The central role of the mitochondrial megachannel in apoptosis: evidence obtained with intact cells, isolated mitochondria, and purified protein complexes

THE MITOCHONDRIAL DEATH/LIFE REGULATOR IN APOPTOSIS AND NECROSIS

1998 • 1,982 citations

The proto-oncogene Bcl-2 and its role in regulating apoptosis

1997 • 1,768 citations

Sequential reduction of mitochondrial transmembrane potential and generation of reactive oxygen species in early programmed cell death.

1995 • 1,556 citations

Mitochondrial control of apoptosis

1997 • 1,500 citations

Mitochondrial control of nuclear apoptosis.

1996 • 1,363 citations

Reduction in mitochondrial potential constitutes an early irreversible step of programmed lymphocyte death in vivo.

1995 • 1,179 citations

Bcl-2 inhibits the mitochondrial release of an apoptogenic protease.

1996 • 1,143 citations

The biochemistry of programmed cell death

1995 • 997 citations

Mitochondrial permeability transition is a central coordinating event of apoptosis.

1996 • 857 citations

The Permeability Transition Pore Complex: A Target for Apoptosis Regulation by Caspases and Bcl-2–related Proteins

1998 • 700 citations

The Central Executioner of Apoptosis: Multiple Connections between Protease Activation and Mitochondria in Fas/APO-1/CD95- and Ceramide-induced Apoptosis

1997 • 625 citations

The apoptosis-necrosis paradox. Apoptogenic proteases activated after mitochondrial permeability transition determine the mode of cell death

1997 • 470 citations

Sequential acquisition of mitochondrial and plasma membrane alterations during early lymphocyte apoptosis.

1996 • 353 citations

Mitochondrial implication in accidental and programmed cell death: apoptosis and necrosis.

1997 • 326 citations

Glutathione depletion is an early and calcium elevation is a late event of thymocyte apoptosis.

1997 • 309 citations

Bcl-2 and Bcl-XL antagonize the mitochondrial dysfunction preceding nuclear apoptosis induced by chemotherapeutic agents.

1997 • 302 citations

Mitochondrial implication in apoptosis. Towards an endosymbiont hypothesis of apoptosis evolution

1997 • 251 citations

Mitochondrial permeability transition triggers lymphocyte apoptosis.

1996 • 238 citations

Nitric oxide induces apoptosis via triggering mitochondrial permeability transition

1997 • 238 citations

Redox regulation of apoptosis: Impact of thiol oxidation status on mitochondrial function

1997 • 214 citations

Apoptosis-associated derangement of mitochondrial function in cells lacking mitochondrial DNA.

1996 • 202 citations

Cytofluorometric detection of mitochondrial alterations in early CD95/Fas/APO-1-triggered apoptosis of Jurkat T lymphoma cells. Comparison of seven mitochondrion-specific fluorochromes

1998 • 196 citations

Potassium Leakage During the Apoptotic Degradation Phase

1998 • 181 citations

Chloromethyl-X-rosamine is an aldehyde-fixable potential-sensitive fluorochrome for the detection of early apoptosis

1996 • 178 citations

The thiol crosslinking agent diamide overcomes the apoptosis-inhibitory effect of Bcl-2 by enforcing mitochondrial permeability transition

1998 • 155 citations

Mitochondrial perturbations define lymphocytes undergoing apoptotic depletion in vivo

1995 • 148 citations

A Cytofluorometric Assay of Nuclear Apoptosis Induced in a Cell-Free System: Application to Ceramide-Induced Apoptosis

1997 • 73 citations

Molecular and Cellular Mechanisms of T Lymphocyte Apoptosis

1998 • 72 citations

The cell biology of apoptosis: Evidence for the implication of mitochondria

1996 • 38 citations

Apoptosis of cells lacking mitochondrial DNA

1996 • 18 citations