The role of advanced glycation in the pathogenesis of diabetic retinopathy

Effect of intensive blood-glucose control with metformin on complications in overweight patients with type 2 diabetes (UKPDS 34)

1998 • 7,971 citations

Diabetic Retinopathy

1974 • 5,744 citations

Normalizing mitochondrial superoxide production blocks three pathways of hyperglycaemic damage

2000 • 4,169 citations

The Rising Global Burden of Diabetes and its Complications: Estimates and Projections to the Year 2010

1997 • 1,777 citations

Aminoguanidine Prevents Diabetes-Induced Arterial Wall Protein Cross-Linking

1986 • 1,154 citations

Formation of glyoxal, methylglyoxal and 3-deoxyglucosone in the glycation of proteins by glucose

1999 • 1,130 citations

Identification of N epsilon-carboxymethyllysine as a degradation product of fructoselysine in glycated protein.

1986 • 830 citations

Activation of the Receptor for Advanced Glycation End Products Triggers a p21 -dependent Mitogen-activated Protein Kinase Pathway Regulated by Oxidant Stress

1997 • 803 citations

Diabetes-Associated Sustained Activation of the Transcription Factor Nuclear Factor-κB

2001 • 801 citations

The glyoxalase system: new developments towards functional characterization of a metabolic pathway fundamental to biological life

1990 • 792 citations

The biology of the receptor for advanced glycation end products and its ligands

2000 • 690 citations

Vascular Endothelial Growth Factor Induces Rapid Phosphorylation of Tight Junction Proteins Occludin and Zonula Occluden 1

1999 • 653 citations

Cellular receptors for advanced glycation end products. Implications for induction of oxidant stress and cellular dysfunction in the pathogenesis of vascular lesions.

1994 • 632 citations

Vascular permeability in experimental diabetes is associated with reduced endothelial occludin content: vascular endothelial growth factor decreases occludin in retinal endothelial cells. Penn State Retina Research Group.

1998 • 571 citations

Aminoguanidine treatment inhibits the development of experimental diabetic retinopathy.

1991 • 522 citations

Glycoxidation and lipoxidation in atherogenesis

2000 • 512 citations

Diabetic Retinopathy

1998 • 484 citations

Development and prevention of advanced diabetic nephropathy in RAGE-overexpressing mice

2001 • 470 citations

Expression of Advanced Glycation End Products and Their Cellular Receptor RAGE in Diabetic Nephropathy and Nondiabetic Renal Disease

2000 • 468 citations

An agent cleaving glucose-derived protein crosslinks in vitro and in vivo

1996 • 466 citations

Advanced glycation end products induce glomerular sclerosis and albuminuria in normal rats.

1994 • 463 citations

Progression of Incipient Diabetic Retinopathy During Good Glycemic Control

1987 • 453 citations

Advanced glycation end products cause epithelial-myofibroblast transdifferentiation via the receptor for advanced glycation end products (RAGE)

2001 • 444 citations

Breakers of advanced glycation end products restore large artery properties in experimental diabetes

1998 • 436 citations

Hypoglycemia in the Diabetes Control and Complications Trial. The Diabetes Control and Complications Trial Research Group

1997 • 430 citations

Advanced glycation end products increase retinal vascular endothelial growth factor expression.

1998 • 413 citations

Interaction of metabolic and haemodynamic factors in mediating experimental diabetic nephropathy

2001 • 378 citations

The maillard reaction in aging, diabetes and nutrition

1990 • 376 citations

Pyridoxamine inhibits early renal disease and dyslipidemia in the streptozotocin-diabetic rat

2002 • 373 citations

Nonenzymatic glycosylation in vitro and in bovine endothelial cells alters basic fibroblast growth factor activity. A model for intracellular glycosylation in diabetes.

1994 • 365 citations

Role of the Maillard Reaction in Aging of Tissue Proteins

1998 • 357 citations

The AGE Inhibitor Pyridoxamine Inhibits Development of Retinopathy in Experimental Diabetes

2002 • 349 citations

Retinal neurodegeneration: early pathology in diabetes

2000 • 343 citations

Molecular identity and cellular distribution of advanced glycation endproduct receptors: relationship of p60 to OST-48 and p90 to 80K-H membrane proteins.

1996 • 340 citations

An advanced glycation endproduct cross-link breaker can reverse age-related increases in myocardial stiffness

2000 • 331 citations

Vascular Endothelial Growth Factor (VEGF)-Induced Retinal Vascular Permeability Is Mediated by Intercellular Adhesion Molecule-1 (ICAM-1)

2000 • 330 citations

Pathophysiology of oxidative stress in diabetes mellitus

2001 • 328 citations

Protein kinase C is activated in glomeruli from streptozotocin diabetic rats. Possible mediation by glucose.

1989 • 324 citations

Advanced glycation end products (AGEs) co-localize with AGE receptors in the retinal vasculature of diabetic and of AGE-infused rats.

1997 • 324 citations

Protein kinase C and the development of diabetic vascular complications

2001 • 314 citations

Chelating Activity of Advanced Glycation End-product Inhibitors

2001 • 311 citations

Advanced glycation end products up-regulate gene expression found in diabetic glomerular disease.

1994 • 298 citations

The AGE‐receptor in the pathogenesis of diabetic complications

2001 • 296 citations

Pentosidine Formation in Skin Correlates With Severity of Complications in Individuals With Long-Standing IDDM

1992 • 286 citations

Advanced Glycation End Products-driven Angiogenesis in Vitro

1997 • 272 citations

Pharmacological Inhibition of Diabetic Retinopathy

2001 • 271 citations

Amadorins: Novel Post-Amadori Inhibitors of Advanced Glycation Reactions

1999 • 271 citations

Response of capillary cell death to aminoguanidine predicts the development of retinopathy: comparison of diabetes and galactosemia.

2000 • 253 citations

Effects of Novel Polymorphisms in the RAGE Gene on Transcriptional Regulation and Their Association With Diabetic Retinopathy

2001 • 247 citations

Pyridoxamine, an Inhibitor of Advanced Glycation Reactions, Also Inhibits Advanced Lipoxidation Reactions

2000 • 245 citations

Formation of glyoxal, methylglyoxal and 3-deoxyglucosone in the glycation of proteins by glucose

1999 • 241 citations

Constitutive nitric oxide synthase expression in retinal vascular endothelial cells is suppressed by high glucose and advanced glycation end products.

1998 • 228 citations

Molecular Mechanisms of Vascular Permeability in Diabetic Retinopathy

1999 • 227 citations

Immunohistochemical detection of advanced glycosylation end products in diabetic tissues using monoclonal antibody to pyrraline.

1992 • 218 citations

A Post-Amadori Inhibitor Pyridoxamine Also Inhibits Chemical Modification of Proteins by Scavenging Carbonyl Intermediates of Carbohydrate and Lipid Degradation

2002 • 214 citations

Advanced Glycation End Products-Induced Apoptosis and Overexpression of Vascular Endothelial Growth Factor in Bovine Retinal Pericytes

2002 • 208 citations

Differential accumulation of advanced glycation end products in the course of diabetic retinopathy

1999 • 204 citations

Expression of transforming growth factor-beta1 and type IV collagen in the renal tubulointerstitium in experimental diabetes: effects of ACE inhibition.

1998 • 203 citations

AGEs induce oxidative stress and activate protein kinase C-β_IIin neonatal mesangial cells

2000 • 199 citations

The relationship between accumulation of advanced glycation end products and expression of vascular endothelial growth factor in human diabetic retinas

1997 • 197 citations

Histological and ultrastructural investigation of retinal microaneurysm development in diabetic patients.

1995 • 196 citations

Regulation of Vascular Endothelial Growth Factor Expression by Advanced Glycation End Products

2001 • 192 citations

Accumulation of carbonyls accelerates the formation of pentosidine, an advanced glycation end product

1998 • 186 citations

A Redox-triggered Ras-Effector Interaction

1998 • 182 citations

Pentosidine: A molecular marker for the cumulative damage to proteins in diabetes, aging, and uremia

1991 • 181 citations

Accelerated diabetic glomerulopathy in galectin‐3/AGE receptor 3 knockout mice

2001 • 180 citations

EWS-erg and EWS-Fli1 fusion transcripts in Ewing's sarcoma and primitive neuroectodermal tumors with variant translocations.

1994 • 161 citations

Effects of aminoguanidine in preventing experimental diabetic nephropathy are related to the duration of treatment

1996 • 160 citations

Overexpression of Cu2+/Zn2+ Superoxide Dismutase Protects Against Early Diabetic Glomerular Injury in Transgenic Mice

2001 • 159 citations

Serum concentrations of advanced glycation endproducts are associated with the development of atherosclerosis as well as diabetic microangiopathy in patients with type 2 diabetes

2000 • 158 citations

Pathways of Formation of Glycoxidation Products during Glycation of Collagen

1995 • 158 citations

Plasma levels of pentosidine in diabetic patients

1998 • 157 citations

Amadori albumin in type 1 diabetic patients: correlation with markers of endothelial function, association with diabetic nephropathy, and localization in retinal capillaries.

1999 • 149 citations

Pathogenetic Potential of Leukocytes in Diabetic Retinopathy

1999 • 147 citations

Differential regulation of protein kinase C and (Na,K)-adenosine triphosphatase activities by elevated glucose levels in retinal capillary endothelial cells.

1989 • 140 citations

Thrombogenic and Fibrinolytic Factors and Cardiovascular Risk in Non-insulin-dependent Diabetes Mellitus

1996 • 140 citations

Localization in human diabetic peripheral nerve of N ε -carboxymethyllysine-protein adducts, an advanced glycation endproduct

1997 • 136 citations

Formation of Crossline as a Fluorescent Advanced Glycation End Productin Vitroandin Vivo

1996 • 134 citations

Toxic action of advanced glycation end products on cultured retinal capillary pericytes and endothelial cells: relevance to diabetic retinopathy

1997 • 130 citations

Detection of d-glucose-derived pyrrole compounds during maillard reaction under physiological conditions

1987 • 126 citations

Aminoguanidine inhibits the development of accelerated diabetic retinopathy in the spontaneous hypertensive rat

1994 • 126 citations

Increased serum levels of advanced glycation end-products and diabetic complications

1998 • 125 citations

Vascular lesions in diabetes are distributed non-uniformly within the retina

1995 • 124 citations

Advanced Glycation End Products Induce Blood–Retinal Barrier Dysfunction in Normoglycemic Rats

2000 • 124 citations

VEGF-induced mobilization of caveolae and increase in permeability of endothelial cells

2002 • 122 citations

Glycation of Skin Collagen in Type I Diabetes Mellitus: Correlation With Long-Term Complications

1986 • 121 citations

The effect of advanced glycation end-product formation upon cell-matrix interactions

1999 • 117 citations

Relevance of oxidative and carbonyl stress to long-term uremic complications

2000 • 116 citations

Advanced Glycation Endproducts Accelerate Calcification in Microvascular Pericytes

1999 • 109 citations

Characterization of the Advanced Glycation End-Product Receptor Complex in Human Vascular Endothelial Cells

1999 • 107 citations

Nϵ-(carboxymethyl)lysine levels in patients with type 2 diabetes: Role of renal function

2001 • 100 citations

The cross-link breaker, N-phenacylthiazolium bromide prevents vascular advanced glycation end-product accumulation

2000 • 100 citations

Modification of vitronectin by advanced glycation alters functional properties in vitro and in the diabetic retina.

1996 • 99 citations

Progression of incipient diabetic retinopathy during good glycemic control

1987 • 99 citations

Modification of Enzymatic Antioxidants in Retinal Microvascular Cells by Glucose or Advanced Glycation End Products

1998 • 93 citations

Possible pathophysiological mechanisms for diabetic angiopathy in type 2 diabetes

2000 • 89 citations

Pentosidine formation in skin correlates with severity of complications in individuals with long-standing IDDM

1992 • 88 citations

A Morphologic and Autoradiographic Study of Cell Death and Regeneration in the Retinal Microvasculature of Normal and Diabetic Rats

1985 • 85 citations

Advanced glycation end products in children and adolescents with diabetes: Relation to glycemic control and early microvascular complications

1999 • 84 citations

The diabetic milieu modulates the advanced glycation end product-receptor complex in the mesangium by inducing or upregulating galectin-3 expression.

2000 • 84 citations

Glycation of Insulin in the Islets of Langerhans of Normal and Diabetic Animals

1996 • 82 citations

Atherogenesis and Advanced Glycation: Promotion, Progression, and Prevention^a

1997 • 79 citations

Caveolae and Vesiculo-Vacuolar Organelles in Bovine Capillary Endothelial Cells Cultured with VPF/VEGF on Floating Matrigel-collagen Gels

1999 • 78 citations

Advanced Glycation End Products and Their Recognition by Macrophage and Macrophage-Derived Cells

1996 • 77 citations

Differential expression of renal AGE-receptor genes in NOD mice: Possible role in nonobese diabetic renal disease

2000 • 77 citations

Secondary intervention with aminoguanidine retards the progression of diabetic retinopathy in the rat model

1995 • 76 citations

Diabetic retinopathy: quantitative variation in capillary basement membrane thickening in arterial or venous environments.

1994 • 76 citations

Therapeutic potential of AGE inhibitors and breakers of AGE protein cross-links

2001 • 75 citations

Nonenzymatic glycation of peripheral and central nervous system proteins in experimental diabetes mellitus

1997 • 74 citations

Role of the Janus kinase (JAK)/signal transducters and activators of transcription (STAT) cascade in advanced glycation end-product-induced cellular mitogenesis in NRK-49F cells

1999 • 73 citations

Inhibition of angiogenesis on glycated collagen lattices

1998 • 73 citations

Glucose, VEGF-A, and Diabetic Complications

2001 • 72 citations

Effects of inhibition of glycation and oxidative stress on the development of cataract and retinal vessel abnormalities in diabetic rats

2000 • 69 citations

Corneal Advanced Glycation End Products Increase in Patients With Proliferative Diabetic Retinopathy

2001 • 68 citations

Selective loss of vascular smooth muscle cells in the retinal microcirculation of diabetic dogs.

1994 • 67 citations

Modulation of Hemodynamic and Vascular Filtration Changes in Diabetic Rats by Dietary myo-inositol

1990 • 67 citations

Immunocytochemical detection of advanced glycated end products in rat renal tissue as a function of age and diabetes

1998 • 66 citations

Polymorphism Screening of Four Genes Encoding Advanced Glycation End-Product Putative Receptors

2001 • 65 citations

Increased Levels of Vascular Endothelial Growth Factor and Advanced Glycation End Products in Aqueous Humor of Patients With Diabetic Retinopathy

2001 • 64 citations

Review Paper: New Insights into the Pathophysiology of Diabetic Retinopathy: Potential Cell-Specific Therapeutic Targets

2000 • 64 citations

Depletion of nitric oxide synthase-containing neurons in the diabetic retina: reversal by aminoguanidine

1998 • 63 citations

Receptors for proteins modified by advanced glycation endproducts (AGE)—their functional role in atherosclerosis

1999 • 62 citations

Polymorphisms in the RAGE gene influence susceptibility to diabetes-associated microvascular dermatoses in NIDDM

2001 • 60 citations

Continued progression of retinopathy despite spontaneous recovery to normoglycemia in a long-term study of streptozotocin-induced diabetes in rats

2000 • 60 citations

The influence of advanced glycation endproducts (AGE) on the expression of human endothelial adhesion molecules

2009 • 56 citations

Advanced glycation end product receptor interactions on microvascular cells occur within caveolin‐rich membrane domains

2000 • 56 citations

Inhibition of nitric oxide synthase activity by early and advanced glycation end products in cultured rabbit proximal tubular epithelial cells

2000 • 53 citations

Aminoguanidine and ramipril prevent diabetes-induced increases in protein kinase C activity in glomeruli, retina and mesenteric artery

2001 • 52 citations

Effects of inhibition of glycation and oxidative stress on the development of cataract and retinal vessel abnormalities in diabetic rats

2000 • 51 citations

Altered proliferation of retinal microvascular cells on glycated matrix.

1995 • 50 citations

Polymorphisms 1704G/T and 2184A/G in the RAGE gene are associated with antioxidant status

2001 • 49 citations

Vascular filtration function in galactose-fed versus diabetic rats: The role of polyol pathway activity

1990 • 49 citations

Effect of Chronic Aminoguanidine Treatment on Age-Related Glycation, Glycoxidation, and Collagen Cross-linking in the Fischer 344 Rat

2001 • 48 citations

Age-related normalization of the browning rate of collagen in diabetic subjects without retinopathy.

1986 • 47 citations

In vitro and in vivo alterations of enzymatic glycosylation in diabetes

1999 • 46 citations

Advanced Glycation End Products Induce Angiogenesis in Vivo

2002 • 46 citations

Immunochemical quantification of crossline as a fluorescent advanced glycation endproduct in erythrocyte membrane proteins from diabetic patients with or without retinopathy

1998 • 43 citations

Reaction of advanced glycation endproducts with renal tissue from normal and streptozotocin-induced diabetic rats: an ultrastructural study using colloidal gold cytochemistry.

1995 • 43 citations

Effects of Advanced Glycation End Products on Cytosolic Ca2+ Signaling of Cultured Human Mesangial Cells

1999 • 43 citations

High concentrations of glucose induce synthesis of argpyrimidine in retinal endothelial cells

2001 • 41 citations

Aminoguanidine does not inhibit the initial phase of experimental diabetic retinopathy in rats

1995 • 40 citations

Advanced glycation endproducts and diabetic nephropathy

1995 • 38 citations

Intracellular protein glycation in cultured retinal capillary pericytes and endothelial cells exposed to high-glucose concentration.

1999 • 37 citations

Angiogenic Effects of Advanced Glycation End Products of the Maillard Reaction on Cultured Human Umbilical Cord Vein Endothelial Cells

1993 • 36 citations

Growth modulation of retinal microvascular cells by early and advanced glycation products

1997 • 35 citations

Aminoguanidine inhibits albuminuria, but not the formation of advanced glycation end-products in skin collagen of diabetic rats

1999 • 34 citations

The retinal blood flow in diabetes.

1993 • 33 citations

Possible Significance of Advanced Glycation End Products in Serum in End-Stage Renal Disease and in Late Complications of Diabetes

1996 • 29 citations

The Interaction between the Renin-Angiotensin System and Vascular Endothelial Growth Factor in the Pathogenesis of Retinal Neovascularization in Diabetes

2001 • 27 citations

Receptor-mediated endocytosis and intracellular trafficking of insulin and low-density lipoprotein by retinal vascular endothelial cells.

1994 • 26 citations

Increased retinal endothelial cell monolayer permeability induced by the diabetic milieu: role of advanced non‐enzymatic glycation and polyol pathway activation

2001 • 26 citations

Advanced glycation end products in adolescents and young adults with diabetic angiopathy

2000 • 25 citations

Increased endocytosis in retinal vascular endothelial cells grown in high glucose medium is modulated by inhibitors of nonenzymatic glycosylation

1995 • 24 citations

Modulation of hemodynamic and vascular filtration changes in diabetic rats by dietary myo-inositol

1990 • 23 citations

Glycation of insulin in the islets of Langerhans of normal and diabetic animals

1996 • 20 citations

Role of the Janus kinase (JAK)/signal transducters and activators of transcription (STAT) cascade in advanced glycation end-product-induced cellular mitogenesis in NRK-49F cells

1999 • 17 citations

Retinal vascular endothelial cell endocytosis increases in early diabetes.

1995 • 15 citations

High glucose and advanced glycation end products induce phospholipid hydrolysis and phospholipid enzyme inhibition in bovine retinal pericytes

2001 • 14 citations

Advanced glycation alters expression of the 67kDa laminin receptor in retinal microvascular endothelial cells

2001 • 14 citations

A Modulatory Role for Advanced Glycation End-Products (AGEs) in Retinal Microvascular Leukostasis

2002 • 3 citations