Identification of vascular endothelial genes differentially responsive to fluid mechanical stimuli: cyclooxygenase-2, manganese superoxide dismutase, and endothelial cell nitric oxide synthase are selectively up-regulated by steady laminar shear stress.

The pathogenesis of atherosclerosis: a perspective for the 1990s

1993 • 10,730 citations

Beyond Cholesterol

1989 • 6,533 citations

Differential Display of Eukaryotic Messenger RNA by Means of the Polymerase Chain Reaction

1992 • 5,105 citations

Flow-mediated endothelial mechanotransduction

1995 • 2,728 citations

Pulsatile flow and atherosclerosis in the human carotid bifurcation. Positive correlation between plaque location and low oscillating shear stress.

1985 • 2,605 citations

Alterations in cellular adhesion and apoptosis in epithelial cells overexpressing prostaglandin endoperoxide synthase 2

1995 • 2,308 citations

Endothelial Leukocyte Adhesion Molecule 1: an Inducible Receptor for Neutrophils Related to Complement Regulatory Proteins and Lectins

1989 • 2,045 citations

Nitric oxide decreases cytokine-induced endothelial activation. Nitric oxide selectively reduces endothelial expression of adhesion molecules and proinflammatory cytokines.

1995 • 1,762 citations

Endothelial Expression of a Mononuclear Leukocyte Adhesion Molecule During Atherogenesis

1991 • 1,703 citations

ApoE-deficient mice develop lesions of all phases of atherosclerosis throughout the arterial tree.

1994 • 1,646 citations

Human cyclooxygenase-2 cDNA.

1992 • 1,493 citations

Carotid bifurcation atherosclerosis. Quantitative correlation of plaque localization with flow velocity profiles and wall shear stress.

1983 • 1,433 citations

Cytokines and endothelial cell biology

1990 • 1,275 citations

Prostaglandin synthase 2 gene disruption causes severe renal pathology in the mouse

1995 • 1,102 citations

Vascular cell adhesion molecule-1 (VCAM-1) gene transcription and expression are regulated through an antioxidant-sensitive mechanism in human vascular endothelial cells.

1993 • 1,079 citations

Inducible isoforms of cyclooxygenase and nitric-oxide synthase in inflammation.

1994 • 1,026 citations

Endoglin is a component of the transforming growth factor-beta receptor system in human endothelial cells.

1992 • 837 citations

Turbulent fluid shear stress induces vascular endothelial cell turnover in vitro.

1986 • 835 citations

Lysophosphatidylcholine, a component of atherogenic lipoproteins, induces mononuclear leukocyte adhesion molecules in cultured human and rabbit arterial endothelial cells.

1992 • 828 citations

Hypertension and the Pathogenesis of Atherosclerosis

1995 • 760 citations

Molecular cloning and characterization of the constitutive bovine aortic endothelial cell nitric oxide synthase.

1992 • 748 citations

Molecular cloning of human prostaglandin endoperoxide synthase type II and demonstration of expression in response to cytokines.

1993 • 710 citations

An atherogenic diet rapidly induces VCAM-1, a cytokine-regulatable mononuclear leukocyte adhesion molecule, in rabbit aortic endothelium.

1993 • 680 citations

Platelet-derived growth factor B chain promoter contains a cis-acting fluid shear-stress-responsive element.

1993 • 638 citations

Arterial Wall Shear and Distribution of Early Atheroma in Man

1969 • 615 citations

Shear stress selectively upregulates intercellular adhesion molecule-1 expression in cultured human vascular endothelial cells.

1994 • 576 citations

Hemodynamic forces are complex regulators of endothelial gene expression

1995 • 547 citations

Endothelial nuclear factor-kappa B and the initiation of the atherosclerotic lesion.

1993 • 525 citations

Induction of cyclooxygenase-2 by interleukin-1 alpha. Evidence for post-transcriptional regulation.

1994 • 478 citations

Nuclear factor-kappa B interacts functionally with the platelet-derived growth factor B-chain shear-stress response element in vascular endothelial cells exposed to fluid shear stress.

1995 • 343 citations

Lysophosphatidylcholine transcriptionally induces growth factor gene expression in cultured human endothelial cells.

1994 • 332 citations

Human Mn-superoxide dismutase in pulmonary epithelial cells of transgenic mice confers protection from oxygen injury.

1992 • 321 citations

Shear Stress Modulates Expression of Cu/Zn Superoxide Dismutase in Human Aortic Endothelial Cells

1996 • 294 citations

The cis-acting phorbol ester "12-O-tetradecanoylphorbol 13-acetate"-responsive element is involved in shear stress-induced monocyte chemotactic protein 1 gene expression.

1995 • 267 citations

Shear stress increases endothelial platelet-derived growth factor mRNA levels

1991 • 208 citations

Shear stress inhibits adhesion of cultured mouse endothelial cells to lymphocytes by downregulating VCAM-1 expression

1994 • 204 citations

Apparatus for subjecting living cells to fluid shear stress

1982 • 174 citations

A quantitative study of the localization of atherosclerotic lesions in the rabbit aorta

1976 • 171 citations

Induction of cyclooxygenase-2 in rat vascular smooth muscle cells in vitro and in vivo.

1994 • 144 citations

Shear‐induced platelet‐derived growth factor gene expression in human endothelial cells is mediated by protein kinase C

1992 • 134 citations

Nitric Oxide in Cardiovascular Disorders

1995 • 112 citations

Endothelial nitric oxide and cardiovascular disease

1994 • 111 citations

Vascular Endothelium

1994 • 107 citations

Eicosanoids in regulation of arterial smooth muscle cell phenotype, proliferative capacity, and cholesterol metabolism.

1989 • 104 citations

Induction of cyclooxygenase-2 in human umbilical vein endothelial cells by lysophosphatidylcholine.

1995 • 88 citations

Flow visualization in isolated transparent natural blood vessels

1983 • 70 citations

Manganese-superoxide dismutase in endothelial cells: localization and mechanism of induction

1993 • 69 citations

Molecular Cardiovascular Medicine

1996 • 47 citations

Antioxidants and atherosclerosis: a molecular perspective.

1994 • 46 citations

Overexpression of manganous superoxide dismutase (MnSOD) in pulmonary endothelial cells confers resistance to hyperoxia

1994 • 35 citations