Molecular basis of functional voltage‐gated K⁺ channel diversity in the mammalian myocardium

A mechanistic link between an inherited and an acquird cardiac arrthytmia: HERG encodes the IKr potassium channel

1995 • 2,391 citations

Coassembly of KVLQT1 and minK (IsK) proteins to form cardiac IKS potassium channel

1996 • 1,741 citations

KvLQT1 and IsK (minK) proteins associate to form the IKS cardiac potassium current

1996 • 1,585 citations

Two components of cardiac delayed rectifier K+ current. Differential sensitivity to block by class III antiarrhythmic agents.

1990 • 1,467 citations

MiRP1 Forms IKr Potassium Channels with HERG and Is Associated with Cardiac Arrhythmia

1999 • 1,344 citations

KCNQ2 and KCNQ3 Potassium Channel Subunits: Molecular Correlates of the M-Channel

1998 • 1,283 citations

HERG, a Human Inward Rectifier in the Voltage-Gated Potassium Channel Family

1995 • 1,216 citations

Cardiac Electrophysiology: From Cell to Bedside

1995 • 1,173 citations

Molecular Diversity of K⁺ Channels

1999 • 1,117 citations

A Potassium Channel Mutation in Neonatal Human Epilepsy

1998 • 1,078 citations

A family of potassium channel genes related to eag in Drosophila and mammals.

1994 • 960 citations

Determination of the subunit stoichiometry of a voltage-activated potassium channel

1991 • 925 citations

Inactivation properties of voltage-gated K+ channels altered by presence of β-subunit

1994 • 845 citations

Electrophysiological remodeling in hypertrophy and heart failure

1999 • 743 citations

Cardiac Ionic Currents and Acute Ischemia: From Channels to Arrhythmias

1999 • 692 citations

Characteristics of the Delayed Rectifier Current (I_Krand I_Ks) in Canine Ventricular Epicardial, Midmyocardial, and Endocardial Myocytes

1995 • 605 citations

Sustained depolarization-induced outward current in human atrial myocytes. Evidence for a novel delayed rectifier K+ current similar to Kv1.5 cloned channel currents.

1993 • 568 citations

Outward K ⁺ Current Densities and Kv1.5 Expression Are Reduced in Chronic Human Atrial Fibrillation

1997 • 545 citations

Moderate loss of function of cyclic-AMP-modulated KCNQ2/KCNQ3 K+ channels causes epilepsy

1998 • 522 citations

Cloning of a Membrane Protein That Induces a Slow Voltage-Gated Potassium Current

1988 • 511 citations

Multiple potassium–channel components are produced by alternative splicing at the Shaker locus in Drosophila

1988 • 495 citations

Evidence for Two Components of Delayed Rectifier K ⁺ Current in Human Ventricular Myocytes

1996 • 463 citations

Ionic bases for electrophysiological distinctions among epicardial, midmyocardial, and endocardial myocytes from the free wall of the canine left ventricle.

1993 • 462 citations

Regional Differences in Current Density and Rate-Dependent Properties of the Transient Outward Current in Subepicardial and Subendocardial Myocytes of Human Left Ventricle

1996 • 459 citations

Transient outward current prominent in canine ventricular epicardium but not endocardium.

1988 • 442 citations

Role of the Kv4.3 K ⁺ Channel in Ventricular Muscle

1996 • 434 citations

Molecular biology of voltage-dependent potassium channels

1992 • 412 citations

Comparison of potassium currents in rabbit atrial and ventricular cells.

1988 • 382 citations

A minK–HERG complex regulates the cardiac potassium current IKr

1997 • 376 citations

βSubunits Promote K+ Channel Surface Expression through Effects Early in Biosynthesis

1996 • 372 citations

A Distinct Potassium Channel Polypeptide Encoded by the Drosophila eag Locus

1991 • 361 citations

Transient outward current in human ventricular myocytes of subepicardial and subendocardial origin.

1994 • 358 citations

Identity of a novel delayed rectifier current from human heart with a cloned K+ channel current.

1993 • 345 citations

K ⁺ Current Diversity Is Produced by an Extended Gene Family Conserved in Drosophila and Mouse

1990 • 323 citations

Four Kinetically Distinct Depolarization-activated K+ Currents in Adult Mouse Ventricular Myocytes

1999 • 309 citations

Quantitative analysis of potassium channel mRNA expression in atrial and ventricular muscle of rats.

1994 • 304 citations

Antisense Oligodeoxynucleotides Directed Against Kv1.5 mRNA Specifically Inhibit Ultrarapid Delayed Rectifier K ⁺ Current in Cultured Adult Human Atrial Myocytes

1997 • 302 citations

Characterization of two distinct depolarization-activated K+ currents in isolated adult rat ventricular myocytes.

1991 • 295 citations

Two Isoforms of the Mouse Ether-a-go-go –Related Gene Coassemble to Form Channels With Properties Similar to the Rapidly Activating Component of the Cardiac Delayed Rectifier K ⁺ Current

1997 • 289 citations

Functional Knockout of the Transient Outward Current, Long-QT Syndrome, and Cardiac Remodeling in Mice Expressing a Dominant-Negative Kv4 α Subunit

1998 • 284 citations

A Family of Putative Potassium Channel Genes in Drosophila

1989 • 281 citations

Calcium-activated chloride current in rabbit ventricular myocytes.

1991 • 279 citations

Structural Elements Involved in Specific K+ Channel Functions

1992 • 268 citations

Potassium channel down-regulation in heart failure

1998 • 263 citations

Regional variations in action potentials and transient outward current in myocytes isolated from rabbit left ventricle.

1991 • 261 citations

4-Aminopyridine and the early outward current of sheep cardiac Purkinje fibers.

1979 • 257 citations

Shaker, Shal, Shab, and Shaw express independent K+ current systems

1991 • 256 citations

Differential Expression of Voltage-Gated K ⁺ Channel Subunits in Adult Rat Heart

1995 • 253 citations

Molecular cloning and characterization of two voltage‐gated K ⁺ channel cDNAs from human ventricle

1991 • 245 citations

Cloning and tissue-specific expression of five voltage-gated potassium channel cDNAs expressed in rat heart.

1991 • 244 citations

Rapid and slow components of delayed rectifier current in human atrial myocytes

1994 • 236 citations

Heterogeneity of action potential waveforms and potassium currents in rat ventricle

1993 • 232 citations

Two types of transient outward currents in adult human atrial cells

1987 • 231 citations

Differences between outward currents of human atrial and subepicardial ventricular myocytes.

1996 • 231 citations

Myocardial Potassium Channels: Electrophysiological and Molecular Diversity

1996 • 230 citations

Existence of two transient outward currents in sheep cardiac Purkinje fibers

1982 • 223 citations

Identification of two nervous system-specific members of the erg potassium channel gene family.

1997 • 217 citations

Two components of transient outward current in canine ventricular myocytes.

1989 • 215 citations

Delayed rectifier outward K+ current is composed of two currents in guinea pig atrial cells

1991 • 215 citations

Electrophysiological Characterization of an Alternatively Processed ERG K ⁺ Channel in Mouse and Human Hearts

1997 • 208 citations

Molecular basis of transient outward K⁺ current diversity in mouse ventricular myocytes

1999 • 207 citations

Delayed rectifier outward current and repolarization in human atrial myocytes.

1993 • 201 citations

Potential Molecular Basis of Different Physiological Properties of the Transient Outward K ⁺ Current in Rabbit and Human Atrial Myocytes

1999 • 198 citations

Structure and function of cardiac potassium channels

1999 • 196 citations

Identification of Two Nervous System-Specific Members of theergPotassium Channel Gene Family

1997 • 194 citations

Distinct spatial and temporal expression patterns of K+ channel mRNAs from different subfamilies

1992 • 193 citations

New Modulatory α Subunits for Mammalian ShabK+ Channels

1997 • 193 citations

Heteropodatoxins: peptides isolated from spider venom that block Kv4.2 potassium channels.

1997 • 190 citations

Cloning and expression of the delayed-rectifier IsK channel from neonatal rat heart and diethylstilbestrol-primed rat uterus.

1990 • 189 citations

Molecular physiology of cardiac potassium channels

1996 • 188 citations

Kvβ1 Subunit Binding Specific for Shaker-Related Potassium Channel α Subunits

1996 • 183 citations

Calcium‐sensitive and insensitive transient outward current in rabbit ventricular myocytes.

1989 • 176 citations

Long QT and ventricular arrhythmias in transgenic mice expressing the N terminus and first transmembrane segment of a voltage-gated potassium channel

1998 • 176 citations

Heteromultimeric assembly of human potassium channels. Molecular basis of a transient outward current?

1993 • 174 citations

Suppression of Neuronal and Cardiac Transient Outward Currents by Viral Gene Transfer of Dominant-Negative Kv4.2 Constructs

1997 • 171 citations

A Novel β Subunit Increases Rate of Inactivation of Specific Voltage-gated Potassium Channel α Subunits

1995 • 168 citations

Distinct Transient Outward Potassium Current (Ito) Phenotypes and Distribution of Fast-inactivating Potassium Channel Alpha Subunits in Ferret Left Ventricular Myocytes

1999 • 167 citations

Expression of Distinct ERG Proteins in Rat, Mouse, and Human Heart

2000 • 163 citations

Shal‐type channels contribute to the Ca2+‐independent transient outward K+ current in rat ventricle.

1997 • 163 citations

Differences in transient outward currents of feline endocardial and epicardial myocytes.

1990 • 161 citations

Attenuation of the Slow Component of Delayed Rectification, Action Potential Prolongation, and Triggered Activity in Mice Expressing a Dominant-Negative Kv2 α Subunit

1999 • 158 citations

Transient outward and delayed rectifier currents in canine atrium: properties and role of isolation methods

1996 • 154 citations

Contributions of a transient outward current to repolarization in human atrium

1989 • 153 citations

Selective Interaction of Voltage-gated K+ Channel β-Subunits with α-Subunits

1996 • 150 citations

Molecular cloning and functional expression of a potassium channel cDNA isolated from a rat cardiac library

1990 • 149 citations

Influence of chloride, potassium, and tetraethylammonium on the early outward current of sheep cardiac Purkinje fibers.

1979 • 145 citations

A K+ Channel Splice Variant Common in Human Heart Lacks a C-terminal Domain Required for Expression of Rapidly Activating Delayed Rectifier Current

1998 • 144 citations

Molecular cloning and sequence analysis of human genomic DNA encoding A novel membrane protein which exhibits a slowly activating potassium channel activity

1989 • 142 citations

Kv8.1, a new neuronal potassium channel subunit with specific inhibitory properties towards Shab and Shaw channels.

1996 • 141 citations

Developmental analysis reveals mismatches in the expression of K+ channel alpha subunits and voltage-gated K+ channel currents in rat ventricular myocytes.

1996 • 136 citations

Transient outward current in human and rat ventricular myocytes

1993 • 133 citations

A Novel K+ Channel β-Subunit (hKvβ1.3) Is Produced via Alternative mRNA Splicing

1995 • 133 citations

Site-specific mutations in a minimal voltage-dependent K+ channel alter ion selectivity and open-channel block

1991 • 132 citations

A rapidly activating sustained K⁺ current modulates repolarization and excitation–contraction coupling in adult mouse ventricle

1997 • 132 citations

IK of rabbit ventricle is composed of two currents: evidence for IKs

1996 • 131 citations

Molecular cloning and functional expression of a novel potassium channel β‐subunit from human atrium

1995 • 128 citations

A novel cardiac potassium channel that is active and conductive at depolarized potentials

1988 • 127 citations

Regional differences in the delayed rectifier current (IKr and IKs) contribute to the differences in action potential duration in basal left ventricular myocytes in guinea-pig

1998 • 122 citations

The conduction pore of a cardiac potassium channel

1998 • 121 citations

Cloning and Expression of a Novel K+ Channel Regulatory Protein, KChAP

1998 • 120 citations

Characterization of an ultrarapid delayed rectifier potassium channel involved in canine atrial repolarization.

1996 • 118 citations

The transient outward current in mice lacking the potassium channel gene Kv1.4

1998 • 117 citations

Background potassium current active during the plateau of the action potential in guinea pig ventricular myocytes.

1993 • 114 citations

Molecular cloning and tissue distribution of an alternatively spliced variant of an A‐type K⁺ channel α‐subunit, Kv4.3 in the rat

1997 • 114 citations

Regional contributions ofKv1.4,Kv4.2, andKv4.3to transient outward K⁺current in rat ventricle

1999 • 113 citations

The calcium-independent transient outward potassium current in isolated ferret right ventricular myocytes. I. Basic characterization and kinetic analysis.

1993 • 111 citations

Differences in rate dependence of transient outward current in rabbit and human atrium

1992 • 111 citations

Potassium rectifier currents differ in myocytes of endocardial and epicardial origin.

1992 • 110 citations

Time-dependent outward current in guinea pig ventricular myocytes. Gating kinetics of the delayed rectifier.

1990 • 108 citations

Decreased Expression of Kv4.2 and Novel Kv4.3 K ⁺ Channel Subunit mRNAs in Ventricles of Renovascular Hypertensive Rats

1997 • 106 citations

Targeted Expression of a Dominant-Negative K _v 4.2 K ⁺ Channel Subunit in the Mouse Heart

1999 • 106 citations

Electrophysiological and pharmacological correspondence between Kv4.2 current and rat cardiac transient outward current

1997 • 105 citations

A New K+ Channel β Subunit to Specifically Enhance Kv2.2 (CDRK) Expression

1996 • 99 citations

Characterization of a Slowly Inactivating Outward Current in Adult Mouse Ventricular Myocytes

1998 • 94 citations

MinK Residues Line a Potassium Channel Pore

1996 • 92 citations

Elimination of the transient outward current and action potential prolongation in mouse atrial myocytes expressing a dominant negative Kv4 α subunit

1999 • 91 citations

Anti-minK Antisense Decreases the Amplitude of the Rapidly Activating Cardiac Delayed Rectifier K ⁺ Current

1995 • 89 citations

A novel type of depolarization-activated K+ current in isolated adult rat atrial myocytes

1991 • 85 citations

Properties of the transient outward current in rabbit atrial cells.

1988 • 83 citations

Two functionally distinct 4-aminopyridine-sensitive outward K+ currents in rat atrial myocytes.

1992 • 82 citations

Isolation and characterization of the human gene encodingI _to: further diversity by alternative mRNA splicing

1998 • 82 citations

Four different components contribute to outward current in rat ventricular myocytes

1999 • 72 citations

Repolarizing K ⁺ Currents in Nonfailing Human Hearts

1995 • 71 citations

Potassium Channels in Cardiovascular Biology

2001 • 70 citations

Developmental cardiac electrophysiology recent advances in cellular physiology

1996 • 70 citations

Expression environment determines K + current properties: Kv1 and Kv4 α-subunit-induced K + currents in mammalian cell lines and cardiac myocytes

1999 • 67 citations

Functional characterization of RK5, a voltage‐gated K⁺ channel cloned from the rat cardiovascular system

1991 • 65 citations

Single delayed rectifier channels in the membrane of rabbit ventricular myocytes.

1993 • 64 citations

Delayed rectification in single cells isolated from guinea pig sinoatrial node

1992 • 62 citations

Suppression of Slow Delayed Rectifier Current by a Truncated Isoform of KvLQT1 Cloned from Normal Human Heart

1997 • 62 citations

Dynamic regulation of K+ channel gene expression in differentiated cells

1998 • 62 citations

Regulation of voltage-gated K+ channel expression in the developing mammalian myocardium

1998 • 60 citations

Identification and functional characterization of a K+ channel alpha-subunit with regulatory properties specific to brain.

1997 • 59 citations

Molecular correlates of the calcium‐independent, depolarization‐activated K⁺ currents in rat atrial myocytes

1999 • 58 citations

Identification and Functional Characterization of a K⁺Channel α-Subunit with Regulatory Properties Specific to Brain

1997 • 57 citations

Two types of delayed rectifying K+ channels in atrial cells of guinea pig heart.

1990 • 55 citations

Regional differences in action potential characteristics and membrane currents of guinea‐pig left ventricular myocytes

1998 • 51 citations

Time- and voltage-dependent modulation of a Kv1.4 channel by a beta-subunit (Kv beta 3) cloned from ferret ventricle

1995 • 47 citations

Functional expression of an inactivating potassium channel (Kv4.3) in a mammalian cell line

1999 • 43 citations

Delayed-rectifier potassium channel activity in isolated membrane patches of guinea pig ventricular myocytes

1991 • 42 citations

Masking of A-type K+ channel in guinea pig cardiac cells by extracellular Ca2+

1993 • 42 citations

Effect of Cd<sup>2+</sup> on Kv4.2 and Kv1.4 Expressed in <i>Xenopus</i> Oocytes and on the Transient Outward Currents in Rat and Rabbit Ventricular Myocytes

1999 • 34 citations

Delayed rectifier potassium channels in ventricle and sinoatrial node of the guinea pig: Molecular and regulatory properties

1993 • 32 citations

Phenylephrine suppresses outward K+ currents in rat atrial myocytes

1996 • 31 citations

Interactions among Inactivating and Noninactivating Kvβ Subunits, and Kvα1.2, Produce Potassium Currents with Intermediate Inactivation

1997 • 30 citations

Repolarization differences between guinea pig atrial endocardium and epicardium: evidence for a role of Ito

1991 • 19 citations

Ca2+-independent transient outward current in mammalian heart

1996 • 17 citations

Molecular Mechanisms Controlling Functional Voltage-Gated K+Channel Diversity and Expression in the Mammalian Heart

2001 • 4 citations