Macrophages prevent the differentiation of autoreactive B cells by secreting CD40 ligand and interleukin-6

Analysis of Relative Gene Expression Data Using Real-Time Quantitative PCR and the 2−ΔΔCT Method

2001 • 156,143 citations

Chromatin–IgG complexes activate B cells by dual engagement of IgM and Toll-like receptors

2002 • 1,877 citations

Dendritic Cells Induce Peripheral T Cell Unresponsiveness under Steady State Conditions in Vivo

2001 • 1,845 citations

Altered immunoglobulin expression and functional silencing of self-reactive B lymphocytes in transgenic mice

1988 • 1,562 citations

Mechanism of antigen-driven selection in germinal centres

1989 • 1,097 citations

Impaired phagocytosis of apoptotic cell material by monocyte-derived macrophages from patients with systemic lupus erythematosus

1998 • 825 citations

RNA-associated autoantigens activate B cells by combined B cell antigen receptor/Toll-like receptor 7 engagement

2005 • 788 citations

Generation of Memory B Cells and Plasma Cells in Vitro

1995 • 585 citations

Induction of self-tolerance in mature peripheral B lymphocytes

1989 • 525 citations

Activation of Autoreactive B Cells by CpG dsDNA

2003 • 523 citations

Expansion or Elimination of B Cells In Vivo: Dual Roles for CD40- and Fas (CD95)-Ligands Modulated by the B Cell Antigen Receptor

1996 • 405 citations

B-cell apoptosis induced by antigen receptor crosslinking is blocked by a T-cell signal through CD40

1993 • 390 citations

B Cell Receptor–independent Stimuli Trigger Immunoglobulin (Ig) Class Switch Recombination and Production of IgG Autoantibodies by Anergic Self-Reactive B Cells

2003 • 223 citations

Maintenance of B cell anergy requires constant antigen receptor occupancy and signaling

2005 • 218 citations

CD19-Regulated Signaling Thresholds Control Peripheral Tolerance and Autoantibody Production in B Lymphocytes

1997 • 193 citations

Resistance to CpG DNA–induced autoimmunity through tolerogenic B cell antigen receptor ERK signaling

2003 • 184 citations

Memory B cell development but not germinal center formation is impaired by in vivo blockade of CD40-CD40 ligand interaction.

1994 • 182 citations

Lupus-Prone Mice Have an Abnormal Response to Thioglycolate and an Impaired Clearance of Apoptotic Cells

2003 • 174 citations

Structural characteristics of CD40 ligand that determine biological function

1994 • 166 citations

Activation and Anergy in Bone Marrow B Cells of a Novel Immunoglobulin Transgenic Mouse that Is Both Hapten Specific and Autoreactive

2001 • 151 citations

Arrest of B Lymphocyte Terminal Differentiation by CD40 Signaling: Mechanism for Lack of Antibody-Secreting Cells in Germinal Centers

1998 • 144 citations

A disease-related rheumatoid factor autoantibody is not tolerized in a normal mouse: implications for the origins of autoantibodies in autoimmune disease.

1996 • 139 citations

Accurate and statistically verified quantification of relative mRNA abundances using SYBR Green I and real-time RT-PCR

2003 • 116 citations

Autoreactive B Cell Regulation: Peripheral Induction of Developmental Arrest by Lupus-Associated Autoantigens

1998 • 103 citations

Early Preplasma Cells Define a Tolerance Checkpoint for Autoreactive B Cells

2006 • 87 citations

Impaired Clearance of Apoptotic Cells Induces the Activation of Autoreactive Anti-Sm Marginal Zone and B-1 B Cells

2004 • 83 citations

Engagement of CD40 lowers the threshold for activation of resting B cells via antigen receptor

1993 • 71 citations

Low-Affinity Anti-Smith Antigen B Cells Are Regulated by Anergy as Opposed to Developmental Arrest or Differentiation to B-1

2002 • 70 citations

CD40 ligand‐independent B cell activation revealed by CD40 ligand‐deficient T cell clones: evidence for distinct activation requirements for antibody formation and B cell proliferation

1995 • 66 citations

Signaling via major histocompatibility complex class II molecules and antigen receptors enhances the B cell response to gp39/CD40 ligand

1995 • 63 citations

The differentiation of human memory B cells into specific antibody‐secreting cells is CD40 independent

1996 • 55 citations

Cytokine Dysregulation Induced by Apoptotic Cells Is a Shared Characteristic of Murine Lupus

2000 • 54 citations

Blimp-1 over-expression abrogates IL-4- and CD40-mediated suppression of terminal B cell differentiation but arrests isotype switching.

2001 • 52 citations

Synergy between CpG- or non-CpG DNA and specific antigen for B cell activation

2003 • 48 citations

B Cell Receptor (BCR) Cross-Talk: CD40 Engagement Creates an Alternate Pathway for BCR Signaling That Activates IκB Kinase/IκBα/NF-κB without the Need for PI3K and Phospholipase Cγ

2005 • 47 citations

Aberrant cytokine expression and autocrine regulation characterize macrophages from young MRL+/+ and NZB/W F1 lupus-prone mice.

1997 • 47 citations

Ligation of CD40 influences the function of human Ig-secreting B cell hybridomas both positively and negatively.

1996 • 43 citations

Cutting Edge: Low-Affinity, Smith Antigen-Specific B Cells Are Tolerized by Dendritic Cells and Macrophages

2005 • 43 citations

Blimp-1 over-expression abrogates IL-4- and CD40-mediated suppression of terminal B cell differentiation but arrests isotype switching

2001 • 41 citations

CD40 cross-linking inhibits specific antibody production by human B cells

1995 • 41 citations

B Cell Receptor (BCR) Cross-Talk: CD40 Engagement Enhances BCR-Induced ERK Activation

2005 • 36 citations

Cutting Edge: CD40 Engagement Eliminates the Need for Bruton’s Tyrosine Kinase in B Cell Receptor Signaling for NF-κB

2003 • 34 citations

Sm and DNA binding by dual reactive B cells requires distinct VH, V kappa, and VH CDR3 structures.

1995 • 29 citations

Imbalanced cytokine production by macrophages from autoimmune-prone mice

1991 • 28 citations

Regulation of B cell growth and differentiation via CD21 and CD40

1996 • 24 citations

Dendritic Cells from Lupus-Prone Mice Are Defective in Repressing Immunoglobulin Secretion

2007 • 19 citations

A new multivalent B cell activation model--anti-IgD bound to Fc gamma RI: properties and comparison with CD40L-mediated activation

1997 • 17 citations