondary lymphoid organs

2000 • 216 citations

Following the Development of a CD4 T Cell Response In Vivo

1999 • 213 citations

Activation of bone marrow–resident memory T cells by circulating, antigen-bearing dendritic cells

2005 • 209 citations

IL-7 regulates basal homeostatic proliferation of antiviral CD4 ⁺ T cell memory

2004 • 197 citations

CD4+ T cell effectors can become memory cells with high efficiency and without further division

2001 • 186 citations

Impairment of immunological memory in the absence of MHC despite survival of memory T cells

2002 • 181 citations

IL-2 negatively regulates IL-7 receptor α chain expression in activated T lymphocytes

2002 • 176 citations

Mechanisms of L-selectin regulation by activated T cells.

1997 • 174 citations

Novel pathways of antigen presentation for the maintenance of memory

1991 • 173 citations

Involvement of Avidity for Major Histocompatibility Complex in Homeostasis of Naive and Memory T Cells

2003 • 163 citations

T Cell Homeostasis

2001 • 163 citations

TCR and IL-7 Receptor Signals Can Operate Independently or Synergize to Promote Lymphopenia-Induced Expansion of Naive T Cells

2002 • 160 citations

CD4 T cells integrate signals delivered during successive DC encounters in vivo

2005 • 158 citations

Establishment and Persistence of Virus‐Specific CD4⁺ and CD8⁺ T Cell Memory

1996 • 155 citations

Extensive lymphopenia due to apoptosis of uninfected lymphocytes in acute measles patients

2000 • 150 citations

Costimulation in antiviral immunity: differential requirements for CD4+ and CD8+ T cell responses

2000 • 148 citations

IL-7 Administration Alters the CD4:CD8 Ratio, Increases T Cell Numbers, and Increases T Cell Function in the Absence of Activation

2001 • 144 citations

On differences between immunity and immunological memory

2002 • 131 citations

Long-Term CD4 Th1 and Th2 Memory following Acute Lymphocytic Choriomeningitis Virus Infection

1998 • 126 citations

Critical Role for CD4⁺T Cells in Controlling Retrovirus Replication and Spread in Persistently Infected Mice

1998 • 125 citations

Lyphocyte migration in L-selectin-deficient mice. Altered subset migration and aging of the immune system.

1996 • 118 citations

Long-Lived Poxvirus Immunity, Robust CD4 Help, and Better Persistence of CD4 than CD8 T Cells

2004 • 114 citations

Activation of Virus-specific Memory B Cells in the Absence of T Cell Help

2004 • 112 citations

The organization of mature T-cell pools

1998 • 108 citations

Deliberate removal of T cell help improves virus-neutralizing antibody production

2004 • 94 citations

Stability of Virus-Specific CD4+ T Cell Frequencies from Acute Infection into Long Term Memory

1998 • 86 citations

Massive Number of Antigen-Specific CD4 T Cells during Vaccination with Live Attenuated Salmonella Causes Interclonal Competition

2004 • 77 citations

Functional plasticity of an antigen-specific memory CD4 T cell population

2002 • 73 citations

Fratricide: a mechanism for T memory-cell homeostasis

2003 • 61 citations

The Role of CD4 and CD8 T Cells in Recovery and Protection from Retroviral Infection: Lessons from the Friend Virus Model

2000 • 58 citations

Interleukin (IL)-4-independent Maintenance of Histone Modification of the IL-4 Gene Loci in Memory Th2 Cells

2004 • 55 citations

Anatomical Heterogeneity of Memory CD4+ T Cells Due to Reversible Adaptation to the Microenvironment

2004 • 50 citations

Longitudinal Analysis of the Acute Sendai Virus-Specific CD4+ T Cell Response and Memory

1998 • 50 citations

CD4 T-cell memory

2004 • 48 citations

A Major Role for Memory CD4 T Cells in the Control of Lymphopenia-Induced Proliferation of Naive CD4 T Cells

2005 • 48 citations

Long-term memory cellular immune response to dengue virus after a natural primary infection

2002 • 46 citations

Transcriptional Activators of Helper T Cell Fate Are Required for Establishment but Not Maintenance of Signature Cytokine Expression

2005 • 45 citations

Bystander T Cell Activation and Attrition

2002 • 26 citations

Functional Consequences of Noncognate Interactions Between CD4+ Memory T Lymphocytes and the Endothelium

2002 • 25 citations

Isolation of viable antigen-specific CD4 T cells by CD40L surface trapping

2005 • 24 citations

Differences in the regulation of CD4 and CD8 T–cell clones during immune responses

2000 • 22 citations

THE INDOPHENOLOXYDASE CONTENT OF TISSUES FROM RABBITS INFECTED WITH PNEUMOCOCCUS

1914 • 1 citations