A ring of uncharged polar amino acids as a component of channel constriction in the nicotinic acetylcholine receptor

Ionic channels of excitable membranes

1985 • 7,199 citations

Efficientin vitrosynthesis of biologically active RNA and RNA hybridization probes from plasmids containing a bacteriophage SP6 promoter

1984 • 6,459 citations

Molecular distinction between fetal and adult forms of muscle acetylcholine receptor

1986 • 979 citations

Structural invariants in protein folding

1975 • 865 citations

Cation Selective Glass Electrodes and their Mode of Operation

1962 • 844 citations

Rings of negatively charged amino acids determine the acetylcholine receptor channel conductance

1988 • 798 citations

Structural homology of Torpedo californica acetylcholine receptor subunits

1983 • 798 citations

Primary structure of α-subunit precursor of Torpedo californica acetylcholine receptor deduced from cDNA sequence

1982 • 730 citations

Recognition of cap structure in splicing in vitro of mRNA precursors

1984 • 575 citations

Primary structures of β- and δ-subunit precursors of Torpedo californica acetylcholine receptor deduced from cDNA sequences

1983 • 527 citations

Location of functional regions of acetylcholine receptor α-subunit by site-directed mutagenesis

1985 • 390 citations

Evidence That the M2 Membrane-Spanning Region Lines the Ion Channel Pore of the Nicotinic Receptor

1988 • 379 citations

The control of gene expression in animal development

1974 • 369 citations

The structure of ion channels in membranes of excitable cells

1989 • 368 citations

Location of a δ-subunit region determining ion transport through the acetylcholine receptor channel

1986 • 315 citations

The ion channel of the nicotinic acetylcholine receptor is formed by the homologous helices M II of the receptor subunits

1986 • 313 citations

Structure of the high-affinity binding site for noncompetitive blockers of the acetylcholine receptor: serine-262 of the delta subunit is labeled by [3H]chlorpromazine.

1986 • 296 citations

An open-channel blocker interacts with adjacent turns of α-helices in the nicotinic acetylcholine receptor

1990 • 275 citations

Role of acetylcholine receptor subunits in gating of the channel

1985 • 272 citations

Structure of the high-affinity binding site for noncompetitive blockers of the acetylcholine receptor: [3H]chlorpromazine labels homologous residues in the .beta. and .delta. chains

1987 • 228 citations

The noncompetitive blocker [3H]chlorpromazine labels three amino acids of the acetylcholine receptor gamma subunit: implications for the alpha-helical organization of regions MII and for the structure of the ion channel.

1990 • 186 citations

Cloning, sequencing and expression of cDNA for a novel subunit of acetylcholine receptor from calf muscle

1985 • 169 citations

Arrangement of the acetylcholine receptor subunits in the resting and desensitized states, determined by cryoelectron microscopy of crystallized Torpedo postsynaptic membranes.

1988 • 167 citations

Isolation and characterization of a cDNA clone for the complete protein coding region of the delta subunit of the mouse acetylcholine receptor.

1984 • 155 citations

Location of a threonine residue in the α -subunit M2 transmembrane segment that determines the ion flow through the acetylcholine receptor channel

1991 • 148 citations

Primary structure of delta subunit precursor of calf muscle acetylcholine receptor deduced from cDNA sequence

1985 • 134 citations

Rings of anionic amino acids as structural determinants of ion selectivity in the acetylcholine receptor channel

1991 • 127 citations

Primary structure and functional expression of the α‐, β‐, γ‐, δ‐ and ɛ‐subunits of the acetylcholine receptor from rat muscle

1990 • 110 citations

Mapping the alpha-subunit site photolabeled by the noncompetitive inhibitor [3H]quinacrine azide in the active state of the nicotinic acetylcholine receptor.

1990 • 104 citations

The reaction site of a non-competitive antagonist in the delta-subunit of the nicotinic acetylcholine receptor.

1986 • 104 citations

The noncompetitive blocker [³H]chlorpromazine labels segment M2 but not segment M 1 of the nicotinic acetylcholine receptor α‐subunit

1989 • 99 citations

Open channel structure and ion binding sites of the nicotinic acetylcholine receptor channel

1989 • 86 citations

Effects of substitution of putative transmembrane segments on nicotinic acetylcholine receptor function

1987 • 75 citations

Voltage-clamp studies of the Na+/glucose cotransporter cloned from rabbit small intestine

1991 • 71 citations

Spontaneous and agonist-induced openings of an acetylcholine receptor channel composed of bovine muscle ?-, ? and ?-subunits

1990 • 48 citations

Role of a key cysteine residue in the gating of the acetylcholine receptor

1991 • 41 citations