Identification of Anergic B Cells within a Wild-Type Repertoire

Predominant Autoantibody Production by Early Human B Cell Precursors

2003 • 1,966 citations

Altered immunoglobulin expression and functional silencing of self-reactive B lymphocytes in transgenic mice

1988 • 1,562 citations

A solid-phase enzyme-linked immunospot (ELISPOT) assay for enumeration of specific antibody-secreting cells

1983 • 1,054 citations

Receptor editing in self-reactive bone marrow B cells.

1993 • 1,026 citations

Clonal deletion of B lymphocytes in a transgenic mouse bearing anti-MHC class I antibody genes

1989 • 1,015 citations

Receptor editing: an approach by autoreactive B cells to escape tolerance.

1993 • 920 citations

B Cell Development in the Spleen Takes Place in Discrete Steps and Is Determined by the Quality of B Cell Receptor–Derived Signals

1999 • 843 citations

Excess BAFF Rescues Self-Reactive B Cells from Peripheral Deletion and Allows Them to Enter Forbidden Follicular and Marginal Zone Niches

2004 • 711 citations

Reduced Competitiveness of Autoantigen-Engaged B Cells due to Increased Dependence on BAFF

2004 • 564 citations

Resolution of Three Nonproliferative Immature Splenic B Cell Subsets Reveals Multiple Selection Points During Peripheral B Cell Maturation

2001 • 548 citations

Competition for follicular niches excludes self-reactive cells from the recirculating B-cell repertoire

1994 • 541 citations

Different Nuclear Signals Are Activated by the B Cell Receptor during Positive Versus Negative Signaling

1997 • 383 citations

NAB2, a Corepressor of NGFI-A (Egr-1) and Krox20, Is Induced by Proliferative and Differentiative Stimuli

1996 • 353 citations

Immunoglobulin signal transduction guides the specificity of B cell-T cell interactions and is blocked in tolerant self-reactive B cells.

1994 • 340 citations

Contribution of Receptor Editing to the Antibody Repertoire

2001 • 312 citations

Characterization of immature B cells by a novel monoclonal antibody, by turnover and by mitogen reactivity

1998 • 267 citations

Protein kinase Cδ controls self-antigen-induced B-cell tolerance

2002 • 265 citations

Reduced life span of anergic self-reactive B cells in a double-transgenic model.

1994 • 256 citations

Receptor editing is the main mechanism of B cell tolerance toward membrane antigens

2004 • 250 citations

Clonal anergy: Persistence in tolerant mice of antigen-binding B lymphocytes incapable of responding to antigen or mitogen

1980 • 250 citations

B Cell Development under the Condition of Allelic Inclusion

1997 • 240 citations

B Cell Receptor–independent Stimuli Trigger Immunoglobulin (Ig) Class Switch Recombination and Production of IgG Autoantibodies by Anergic Self-Reactive B Cells

2003 • 223 citations

Maintenance of B cell anergy requires constant antigen receptor occupancy and signaling

2005 • 218 citations

Receptor Editing Occurs Frequently during Normal B Cell Development

1998 • 205 citations

Neurogranin/RC3 Enhances Long-Term Potentiation and Learning by Promoting Calcium-Mediated Signaling

2004 • 193 citations

B‐lymphocyte quiescence, tolerance and activation as viewed by global gene expression profiling on microarrays

2000 • 186 citations

Characterization of marginal zone B cell precursors

2005 • 181 citations

Deletion of the immunoglobulin kappa chain intron enhancer abolishes kappa chain gene rearrangement in cis but not lambda chain gene rearrangement in trans.

1993 • 168 citations

Activation and Anergy in Bone Marrow B Cells of a Novel Immunoglobulin Transgenic Mouse that Is Both Hapten Specific and Autoreactive

2001 • 151 citations

Murine CD93 (C1qRp) Contributes to the Removal of Apoptotic Cells In Vivo but Is Not Required for C1q-Mediated Enhancement of Phagocytosis

2004 • 139 citations

Enforced Bcl-2 Expression Inhibits Antigen-mediated Clonal Elimination of Peripheral B Cells in an Antigen Dose–dependent Manner and Promotes Receptor Editing in Autoreactive, Immature B Cells

1997 • 132 citations

Early Growth Response Gene-2, a Zinc-Finger Transcription Factor, Is Required for Full Induction of Clonal Anergy in CD4+ T Cells

2004 • 132 citations

Cell surface antigens expressed by subsets of pre-B cells and B cells.

1984 • 111 citations

Anergic self-reactive B cells present self antigen and respond normally to CD40-dependent T-cell signals but are defective in antigen-receptor-mediated functions.

1994 • 111 citations

Intrinsic B-cell hyporesponsiveness accounts for self-tolerance in lysozyme/anti-lysozyme double-transgenic mice.

1990 • 92 citations

Distinct Signal Thresholds for the Unique Antigen Receptor–Linked Gene Expression Programs in Mature and Immature B Cells

1999 • 89 citations

Characterization of anergic anti-DNA B cells: B cell anergy is a T cell-independent and potentially reversible process

1999 • 83 citations

In Vivo Assessment of the Relative Contributions of Deletion, Anergy, and Editing to B Cell Self-Tolerance

2005 • 79 citations

Uncoupling of Anergy from Developmental Arrest in Anti-Insulin B Cells Supports the Development of Autoimmune Diabetes

2005 • 76 citations

Antigen receptor ‘capacity’ and the sensitivity of self-tolerance

1996 • 75 citations

Low-Affinity Anti-Smith Antigen B Cells Are Regulated by Anergy as Opposed to Developmental Arrest or Differentiation to B-1

2002 • 70 citations

Nab proteins mediate a negative feedback loop controlling Krox-20 activity in the developing hindbrain

2000 • 57 citations

B cells are anergic in transgenic mice that express IgM anti‐DNA antibodies

1993 • 44 citations

Transcriptional Program of Apoptosis Induction following Interleukin 2 Deprivation: Identification of RC3, a Calcium/Calmodulin Binding Protein, as a Novel Proapoptotic Factor

2003 • 37 citations

The regulation and activation of lupus‐associated B cells

2005 • 28 citations

PLCγ2 regulates Bcl‐2 levels and is required for survival rather than differentiation of marginal zone and follicular B cells

2004 • 28 citations

Clonal anergy: Inhibition of antigen‐driven proliferation among single B lymphocytes from tolerant animals, and partial breakage of anergy by mitogens

1983 • 15 citations

Persistence of partially functional double-stranded (ds) DNA binding B cells in mice transgenic for the IgM heavy chain of an anti-dsDNA antibody

2002 • 11 citations