Recent advances in understanding sex differences in cardiac repolarization

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1996 • 459 citations

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2004 • 457 citations

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1996 • 447 citations

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2003 • 445 citations

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2000 • 441 citations

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1996 • 438 citations

Androgen Receptors Mediate Hypertrophy in Cardiac Myocytes

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2002 • 387 citations

Cardiac myocytes and fibroblasts contain functional estrogen receptors¹

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Ionic and Cellular Basis for the Predominance of the Brugada Syndrome Phenotype in Males

2002 • 383 citations

Ionic Current Basis of Electrocardiographic Waveforms

2002 • 382 citations

Electrophysiologic characteristics of cells spanning the left ventricular wall of human heart: Evidence for presence of M cells

1995 • 382 citations

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2002 • 379 citations

Sex Hormones Prolong the QT Interval and Downregulate Potassium Channel Expression in the Rabbit Heart

1996 • 368 citations

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1999 • 357 citations

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2000 • 351 citations

Electrical heterogeneity within the ventricular wall

2001 • 330 citations

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1997 • 329 citations

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2000 • 328 citations

Specific pattern of ionic channel gene expression associated with pacemaker activity in the mouse heart

2004 • 327 citations

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2002 • 318 citations

Four Kinetically Distinct Depolarization-activated K+ Currents in Adult Mouse Ventricular Myocytes

1999 • 309 citations

Unique Topographical Distribution of M Cells Underlies Reentrant Mechanism of Torsade de Pointes in the Long-QT Syndrome

2002 • 305 citations

Quantitative analysis of potassium channel mRNA expression in atrial and ventricular muscle of rats.

1994 • 304 citations

Drug-Induced QT Prolongation in Women During the Menstrual Cycle

2001 • 301 citations

Characterization of two distinct depolarization-activated K+ currents in isolated adult rat ventricular myocytes.

1991 • 295 citations

Transmural Electrophysiological Heterogeneities Underlying Arrhythmogenesis in Heart Failure

2003 • 293 citations

Rectification of the Background Potassium Current

2001 • 292 citations

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2003 • 291 citations

Estrogen Regulation of Angiotensin-Converting Enzyme mRNA

1999 • 287 citations

HERG K+ channels: friend and foe

2001 • 284 citations

Regulation of KChIP2 potassium channel β subunit gene expression underlies the gradient of transient outward current in canine and human ventricle

2001 • 281 citations

Ventricular repolarization components on the electrocardiogram

2003 • 279 citations

Plasma Membrane Estrogen Receptors Are Coupled to Endothelial Nitric-oxide Synthase through Gαi

2001 • 279 citations

Modulating effects of age and gender on the clinical course of long QT syndrome by genotype

2003 • 275 citations

Phase 2 Early Afterdepolarization as a Trigger of Polymorphic Ventricular Tachycardia in Acquired Long-QT Syndrome

2001 • 269 citations

Potassium channel down-regulation in heart failure

1998 • 263 citations

Regional variations in action potentials and transient outward current in myocytes isolated from rabbit left ventricle.

1991 • 261 citations

Physicochemical Features of the hERG Channel Drug Binding Site

2004 • 259 citations

KCNJ2 Mutation Results in Andersen Syndrome with Sex-Specific Cardiac and Skeletal Muscle Phenotypes

2002 • 258 citations

Regional Differences in Electrophysiological Properties of Epicardium, Midmyocardium, and Endocardium

1996 • 254 citations

Larger late sodium conductance in M cells contributes to electrical heterogeneity in canine ventricle

2001 • 253 citations

Sex differences on the electrocardiographic pattern of cardiac repolarization: Possible role of testosterone

2000 • 251 citations

I(to) and action potential notch are smaller in left vs. right canine ventricular epicardium

1996 • 249 citations

ACC/AHA/ESC guidelines for the management of patients with supraventricular arrhythmias—executive summary A Report of the American College of Cardiology/American HeartAssociation Task Force on Practice Guidelines and the European Society of Cardiology Committee for Practice Guidelines(Writing Committee to Develop Guidelines for the Management of Patients With Supraventricular Arrhythmias)Developed in collaboration with NASPE–Heart Rhythm Society

2003 • 248 citations

Testosterone Signaling through Internalizable Surface Receptors in Androgen Receptor-free Macrophages

1999 • 245 citations

Analysis of 12-Lead T-Wave Morphology for Risk Stratification After Myocardial Infarction

2000 • 242 citations

Trapping of a Methanesulfonanilide by Closure of the Herg Potassium Channel Activation Gate

2000 • 242 citations

Transmural heterogeneity of action potentials andI _to1 in myocytes isolated from the human right ventricle

1998 • 241 citations

Cellular basis for QT dispersion

1998 • 241 citations

The consequences of disrupting cardiac inwardly rectifying K⁺ current (I_K1) as revealed by the targeted deletion of the murine Kir2.1 and Kir2.2 genes

2001 • 237 citations

Estradiol induces the calcium-dependent translocation of endothelial nitric oxide synthase

1999 • 231 citations

Female Gender as a Risk Factor for Drug-Induced Cardiac Arrhythmias: Evaluation of Clinical and Experimental Evidence

1998 • 228 citations

Slick (Slo2.1), a Rapidly-Gating Sodium-Activated Potassium Channel Inhibited by ATP

2003 • 228 citations

Sex Differences in Cardiac Arrest Survivors

1996 • 223 citations

The role of the delayed rectifier component I_Ks in dog ventricular muscle and Purkinje fibre repolarization

2000 • 223 citations

Ovariectomy and 17β-estradiol modulate the levels of Alzheimer’s amyloid β peptides in brain

2000 • 221 citations

Brugada Syndrome

2002 • 221 citations

Two components of transient outward current in canine ventricular myocytes.

1989 • 215 citations

Regulation of cardiac and smooth muscle Ca²⁺channels (Ca_V1.2a,b) by protein kinases

2001 • 214 citations

Role of the Calcium-Independent Transient Outward Current I _to1 in Shaping Action Potential Morphology and Duration

2000 • 213 citations

Phase 2 reentry as a mechanism of initiation of circus movement reentry in canine epicardium exposed to simulated ischemia

1996 • 212 citations

Gender difference in the cycle length-dependent QT and potassium currents in rabbits.

1998 • 208 citations

Risk for systemic embolization of atrial fibrillation without mitral stenosis

1990 • 206 citations

Gender and the relationship between ventricular repolarization and cardiac cycle length during 24-h Holter recordings

1997 • 206 citations

[Sudden cardiac death].

1989 • 200 citations

Effects of Overexpression of the Na ⁺ -Ca ²⁺ Exchanger on [Ca ²⁺ ] _i Transients in Murine Ventricular Myocytes

1998 • 200 citations

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2003 • 199 citations

Potential Molecular Basis of Different Physiological Properties of the Transient Outward K ⁺ Current in Rabbit and Human Atrial Myocytes

1999 • 198 citations

Structure and function of cardiac potassium channels

1999 • 196 citations

Age-Gender Influence on the Rate-Corrected QT Interval and the QT-Heart Rate Relation in Families With Genotypically Characterized Long QT Syndrome

1997 • 193 citations

Remodeling of cardiomyocyte ion channels in human atrial fibrillation

2003 • 191 citations

Sex, hormones, and repolarization

2002 • 189 citations

Cloning and expression of the delayed-rectifier IsK channel from neonatal rat heart and diethylstilbestrol-primed rat uterus.

1990 • 189 citations

Gender-Specific Differences in the QT Interval and the Effect of Autonomic Tone and Menstrual Cycle in Healthy Adults

1997 • 187 citations

Overexpression of the Cardiac Na ⁺ /Ca ²⁺ Exchanger Increases Susceptibility to Ischemia/Reperfusion Injury in Male, but Not Female, Transgenic Mice

1998 • 187 citations

Basic Mechanisms of Atrial Fibrillation—Very New Insights into Very Old Ideas

2000 • 186 citations

Increased Expression of the Cardiac L-type Calcium Channel in Estrogen Receptor–deficient Mice

1997 • 182 citations

SUDDEN DEATH IN THE FRAMINGHAM HEART STUDY: DIFFERENCES IN INCIDENCE AND RISK FACTORS BY SEX AND CORONARY DISEASE STATUS

1984 • 180 citations

The electrophysiologic mechanism of ST-segment elevation in Brugada syndrome

2002 • 177 citations

Cellular uncoupling can unmask dispersion of action potential duration in ventricular myocardium. A computer modeling study.

1989 • 172 citations

Familial And Acquired Long QT Syndrome And The Cardiac Rapid Delayed Rectifier Potassium Current

2000 • 172 citations

Heterogeneity of the action potential in isolated rat ventricular myocytes and tissue.

1983 • 171 citations

Distinct Transient Outward Potassium Current (Ito) Phenotypes and Distribution of Fast-inactivating Potassium Channel Alpha Subunits in Ferret Left Ventricular Myocytes

1999 • 167 citations

Disappearance of the Brugada‐Type Electrocardiogram After Surgical Castration:

2003 • 165 citations

Estrogenic hormone action in the heart: regulatory network and function

2002 • 164 citations

Testosterone is a potent inhibitor of L-type Ca2+ channels

2004 • 163 citations

Prognostic Significance of Corrected QT and Corrected JT Interval for Incident Coronary Heart Disease in a General Population Sample Stratified by Presence or Absence of Wide QRS Complex

2003 • 163 citations

Differences in transient outward currents of feline endocardial and epicardial myocytes.

1990 • 161 citations

Hallmarks of ion channel gene expression in end‐stage heart failure

2003 • 161 citations

Phase 2 Reentry as a Trigger to Initiate Ventricular Fibrillation During Early Acute Myocardial Ischemia

2004 • 157 citations

Menstrual Cycle Effects on the Neurohumoral and Autonomic Nervous Systems Regulating the Cardiovascular System

2002 • 154 citations

I _NaCa contributes to electrical heterogeneity within the canine ventricle

2000 • 154 citations

Comparison of cloned Kir2 channels with native inward rectifier K⁺ channels from guinea‐pig cardiomyocytes

2001 • 151 citations

Age at onset and gender of patients with different types of supraventricular tachycardias

1992 • 150 citations

Sex-specific increase in the prevalence of atrial fibrillation (The Copenhagen City Heart Study)

2003 • 150 citations

Gender-Based Differences in Cardiac Repolarization in Mouse Ventricle

2001 • 149 citations

Pinacidil-induced electrical heterogeneity and extrasystolic activity in canine ventricular tissues. Does activation of ATP-regulated potassium current promote phase 2 reentry?

1993 • 149 citations

Experimental models of torsade de pointes

1998 • 145 citations

Heterogeneity of the early outward current in ventricular cells isolated from normal and hypertrophied rat hearts.

1993 • 141 citations

Slow inactivation of the sodium current in rabbit cardiac Purkinje fibres

1987 • 140 citations

Impact of Sex and Gonadal Steroids on Prolongation of Ventricular Repolarization and Arrhythmias Induced by I _K -Blocking Drugs

2001 • 139 citations

Blinded Test in Isolated Female Rabbit Heart Reliably Identifies Action Potential Duration Prolongation and Proarrhythmic Drugs: Importance of Triangulation, Reverse Use Dependence, and Instability

2003 • 135 citations

The normal duration of the Q-T interval

1942 • 135 citations

Heterogeneous distribution of the two components of delayed rectifier K+ current: a potential mechanism of the proarrhythmic effects of methanesulfonanilideclass III agents

1999 • 134 citations

Remodeling of Kv4.3 Potassium Channel Gene Expression under the Control of Sex Hormones

2001 • 134 citations

Review of the predictive value of the Langendorff heart model (Screenit system) in assessing the proarrhythmic potential of drugs

2004 • 134 citations

Testosterone, cytochrome P450, and cardiac hypertrophy

2002 • 134 citations

Heat-shock factor-1, steroid hormones, and regulation of heat-shock protein expression in the heart

2001 • 132 citations

Sex differences in ventricular repolarization: from cardiac electrophysiology to Torsades de Pointes

2004 • 130 citations

Estradiol Signaling via Sequestrable Surface Receptors

2001 • 130 citations

Effects of Sex and Age on Electrocardiographic and Cardiac Electrophysiological Properties in Adults

2001 • 127 citations

The role of Na-Ca exchange current in the cardiac action potential

1996 • 126 citations

Slow inactivation of a tetrodotoxin-sensitive current in canine cardiac Purkinje fibers

1984 • 126 citations

Sex and strain differences in adult mouse cardiac repolarization: importance of androgens

2004 • 125 citations

QT interval-heart rate relation during exercise in normal men and women: Definition by linear regression analysis

1996 • 124 citations

Cardiac Ultrarapid Delayed Rectifiers

1999 • 122 citations

Regional differences in the delayed rectifier current (IKr and IKs) contribute to the differences in action potential duration in basal left ventricular myocytes in guinea-pig

1998 • 122 citations

Effects of gonadal steroids on ventricular repolarization and on the response to E4031.

1998 • 122 citations

Functional properties of K⁺ currents in adult mouse ventricular myocytes

2004 • 122 citations

Gender differences in heart rate before and after autonomic blockade: Evidence against an intrinsic gender effect

1996 • 121 citations

Molecular biology of K+ channels and their role in cardiac arrhythmias11Am J Med. 2001;110-50-59.

2001 • 119 citations

Distribution of a Persistent Sodium Current Across the Ventricular Wall in Guinea Pigs

2000 • 118 citations

Gonadectomy of adult male rats reduces contractility of isolated cardiac myocytes

2003 • 118 citations

Gender-specific difference in cardiac ATP-sensitive K+channels

2001 • 117 citations

Ventricular action potentials, ventricular extracellular potentials, and the ECG of guinea pig.

1985 • 117 citations

Risk of proarrhythmia with class III antiarrhythmic agents: sex-based differences and other issues

2003 • 116 citations

Drugs, hERG and sudden death

2004 • 115 citations

Regional contributions ofKv1.4,Kv4.2, andKv4.3to transient outward K⁺current in rat ventricle

1999 • 113 citations

Evidence for the Presence of M Cells in the Guinea Pig Ventricle

1996 • 112 citations

Intercellular coupling through gap junctions masks M cells in the human heart

2004 • 111 citations

M cells and transmural heterogeneity of action potential configuration in myocytes from the left ventricular wall of the pig heart

2000 • 111 citations

Potassium rectifier currents differ in myocytes of endocardial and epicardial origin.

1992 • 110 citations

Diagnosis and long-term follow-up of the Brugada syndrome in patients with idiopathic ventricular fibrillation

2001 • 110 citations

Effects of gonadal steroids on gender-related differences in transmural dispersion of L-type calcium current

2002 • 109 citations

Control of L‐type calcium current during the action potential of guinea‐pig ventricular myocytes

1998 • 106 citations

Targeted Replacement of Kv1.5 in the Mouse Leads to Loss of the 4-Aminopyridine–Sensitive Component of I _K,slow and Resistance to Drug-Induced QT Prolongation

2001 • 106 citations

association between HERG K897T polymorphism and QT interval in middle-aged finnish women

2002 • 105 citations

Amiodarone reduces transmural heterogeneity of repolarization in the human heart

1998 • 105 citations

Novel KCNJ2 Mutation in Familial Periodic Paralysis With Ventricular Dysrhythmia

2002 • 103 citations

Abnormal Cardiac Na ⁺ Channel Properties and QT Heart Rate Adaptation in Neonatal Ankyrin _B Knockout Mice

2000 • 102 citations

Are gender differences in QTc present at birth?

1995 • 101 citations

Kv1.5 Is an Important Component of Repolarizing K ⁺ Current in Canine Atrial Myocytes

2003 • 101 citations

Transmural changes in size, contractile and electrical properties of SHR left ventricular myocytes during compensated hypertrophy

2004 • 98 citations

Regional Localization of ERG , the Channel Protein Responsible for the Rapid Component of the Delayed Rectifier, K ⁺ Current in the Ferret Heart

1997 • 97 citations

Detection of Proarrhythmia in the Female Rabbit Heart:

2003 • 96 citations

Age and gender differences in excitation‐contraction coupling of the rat ventricle

1998 • 95 citations

Genomics in Sudden Cardiac Death

2004 • 95 citations

Increased Propensity of Women to Develop Torsades de Pointes During Complete Heart Block

1995 • 92 citations

Rapid modulation of L‐type calcium current by acutely applied oestrogens in isolated cardiac myocytes from human, guinea‐pig and rat

1998 • 92 citations

Estrogen-mediated cytoplasmic and nuclear distribution of rat cardiovascular estrogen receptors.

1985 • 91 citations

Sex differences in repolarization homogeneity and its circadian pattern

2002 • 91 citations

Impact of estrogen replacement on ventricular myocyte contractile function and protein kinase B/Akt activation

2003 • 90 citations

Female preponderance in ibutilide-induced torsade de pointes

2004 • 90 citations

Influence of menstrual cycle on baroreflex control of heart rate: comparison with male volunteers

2003 • 89 citations

Heart Rate and its Variability Change After the Menopause

2000 • 88 citations

Hormone receptors of the baboon cardiovascular system. Biochemical characterization of aortic and myocardial cytoplasmic progesterone receptors.

1982 • 87 citations

Lack of evidence of M-cells in porcine left ventricular myocardium

1997 • 83 citations

Differential expression of KvLQT1 isoforms across the human ventricular wall

2000 • 83 citations

Left Ventricular Hypertrophy Decreases Slowly but Not Rapidly Activating Delayed Rectifier Potassium Currents of Epicardial and Endocardial Myocytes in Rabbits

2001 • 80 citations

Antiarrhythmic effect and its underlying ionic mechanism of 17β‐estradiol in cardiac myocytes

1999 • 79 citations

Profile and kinetics of L-type calcium current during the cardiac ventricular action potential compared in guinea-pigs, rats and rabbits

2000 • 78 citations

Female Gender is a Risk Factor for Drug‐Induced Long QT and Cardiac Arrhythmias in an In Vivo Rabbit Model

2001 • 77 citations

Ca²⁺loading and adrenergic stimulation reveal male/female differences in susceptibility to ischemia-reperfusion injury

2002 • 77 citations

Effects of estrogen on action potential and membrane currents in guinea pig ventricular myocytes

1999 • 75 citations

Acute Treatment of Atrial Fibrillation: Why and When to Maintain Sinus Rhythm

1998 • 73 citations

Four different components contribute to outward current in rat ventricular myocytes

1999 • 72 citations

Gender Influences [Ca ²⁺ ] _i During Metabolic Inhibition in Myocytes Overexpressing the Na ⁺ -Ca ²⁺ Exchanger

2001 • 71 citations

Sex differences in the rate dependence of the T wave descending limb

2003 • 70 citations

Properties, Expression and Potential Roles of Cardiac K + Channel Accessory Subunits: MinK, MiRPs, KChIP, and KChAP

2003 • 69 citations

Female Gender is a Risk Factor for Torsades de Pointes in an In Vitro Animal Model

1999 • 69 citations

Testosterone Diminishes the Proarrhythmic Effects of Dofetilide in Normal Female Rabbits

2002 • 68 citations

Effect of androgen deficiency on mouse ventricular repolarization

2003 • 67 citations

Functional and transmural modulation of M cell behavior in canine ventricular wall

2004 • 66 citations

Regulation of DHP receptor expression by elements in the 5′-flanking sequence

2000 • 66 citations

QT dispersion as a risk factor for sudden cardiac death and fatal myocardial infarction in a coronary risk population.

1997 • 64 citations

Gender-related differences in ventricular myocyte repolarization in the guinea pig

2004 • 63 citations

Molecular determinants of high-affinity drug binding to HERG channels.

2003 • 63 citations

Predicting sudden death in patients with mild to moderate chronic heart failure

2004 • 63 citations

A prospective evaluation of the risk of QT prolongation with hormone replacement therapy: the atherosclerosis risk in communities study

2003 • 61 citations

Calcium channel heterogeneity in canine left ventricular myocytes

2003 • 61 citations

Canine Ventricular KCNE2 Expression Resides Predominantly in Purkinje Fibers

2003 • 61 citations

Influence of endogenous oestrogens on QT interval duration

2003 • 60 citations

Castration Reduces mRNA Levels for Calcium Regulatory Proteins in Rat Heart

2002 • 60 citations

Rate- and Site-Dependent Effects of Propafenone, Dofetilide, and the New I _Ks -Blocking Agent Chromanol 293b on Individual Muscle Layers of the Intact Canine Heart

1999 • 60 citations

SVD-based on-line exercise ECG signal orthogonalization

1999 • 59 citations

Testosterone-mediated modulation of HERG blockade by proarrhythmic agents11Abbreviations: TdP, torsades de pointes; HERG, human ether-a-go-go related gene; DMSO, dimethyl sulfoxide.

2001 • 58 citations

Effect of Gender on Atrial Electrophysiologic Changes Induced by Rapid Atrial Pacing and Elevation of Atrial Pressure

2001 • 57 citations

Gender Differences in the Electrophysiological Characteristics of Atrioventricular Conduction System and their Clinical Implications

2001 • 57 citations

Tamoxifen inhibits Na⁺ and K⁺ currents in rat ventricular myocytes

2003 • 56 citations

Progesterone stimulates cardiac muscle protein synthesis via receptor-dependent pathway

2004 • 55 citations

Effects of progestin–estrogen replacement therapy on QT-dispersion in postmenopausal women

2000 • 55 citations

Ageing is associated with a decrease in the number of sarcolemmal ATP-sensitive K+ channels in a gender-dependent manner

2002 • 54 citations

Reduced repolarization reserve in ventricular myocytes from female mice

2002 • 54 citations

Enhanced responses to 17beta-estradiol in rat hearts treated with isoproterenol: involvement of a cyclic AMP-dependent pathway.

2000 • 53 citations

Calcium channel heterogeneity in canine left ventricular myocytes

2003 • 53 citations

Effects of 17β-estradiol on action potentials and ionic currents in male rat ventricular myocytes

1997 • 53 citations

Inhibition of HERG K⁺ Current and Prolongation of the Guinea‐Pig Ventricular Action Potential by 4‐Aminopyridine

2003 • 52 citations

Female Mice Lacking Estrogen Receptor β Display Prolonged Ventricular Repolarization and Reduced Ventricular Automaticity After Myocardial Infarction

2005 • 51 citations

Regional differences in action potential characteristics and membrane currents of guinea‐pig left ventricular myocytes

1998 • 51 citations

I _Kr drug response is modulated by KCR1 in transfected cardiac and noncardiac cell lines

2003 • 51 citations

Plasma concentrations of quinidine, its major metabolites, and dihydroquinidine in patients with torsades de pointes

1988 • 51 citations

Effect of testosterone therapy on QT dispersion in men with heart failure

2003 • 50 citations

Phenotypic Characterization of a Large European Family with Brugada Syndrome Displaying a Sudden Unexpected Death Syndrome Mutation in SCN5A:

2004 • 49 citations

Differences in action potential and early afterdepolarization properties in LQT2 and LQT3 models of long QT syndrome

2001 • 49 citations

The Brugada syndrome.

2002 • 49 citations

Gender Differences in Ventricular Repolarization:

2003 • 48 citations

Signal‐Averaged P‐Wave Analysis of Normal Controls and Patients with Paroxysmal Atrial Fibrillation: A Study in Gender Differences, Age Dependence, and Reproducibility

2002 • 48 citations

Secretion of Ovarian Inhibin and Its Physiologic Roles in the Regulation of Follicle-Stimulating Hormone Secretion during the Estrous Cycle of the Female Guinea Pig1

1999 • 47 citations

Maximal ascending and descending slopes of the T wave in men and women

1997 • 46 citations

Effect of low estrogen states in healthy women on dispersion of ventricular repolarization

2001 • 45 citations

Disturbed atrio-ventricular conduction and normal contractile function in isolated hearts from Ca v 1.3-knockout mice

2004 • 45 citations

Evidence for gender differences in electrophysiological properties of canine Purkinje fibres

2004 • 45 citations

Torsade de Pointes and Marked QT Prolongation in Association with Hypothyroidism

1987 • 45 citations

Global Repolarization Sequence of the Ventricular Endocardium: Monophasic Action Potential Mapping in Swine and Humans

2001 • 45 citations

Selective elimination ofI_K,slow1in mouse ventricular myocytes expressing a dominant negative Kv1.5α subunit

2004 • 44 citations

Effects of eicosapentaenoic acid on cardiac SR Ca2+-release and ryanodine receptor function

2003 • 43 citations

Tissue-specific regulation of Ca2+ channel protein expression by sex hormones

2002 • 41 citations

Gender and atrioventricular conduction properties of patients with symptomatic atrioventricular nodal reentrant tachycardia and Wolff-Parkinson-White syndrome

2001 • 41 citations

Gender‐dependent attenuation of cardiac potassium currents in type 2 diabetic db/db mice

2003 • 39 citations

Effects of Aging and Gender on QT Dispersion in an Overtly Healthy Population

2000 • 38 citations

Developmental changes of cardiac repolarization in rabbits Implications for the role of sex hormones

2003 • 37 citations

ETHNIC DIFFERENCES IN BLOOD PRESSURE AND HEART RATE OF CHICAGO SCHOOL CHILDREN

1985 • 36 citations

Antiarrhythmics---from cell to clinic: past, present, and future

2000 • 34 citations

Effects of the IKr-Blocking Agent Dofetilide and of the IKs-Blocking Agent Chromanol 293b on Regional Disparity of Left Ventricular Repolarization in the Intact Canine Heart

2002 • 33 citations

Gender differences in ANG II levels and action on multiple K⁺current modulation pathways in diabetic rats

2004 • 32 citations

Mice Display Sex Differences in Halothane-Induced Polymorphic Ventricular Tachycardia

2002 • 32 citations

Profile and kinetics of L-type calcium current during the cardiac ventricular action potential compared in guinea-pigs, rats and rabbits

2000 • 32 citations

Relation of Age and Sex to Atrial Electrophysiological Properties in Patients with No History of Atrial Fibrillation

2003 • 32 citations

Characteristics of a transient outward current (sensitive to 4-aminopyridine) in Ca 2+ -tolerant myocytes isolated from the rabbit atrioventricular node

1999 • 32 citations

Effects of Endothelin-1 on K+ Currents from Rat Ventricular Myocytes

2001 • 32 citations

Congenital Long QT syndrome.

2002 • 31 citations

Sex differences in the modulation of K⁺ currents in diabetic rat cardiac myocytes

2003 • 30 citations

Gender differences in the proarrhythmic potential of QT-prolonging drugs.

2002 • 30 citations

Sexual dimorphism characterizes baboon myocardial androgen receptors but not myocardial estrogen and progesterone receptors

1990 • 30 citations

Male/female differences in intracellular Na+regulation during ischemia/reperfusion in mouse heart

2004 • 29 citations

The effect of estrogen replacement therapy on ventricular repolarization dynamics in healthy postmenopausal women

2001 • 29 citations

Repolarization measures and their relation to sex hormones in postmenopausal women with cardiovascular disease receiving hormone replacement therapy

2002 • 25 citations

Distribution of action potential durations in the canine left ventricle.

1984 • 24 citations

Absence of Effects of Short‐Term Estrogen Replacement Therapy on Resting and Exertional QT and QT_c Dispersion in Postmenopausal Women with Coronary Artery Disease

1998 • 23 citations

Resting ECG is modified after oophorectomy and regresses with estrogen replacement therapy in premenopausal women

2000 • 22 citations

Molecular basis for the transmural distribution of the transient outward current

2001 • 22 citations

Effects of Long-term Oral Administration of Amiodarone on the Ventricular Repolarization of Rabbit Hearts

1996 • 21 citations

Gender determines the acute actions of genistein on intracellular calcium regulation in the guinea-pig heart

2003 • 21 citations

Transmural Heterogeneity of the Action Potential Configuration in the Feline Left Ventricle

2003 • 20 citations

A Longitudinal Study of Electrocardiographic Intervals in Healthy Children

1961 • 19 citations

Inhibitory Effects of the Antiestrogen Agent Clomiphene on Cardiac Sarcolemmal Anionic and Cationic Currents

2002 • 18 citations

Effect of estrogen on ventricular repolarization in menopausal patients with syndrome X and effects of nicorandil

1999 • 18 citations

Is there an A-type K⁺ current in guinea pig ventricular myocytes?

2003 • 18 citations

Sex differences in (3H)nitrendipine binding and effects of sex steroid hormones in rat cardiac and cerebral membranes.

1988 • 17 citations

An Altered Repolarizing Potassium Current in Rat Cardiac Myocytes after Subtotal Nephrectomy

2000 • 16 citations

Anchors Aweigh!

2000 • 16 citations

Evidence for a Novel K⁺Channel Modulated by α_1A-Adrenoceptors in Cardiac Myocytes

2004 • 16 citations

Untitled

1998 • 15 citations

Hormone Replacement Therapy Shortens QT Dispersion in Healthy Postmenopausal Women

2001 • 15 citations

Experimental study on the mechanism of sex difference in the risk of torsade de pointes.

2004 • 14 citations

Effects of Long-Term Hormone Replacement Therapy on QT and Corrected QT Dispersion during Resting and Peak Exercise Electrocardiography in Post-Menopausal Women.

2002 • 14 citations

Components of Q-T and Q-U Intervals of the Electrocardiogram In Normals

1956 • 13 citations

Physiology and Pharmacology of the Heart

1997 • 12 citations

Experimental study on the mechanism of sex difference in the risk of torsade de pointes

2004 • 8 citations

Effects of surgical menopause and estrogen replacement therapy on atrio-ventricular conduction and ventricular repolarization

2001 • 7 citations

Gender differences in effects of pinacidil but not diazoxide on heart automatism in the isolated guinea pig right atria.

2003 • 7 citations

Does Subclinical Hypothyroidism Explain the Increased Susceptibility of Women to Torsades de Pointes?

1997 • 7 citations

Actions of the anti-oestrogen agent clomiphene on outward K+ currents in rat ventricular myocytes

2004 • 6 citations

Sex Differences in [3H]Nitrendipine Binding and Effects of Sex Steroid Hormones in Rat Cardiac and Cerebral Membranes

1988 • 5 citations

Long Q-T interval and Torsade de Pointes in hypothyroidism.

1995 • 2 citations

Contribution of a Ca-dependent component to the transient outward current in rabbit ventricular fibres.

1988 • 2 citations