Bcl-2 Phosphorylation by p38 MAPK

Mass Spectrometric Sequencing of Proteins from Silver-Stained Polyacrylamide Gels

1996 • 8,994 citations

Mitochondrial control of cell death

2000 • 3,098 citations

Femtomole sequencing of proteins from polyacrylamide gels by nano-electrospray mass spectrometry

1996 • 1,687 citations

X-ray and NMR structure of human Bcl-xL, an inhibitor of programmed cell death

1996 • 1,456 citations

BH1 and BH2 domains of Bcl-2 are required for inhibition of apoptosis and heterodimerization with Bax

1994 • 1,303 citations

Conversion of Bcl-2 to a Bax-like Death Effector by Caspases

1997 • 1,116 citations

Bcl-xL forms an ion channel in synthetic lipid membranes

1997 • 817 citations

Taxol induces bcl-2 phosphorylation and death of prostate cancer cells.

1996 • 662 citations

Bcl-2 Phosphorylation Required for Anti-apoptosis Function

1997 • 540 citations

Translocation of SAPK/JNK to Mitochondria and Interaction with Bcl-xL in Response to DNA Damage

2000 • 421 citations

Bcl-2 Undergoes Phosphorylation by c-Jun N-terminal Kinase/Stress-activated Protein Kinases in the Presence of the Constitutively Active GTP-binding Protein Rac1

1997 • 406 citations

Taxol-induced apoptosis and phosphorylation of Bcl-2 protein involves c-Raf-1 and represents a novel c-Raf-1 signal transduction pathway.

1996 • 376 citations

Microtubule-interfering Agents Activate c-Jun N-terminal Kinase/Stress-activated Protein Kinase through Both Ras and Apoptosis Signal-regulating Kinase Pathways

1998 • 353 citations

p38 Mitogen-Activated Protein Kinase Inhibitors— Mechanisms and Therapeutic Potentials

1999 • 348 citations

Requirement for p38α in Erythropoietin Expression

2000 • 343 citations

Deletion of the loop region of Bcl-2 completely blocks paclitaxel-induced apoptosis

1999 • 338 citations

Bcl-2 mutants with restricted subcellular location reveal spatially distinct pathways for apoptosis in different cell types.

1996 • 335 citations

An Inhibitor of p38 Mitogen-activated Protein Kinase Protects Neonatal Cardiac Myocytes from Ischemia

1999 • 300 citations

Bcl-2 family proteins as ion-channels

1998 • 299 citations

Vinblastine-induced Phosphorylation of Bcl-2 and Bcl-XL Is Mediated by JNK and Occurs in Parallel with Inactivation of the Raf-1/MEK/ERK Cascade

2000 • 291 citations

Regulation of mitochondrial membrane permeabilization by BCL-2 family proteins and caspases

2004 • 255 citations

Targeted Inhibition of p38 Mitogen-activated Protein Kinase Antagonizes Cardiac Injury and Cell Death Following Ischemia-Reperfusion in Vivo

2004 • 230 citations

p38α Mitogen-activated Protein Kinase Sensitizes Cells to Apoptosis Induced by Different Stimuli

2003 • 228 citations

Suppression by Metallothionein of Doxorubicin-induced Cardiomyocyte Apoptosis through Inhibition of p38 Mitogen-activated Protein Kinases

2000 • 209 citations

Megamitochondria formation ‐ physiology and pathology

2002 • 178 citations

MAPK Superfamily Plays an Important Role in Daunomycin-Induced Apoptosis of Cardiac Myocytes

1999 • 163 citations

Cells en route to apoptosis are characterized by the upregulation of c‐fos, c‐myc, c‐jun, cdc2, and RB phosphorylation, resembling events of early cell‐cycle traverse

1995 • 144 citations

Phosphorylation of Bcl-2 Protein and Association with p21Ras in Ras-induced Apoptosis

1996 • 132 citations

p38 MAPK mediates TNF-induced apoptosis in endothelial cells via phosphorylation and downregulation of Bcl-xL

2004 • 130 citations

Unwinding the loop of Bcl-2 phosphorylation

2001 • 129 citations

Human p53 Is Phosphorylated on Serines 6 and 9 in Response to DNA Damage-inducing Agents

2000 • 125 citations

Nerve Growth Factor Inhibits Apoptosis in Memory B Lymphocytes via Inactivation of p38 MAPK, Prevention of Bcl-2 Phosphorylation, and Cytochrome c Release

2001 • 121 citations

Phosphorylation of Bcl-2 in G2/M Phase-arrested Cells following Photodynamic Therapy with Hypericin Involves a CDK1-mediated Signal and Delays the Onset of Apoptosis

2002 • 117 citations

Phosphorylation of Bcl-2 Protein by CDC2 Kinase during G2/M Phases and Its Role in Cell Cycle Regulation

2000 • 111 citations

The central role of the mitochondrial megachannel in apoptosis: evidence obtained with intact cells, isolated mitochondria, and purified protein complexes

1998 • 85 citations

Involvement of a p38 Mitogen-activated Protein Kinase Phosphatase in Protecting Neonatal Rat Cardiac Myocytes from Ischemia

2000 • 58 citations

Association of Insulin Receptor Substrate Proteins with Bcl-2 and Their Effects on Its Phosphorylation and Antiapoptotic Function

2000 • 56 citations

Regulation of Bax translocation through phosphorylation at Ser-70 of Bcl-2 by MAP kinase in NO-induced neuronal apoptosis

2003 • 56 citations

Hypoxia, angiotensin‐II, and norepinephrine mediated apoptosis is stimulus specific in canine failed cardiomyocytes: a role for p38 MAPK, Fas‐L and cyclin D₁

2003 • 47 citations

A day in the life of the Bcl-2 protein: Does the turnover rate of Bcl-2 serve as a biological clock for cellular lifespan regulation?

1996 • 42 citations

NGF Withdrawal Induces Apoptosis in CESS B Cell Line through p38 MAPK Activation and Bcl-2 Phosphorylation

2000 • 41 citations

Signal-induced site specific phosphorylation targets Bcl2 to the proteasome pathway

2002 • 35 citations

Nerve Growth Factor-dependent Survival of CESS B Cell Line Is Mediated by Increased Expression and Decreased Degradation of MAPK Phosphatase 1

2004 • 32 citations

A multimeric model for murine anti-apoptotic protein Bcl-2 and structural insights for its regulation by post-translational modification.

2003 • 13 citations