Impaired Clearance of Apoptotic Cells Induces the Activation of Autoreactive Anti-Sm Marginal Zone and B-1 B Cells

A novel assay for apoptosis Flow cytometric detection of phosphatidylserine expression on early apoptotic cells using fluorescein labelled Annexin V

1995 • 5,208 citations

Autoantigens targeted in systemic lupus erythematosus are clustered in two populations of surface structures on apoptotic keratinocytes.

1994 • 1,722 citations

Antinuclear Antibodies: Diagnostic Markers for Autoimmune Diseases and Probes for Cell Biology

1989 • 1,543 citations

Homozygous C1q deficiency causes glomerulonephritis associated with multiple apoptotic bodies

1998 • 1,431 citations

Phagocytosis and clearance of apoptotic cells is mediated by MER

2001 • 1,153 citations

Annexins: the problem of assessing the biological role for a gene family of multifunctional calcium- and phospholipid-binding proteins

1994 • 1,113 citations

Marginal Zone and B1 B Cells Unite in the Early Response against T-Independent Blood-Borne Particulate Antigens

2001 • 955 citations

Repeat-induced gene silencing in mammals

1998 • 884 citations

Impaired phagocytosis of apoptotic cell material by monocyte-derived macrophages from patients with systemic lupus erythematosus

1998 • 825 citations

The "Ly-1 B" cell subpopulation in normal immunodefective, and autoimmune mice.

1983 • 810 citations

Homeostatic Regulation of the Immune System by Receptor Tyrosine Kinases of the Tyro 3 Family

2001 • 673 citations

Ly-1 B cells: functionally distinct lymphocytes that secrete IgM autoantibodies.

1984 • 652 citations

Delayed Apoptotic Cell Clearance and Lupus-like Autoimmunity in Mice Lacking the c-mer Membrane Tyrosine Kinase

2002 • 627 citations

Systemic Exposure to Irradiated Apoptotic Cells Induces Autoantibody Production

1998 • 573 citations

Impaired uptake of apoptotic cells into tingible body macrophages in germinal centers of patients with systemic lupus erythematosus

2002 • 549 citations

A novel assay to measure loss of plasma membrane asymmetry during apoptosis of adherent cells in culture

1996 • 534 citations

Surface blebs on apoptotic cells are sites of enhanced procoagulant activity: implications for coagulation events and antigenic spread in systemic lupus erythematosus.

1996 • 485 citations

The extent of affinity maturation differs between the memory and antibody-forming cell compartments in the primary immune response

1997 • 437 citations

The bone marrow: the major source of serum immunoglobulins, but still a neglected site of antibody formation.

1981 • 359 citations

Many of the IgA producing plasma cells in murine gut are derived from self-replenishing precursors in the peritoneal cavity

1989 • 351 citations

Autoantigens as substrates for apoptotic proteases: implications for the pathogenesis of systemic autoimmune disease

1999 • 350 citations

In Situ Studies of the Primary Immune Response to (4-Hydroxy-3-Nitrophenyl)Acetyl. V. Affinity Maturation Develops in Two Stages of Clonal Selection

1998 • 349 citations

Ultraviolet light induces binding of antibodies to selected nuclear antigens on cultured human keratinocytes.

1984 • 334 citations

Intrinsic Constraint on Plasmablast Growth and Extrinsic Limits of Plasma Cell Survival

2000 • 311 citations

A novel receptor tyrosine kinase, Mer, inhibits TNF-alpha production and lipopolysaccharide-induced endotoxic shock.

1999 • 310 citations

CD5-Mediated Negative Regulation of Antigen Receptor-Induced Growth Signals in B-1 B Cells

1996 • 306 citations

Cutting Edge: Expansion and Activation of A Population of Autoreactive Marginal Zone B Cells in a Model of Estrogen-Induced Lupus

2001 • 290 citations

Antigen-induced apoptotic death of Ly-1 B cells responsible for autoimmune disease in transgenic mice

1992 • 281 citations

Distinct short‐lived and long‐lived antibody‐producing cell populations

1986 • 276 citations

A Novel Receptor Tyrosine Kinase, Mer, Inhibits TNF-α Production and Lipopolysaccharide-Induced Endotoxic Shock

1999 • 266 citations

Autoreactive B Cells in the Marginal Zone that Express Dual Receptors

2002 • 260 citations

Breakdown of self-tolerance in anergic B lymphocytes

1991 • 254 citations

Genetic dissection of systemic lupus erythematosus pathogenesis: Sle2 on murine chromosome 4 leads to B cell hyperactivity.

1997 • 234 citations

Hereditary C1q deficiency and systemic lupus erythematosus

1994 • 213 citations

Negative Selection of Immature B Cells by Receptor Editing or Deletion Is Determined by Site of Antigen Encounter

1999 • 209 citations

Development of B-1 cells: segregation of phosphatidyl choline-specific B cells to the B-1 population occurs after immunoglobulin gene expression.

1994 • 181 citations

Lupus-Prone Mice Have an Abnormal Response to Thioglycolate and an Impaired Clearance of Apoptotic Cells

2003 • 174 citations

Cutting Edge: A Role for CD1 in the Pathogenesis of Lupus in NZB/NZW Mice

2000 • 169 citations

Enhanced membrane binding of autoantibodies to cultured keratinocytes of systemic lupus erythematosus patients after ultraviolet B/ultraviolet A irradiation.

1992 • 167 citations

Dendritic cells associated with plasmablast survival

1999 • 144 citations

Clonal Deletion of Autospecific B Lymphocytes

1991 • 137 citations

Germinal Centers and Antibody Production in Bone Marrow

1992 • 135 citations

Accumulation of splenic B1a cells with potent antigen-presenting capability in NZM2410 lupus-prone mice

1998 • 127 citations

Structural basis for autoantibody recognition of phosphatidylserine-β2 glycoprotein I and apoptotic cells

2001 • 105 citations

Autoreactive B Cell Regulation: Peripheral Induction of Developmental Arrest by Lupus-Associated Autoantigens

1998 • 103 citations

Anti–DNA B Cells in MRL/lpr Mice Show Altered Differentiation and Editing Pattern

2002 • 103 citations

Activated B Cells Express Increased Levels of Costimulatory Molecules in Young Autoimmune NZB and (NZB × NZW)F1 Mice

2000 • 97 citations

Lupus-Specific Antiribonucleoprotein B Cell Tolerance in Nonautoimmune Mice Is Maintained by Differentiation to B-1 and Governed by B Cell Receptor Signaling Thresholds

2001 • 84 citations

The Yaa Mutation Promoting Murine Lupus Causes Defective Development of Marginal Zone B Cells

2003 • 84 citations

Conventional B cells, not B-1 cells, are responsible for producing autoantibodies in lpr mice.

1993 • 78 citations

Evidence that intestinal IgA plasma cells in μ,ϰ transgenic mice are derived from B-1 (Ly-1 B) cells

1993 • 75 citations

Genetic dissection of B cell traits in New Zealand black mice. The expanded population of B cells expressing up-regulated costimulatory molecules shows linkage toNba2

2000 • 74 citations

Induction of Anti-Phospholipid Autoantibodies by β2-glycoprotein I Bound to Apoptotic Thymocytes

1998 • 71 citations

Low-Affinity Anti-Smith Antigen B Cells Are Regulated by Anergy as Opposed to Developmental Arrest or Differentiation to B-1

2002 • 70 citations

Migration and Differentiation of Autoreactive B-1 Cells Induced by Activated γ/δ T Cells in Antierythrocyte Immunoglobulin Transgenic Mice

2000 • 53 citations

Anti-Sm B Cell Differentiation in Ig Transgenic MRL/Mp-lpr/lprMice: Altered Differentiation and an Accelerated Response

2001 • 49 citations

Autoantibodies to the Sm antigen: immunological approach to clinical aspects of systemic lupus erythematosus.

1987 • 46 citations

Activation and Differentiation of Autoreactive B-1 Cells by Interleukin 10 Induce Autoimmune Hemolytic Anemia in Fas-deficient Antierythrocyte Immunoglobulin Transgenic Mice

2002 • 43 citations

Monoclonal Antibodies Derived from BALB/c Mice Immunized with Apoptotic Jurkat T cells Recognize Known Autoantigens

2001 • 36 citations

Sm and DNA binding by dual reactive B cells requires distinct VH, V kappa, and VH CDR3 structures.

1995 • 29 citations