Cbl-transforming Variants Trigger a Cascade of Molecular Alterations That Lead to Epithelial Mesenchymal Conversion

Single-step purification of polypeptides expressed in Escherichia coli as fusions with glutathione S-transferase

1988 • 6,107 citations

An Overview of Epithelio-Mesenchymal Transformation

1995 • 1,505 citations

DNA-mediated transfer of the adenine phosphoribosyltransferase locus into mammalian cells.

1979 • 1,339 citations

The Tyrosine Kinase Negative Regulator c-Cbl as a RING-Type, E2-Dependent Ubiquitin-Protein Ligase

1999 • 1,045 citations

Ubiquitin Ligase Activity and Tyrosine Phosphorylation Underlie Suppression of Growth Factor Signaling by c-Cbl/Sli-1

1999 • 1,000 citations

c-Cbl/Sli-1 regulates endocytic sorting and ubiquitination of the epidermal growth factor receptor

1998 • 865 citations

A Grb2-associated docking protein in EGF- and insulin-receptor signalling

1996 • 674 citations

Interaction between Gab1 and the c-Met receptor tyrosine kinase is responsible for epithelial morphogenesis

1996 • 572 citations

The Met receptor tyrosine kinase transduces motility, proliferation, and morphogenic signals of scatter factor/hepatocyte growth factor in epithelial cells.

1993 • 409 citations

Tissue Hyperplasia and Enhanced T-Cell Signalling via ZAP-70 in c-Cbl-Deficient Mice

1998 • 371 citations

Activation of Both MAP Kinase and Phosphatidylinositide 3-Kinase by Ras Is Required for Hepatocyte Growth Factor/Scatter Factor–induced Adherens Junction Disassembly

1998 • 330 citations

Ligand-induced Ubiquitination of the Epidermal Growth Factor Receptor Involves the Interaction of the c-Cbl RING Finger and UbcH7

1999 • 328 citations

v-cbl, an oncogene from a dual-recombinant murine retrovirus that induces early B-lineage lymphomas.

1989 • 316 citations

The RING Finger of c-Cbl Mediates Desensitization of the Epidermal Growth Factor Receptor

1999 • 308 citations

Structure of the amino-terminal domain of Cbl complexed to its binding site on ZAP-70 kinase

1999 • 299 citations

Similarity of sli-1 , a Regulator of Vulval Development in C. elegans , to the Mammalian Proto-Oncogene c- cbl

1995 • 298 citations

The Cbl protooncoprotein stimulates CSF-1 receptor multiubiquitination and endocytosis, and attenuates macrophage proliferation

1999 • 291 citations

c-Cbl is downstream of c-Src in a signalling pathway necessary for bone resorption

1996 • 285 citations

A beta 1 integrin signaling pathway involving Src-family kinases, Cbl and PI-3 kinase is required for macrophage spreading and migration

1998 • 283 citations

Activation of Cdc42, Rac, PAK, and Rho-Kinase in Response to Hepatocyte Growth Factor Differentially Regulates Epithelial Cell Colony Spreading and Dissociation

2000 • 276 citations

Epithelial-Mesenchymal Transitions in Cancer Progression

1996 • 271 citations

The tyrosine kinase regulator Cbl enhances the ubiquitination and degradation of the platelet-derived growth factor receptor α

1998 • 257 citations

The Product of the Proto-Oncogene c- cbl : A Negative Regulator of the Syk Tyrosine Kinase

1997 • 251 citations

Hepatocyte Growth Factor-induced Scatter of Madin-Darby Canine Kidney Cells Requires Phosphatidylinositol 3-Kinase

1995 • 239 citations

Tumour induction by activated abl involves tyrosine phosphorylation of the product of the cbl oncogene.

1994 • 232 citations

Degradation of the Met Tyrosine Kinase Receptor by the Ubiquitin-Proteasome Pathway

1997 • 221 citations

The Cbl Phosphotyrosine-binding Domain Selects a D(N/D)XpY Motif and Binds to the Tyr292Negative Regulatory Phosphorylation Site of ZAP-70

1997 • 215 citations

A Novel Phosphotyrosine-binding Domain in the N-terminal Transforming Region of Cbl Interacts Directly and Selectively with ZAP-70 in T Cells

1996 • 201 citations

The Gab1 PH Domain Is Required for Localization of Gab1 at Sites of Cell-Cell Contact and Epithelial Morphogenesis Downstream from the Met Receptor Tyrosine Kinase

1999 • 194 citations

Association of the Multisubstrate Docking Protein Gab1 with the Hepatocyte Growth Factor Receptor Requires a Functional Grb2 Binding Site Involving Tyrosine 1356

1997 • 165 citations

sli-1, a negative regulator of let-23-mediated signaling in C. elegans.

1995 • 149 citations

Fyn Associates with Cbl and Phosphorylates Tyrosine 731 in Cbl, A Binding Site for Phosphatidylinositol 3-Kinase

1999 • 142 citations

Alternative splicing generates isoforms of the met receptor tyrosine kinase which undergo differential processing.

1991 • 139 citations

Tyrosine 1356 in the carboxyl-terminal tail of the HGF/SF receptor is essential for the transduction of signals for cell motility and morphogenesis.

1994 • 130 citations

Phosphotyrosine Binding Domain-Dependent Upregulation of the Platelet-Derived Growth Factor Receptor α Signaling Cascade by Transforming Mutants of Cbl: Implications for Cbl’s Function and Oncogenicity

1997 • 119 citations

Efficient Cellular Transformation by the Met Oncoprotein Requires a Functional Grb2 Binding Site and Correlates with Phosphorylation of the Grb2-associated Proteins, Cbl and Gab1

1997 • 116 citations

The Proto-oncogene Product p120 Links c-Src and Phosphatidylinositol 3′-Kinase to the Integrin Signaling Pathway

1997 • 94 citations

The Cbl Protooncogene Product: From an Enigmatic Oncogene to Center Stage of Signal Transduction

1997 • 88 citations

c-Cbl localizes to actin lamellae and regulates lamellipodia formation and cell morphology

2000 • 80 citations

Antisense Repression of Proto-oncogene c-Cbl Enhances Activation of the JAK-STAT Pathway but Not the Ras Pathway in Epidermal Growth Factor Receptor Signaling

1997 • 74 citations

Efficient cell transformation by the Tpr-Met oncoprotein is dependent upon tyrosine 489 in the carboxy-terminus.

1995 • 68 citations

Receptor chimeras indicate that the met tyrosine kinase mediates the motility and morphogenic responses of hepatocyte growth/scatter factor.

1994 • 64 citations

The cell dissociation and motility triggered by scatter factor/hepatocyte growth factor are mediated through the cytoplasmic domain of the c-Met receptor.

1993 • 61 citations

Regulation of β1-integrin-mediated cell adhesion by the CbI adaptor protein

1998 • 57 citations

Tyrosine kinase activity of the EGF receptor is enhanced by the expression of oncogenic 70Z-Cbl

1997 • 57 citations

Tyrosine phosphorylation of C-Cbl facilitates adhesion and spreading while suppressing anchorage-independent growth of V-Abl-transformed NIH3T3 fibroblasts

1999 • 53 citations

Model Systems of Epithelium Mesenchyme Transitions

1996 • 46 citations

A direct interaction between the adaptor protein Cbl-b and the kinase Zap-70 induces a positive signal in T cells

1999 • 44 citations

Activation of Nuclear Factor of Activated T Cells-(NFAT) and Activating Protein 1 (AP-1) by Oncogenic 70Z Cbl Requires an Intact Phosphotyrosine Binding Domain but Not Crk(L) or p85 Phosphatidylinositol 3-Kinase Association

1999 • 33 citations

Alternative Splicing Generates Isoforms of the met Receptor Tyrosine Kinase Which Undergo Differential Processing

1991 • 32 citations

Tyrosine phosphorylation of the product of the c-cbl protooncogene is [corrected] induced after integrin stimulation.

1997 • 29 citations

Growth factors and cell movement

1991 • 25 citations

Isoforms of the met receptor tyrosine kinase.

1993 • 17 citations