The Two-Handed E Box Binding Zinc Finger Protein SIP1 Downregulates E-Cadherin and Induces Invasion

TGF-β SIGNAL TRANSDUCTION

1998 • 7,582 citations

Tight control of gene expression in mammalian cells by tetracycline-responsive promoters.

1992 • 4,885 citations

The transcription factor Snail controls epithelial–mesenchymal transitions by repressing E-cadherin expression

2000 • 3,504 citations

Functional interaction of β-catenin with the transcription factor LEF-1

1996 • 2,847 citations

The transcription factor Snail is a repressor of E-cadherin gene expression in epithelial tumour cells

2000 • 2,569 citations

Transcriptional Activation by Tetracyclines in Mammalian Cells

1995 • 2,458 citations

Synergy of demethylation and histone deacetylase inhibition in the re-expression of genes silenced in cancer

1999 • 1,865 citations

Methylation-Induced Repression— Belts, Braces, and Chromatin

1999 • 1,823 citations

Genetic manipulation of E-cadherin expression by epithelial tumor cells reveals an invasion suppressor role

1991 • 1,686 citations

The cadherins: cell-cell adhesion molecules controlling animal morphogenesis

1988 • 1,626 citations

E-cadherin-mediated cell-cell adhesion prevents invasiveness of human carcinoma cells.

1991 • 1,592 citations

A causal role for E-cadherin in the transition from adenoma to carcinoma

1998 • 1,415 citations

Neonatal lethality and lymphopenia in mice with a homozygous disruption of the c-abl proto-oncogene

1991 • 1,317 citations

Transcriptional Activators of TGF-β Responses: Smads

1998 • 1,024 citations

Dissecting tumor cell invasion: epithelial cells acquire invasive properties after the loss of uvomorulin-mediated cell-cell adhesion.

1989 • 961 citations

TGF-beta induced transdifferentiation of mammary epithelial cells to mesenchymal cells: involvement of type I receptors.

1994 • 937 citations

Prediction of the Coding Sequences of Unidentified Human Genes. IX. The Complete Sequences of 100 New cDNA Clones from Brain Which Can Code for Large Proteins in vitro

1998 • 848 citations

E-cadherin expression is silenced by DNA hypermethylation in human breast and prostate carcinomas.

1995 • 803 citations

N-Cadherin Promotes Motility in Human Breast Cancer Cells Regardless of Their E-Cadherin Expression

1999 • 773 citations

E-cadherin gene mutations provide clues to diffuse type gastric carcinomas.

1994 • 772 citations

E-cadherin is a tumour/invasion suppressor gene mutated in human lobular breast cancers.

1995 • 763 citations

The Xenopus Wnt effector XTcf-3 interacts with Groucho-related transcriptional repressors

1998 • 679 citations

Silencing of the E-cadherin invasion-suppressor gene by CpG methylation in human carcinomas.

1995 • 635 citations

Mutations of the human E-cadherin (CDH1) gene

1998 • 598 citations

A Smad Transcriptional Corepressor

1999 • 563 citations

SIP1, a Novel Zinc Finger/Homeodomain Repressor, Interacts with Smad Proteins and Binds to 5′-CACCT Sequences in Candidate Target Genes

1999 • 492 citations

OAZ Uses Distinct DNA- and Protein-Binding Zinc Fingers in Separate BMP-Smad and Olf Signaling Pathways

2000 • 428 citations

TGF-β type I receptor/ALK-5 and Smad proteins mediate epithelial to mesenchymal transdifferentiation in NMuMG breast epithelial cells

1999 • 419 citations

Mutations in SIP1, encoding Smad interacting protein-1, cause a form of Hirschsprung disease

2001 • 325 citations

New mode of DNA binding of multi-zinc finger transcription factors: delta EF1 family members bind with two hands to two target sites

1999 • 262 citations

Quantitation of MYC gene expression in sporadic breast tumors with a real-time reverse transcription-PCR assay.

1999 • 251 citations

The E-cadherin promoter: functional analysis of a G.C-rich region and an epithelial cell-specific palindromic regulatory element.

1991 • 216 citations

E-cadherin: a differentiation marker in thyroid malignancies.

1993 • 172 citations

Nuclear localization of the p120 ^ctn Armadillo-like catenin is counteracted by a nuclear export signal and by E-cadherin expression

1999 • 153 citations

Progression of carcinoma cells is associated with alterations in chromatin structure and factor binding at the E-cadherin promoter in vivo.

1995 • 147 citations

Differential expression and function of members of the zfh-1 family of zinc finger/homeodomain repressors

2000 • 137 citations

Role of E Boxes in the Repression of E-Cadherin Expression

1997 • 135 citations

Plakophilin-3, a novel Armadillo-like protein present in nuclei and desmosomes of epithelial cells

1999 • 130 citations

Role of morphogenetic factors in metastasis of mammary carcinoma cells

1998 • 122 citations

The Cadherin-Catenin System: Implications for Growth and Differentiation of Endocrine Tissues

1999 • 120 citations

Extinction of E-cadherin expression in breast cancer via a dominant repression pathway acting on proximal promoter elements

1999 • 116 citations

Identification of high mobility group protein I(Y) as potential progression marker for prostate cancer by differential hybridization analysis.

1991 • 113 citations

Retinoic acid modulates both invasion and plasma membrane ruffling of MCF-7 human mammary carcinoma cells in vitro

1991 • 98 citations

Insulin-like growth factor I activates the invasion suppressor function of E-cadherin in MCF-7 human mammary carcinoma cells in vitro

1993 • 96 citations

Transcriptional defects underlie loss of E-cadherin expression in breast cancer.

1997 • 89 citations

Integrins and E-cadherin cooperate with IGF-I to induce migration of epithelial colonic cells

1999 • 87 citations

XSIP1, a Member of Two-Handed Zinc Finger Proteins, Induced Anterior Neural Markers in Xenopus laevis Animal Cap

2000 • 66 citations

XSIP1, a Xenopus zinc finger/homeodomain encoding gene highly expressed during early neural development

2000 • 52 citations

Cell Aggregation Assays

2003 • 50 citations

Internalization of the E-Cadherin/Catenin Complex and Scattering of Human Mammary Carcinoma Cells MCF-7/AZ after Treatment with Conditioned Medium from Human Skin Squamous Carcinoma Cells COLO 16

2000 • 28 citations