Homeostatic control of T-cell generation in neonates

Changes in thymic function with age and during the treatment of HIV infection

1998 • 1,887 citations

Age, Thymopoiesis, and CD4+ T-Lymphocyte Regeneration after Intensive Chemotherapy

1995 • 1,066 citations

A Direct Estimate of the Human αβ T Cell Receptor Diversity

1999 • 893 citations

The Peptide Ligands Mediating Positive Selection in the Thymus Control T Cell Survival and Homeostatic Proliferation in the Periphery

1999 • 742 citations

Selecting and maintaining a diverse T-cell repertoire

1999 • 712 citations

Analysing cell division in vivo and in vitro using flow cytometric measurement of CFSE dye dilution

2000 • 679 citations

Differential regulation of antiviral T-cell immunity results in stable CD8+ but declining CD4+ T-cell memory

2001 • 600 citations

POPULATION BIOLOGY OF HIV-1 INFECTION: Viral and CD4⁺T Cell Demographics and Dynamics in Lymphatic Tissues

1999 • 549 citations

Low-Affinity Ligands for the TCR Drive Proliferation of Mature CD8+ T Cells in Lymphopenic Hosts

1999 • 548 citations

T cell homeostasis in patients with rheumatoid arthritis

2000 • 453 citations

The Involution of the Ageing Human Thymic Epithelium is Independent of Puberty

1985 • 434 citations

Thymic-independent T cell regeneration occurs via antigen-driven expansion of peripheral T cells resulting in a repertoire that is limited in diversity and prone to skewing.

1996 • 418 citations

T Cell Selection in the Thymus

1988 • 405 citations

Value of Immunological Markers in Predicting Responsiveness to Influenza Vaccination in Elderly Individuals

2001 • 395 citations

Distinctions Between CD8+ and CD4+ T-Cell Regenerative Pathways Result in Prolonged T-Cell Subset Imbalance After Intensive Chemotherapy

1997 • 388 citations

Changes in the Human Thymus During Aging

1986 • 341 citations

Turnover of CD4+ and CD8+ T Lymphocytes in HIV-1 Infection as Measured by Ki-67 Antigen

1998 • 337 citations

T cell receptor excision circles as markers for recent thymic emigrants: basic aspects, technical approach, and guidelines for interpretation

2001 • 327 citations

Designing and Maintaining the Mature TCR Repertoire

1999 • 323 citations

The generation and fate of thymocytes.

1990 • 309 citations

Size Estimate of the αβ TCR Repertoire of Naive Mouse Splenocytes

2000 • 297 citations

The Role of the Thymus and Recent Thymic Migrants in the Maintenance of the Adult Peripheral Lymphocyte Pool

1998 • 294 citations

T-cell regeneration after bone marrow transplantation: differential CD45 isoform expression on thymic-derived versus thymic-independent progeny

1993 • 293 citations

Perturbation of the T cell repertoire in rheumatoid arthritis

1998 • 273 citations

Evidence for Increased T Cell Turnover and Decreased Thymic Output in HIV Infection

2001 • 260 citations

Transplantation of Thymus Tissue in Complete DiGeorge Syndrome

1999 • 256 citations

T-cell regeneration after bone marrow transplantation: differential CD45 isoform expression on thymic-derived versus thymic-independent progeny

1993 • 250 citations

T-cell regeneration: all repertoires are not created equal

1997 • 246 citations

Distribution of lymphocyte subsets and natural killer cells in the human body

1992 • 238 citations

IL-7-Dependent Extrathymic Expansion of CD45RA+ T Cells Enables Preservation of a Naive Repertoire

1998 • 230 citations

Telomerase Activity in Candidate Stem Cells From Fetal Liver and Adult Bone Marrow

1998 • 214 citations

Modulation of CD28 Expression: Distinct Regulatory Pathways During Activation and Replicative Senescence

1999 • 204 citations

Interleukin 7 is produced by murine and human keratinocytes.

1993 • 198 citations

Evidence for extrathymic generation of intermediate T cell receptor cells in the liver revealed in thymectomized, irradiated mice subjected to bone marrow transplantation.

1995 • 194 citations

Thymic Function Can Be Accurately Monitored by the Level of Recent T Cell Emigrants in the Circulation

1998 • 193 citations

A central role for thymic emigrants in peripheral T cell homeostasis

1999 • 167 citations

T-cell receptor excision circle and T-cell dynamics after allogeneic stem cell transplantation are related to clinical events

2002 • 163 citations

Early human T cell development: analysis of the human thymus at the time of initial entry of hematopoietic stem cells into the fetal thymic microenvironment.

1995 • 157 citations

The Human Thymus During Aging

2000 • 150 citations

Effects of exogenous interleukin-7 on human thymus function

2002 • 143 citations

The Role of CD8+ CD40L+ T Cells in the Formation of Germinal Centers in Rheumatoid Synovitis

1998 • 142 citations

Thymic function and peripheral T-cell homeostasis in rheumatoid arthritis

2001 • 139 citations

Human Recent Thymic Emigrants–Identification, Expansion, And Survival Characteristics

2001 • 133 citations

IL-7 differentially regulates cell cycle progression and HIV-1-based vector infection in neonatal and adult CD4⁺T cells

2001 • 108 citations

Emergence of oligoclonal t cell populations following therapeutic t cell depletion in rheumatoid arthritis

1995 • 97 citations

Quantification of thymic function by measuring T cell receptor excision circles within peripheral blood and lymphoid tissues in monkeys

2000 • 81 citations

An Essential Role for the IL-7 Receptor During Intrathymic Expansion of the Positively Selected Neonatal T Cell Repertoire

2000 • 73 citations

T‐Cell Specificity and Repertoire

1988 • 71 citations

Thymic T cell export is not influenced by the peripheral T cell pool

1997 • 66 citations

Maintaining the status quo: T-cell homeostasis

2002 • 55 citations

Phenotypic and functional analysis of human T lymphocytes in early second- and third-trimester fetuses

2002 • 54 citations

Hematologic Values and Lymphocyte Subsets in Fetal Blood

1988 • 51 citations

The role of telomerase expression and telomere length maintenance in human and mouse.

2000 • 49 citations

Development of CD4 and CD8 single positive T cells in human thymus organ culture: IL-7 promotes human T cell production by supporting immature T cells

1996 • 19 citations