Diabetes-Associated Sustained Activation of the Transcription Factor Nuclear Factor-κB

Function and Activation of NF-kappaB in the Immune System

1994 • 4,698 citations

Nuclear Factor-κB — A Pivotal Transcription Factor in Chronic Inflammatory Diseases

1997 • 4,661 citations

Normalizing mitochondrial superoxide production blocks three pathways of hyperglycaemic damage

2000 • 4,169 citations

Role of Oxidative Stress in Development of Complications in Diabetes

1991 • 3,774 citations

An Essential Role for NF-κB in Preventing TNF-α-Induced Cell Death

1996 • 3,094 citations

NF-κB: Ten Years After

1996 • 3,008 citations

Suppression of TNF-α-Induced Apoptosis by NF-κB

1996 • 2,623 citations

RAGE and amyloid-β peptide neurotoxicity in Alzheimer's disease

1996 • 1,955 citations

Oxidative Stress and Diabetic Vascular Complications

1996 • 1,947 citations

RAGE Mediates a Novel Proinflammatory Axis

1999 • 1,807 citations

Rel/NF-kappa B/I kappa B family: intimate tales of association and dissociation.

1995 • 1,739 citations

Modulation of endothelial cell hemostatic properties by tumor necrosis factor.

1986 • 1,335 citations

Enhanced cellular oxidant stress by the interaction of advanced glycation end products with their receptors/binding proteins

1994 • 1,311 citations

Blockade of RAGE–amphoterin signalling suppresses tumour growth and metastases

2000 • 1,200 citations

Suppression of accelerated diabetic atherosclerosis by the soluble receptor for advanced glycation endproducts

1998 • 1,102 citations

Activation of NADPH oxidase by AGE links oxidant stress to altered gene expression via RAGE

2001 • 1,017 citations

Advanced Glycosylation End Products in Patients with Diabetic Nephropathy

1991 • 925 citations

Advanced glycation endproducts interacting with their endothelial receptor induce expression of vascular cell adhesion molecule-1 (VCAM-1) in cultured human endothelial cells and in mice. A potential mechanism for the accelerated vasculopathy of diabetes.

1995 • 886 citations

Pathogenic effects of advanced glycosylation: biochemical, biologic, and clinical implications for diabetes and aging.

1994 • 863 citations

N ε-(Carboxymethyl)Lysine Adducts of Proteins Are Ligands for Receptor for Advanced Glycation End Products That Activate Cell Signaling Pathways and Modulate Gene Expression

1999 • 848 citations

Local administration of antisense phosphorothiate olignucleotides to the p65 subunit of NF–κB abrogates established experimental colitis in mice

1996 • 839 citations

AP-1 transcriptional activity is regulated by a direct association between thioredoxin and Ref-1

1997 • 836 citations

The I kappa B proteins: multifunctional regulators of Rel/NF-kappa B transcription factors.

1993 • 819 citations

Activation of the Receptor for Advanced Glycation End Products Triggers a p21 -dependent Mitogen-activated Protein Kinase Pathway Regulated by Oxidant Stress

1997 • 803 citations

Activated transcription factor nuclear factor-kappa B is present in the atherosclerotic lesion.

1996 • 795 citations

Role of oxidative stress in development of complications in diabetes

1991 • 787 citations

Heme oxygenase: A novel target for the modulation of inflammatory response

1996 • 784 citations

IκB-β regulates the persistent response in a biphasic activation of NF-κB

1995 • 780 citations

Activation of Receptor for Advanced Glycation End Products

1999 • 775 citations

Orally absorbed reactive glycation products (glycotoxins): An environmental risk factor in diabetic nephropathy

1997 • 774 citations

Survey of the distribution of a newly characterized receptor for advanced glycation end products in tissues.

1993 • 764 citations

RNA Oxidation Is a Prominent Feature of Vulnerable Neurons in Alzheimer’s Disease

1999 • 718 citations

Aberrant nuclear factor-kappaB/Rel expression and the pathogenesis of breast cancer.

1997 • 717 citations

Advanced Maillard reaction end products are associated with Alzheimer disease pathology.

1994 • 712 citations

Induction and Stabilization of IκBα by Nitric Oxide Mediates Inhibition of NF-κB

1995 • 707 citations

Increased accumulation of the glycoxidation product N(epsilon)-(carboxymethyl)lysine in human tissues in diabetes and aging.

1997 • 701 citations

Nuclear factor κB is activated in macrophages and epithelial cells of inflamed intestinal mucosa

1998 • 696 citations

Cellular receptors for advanced glycation end products. Implications for induction of oxidant stress and cellular dysfunction in the pathogenesis of vascular lesions.

1994 • 632 citations

Receptor-mediated endothelial cell dysfunction in diabetic vasculopathy. Soluble receptor for advanced glycation end products blocks hyperpermeability in diabetic rats.

1996 • 551 citations

AGEs and their interaction with AGE-receptors in vascular disease and diabetes mellitus. I. The AGE concept

1998 • 547 citations

Characterization and Functional Analysis of the Promoter of RAGE, the Receptor for Advanced Glycation End Products

1997 • 525 citations

Endothelial nuclear factor-kappa B and the initiation of the atherosclerotic lesion.

1993 • 525 citations

Role of NFkappaB in the mortality of sepsis.

1997 • 464 citations

Advanced glycation end products induce glomerular sclerosis and albuminuria in normal rats.

1994 • 463 citations

Stimulation-dependent I kappa B alpha phosphorylation marks the NF-kappa B inhibitor for degradation via the ubiquitin-proteasome pathway.

1995 • 438 citations

Leukocyte-endothelial interaction is augmented by high glucose concentrations and hyperglycemia in a NF-kB-dependent fashion.

1998 • 434 citations

Transcriptional Activation by NF-κB Requires Multiple Coactivators

1999 • 433 citations

NF-kappa B and I kappa B alpha: an inducible regulatory system in endothelial activation.

1994 • 416 citations

NF-κB as a primary regulator of the stress response

1999 • 407 citations

Non-enzymatically glycated tau in Alzheimer's disease induces neuronal oxidant stress resulting in cytokine gene expression and release of amyloid β-peptide

1995 • 401 citations

Endothelial receptor-mediated binding of glucose-modified albumin is associated with increased monolayer permeability and modulation of cell surface coagulant properties.

1989 • 383 citations

Rel/NF-κB and IκB proteins: an overview

1997 • 372 citations

Advanced Glycation End Product-Induced Activation of NF-κB is Suppressed by α-Lipoic Acid in Cultured Endothelial Cells

1997 • 372 citations

Advanced glycation end products (AGEs) on the surface of diabetic erythrocytes bind to the vessel wall via a specific receptor inducing oxidant stress in the vasculature: a link between surface-associated AGEs and diabetic complications.

1994 • 351 citations

The myeloperoxidase system of human phagocytes generates Nε-(carboxymethyl)lysine on proteins: a mechanism for producing advanced glycation end products at sites of inflammation

1999 • 346 citations

Cytokine-inducible expression in endothelial cells of an I kappa B alpha-like gene is regulated by NF kappa B.

1993 • 338 citations

Receptor-dependent cell stress and amyloid accumulation in systemic amyloidosis

2000 • 337 citations

Involvement of beta 2-microglobulin modified with advanced glycation end products in the pathogenesis of hemodialysis-associated amyloidosis. Induction of human monocyte chemotaxis and macrophage secretion of tumor necrosis factor-alpha and interleukin-1.

1994 • 335 citations

The ER-overload response: activation of NF-κB

1997 • 334 citations

Advanced glycation end products (AGEs) co-localize with AGE receptors in the retinal vasculature of diabetic and of AGE-infused rats.

1997 • 324 citations

Advanced glycation end products up-regulate gene expression found in diabetic glomerular disease.

1994 • 298 citations

Constitutive Activation of NF-κB in Primary Adult T-Cell Leukemia Cells

1999 • 292 citations

Alzheimer's disease – synergistic effects of glucose deficit, oxidative stress and advanced glycation endproducts

1998 • 292 citations

Molecular mechanisms of constitutive NF-κB/Rel activation in Hodgkin/Reed-Sternberg cells

1999 • 285 citations

Endothelin 1 transcription is controlled by nuclear factor-kappaB in AGE-stimulated cultured endothelial cells.

2000 • 275 citations

Overexpression of I Kappa B Alpha Without Inhibition of NF-κB Activity and Mutations in the I Kappa B Alpha Gene in Reed-Sternberg Cells

1999 • 267 citations

The Nuclear Factor κ-B Signaling Pathway Participates in Dysregulation of Vascular Smooth Muscle Cells in Vitroand in Human Atherosclerosis

1997 • 265 citations

The Maillard Reaction in Foods and Medicine

1998 • 248 citations

Role of Unphosphorylated, Newly Synthesized IκBβ in Persistent Activation of NF-κB

1996 • 228 citations

Distinct NF-κB/Rel transcription factors are responsible for tissue-specific and inducible gene activation

1993 • 225 citations

Protective genes expressed in endothelial cells: a regulatory response to injury

1997 • 222 citations

Advanced Glycation End Product (AGE)–Mediated Induction of Tissue Factor in Cultured Endothelial Cells Is Dependent on RAGE

1997 • 221 citations

Maillard Reactions in Chemistry, Food and Health

1994 • 197 citations

Peripheral blood mononuclear cells isolated from patients with diabetic nephropathy show increased activation of the oxidative-stress sensitive transcription factor NF-kB

1999 • 190 citations

Prevention of cardiovascular and renal pathology of aging by the advanced glycation inhibitor aminoguanidine.

1996 • 180 citations

Synergistic Activation of NF-κB by Tumor Necrosis Factor Alpha and Gamma Interferon via Enhanced IκBα Degradation and De Novo IκBβ Degradation

1997 • 179 citations

Bcl-2 and Bcl-XL serve an anti-inflammatory function in endothelial cells through inhibition of NF-κB

1999 • 174 citations

The Dietary Pigment Curcumin Reduces Endothelial Tissue Factor Gene Expression by Inhibiting Binding of AP-1 to the DNA and Activation of NF-κB

1997 • 165 citations

Insufficient Glycemic Control Increases Nuclear Factor-κB Binding Activity in Peripheral Blood Mononuclear Cells Isolated From Patients With Type 1 Diabetes

1998 • 165 citations

Expression of receptors for advanced glycation end products in peripheral occlusive vascular disease.

1995 • 151 citations

Tumor Necrosis Factor-α Activation of Nuclear Transcription Factor-κB in Marrow Macrophages Is Mediated by c-Src Tyrosine Phosphorylation of IκBα

1998 • 145 citations

Induction of the transcription factor Sp1 during human cytomegalovirus infection mediates upregulation of the p65 and p105/p50 NF-kappaB promoters

1997 • 141 citations

Immunological Evidence for the Presence of Advanced Glycosylation End Products in Atherosclerotic Lesions of Euglycemic Rabbits

1995 • 135 citations

Mechanism of the Tumor Necrosis Factor α-mediated Induction of Endothelial Tissue Factor

1995 • 125 citations

Specific Quantitation by HPLC of Protein (Lysine) Bound Glucose in Human Serum Albumin and Other Glycosylated Proteins

1981 • 113 citations

A Sustained Reduction in IκB-β May Contribute to Persistent NF-κB Activation in Human Endothelial Cells

1996 • 110 citations

Elevated plasma levels of vascular cell adhesion molecule‐1 (VCAM‐1) in diabetic patients with microalbuminuria: a marker of vascular dysfunction and progressive vascular disease

1996 • 106 citations

Inducible Degradation of IκBα In Vitro and In Vivo Requires the Acidic C-Terminal Domain of the Protein

1995 • 103 citations

Detection and quantification of pentosidine in foods

1997 • 100 citations

Listeria monocytogenes infection of P388D ₁ macrophages results in a biphasic NF-κB (RelA/p50) activation induced by lipoteichoic acid and bacterial phospholipases and mediated by IκBα and IκBβ degradation

1997 • 97 citations

Carbonyl Stress in the Pathogenesis of Diabetic Nephropathy.

1999 • 97 citations

Genistein Inhibits Constitutive and Inducible NFκB Activation and Decreases IL-8 Production by Human Cystic Fibrosis Bronchial Gland Cells

1999 • 96 citations

Long-term assessment of glucose control by haemoglobin-AGE measurement

1996 • 91 citations

The advanced glycation end product Nepsilon-(carboxymethyl)lysine is increased in serum from children and adolescents with type 1 diabetes.

1998 • 90 citations

Expression of NF-kappa B and I kappa B-alpha by aortic endothelium in an arterial injury model.

1996 • 84 citations

Efficient determination of individual maillard compounds in heat-treated milk products by amino acid analysis

1991 • 83 citations

Expression of receptors for advanced glycosylated end-products in renal disease

1995 • 80 citations

Cell specific effects of glucocorticoid treatment on the NF-kappa Bp65/Ikappa Balpha system in patients with Crohn's disease

1999 • 80 citations

c-Jun NH2-terminal Kinase-mediated Redox-dependent Degradation of IκB

2001 • 80 citations

Increased Serum Levels of Advanced Glycation End Products (AGEs) in Children and Adolescents With IDDM

1997 • 69 citations

Oxidative Stress and Atherosclerosis: Its Relationship to Growth Factors, Thrombus Formation and Therapeutic Approaches

1999 • 67 citations

Arson: Tracking the Culprit in Alzheimer's Disease

2000 • 66 citations

Synthesis of pyrraline reference material

1996 • 65 citations

Activation of primary human T-lymphocytes through CD2 plus CD28 adhesion molecules induces long-term nuclear expression of NF-kappa B.

1993 • 56 citations

BB/O(ttawa)K(arlsburg) rats: features of a subline of diabetes-prone BB rats.

1991 • 53 citations

Receptors for advanced glycation end-products (AGE)--expression by endothelial cells in non-diabetic uraemic patients

1996 • 45 citations

Molecular cloning of genes differentially regulated by TNF-α in bovine aortic endothelial cells, fibroblasts and smooth muscle cells

1998 • 44 citations

The CD2 and CD28 adhesion molecules induce long-term autocrine proliferation of CD4+ T cells

1993 • 43 citations

Molecular mechanism of blood monocyte adhesion to vascular endothelial cells.

1992 • 41 citations

Oncostatin M promotes biphasic tissue factor expression in smooth muscle cells: evidence for Erk-1/2 activation

2001 • 39 citations

Temporal and Subunit-specific Modulations of the Rel/NF-κB Transcription Factors Through CD28 Costimulation

1997 • 37 citations

Circulating advanced glycation end product levels in rats rapidly increase with acute renal failure

2001 • 27 citations

Increased nuclear factor-kappaB activation in colitis of interleukin-2-deficient mice

1999 • 24 citations

Simultaneous Determination of Protein-bound Maillard Products by Ion Exchange Chromatography and Photodiode Array Detection

2005 • 21 citations

Protein-Bound Maillard Compounds in Foods: Analytical and Technological Aspects

2005 • 19 citations

Regulation of expression of nuclear factor kappa B RelA in oligodendrocytes

2000 • 12 citations

CONSTITUTIVE ACTIVATION OF NF- κ B IN PRIMARY ADULT T-CELL LEUKEMIA CELLS

1999 • 7 citations

Circulating advanced glycation end product levels in rats rapidly increase with acute renal failure

2001 • 2 citations

Deleted Work

1955 • 0 citations