Germline E-cadherin Gene (CDH1) Mutations Predispose to Familial Gastric Cancer and Colorectal Cancer

Lessons from Hereditary Colorectal Cancer

1996 • 4,900 citations

E-cadherin germline mutations in familial gastric cancer

1998 • 1,629 citations

Association between infection with Helicobacter pylori and risk of gastric cancer: evidence from a prospective investigation.

1991 • 1,399 citations

Hereditary cancer, oncogenes, and antioncogenes.

1985 • 1,261 citations

THE DECLINE IN GASTRIC CANCER: EPIDEMIOLOGY OF AN UNPLANNED TRIUMPH

1986 • 810 citations

E-cadherin expression is silenced by DNA hypermethylation in human breast and prostate carcinomas.

1995 • 803 citations

E-cadherin gene mutations provide clues to diffuse type gastric carcinomas.

1994 • 772 citations

E-cadherin is a tumour/invasion suppressor gene mutated in human lobular breast cancers.

1995 • 763 citations

Life‐time risk of different cancers in hereditary non‐polyposis colorectal cancer (hnpcc) syndrome

1995 • 597 citations

Genetic instability occurs in the majority of young patients with colorectal cancer

1995 • 378 citations

Identification of germ-line E-cadherin mutations in gastric cancer families of European origin.

1998 • 330 citations

Mutations of the E–cadherin gene in human gynecologic cancers

1994 • 280 citations

An update of HNPCC (Lynch syndrome)

1997 • 226 citations

Familial occurrence of gastric cancer in the 2-year experience of a population-based registry

1990 • 209 citations

THE INTERACTIONS OF APC, E-CADHERIN AND β-CATENIN IN TUMOUR DEVELOPMENT AND PROGRESSION

1997 • 171 citations

Inactivation of the E‐Cadherin Gene in Primary Gastric Carcinomas and Gastric Carcinoma Cell Lines

1996 • 111 citations

Microsatellite instability in adenocarcinomas of the upper gastrointestinal tract. Relation to clinicopathological data and family history.

1995 • 89 citations

An extended Li-Fraumeni kindred with gastric carcinoma and a codon 175 mutation in TP53.

1995 • 83 citations

Predisposition to cancer in the Bonaparte family

1938 • 63 citations

Allele loss, replication errors and loss of expression of E-cadherin in colorectal cancers.

1997 • 53 citations

Frequent Somatic Allelic Inactivation of the E-cadherin Gene in Gastric Carcinomas

1995 • 52 citations

Feasibility of using decades-old archival tissues in molecular oncology/epidemiology.

1996 • 43 citations

Microsatellite instability in early onset and familial colorectal cancer.

1996 • 40 citations

RER phenotype and its associated mutations in familial gastric cancer

1998 • 35 citations

Changes in Gene Structure and Regulation of E-Cadherin during Epithelial Development, Differentiation, and Disease

1997 • 28 citations