Fas‐induced programmed cell death is mediated by a Ras‐regulated O₂⁻ synthesis

Apoptosis: A Basic Biological Phenomenon with Wideranging Implications in Tissue Kinetics

1972 • 15,349 citations

Cell Death: The Significance of Apoptosis

1980 • 7,281 citations

Reactive oxygen intermediates as apparently widely used messengers in the activation of the NF-kappa B transcription factor and HIV-1.

1991 • 3,819 citations

Bcl-2 functions in an antioxidant pathway to prevent apoptosis

1993 • 3,465 citations

Induction of apoptosis in fibroblasts by c-myc protein

1992 • 2,977 citations

Lymphoproliferation disorder in mice explained by defects in Fas antigen that mediates apoptosis

1992 • 2,932 citations

The polypeptide encoded by the cDNA for human cell surface antigen Fas can mediate apoptosis

1991 • 2,815 citations

Social controls on cell survival and cell death

1992 • 2,641 citations

A novel heterodimeric cysteine protease is required for interleukin-1βprocessing in monocytes

1992 • 2,495 citations

Hydrogen peroxide mediates amyloid β protein toxicity

1994 • 2,065 citations

Proteins regulating Ras and its relatives

1993 • 1,930 citations

The TNF receptor superfamily of cellular and viral proteins: Activation, costimulation, and death

1994 • 1,920 citations

Requirement for ceramide-initiated SAPK/JNK signalling in stress-induced apoptosis

1996 • 1,784 citations

Programmed Cell Death Induced by Ceramide

1993 • 1,779 citations

Altered Cytokine Export and Apoptosis in Mice Deficient in Interleukin-1β Converting Enzyme

1995 • 1,625 citations

Sequential reduction of mitochondrial transmembrane potential and generation of reactive oxygen species in early programmed cell death.

1995 • 1,556 citations

Generalized lymphoproliferative disease in mice, caused by a point mutation in the fas ligand

1994 • 1,549 citations

Dominant interfering fas gene mutations impair apoptosis in a human autoimmune lymphoproliferative syndrome

1995 • 1,477 citations

Mice deficient in IL-1β-converting enzyme are defective in production of mature IL-1β and resistant to endotoxic shock

1995 • 1,413 citations

Induction of apoptosis in fibroblasts by IL-1β-converting enzyme, a mammalian homolog of the C. elegans cell death gene ced-3

1993 • 1,387 citations

Mutations in Fas Associated with Human Lymphoproliferative Syndrome and Autoimmunity

1995 • 1,306 citations

Rapid proteolysis of IκB-α is necessary for activation of transcription factor NF-κB

1993 • 1,129 citations

Molecular Cloning of the Interleukin-1β Converting Enzyme

1992 • 1,115 citations

Sensitization of T cells to CD95-mediated apoptosis by HIV-1 Tat and gp120

1995 • 983 citations

Apoptosis

1993 • 972 citations

Fas and Fas ligand: lpr and gld mutations

1995 • 906 citations

An essential role for Rac in Ras transformation

1995 • 895 citations

Cloning and functional analysis of BAG-1: A novel Bcl-2-binding protein with anti-cell death activity

1995 • 863 citations

Purification and molecular cloning of the APO-1 cell surface antigen, a member of the tumor necrosis factor/nerve growth factor receptor superfamily. Sequence identity with the Fas antigen.

1992 • 857 citations

Ich-1, an Ice/ced-3-related gene, encodes both positive and negative regulators of programmed cell death

1994 • 843 citations

Ceramide synthase mediates daunorubicin-induced apoptosis: An alternative mechanism for generating death signals

1995 • 835 citations

Involvement of an ICE-like protease in Fas-mediated apoptosis

1995 • 757 citations

Reactive oxygen species and programmed cell death

1996 • 745 citations

The fas antigen is involved in peripheral but not thymic deletion of T lymphocytes in T cell receptor transgenic mice

1994 • 708 citations

Role for c-myc in Activation-Induced Apoptotic Cell Death in T Cell Hybridomas

1992 • 705 citations

Programmed cell death and Bcl-2 protection in very low oxygen

1995 • 638 citations

Prevention of hypoxia-induced cell death by Bcl-2 and Bcl-xL

1995 • 611 citations

Apoptotic signaling through CD95 (Fas/Apo-1) activates an acidic sphingomyelinase.

1994 • 582 citations

Premature p34 ^cdc2 Activation Required for Apoptosis

1994 • 568 citations

Cellular commitment to oncogene-induced transformation or apoptosis is dependent on the transcription factor IRF-1

1994 • 490 citations

Effect of bcl-2 on Fas antigen-mediated cell death.

1993 • 442 citations

Unraveling Function in the TNF Ligand and Receptor Families

1994 • 431 citations

FAS-induced apoptosis is mediated via a ceramide-initiated RAS signaling pathway

1995 • 411 citations

Expression and involvement of c-fos and c-jun protooncogenes in programmed cell death induced by growth factor deprivation in lymphoid cell lines.

1992 • 401 citations

DNA fragmentation and cell death is selectively triggered in activated human lymphocytes by Fas antigen engagement

1992 • 392 citations

N-acetyl-L-cysteine is a pluripotent protector against cell death and enhancer of trophic factor-mediated cell survival in vitro.

1994 • 373 citations

Overexpression of mitochondrial manganese superoxide dismutase promotes the survival of tumor cells exposed to interleukin‐1, tumor necrosis factor, selected anticancer drugs, and ionizing radiation

1993 • 351 citations

Divergent signalling via APO-1/Fas and the TNF receptor, two homologous molecules involved in physiological cell death.

1994 • 304 citations

Reactive oxygen intermediates activate NF-kappa B in a tyrosine kinase- dependent mechanism and in combination with vanadate activate the p56lck and p59fyn tyrosine kinases in human lymphocytes

1993 • 260 citations

Fas mediates apoptosis in human monocytes by a reactive oxygen intermediate dependent pathway.

1996 • 228 citations

Lipid hydroperoxides induce apoptosis in T cells displaying a HIV-associated glutathione peroxidase deficiency.

1994 • 205 citations

Protective activity of adult T cell leukemia-derived factor (ADF) against tumor necrosis factor-dependent cytotoxicity on U937 cells.

1991 • 201 citations

Rodent fibroblast tumours expressing human myc and ras genes: growth, metastasis and endogenous oncogene expression

1987 • 179 citations

Purification and characterization of Rac 2. A cytosolic GTP-binding protein that regulates human neutrophil NADPH oxidase.

1992 • 176 citations

Fas‐mediated apoptosis is modulated by intracellular glutathione in human T cells

1996 • 169 citations

[14] Assessing oxygen radicals as mediators in activation of inducible eukaryotic transcription factor NF-κB

1994 • 168 citations

Correction of accelerated autoimmune disease by early replacement of the mutated lpr gene with the normal Fas apoptosis gene in the T cells of transgenic MRL-lpr/lpr mice.

1994 • 145 citations

R-Ras promotes apoptosis caused by growth factor deprivation via a Bcl-2 suppressible mechanism.

1995 • 142 citations

Inhibition of superoxide production in B lymphocytes by rac antisense oligonucleotides.

1992 • 120 citations

Clastogenic action of hydroperoxy-5,8,11,13-icosatetraenoic acids on the mouse embryo fibroblasts C3H/10T1/2.

1987 • 82 citations

N-(2-mercaptoethyl)-1,3-propanediamine (WR-1065) protects thymocytes from programmed cell death.

1992 • 78 citations

Fragmentation of DNA in P388D₁ macrophages exposed to oxidised low‐density lipoprotein

1993 • 61 citations