Targeted Inhibition of p38 Mitogen-activated Protein Kinase Antagonizes Cardiac Injury and Cell Death Following Ischemia-Reperfusion in Vivo

Organization and regulation of mitogen-activated protein kinase signaling pathways

1999 • 1,288 citations

Cardiac Muscle Cell Hypertrophy and Apoptosis Induced by Distinct Members of the p38 Mitogen-activated Protein Kinase Family

1998 • 855 citations

The permeability transition pore complex: another view

2002 • 702 citations

Phosphorylation of human p53 by p38 kinase coordinates N-terminal phosphorylation and apoptosis in response to UV radiation

1999 • 690 citations

Inhibition of p38 Mitogen-Activated Protein Kinase Decreases Cardiomyocyte Apoptosis and Improves Cardiac Function After Myocardial Ischemia and Reperfusion

1999 • 504 citations

Conditional Expression of the Mitogen-activated Protein Kinase (MAPK) Phosphatase MKP-1 Preferentially Inhibits p38 MAPK and Stress-activated Protein Kinase in U937 Cells

1997 • 435 citations

Mitochondrial PKCε and MAPK Form Signaling Modules in the Murine Heart

2002 • 417 citations

p38 Map Kinase Mediates Bax Translocation in Nitric Oxide–Induced Apoptosis in Neurons

2000 • 391 citations

TAK1 is activated in the myocardium after pressure overload and is sufficient to provoke heart failure in transgenic mice

2000 • 340 citations

The in vivo role of p38 MAP kinases in cardiac remodeling and restrictive cardiomyopathy

2001 • 335 citations

p38 MAPK and NF-κB Collaborate to Induce Interleukin-6 Gene Expression and Release

2000 • 330 citations

Stress-activated Protein Kinases: Activation, Regulation and Function

1997 • 327 citations

Mitochondrial intermembrane junctional complexes and their role in cell death

2000 • 314 citations

Targeted inhibition of p38 MAPK promotes hypertrophic cardiomyopathy through upregulation of calcineurin-NFAT signaling

2003 • 311 citations

An Inhibitor of p38 Mitogen-activated Protein Kinase Protects Neonatal Cardiac Myocytes from Ischemia

1999 • 300 citations

Brain Genomic Response following Hypoxia and Re-oxygenation in the Neonatal Rat

2002 • 293 citations

Targeted inhibition of p38 MAPK promotes hypertrophic cardiomyopathy through upregulation of calcineurin-NFAT signaling

2003 • 270 citations

p38 Mitogen-activated Protein Kinase Mediates Bid Cleavage, Mitochondrial Dysfunction, and Caspase-3 Activation during Apoptosis Induced by Singlet Oxygen but Not by Hydrogen Peroxide

2000 • 270 citations

Adenovirus-mediated transfer of the muscle glycogen phosphorylase gene into hepatocytes confers altered regulation of glycogen metabolism.

1992 • 248 citations

Calcineurin Promotes Protein Kinase C and c-Jun NH2-terminal Kinase Activation in the Heart

2000 • 232 citations

Calcineurin-Mediated Hypertrophy Protects Cardiomyocytes From Apoptosis In Vitro and In Vivo

2000 • 228 citations

MKK6 Activates Myocardial Cell NF-κB and Inhibits Apoptosis in a p38 Mitogen-activated Protein Kinase-dependent Manner

1998 • 227 citations

Suppression by Metallothionein of Doxorubicin-induced Cardiomyocyte Apoptosis through Inhibition of p38 Mitogen-activated Protein Kinases

2000 • 209 citations

Disruption of the erp/mkp-1 gene does not affect mouse development: normal MAP kinase activity in ERP/MKP-1-deficient fibroblasts.

1996 • 203 citations

Twisting integrin receptors increases endothelin-1 gene expression in endothelial cells

2001 • 193 citations

Cardiac functional improvement by a human Bcl-2 transgene in a mouse model of ischemia/reperfusion injury

2000 • 192 citations

MAPK Superfamily Plays an Important Role in Daunomycin-Induced Apoptosis of Cardiac Myocytes

1999 • 163 citations

The Dual-Specificity Phosphatase MKP-1 Limits the Cardiac Hypertrophic Response In Vitro and In Vivo

2001 • 163 citations

p38 Mitogen-activated Protein Kinase Pathway Protects Adult Rat Ventricular Myocytes against β-Adrenergic Receptor-stimulated Apoptosis

2000 • 161 citations

αB-crystallin Gene Induction and Phosphorylation by MKK6-activated p38

2000 • 152 citations

Inhibition of the Cardiac p38-MAPK Pathway by SB203580 Delays Ischemic Cell Death

2000 • 138 citations

p38 protects human melanoma cells from UV-induced apoptosis through down-regulation of NF-κB activity and Fas expression

2000 • 126 citations

Hydrogen peroxide induces tumor necrosis factor α–mediated cardiac injury by a P38 mitogen-activated protein kinase–dependent mechanism

1998 • 114 citations

Role of p38 Mitogen-Activated Protein Kinases in Preconditioning

2000 • 98 citations

Activation of p38 Mitogen-Activated Protein Kinase In Vivo Selectively Induces Apoptosis of CD8⁺ but Not CD4⁺ T Cells

2000 • 98 citations

Decreased p38 MAPK Activity in End-Stage Failing Human Myocardium: p38 MAPK α is the Predominant Isoform Expressed in Human Heart

2001 • 92 citations

Disruption of a single copy of the p38α MAP kinase gene leads to cardioprotection against ischemia–reperfusion

2003 • 72 citations

Bcl-xL gene transfer protects the heart against ischemia/reperfusion injury

2003 • 63 citations

Involvement of a p38 Mitogen-activated Protein Kinase Phosphatase in Protecting Neonatal Rat Cardiac Myocytes from Ischemia

2000 • 58 citations

Single‐Dose Pharmacokinetics and Pharmacodynamics of RWJ 67657, a Specific p38 Mitogen‐Activated Protein Kinase Inhibitor: A First‐in‐Human Study

2003 • 53 citations

Hypoxia, angiotensin‐II, and norepinephrine mediated apoptosis is stimulus specific in canine failed cardiomyocytes: a role for p38 MAPK, Fas‐L and cyclin D₁

2003 • 47 citations

Varying susceptibility to myocardial infarction among C57BL/6 mice of different genetic background

2003 • 29 citations

The Balance Between Pro-Apoptotic and Anti-Apoptotic Pathways in the Failing Myocardium

2003 • 23 citations