Thrombogenic and Fibrinolytic Factors and Cardiovascular Risk in Non-insulin-dependent Diabetes Mellitus

Adipose Expression of Tumor Necrosis Factor-α: Direct Role in Obesity-Linked Insulin Resistance

1993 • 7,219 citations

HAEMOSTATIC FUNCTION AND ISCHAEMIC HEART DISEASE: PRINCIPAL RESULTS OF THE NORTHWICK PARK HEART STUDY

1986 • 1,989 citations

Hemostatic Factors and the Risk of Myocardial Infarction or Sudden Death in Patients with Angina Pectoris

1995 • 1,807 citations

PLASMINOGEN ACTIVATOR INHIBITOR IN PLASMA: RISK FACTOR FOR RECURRENT MYOCARDIAL INFARCTION

1987 • 1,516 citations

Fibrinogen as a Cardiovascular Risk Factor

1993 • 1,015 citations

Obituary. Rupert Samuel Bruce Pearson.

1974 • 760 citations

Allele-specific increase in basal transcription of the plasminogen-activator inhibitor 1 gene is associated with myocardial infarction.

1995 • 734 citations

Fibrinolytic activity, clotting factors, and long-term incidence of ischaemic heart disease in the Northwick Park Heart Study

1993 • 727 citations

Endogenous tissue-type plasminogen activator and risk of myocardial infarction

1993 • 590 citations

The two allele sequences of a common polymorphism in the promoter of the plasminogen activator inhibitor-1 (PAI-1) gene respond differently to interleukin-1 in HepG2 cells

1993 • 583 citations

Fibrinogen and factor VII in the prediction of coronary risk. Results from the PROCAM study in healthy men.

1994 • 572 citations

Increased plasma plasminogen activator inhibitor 1 levels. A possible link between insulin resistance and atherothrombosis

1991 • 572 citations

Increased type 1 plasminogen activator inhibitor gene expression in atherosclerotic human arteries.

1992 • 547 citations

Correlation between blood fibrinolytic activity, plasminogen activator inhibitor level, plasma insulin level, and relative body weight in normal and obese subjects

1986 • 449 citations

Associations of Factor VIII and von Willebrand Factor with Age, Race, Sex, and Risk Factors for Atherosclerosis

1993 • 432 citations

Regulation of murine type 1 plasminogen activator inhibitor gene expression in vivo. Tissue specificity and induction by lipopolysaccharide, tumor necrosis factor-alpha, and transforming growth factor-beta.

1991 • 413 citations

Plasminogen activator inhibitor-1 gene-deficient mice. II. Effects on hemostasis, thrombosis, and thrombolysis.

1993 • 399 citations

von Willebrand factor in plasma: a novel risk factor for recurrent myocardial infarction and death.

1991 • 369 citations

Epidemiological Study on Factor VII, Factor VIII and Fibrinogen in an Industrial Population: I. Baseline Data on the Relation to Age, Gender, Body-Weight, Smoking, Alcohol, Pill-Using, and Menopause

1985 • 348 citations

Abdominal obesity is associated with an impaired fibrinolytic activity and elevated plasminogen activator inhibitor-1

1990 • 340 citations

Population correlates of plasma fibrinogen and factor VII, putative cardiovascular risk factors

1991 • 334 citations

Genetic variation at the plasminogen activator inhibitor-1 locus is associated with altered levels of plasma plasminogen activator inhibitor-1 activity.

1991 • 327 citations

Involvement of the hemostatic system in the insulin resistance syndrome. A study of 1500 patients with angina pectoris. The ECAT Angina Pectoris Study Group.

1993 • 324 citations

Elevated fibrinogen and plasminogen activator inhibitor (PAI‐1) in hypertension are related to metabolic risk factors for cardiovascular disease

1990 • 309 citations

Adipsin and Complement Factor D Activity: An Immune-Related Defect in Obesity

1989 • 303 citations

Insulin Stimulates the Synthesis of Plasminogen Activator Inhibitor 1 by the Human Hepatocellular Cell Line Hep G2

1988 • 303 citations

Secretion of plasminogen activator inhibitor-1 from cultured human umbilical vein endothelial cells is induced by very low density lipoprotein.

1990 • 300 citations

Increased Plasminogen Activator Inhibitor Activity in Non Insulin Dependent Diabetic Patients – Relationship with Plasma Insulin

1989 • 296 citations

Factors Responsible for Impaired Fibrinolysis in Obese Subjects and NIDDM Patients

1994 • 295 citations

Lipoprotein (a) regulates plasminogen activator inhibitor-1 expression in endothelial cells. A potential mechanism in thrombogenesis

1991 • 289 citations

A common genetic polymorphism associated with lower coagulation factor VII levels in healthy individuals.

1991 • 289 citations

Relation between extent of coronary artery disease and blood viscosity.

1980 • 283 citations

Tissue-type plasminogen activator antigen and plasminogen activator inhibitor in diabetes mellitus.

1988 • 280 citations

Factor VIII, ABO blood group and the incidence of ischaemic heart disease

1994 • 275 citations

Identification and distribution of fibrinogen, fibrin, and fibrin(ogen) degradation products in atherosclerosis. Use of monoclonal antibodies.

1989 • 269 citations

Development of venous occlusions in mice transgenic for the plasminogen activator inhibitor-1 gene

1990 • 268 citations

Localization and production of plasminogen activator inhibitor-1 in human healthy and atherosclerotic arteries.

1993 • 264 citations

Predictive value of tissue plasminogen activator mass concentration on long-term mortality in patients with coronary artery disease. A 7-year follow-up.

1993 • 246 citations

ROLE OF GENETIC VARIATION AT THE FIBRINOGEN LOCUS IN DETERMINATION OF PLASMA FIBRINOGEN CONCENTRATIONS

1987 • 243 citations

Impact of weight loss on plasminogen activator inhibitor (PAI-1), factor VII, and other hemostatic factors in moderately overweight adults.

1993 • 227 citations

Association between dietary fat intake and plasma factor VII coagulant activity — A predictor of cardiovascular mortality

1986 • 226 citations

Determinants of plasma fibrinogen: relation to body weight, waist-to-hip ratio, smoking, alcohol, age, and sex. Results from the second MONICA Augsburg survey 1989-1990.

1992 • 224 citations

Plasma plasminogen activator inhibitor-1 in angina pectoris. Influence of plasma insulin and acute-phase response.

1989 • 209 citations

Plasma fibrinogen and coronary risk factors: The Scottish heart health study

1990 • 206 citations

Plasminogen Activator Inhibitor 1 and Atherothrombosis

1993 • 198 citations

The relationships of concentrations of insulin, intact proinsulin and 32?33 split proinsulin with cardiovascular risk factors in Type 2 (non-insulin-dependent) diabetic subjects

1990 • 198 citations

Association of hemostatic variables with prevalent cardiovascular disease and asymptomatic carotid artery atherosclerosis. The Atherosclerosis Risk in Communities (ARIC) Study Investigators.

1993 • 191 citations

Induction of Plasminogen Activator Inhibitor Type-1 (PAI-1) by Proinsulin and Insulin In Vivo

1995 • 190 citations

Plasminogen Activator Inhibitor 1: Biosynthesis and mRNA Level Are Increased by Insulin in Cultured Human Hepatocytes

1989 • 190 citations

Haemostatic function in myocardial infarction.

1986 • 189 citations

Hyperfibrinogenemia: An important risk factor for vascular complications in diabetes

1992 • 178 citations

Tissue plasminogen activator and other risk factors as predictors of cardiovascular events in patients with severe angina pectoris

1991 • 173 citations

Identification and distribution of fibrinogen, fibrin and fibrin (ogen) degradation products in atherosclerosis

1989 • 168 citations

4 Fibrinogen, Fibrin and Fibrin Degradation Products in Relation to Atherosclerosis

1986 • 167 citations

Metformin Decreases the High Plasminogen Activator Inhibition Capacity, Plasma Insulin and Triglyceride Levels in Non-Diabetic Obese Subjects

1987 • 166 citations

Augmentation of synthesis of plasminogen activator inhibitor type 1 by insulin and insulin-like growth factor type I: implications for vascular disease in hyperinsulinemic states.

1991 • 165 citations

Determinants of Plasminogen Activator Inhibitor 1 Activity in Treated NIDDM and Its Relation to a Polymorphism in the Plasminogen Activator Inhibitor 1 Gene

1995 • 165 citations

Augmentation of the synthesis of plasminogen activator inhibitor type-1 by precursors of insulin. A potential risk factor for vascular disease.

1994 • 158 citations

Hypertriglyceridemia and regulation of fibrinolytic activity.

1992 • 157 citations

Activation of Tissue Factor–Induced Coagulation and Endothelial Cell Dysfunction in Non–Insulin-Dependent Diabetic Patients With Microalbuminuria

1995 • 147 citations

ECAT angina pectoris study: baseline associations of haemostatic factors with extent of coronary arteriosclerosis and other coronary risk factors in 3000 patients with angina pectoris undergoing coronary angiography

1993 • 141 citations

Haemostasis Factors in Angina Pectoris; Relation to Gender, Age and Acute-phase Reaction

1995 • 128 citations

Augmentation of synthesis of plasminogen activator inhibitor type-1 in arterial endothelial cells by glucose and its implications for local fibrinolysis.

1993 • 127 citations

Genetic variation at the beta-fibrinogen locus in relation to plasma fibrinogen concentrations and risk of myocardial infarction. The ECTIM Study.

1993 • 124 citations

Relationship between plasma plasminogen activator inhibitor-1 activity and VLDL triglyceride concentration, insulin levels and insulin sensitivity: studies in randomly selected normo- and hypertriglyceridaemic men

1993 • 122 citations

Stimulation by Proinsulin of Expression of Plasminogen Activator Inhibitor Type-I in Endothelial Cells

1992 • 122 citations

Activation of coagulation factor VII during alimentary lipemia.

1994 • 121 citations

Plasminogen activator inhibitor in plasma is related to testosterone in men

1989 • 115 citations

Regional wall motion abnormalities in stunned and hibernating myocardium

1993 • 113 citations

Insulin Therapy in Type 2 Diabetic Subjects Suppresses Plasminogen Activator Inhibitor (PAI‐1) Activity and Proinsulin‐like Molecules Independently of Glycaemic Control

1993 • 113 citations

Stimulating effect of oxidized low density lipoproteins on plasminogen activator inhibitor-1 synthesis by endothelial cells.

1991 • 110 citations

Dietary regulation of fibrinolytic factors

1990 • 110 citations

Plasminogen Activator Inhibitor-1 Expression in Human Liver and Healthy or Atherosclerotic Vessel Walls

1994 • 109 citations

Thrombolysis and Reocclusion in Experimental Jugular Vein and Coronary Artery Thrombosis

1995 • 108 citations

Factor VII coagulant activity and antigen levels in healthy men are determined by interaction between factor VII genotype and plasma triglyceride concentration.

1994 • 104 citations

Fibrinogen and fibrinolytic variables in relation to anthropometry, lipids and blood pressure. The Northern Sweden Monica study

1994 • 98 citations

Increased blood fibrinolytic activity after physical exercise: Comparative study in individuals with different sporting activities and in patients after myocardial infarction taking part in a rehabilitation sports program

1988 • 93 citations

On the Usefulness of Fibrinolysis Variables in the Characterization of a Risk Group for Myocardial Reinfarction

1987 • 88 citations

Fibrinolytic variables are related to age, sex, blood pressure, and body build measurements: A cross-sectional study in Norsjö, Sweden

1989 • 82 citations

The Acute Effect of Insulin on Tissue Plasminogen Activator and Plasminogen Activator Inhibitor in Man

1991 • 74 citations

Short-Term Infusions of Insulin, Triacylglycerol and Glucose do not Cause Acute Increases in Plasminogen Activator Inhibitor-1 Concentrations in Man

1990 • 73 citations

Increased synthesis of plasminogen activator inhibitor-1 by cultured human endothelial cells exposed to native and modified LDLs. An LDL receptor-independent phenomenon.

1993 • 73 citations

Plasminogen activator inhibitor-1 synthesis in the human hepatoma cell line Hep G2. Metformin inhibits the stimulating effect of insulin.

1993 • 72 citations

Plasminogen activator inhibitor: a risk factor for myocardial infarction in diabetic patients.

1993 • 66 citations

Plasminogen activator inhibitor activity in diabetic and nondiabetic survivors of myocardial infarction.

1993 • 65 citations

Hypofibrinolysis associated with vasculopathy in non insulin dependent diabetes mellitus

1990 • 63 citations

Insulin sensitivity is not an independent determinant of plasma plasminogen activator inhibitor-1 activity.

1994 • 59 citations

Reduction of elevated plasminogen activator inhibitor levels during modest weight loss

1989 • 58 citations

Reactivated Recombinant Plasminogen Activator Inhibitor-1 (rPAI-1) Effectively Prevents Thrombolysis In Vivo

1992 • 57 citations

Influence of a rehabilitation sports programme on the fibrinolytic activity of patients after myocardial infarction

1989 • 53 citations

Hyperinsulinemia predicts low tissue plasminogen activator activity in a healthy population: The Northern Sweden MONICA study

1994 • 52 citations

Haemostatic Measures in Type 2 Diabetic Patients with Microalbuminuria

1990 • 51 citations

Fibrinogen: An Important Risk Factor for Atherothrombotic Diseases

1994 • 48 citations

Platelet Plasminogen Activator Inhibitor 1 in Patients With Type II Diabetes

1994 • 42 citations

Acute exogenous hyperinsulinaemia does not result in elevation of plasma plasminogen activator inhibitor-1 (PAI-1) in humans

1990 • 37 citations

Hypofibrinolysis and insulin-resistance.

1991 • 37 citations

Changes in fibrinolytic parameters in male patients with type 2 (non-insulin-dependent) diabetes mellitus

1993 • 34 citations

The Effects of Insulin-Like Growth Factor-1 on Plasminogen Activator Inhibitor-1 Synthesis and Secretion: Results from In Vitro and In Vivo Studies

1993 • 32 citations

The Effect of Insulin Treatment on the Balance between Tissue Plasminogen Activator and Plasminogen Activator Inhibitor-1 in Type 2 Diabetic Patients

1992 • 32 citations

Impact of physical training on plasminogen activator inhibitor activity in sedentary men

1990 • 31 citations

Can physical activity explain the differences in insulin levels and fibrinolytic activity between young indo-origin and European relatives of patients with coronary artery disease?

1995 • 31 citations

Phosphatidylinositol turnover during stimulation of plasminogen activator inhibitor-1 secretion induced by oxidized low density lipoproteins in human endothelial cells.

1993 • 29 citations

The study of gene-environment interactions that influence thrombosis and fibrinolysis. Genetic variation at the loci for factor VII and plasminogen activator inhibitor-1.

1992 • 28 citations

Fatty acids, fibrinogen and blood flow: A general mechanism for hyperfibrinogenemia and its pathologic consequences

1980 • 28 citations

Relationships of Insulin and Intact and Split Proinsulin to Haemostatic Function in Young Men with and without Coronary Artery Disease

1995 • 27 citations

Determinants of Plasminogen Activator Inhibitor-1 Activity in Survivors of Myocardial Infarction

1995 • 26 citations

von Willebrand factor and fibrinolytic variables are differently affected in the insulin resistance syndrome

1994 • 25 citations

Characterization of Epitheloid Cells from Human Omentum: Comparison with Endothelial Cells from Umbilical Veins

1991 • 24 citations

Relationship of plasminogen activator inhibitor-1 with plasma insulin, glucose, triglyceride and cholesterol in Chinese patients with diabetes

1993 • 23 citations

Plasminogen activator inhibitor activity in various types of endogenous hypertriglyceridemia

1993 • 23 citations

Alteration of oxide reductive and haemostatic factors in type 2 diabetics

1994 • 22 citations

Fibrinolysis in insulin dependent diabetic patients with or without nephropathy

1992 • 21 citations

Up-regulation of PAI-1 synthesis by insulin and proinsulin in HEP G2 cells but not in endothelial cells

1995 • 21 citations

Up-Regulated Expression of Plasminogen Activator Inhibitor-1 in Hep G2 Cells: Interrelationship between Insulin and Insulin-Like Growth Factor 1

1995 • 20 citations

Fibrinolytic Activity in Chinese Patients with Diabetes or Hyperlipidemia in Comparison with Healthy Controls

1991 • 20 citations

Body composition and weight reduction in relation to antigen and activity of plasminogen activitor inhibitor (PAI-1) in overweight individuals

1990 • 19 citations

Interactions amongst insulin, lipoproteins and haemostatic function relevant to coronary heart disease.

1994 • 17 citations

Plasminogen activator inhibitor 1 and insulin levels in various insulin resistance states.

1992 • 14 citations

Does weight loss reduce plasma fibrinogen?

1993 • 11 citations

Fibrinolytic anomalies associated with insulin resistance. Effect of metformin. Results of the Bigpro trial

1994 • 3 citations