Molecular and Cellular Mechanisms of Cardiac Arrhythmias

A mechanistic link between an inherited and an acquird cardiac arrthytmia: HERG encodes the IKr potassium channel

1995 • 2,391 citations

A molecular basis for cardiac arrhythmia: HERG mutations cause long QT syndrome

1995 • 2,263 citations

Genetic basis and molecular mechanism for idiopathic ventricular fibrillation

1998 • 1,803 citations

Positional cloning of a novel potassium channel gene: KVLQT1 mutations cause cardiac arrhythmias

1996 • 1,746 citations

Coassembly of KVLQT1 and minK (IsK) proteins to form cardiac IKS potassium channel

1996 • 1,741 citations

SCN5A mutations associated with an inherited cardiac arrhythmia, long QT syndrome

1995 • 1,686 citations

Congenital deaf-mutism, functional heart disease with prolongation of the Q-T interval, and sudden death

1957 • 1,593 citations

KvLQT1 and IsK (minK) proteins associate to form the IKS cardiac potassium current

1996 • 1,585 citations

Two components of cardiac delayed rectifier K+ current. Differential sensitivity to block by class III antiarrhythmic agents.

1990 • 1,467 citations

Mutations in the Cardiac Ryanodine Receptor Gene ( hRyR2 ) Underlie Catecholaminergic Polymorphic Ventricular Tachycardia

2001 • 1,360 citations

MiRP1 Forms IKr Potassium Channels with HERG and Is Associated with Cardiac Arrhythmia

1999 • 1,344 citations

Spectrum of Mutations in Long-QT Syndrome Genes

2000 • 1,229 citations

HERG, a Human Inward Rectifier in the Voltage-Gated Potassium Channel Family

1995 • 1,216 citations

A novel potassium channel gene, KCNQ2, is mutated in an inherited epilepsy of newborns

1998 • 1,191 citations

Diagnostic criteria for the long QT syndrome. An update.

1993 • 1,160 citations

Molecular mechanism for an inherited cardiac arrhythmia

1995 • 964 citations

A family of potassium channel genes related to eag in Drosophila and mammals.

1994 • 960 citations

A pore mutation in a novel KQT-like potassium channel gene in an idiopathic epilepsy family

1998 • 937 citations

A structural basis for drug-induced long QT syndrome

2000 • 911 citations

A novel mutation in the potassium channel gene KVLQT1 causes the Jervell and Lange-Nielsen cardioauditory syndrome

1997 • 878 citations

KCNQ4, a Novel Potassium Channel Expressed in Sensory Outer Hair Cells, Is Mutated in Dominant Deafness

1999 • 853 citations

A NEW FAMILIAL CARDIAC SYNDROME IN CHILDREN.

1964 • 842 citations

Mutations in the hminK gene cause long QT syndrome and suppress lKs function

1997 • 763 citations

The inward rectification mechanism of the HERG cardiac potassium channel

1996 • 754 citations

Right Bundle-Branch Block and ST-Segment Elevation in Leads V ₁ Through V ₃

1998 • 718 citations

Circadian variation in the incidence of sudden cardiac death in the framingham heart study population

1987 • 657 citations

The Spectrum of Symptoms and QT Intervals in Carriers of the Gene for the Long-QT Syndrome

1992 • 633 citations

Multiple Mechanisms in the Long-QT Syndrome

1996 • 631 citations

Primary structure and functional expression of the human cardiac tetrodotoxin-insensitive voltage-dependent sodium channel.

1992 • 624 citations

ECG T-Wave Patterns in Genetically Distinct Forms of the Hereditary Long QT Syndrome

1995 • 618 citations

Linkage of a Cardiac Arrhythmia, the Long QT Syndrome, and the Harvey ras -1 Gene

1991 • 526 citations

Cloning of a Membrane Protein That Induces a Slow Voltage-Gated Potassium Current

1988 • 511 citations

Ion Channels and Disease

2000 • 485 citations

A common polymorphism associated with antibiotic-induced cardiac arrhythmia

2000 • 477 citations

Spectrum of HERG K+-channel dysfunction in an inherited cardiac arrhythmia.

1996 • 465 citations

Crystal Structure and Functional Analysis of the HERG Potassium Channel N Terminus

1998 • 439 citations

Fast inactivation causes rectification of the IKr channel.

1996 • 395 citations

Inner Ear Defects Induced by Null Mutationof the isk Gene

1996 • 395 citations

HERG Channel Dysfunction in Human Long QT Syndrome

1998 • 377 citations

A minK–HERG complex regulates the cardiac potassium current IKr

1997 • 376 citations

Ventricular fibrillation without apparent heart disease: Description of six cases

1989 • 365 citations

Mapping of a gene for long QT syndrome to chromosome 4q25-27.

1995 • 356 citations

Human KVLQT1 gene shows tissue-specific imprinting and encompasses Beckwith-Wiedemann syndrome chromosomal rearrangements

1997 • 354 citations

Molecular Basis of the Long-QT Syndrome Associated with Deafness

1997 • 350 citations

Multiple Mechanisms of Na ⁺ Channel– Linked Long-QT Syndrome

1996 • 340 citations

Cardiac sodium channel mutations in patients with long QT syndrome, an inherited cardiac arrhythmia

1995 • 337 citations

Blocker protection in the pore of a voltage-gated K+ channel and its structural implications

2000 • 336 citations

Genetically Defined Therapy of Inherited Long-QT Syndrome

1996 • 311 citations

Molecular Determinants of Dofetilide Block of HERG K ⁺ Channels

1998 • 280 citations

Two long QT syndrome loci map to chromosomes 3 and 7 with evidence for further heterogeneity

1994 • 270 citations

Trapping of a Methanesulfonanilide by Closure of the Herg Potassium Channel Activation Gate

2000 • 242 citations

Molecular determinant of high-affinity dofetilide binding to HERG1 expressed in Xenopus oocytes: involvement of S6 sites.

2000 • 241 citations

Long QT Syndrome-associated Mutations in the Per-Arnt-Sim (PAS) Domain of HERG Potassium Channels Accelerate Channel Deactivation

1999 • 219 citations

KvLQT1, a voltage-gated potassium channel responsible for human cardiac arrhythmias

1997 • 214 citations

Mutation of the Gene for I sK Associated With Both Jervell and Lange-Nielsen and Romano-Ward Forms of Long-QT Syndrome

1998 • 206 citations

Functional Expression of Two KvLQT1-related Potassium Channels Responsible for an Inherited Idiopathic Epilepsy

1998 • 199 citations

Pathophysiological Mechanisms of Dominant and Recessive KvLQT1 K+ Channel Mutations Found in Inherited Cardiac Arrhythmias

1997 • 192 citations

Sudden death risk in overt coronary heart disease: The Framingham Study

1987 • 183 citations

Sodium channel block produces opposite electrophysiological effects in canine ventricular epicardium and endocardium.

1991 • 150 citations

Subunit composition of mink potassium channels

1995 • 127 citations

Mechanisms and management of proarrhythmia

1998 • 125 citations

A new form of long QT syndrome associated with syndactyly

1995 • 119 citations

Functional Effects of Mutations in KvLQT1 that Cause Long QT Syndrome

1999 • 95 citations

The Human ∆1261 Mutation of the HERG Potassium Channel Results in a Truncated Protein That Contains a Subunit Interaction Domain and Decreases the Channel Expression

1997 • 93 citations

Homozygous Premature Truncation of the HERG Protein

1999 • 71 citations

MinK Potassium Channels Are Heteromultimeric Complexes

1997 • 30 citations

The Sympathetic Imbalance Hypothesis of QT Interval Prolongation

1991 • 17 citations

Update on MADIT: The multkenter automatic defibrillator implantation trial

1997 • 17 citations