Receptors for proteins modified by advanced glycation endproducts (AGE)—their functional role in atherosclerosis

Binding site on macrophages that mediates uptake and degradation of acetylated low density lipoprotein, producing massive cholesterol deposition

1979 • 2,458 citations

LIPOPROTEIN METABOLISM IN THE MACROPHAGE: Implications for Cholesterol Deposition in Atherosclerosis

1983 • 2,306 citations

RAGE and amyloid-β peptide neurotoxicity in Alzheimer's disease

1996 • 1,955 citations

Cloning and expression of a cell surface receptor for advanced glycosylation end products of proteins.

1992 • 1,488 citations

An endothelial receptor for oxidized low-density lipoprotein

1997 • 1,334 citations

CD36 is a receptor for oxidized low density lipoprotein

1993 • 1,271 citations

A role for macrophage scavenger receptors in atherosclerosis and susceptibility to infection

1997 • 1,210 citations

The Receptor for Advanced Glycation End Products (RAGE) Is a Cellular Binding Site for Amphoterin

1995 • 1,116 citations

Type I macrophage scavenger receptor contains α-helical and collagen-like coiled coils

1990 • 1,039 citations

Advanced Glycosylation End Products in Patients with Diabetic Nephropathy

1991 • 925 citations

Advanced glycation endproducts interacting with their endothelial receptor induce expression of vascular cell adhesion molecule-1 (VCAM-1) in cultured human endothelial cells and in mice. A potential mechanism for the accelerated vasculopathy of diabetes.

1995 • 886 citations

Pathogenic effects of advanced glycosylation: biochemical, biologic, and clinical implications for diabetes and aging.

1994 • 863 citations

Expression cloning of SR-BI, a CD36-related class B scavenger receptor.

1994 • 818 citations

Isolation and characterization of two binding proteins for advanced glycosylation end products from bovine lung which are present on the endothelial cell surface.

1992 • 808 citations

Survey of the distribution of a newly characterized receptor for advanced glycation end products in tissues.

1993 • 764 citations

Action des acides amines sur les sucres : formation des melanoidines par voie methodique

1912 • 555 citations

Cloning of a novel bacteria-binding receptor structurally related to scavenger receptors and expressed in a subset of macrophages

1995 • 501 citations

Identification of Galectin-3 As a High-Affinity Binding Protein for Advanced Glycation End Products (AGE): A New Member of the AGE-Receptor Complex

1995 • 410 citations

beta 2-Microglobulin modified with advanced glycation end products is a major component of hemodialysis-associated amyloidosis.

1993 • 405 citations

Human macrophage scavenger receptors: primary structure, expression, and localization in atherosclerotic lesions.

1990 • 360 citations

Receptor-specific increase in extracellular matrix production in mouse mesangial cells by advanced glycosylation end products is mediated via platelet-derived growth factor.

1992 • 353 citations

Molecular identity and cellular distribution of advanced glycation endproduct receptors: relationship of p60 to OST-48 and p90 to 80K-H membrane proteins.

1996 • 340 citations

High-affinity-receptor-mediated uptake and degradation of glucose-modified proteins: a potential mechanism for the removal of senescent macromolecules.

1985 • 312 citations

The 94- to 97-kDa mouse macrophage membrane protein that recognizes oxidized low density lipoprotein and phosphatidylserine-rich liposomes is identical to macrosialin, the mouse homologue of human CD68.

1995 • 310 citations

Immunohistochemical and ultrastructural detection of advanced glycation end products in atherosclerotic lesions of human aorta with a novel specific monoclonal antibody.

1995 • 291 citations

Immunohistochemical localization of advanced glycosylation end products in coronary atheroma and cardiac tissue in diabetes mellitus.

1993 • 286 citations

Advanced Glycation End Products-driven Angiogenesis in Vitro

1997 • 272 citations

Immunochemical approach to characterize advanced glycation end products of the Maillard reaction

1991 • 266 citations

Receptor-specific induction of insulin-like growth factor I in human monocytes by advanced glycosylation end product-modified proteins.

1992 • 261 citations

Human and rat mesangial cell receptors for glucose-modified proteins: potential role in kidney tissue remodelling and diabetic nephropathy.

1991 • 243 citations

Macrophage Scavenger Receptor Mediates the Endocytic Uptake and Degradation of Advanced Glycation End Products of the Maillard Reaction

1995 • 236 citations

Amphoterin, the 30-kDa protein in a family of HMG1-type polypeptides. Enhanced expression in transformed cells, leading edge localization, and interactions with plasminogen activation.

1993 • 218 citations

Advanced glycation end products are eliminated by scavenger-receptor-mediated endocytosis in hepatic sinusoidal Kupffer and endothelial cells

1997 • 218 citations

Expression of type I and type II bovine scavenger receptors in Chinese hamster ovary cells: lipid droplet accumulation and nonreciprocal cross competition by acetylated and oxidized low density lipoprotein.

1991 • 214 citations

Expression Cloning of a Novel Scavenger Receptor from Human Endothelial Cells

1997 • 197 citations

A macrophage Fc receptor for IgG is also a receptor for oxidized low density lipoprotein.

1992 • 194 citations

Two novel rat liver membrane proteins that bind advanced glycosylation endproducts: relationship to macrophage receptor for glucose-modified proteins.

1991 • 189 citations

Effect of Aminoguanidine on Functional and Structural Abnormalities in Peripheral Nerve of STZ-Induced Diabetic Rats

1992 • 178 citations

Photo-Enhanced Modification of Human Skin Elastin in Actinic Elastosis by N∈-(Carboxymethyl)lysine, One of the Glycoxidation Products of the Maillard Reaction

1997 • 157 citations

Endocytic uptake of nonenzymatically glycosylated proteins is mediated by a scavenger receptor for aldehyde-modified proteins.

1988 • 156 citations

Novel macrophage receptor for glucose-modified proteins is distinct from previously described scavenger receptors.

1986 • 156 citations

Ultrastructure of nonenzymatically glycated mesangial matrix in diabetic nephropathy

1995 • 145 citations

Coexpression of type I and type II human macrophage scavenger receptors in macrophages of various organs and foam cells in atherosclerotic lesions.

1992 • 144 citations

THE USE OF FORMALDEHYDE-TREATED 131I-ALBUMIN IN THE STUDY OF DIGESTIVE VACUOLES AND SOME PROPERTIES OF THESE PARTICLES FROM MOUSE LIVER

1967 • 133 citations

Rabbit aortic smooth muscle cells express inducible macrophage scavenger receptor messenger RNA that is absent from endothelial cells.

1992 • 125 citations

Immunochemical Detection of Advanced Glycation End Products in Lens Crystallins From Streptozocin-Induced Diabetic Rat

1993 • 124 citations

Oxidized or acetylated low density lipoproteins are rapidly cleared by the liver in mice with disruption of the scavenger receptor class A type I/II gene.

1997 • 119 citations

The Receptor for Advanced Glycation End Products Mediates the Chemotaxis of Rabbit Smooth Muscle Cells

1997 • 98 citations

Scavenger receptor for aldehyde-modified proteins.

1986 • 91 citations

Characterization of a membrane-associated receptor from rat sinusoidal liver cells that binds formaldehyde-treated serum albumin.

1985 • 90 citations

The 48-kDa subunit of the mammalian oligosaccharyltransferase complex is homologous to the essential yeast protein WBP1.

1992 • 88 citations

Isolation of Surface Binding Protein Specific for Advanced Glycosylation End Products From Mouse Macrophage-Derived Cell Line RAW 264.7

1990 • 61 citations

Nonenzymatic Glycosylation of Laminin and the Laminin Peptide CIKVAVS Inhibits Neurite Outgrowth

1993 • 59 citations

Scavenger function of sinusoidal liver cells. Acetylated low-density lipoprotein is endocytosed via a route distinct from formaldehyde-treated serum albumin.

1985 • 59 citations

Insulin Enhances Macrophage Scavenger Receptor-mediated Endocytic Uptake of Advanced Glycation End Products

1998 • 58 citations

Purification of two distinct proteins of approximate Mr 80,000 from human epithelial cells and identification as proper substrates for protein kinase C

1990 • 56 citations

Deleted Work

1955 • 0 citations