Heterogeneous distribution of the two components of delayed rectifier K+ current: a potential mechanism of the proarrhythmic effects of methanesulfonanilideclass III agents

Two components of cardiac delayed rectifier K+ current. Differential sensitivity to block by class III antiarrhythmic agents.

1990 • 1,467 citations

Electrophysiological mechanisms of ventricular arrhythmias resulting from myocardial ischemia and infarction

1989 • 995 citations

Heterogeneity within the ventricular wall. Electrophysiology and pharmacology of epicardial, endocardial, and M cells.

1991 • 731 citations

Characteristics of the Delayed Rectifier Current (I_Krand I_Ks) in Canine Ventricular Epicardial, Midmyocardial, and Endocardial Myocytes

1995 • 605 citations

Evidence for Two Components of Delayed Rectifier K ⁺ Current in Human Ventricular Myocytes

1996 • 463 citations

Ionic bases for electrophysiological distinctions among epicardial, midmyocardial, and endocardial myocytes from the free wall of the canine left ventricle.

1993 • 462 citations

Regional Differences in Current Density and Rate-Dependent Properties of the Transient Outward Current in Subepicardial and Subendocardial Myocytes of Human Left Ventricle

1996 • 459 citations

Electrophysiologic characteristics of cells spanning the left ventricular wall of human heart: Evidence for presence of M cells

1995 • 382 citations

Comparison of potassium currents in rabbit atrial and ventricular cells.

1988 • 382 citations

Transient outward current in human ventricular myocytes of subepicardial and subendocardial origin.

1994 • 358 citations

Voltage- and time-dependent block of the delayed K+ current in cardiac myocytes by dofetilide.

1992 • 316 citations

Electrophysiologic substrate of torsade de pointes: Dispersion of repolarization or early afterdepolarizations?

1989 • 276 citations

Electrophysiologic Mechanisms of the Long QT Interval Syndromes and Torsade de Pointes

1995 • 269 citations

Regional variations in action potentials and transient outward current in myocytes isolated from rabbit left ventricle.

1991 • 261 citations

QTU-Prolongation and Torsades de Pointes Induced by Putative Class III Antiarrhythmic Agents in the Rabbit

1990 • 238 citations

Characteristics of transient outward current in human ventricular myocytes from patients with terminal heart failure.

1993 • 233 citations

Heterogeneity of action potential waveforms and potassium currents in rat ventricle

1993 • 232 citations

Role of external Ca2+ and K+ in gating of cardiac delayed rectifier K+ currents

1992 • 190 citations

Calcium‐sensitive and insensitive transient outward current in rabbit ventricular myocytes.

1989 • 176 citations

Different electrophysiological responses of canine endocardium and epicardium to combined hyperkalemia, hypoxia, and acidosis.

1980 • 164 citations

Differences in transient outward currents of feline endocardial and epicardial myocytes.

1990 • 161 citations

Inhibition of IKs in guinea pig cardiac myocytes and guinea pig IsK channels by the chromanol 293B

1996 • 148 citations

Two Components of Delayed Rectifier Current in Canine Atrium and Ventricle

1996 • 139 citations

Effects of MS‐551, a new class III antiarrhythmic drug, on action potential and membrane currents in rabbit ventricular myocytes

1993 • 137 citations

Distribution of M Cells in the Canine Ventricle

1994 • 133 citations

IK of rabbit ventricle is composed of two currents: evidence for IKs

1996 • 131 citations

Evidence for the Presence of M Cells in the Guinea Pig Ventricle

1996 • 112 citations

Potassium rectifier currents differ in myocytes of endocardial and epicardial origin.

1992 • 110 citations

Regional Localization of ERG , the Channel Protein Responsible for the Rapid Component of the Delayed Rectifier, K ⁺ Current in the Ferret Heart

1997 • 97 citations

Delayed K+ current and external K+ in single cardiac Purkinje cells

1989 • 76 citations

Delayed Rectifier Channels in Human Ventricular Myocytes

1995 • 74 citations

Single delayed rectifier channels in the membrane of rabbit ventricular myocytes.

1993 • 64 citations

Transient outward current and rate dependence of action potential duration in rabbit cardiac ventricular muscle

1983 • 63 citations

Emerging class III antiarrhythmic agents: mechanism of action and proarrhythmic potential.

1997 • 53 citations

Potassium channel blockers as antiarrhythmic drugs

1994 • 50 citations

Ionic Mechanisms for Prolongation of Refractoriness and Their Proarrhythmic and Antiarrhythmic Correlates**This work was supported in part by grants from the United States Public Health Service (HL49989, HL46681). Dr. Roden is the holder of the William Stokes Chair in Experimental Therapeutics, a gift from the Daiichi Corporation.

1996 • 46 citations

Characteristics of the delayed rectifier K current compared in myocytes isolated from the atrioventricular node and ventricle of the rabbit heart

1996 • 44 citations

Differences in outward currents between neonatal and adult rabbit ventricular cells

1994 • 41 citations

Effects of Long-term Oral Administration of Amiodarone on the Ventricular Repolarization of Rabbit Hearts

1996 • 21 citations

Ionic currents in ventricular myocytes isolated from the heart of a patient with idiopathic cardiomyopathy.

1992 • 15 citations

Experience with directional coronary atherectomy since pre-market approval

1993 • 12 citations

Rate-Dependent Effects of Sematilide on Ventricular Monophasic Action Potential Duration and Delayed Rectifier K+ Current in Rabbits

1996 • 12 citations