Cardiac Ultrarapid Delayed Rectifiers

Improved patch-clamp techniques for high-resolution current recording from cells and cell-free membrane patches

1981 • 18,584 citations

Two components of cardiac delayed rectifier K+ current. Differential sensitivity to block by class III antiarrhythmic agents.

1990 • 1,467 citations

Ionic mechanisms underlying human atrial action potential properties: insights from a mathematical model

1998 • 1,173 citations

Pharmacological characterization of five cloned voltage-gated K+ channels, types Kv1.1, 1.2, 1.3, 1.5, and 3.1, stably expressed in mammalian cell lines.

1994 • 763 citations

Mutations Affecting Tea Blockade and Ion Permeation in Voltage-activated K ⁺ Channels

1990 • 569 citations

Sustained depolarization-induced outward current in human atrial myocytes. Evidence for a novel delayed rectifier K+ current similar to Kv1.5 cloned channel currents.

1993 • 568 citations

Outward K ⁺ Current Densities and Kv1.5 Expression Are Reduced in Chronic Human Atrial Fibrillation

1997 • 545 citations

Mathematical Model of an Adult Human Atrial Cell

1998 • 524 citations

The kinetics and rectifier properties of the slow potassium current in cardiac Purkinje fibres

1968 • 488 citations

Evidence for Two Components of Delayed Rectifier K ⁺ Current in Human Ventricular Myocytes

1996 • 463 citations

Antisense Oligodeoxynucleotides Directed Against Kv1.5 mRNA Specifically Inhibit Ultrarapid Delayed Rectifier K ⁺ Current in Cultured Adult Human Atrial Myocytes

1997 • 302 citations

Characterization of two distinct depolarization-activated K+ currents in isolated adult rat ventricular myocytes.

1991 • 295 citations

Ionic targets for drug therapy and atrial fibrillation-induced electrical remodeling: insights from a mathematical model

1999 • 283 citations

A rapidly activating and slowly inactivating potassium channel cloned from human heart. Functional analysis after stable mammalian cell culture expression.

1993 • 265 citations

Differences between outward currents of human atrial and subepicardial ventricular myocytes.

1996 • 231 citations

Cellular and Ionic Basis of Arrhythmias in Postinfarction Remodeled Ventricular Myocardium

1996 • 221 citations

Time-, voltage-, and state-dependent block by quinidine of a cloned human cardiac potassium channel.

1992 • 220 citations

Delayed rectifier outward K+ current is composed of two currents in guinea pig atrial cells

1991 • 215 citations

Alpha 1-adrenergic agonists selectively suppress voltage-dependent K+ current in rat ventricular myocytes.

1988 • 213 citations

Voltage-activated potassium channels in mammalian neurons and their block by novel pharmacological agents

1998 • 191 citations

Effects of flecainide, quinidine, and 4-aminopyridine on transient outward and ultrarapid delayed rectifier currents in human atrial myocytes.

1995 • 171 citations

Inhomogeneity of Cellular Refractoriness in Human Atrium: Factor of Arrhythmia?

1986 • 160 citations

Interaction between tetraethylammonium and amino acid residues in the pore of cloned voltage-dependent potassium channels.

1991 • 146 citations

Differential Expression of Voltage-Gated K ⁺ Channel Genes in Left Ventricular Remodeled Myocardium After Experimental Myocardial Infarction

1996 • 136 citations

A rapidly activating sustained K⁺ current modulates repolarization and excitation–contraction coupling in adult mouse ventricle

1997 • 132 citations

Molecular Analysis of a Binding Site for Quinidine in a Human Cardiac Delayed Rectifier K ⁺ Channel

1996 • 132 citations

Adrenergic Modulation of Ultrarapid Delayed Rectifier K+ Current in Human Atrial Myocytes

1996 • 124 citations

Electrophysiological and pharmacological characterization of a mammalian Shaw channel expressed in NIH 3T3 fibroblasts

1995 • 120 citations

Characterization of an ultrarapid delayed rectifier potassium channel involved in canine atrial repolarization.

1996 • 118 citations

Segmental exchanges define 4-aminopyridine binding and the inner mouth of K+ pores

1993 • 116 citations

Age-related appearance of outward currents may contribute to developmental differences in ventricular repolarization.

1992 • 115 citations

Background potassium current active during the plateau of the action potential in guinea pig ventricular myocytes.

1993 • 114 citations

Dexamethasone rapidly induces Kv1.5 K+ channel gene transcription and expression in clonal pituitary cells

1993 • 108 citations

Glucocorticoid induced up-regulation of a pituitary K+ channel mRNA in vitro and in vivo.

1993 • 107 citations

Newer developments in the management of atrial fibrillation

1995 • 97 citations

When, where, and how much? Expression of the Kv3.1 potassium channel in high-frequency firing neurons

1998 • 96 citations

Glucocorticoid induction of Kv1.5 K+ channel gene expression in ventricle of rat heart.

1994 • 95 citations

Characterization of a Slowly Inactivating Outward Current in Adult Mouse Ventricular Myocytes

1998 • 94 citations

Identification of amino acid residues involved in dendrotoxin block of rat voltage-dependent potassium channels.

1991 • 93 citations

Class III Antiarrhythmic Effects of Zatebradine

1996 • 92 citations

A novel type of depolarization-activated K+ current in isolated adult rat atrial myocytes

1991 • 85 citations

Sequence and functional expression in Xenopus oocytes of a human insulinoma and islet potassium channel.

1991 • 83 citations

Ultrarapid delayed rectifier current inactivation in human atrial myocytes: properties and consequences

1998 • 83 citations

Thalamocortical projections have a K+ channel that is phosphorylated and modulated by cAMP-dependent protein kinase

1995 • 82 citations

Age-related appearance of outward currents may contribute to developmental differences in ventricular repolarization.

1992 • 80 citations

Molecular basis of cardiac potassium channel stimulation by protein kinase A.

1994 • 72 citations

Molecular Biology of the Voltage‐Gated Potassium Channels of the Cardiovascular System

1993 • 71 citations

Mutational analysis of ion conduction and drug binding sites in the inner mouth of voltage-gated K+ channels

1994 • 71 citations

Multiple mRNA isoforms encoding the mouse cardiac Kv1-5 delayed rectifier K+ channel.

1993 • 62 citations

Effects of class III antiarrhythmic drugs on transient outward and ultra-rapid delayed rectifier currents in human atrial myocytes.

1997 • 58 citations

Overexpression of nerve growth factor in the heart alters ion channel activity and β‐adrenergic signalling in an adult transgenic mouse

1998 • 52 citations

Effects of propafenone and 5‐hydroxy‐propafenone on hKv1.5 channels

1998 • 52 citations

Pharmacodynamics and side effects of flecainide acetate

1986 • 49 citations

Cloning and Characterization of the Promoter for a Potassium Channel Expressed in High Frequency Firing Neurons

1996 • 48 citations

Mechanism of clofilium block of the human Kv1.5 delayed rectifier potassium channel.

1995 • 46 citations

Selective inhibition of potassium currents in rat ventricle by clofilium and its tertiary homolog.

1991 • 44 citations

Adrenergic control of the ultrarapid delayed rectifier current in canine atrial myocytes

1999 • 38 citations

Modulation by protein kinase A of a cloned rat brain potassium channel expressed in Xenopus oocytes

1994 • 37 citations

Dexamethasone and stress upregulate Kv1.5 K+ channel gene expression in rat ventricular myocytes.

1996 • 36 citations

Characterization of a beta‐adrenergically inhibited K+ current in rat cardiac ventricular cells.

1996 • 35 citations

Gating charge and ionic currents associated with quinidine block of human Kv1.5 delayed rectifier channels.

1997 • 35 citations

Effects of the class III antiarrhythmic drug ambasilide on outward currents in human atrial myocytes

1996 • 32 citations

Phenylephrine suppresses outward K+ currents in rat atrial myocytes

1996 • 31 citations

Propafenone Inhibition of Human Atrial Myocyte Repolarizing Currents

1998 • 30 citations

Quinidine Interactions With Human Atrial Potassium Channels

1998 • 27 citations

Altered K⁺ Channel Subunit Composition following Hormone Induction of Kv1.5 Gene Expression

1996 • 27 citations

Effects of Thyroid and Glucocorticoid Hormones on Kv1.5 Potassium Channel Gene Expression in the Rat Left Ventricle

1997 • 20 citations

Estimation of outward currents in isolated human atrial myocytes using inactivation time course analysis

1998 • 17 citations

Regulation of Cardiac Kv1.5 K+Channel Expression by Cardiac Fibroblasts and Mechanical Load in Cultured Newborn Rat Ventricular Myocytes

1998 • 16 citations

Multiple protein kinases are required for basal Kv1.5 K+ channel gene expression in GH3 clonal pituitary cells

1995 • 13 citations

α 1 -Adrenoceptor agonists and IGF-1, myocardial hypertrophic factors, regulate the Kv1.5 K + channel expression differentially in cultured newborn rat ventricular cells

1998 • 12 citations