Changes in the Human Thymus During Aging

Apoptosis: A Basic Biological Phenomenon with Wideranging Implications in Tissue Kinetics

1972 • 15,349 citations

Production of a mouse monoclonal antibody reactive with a human nuclear antigen associated with cell proliferation

1983 • 2,745 citations

The differentiation and function of human T lymphocytes

1980 • 1,548 citations

IMMUNOLOGICAL FUNCTION OF THE THYMUS

1961 • 1,359 citations

THE MAINTENANCE OF THE ACCURACY OF PROTEIN SYNTHESIS AND ITS RELEVANCE TO AGEING

1963 • 950 citations

The Kinetics of Cellular Proliferation

1960 • 948 citations

Malignant Lymphomas Other than Hodgkin’s Disease

1978 • 871 citations

On the thymus in the differentiation of "H-2 self-recognition" by T cells: evidence for dual recognition?

1978 • 870 citations

Correlation Between Deoxyribonucleic Acid Excision-Repair and Life-Span in a Number of Mammalian Species

1974 • 738 citations

Cell death: a new classification separating apoptosis from necrosis

1981 • 575 citations

Immunological studies of aging. Decreased production of and response to T cell growth factor by lymphocytes from aged humans.

1981 • 473 citations

The Involution of the Ageing Human Thymic Epithelium is Independent of Puberty

1985 • 434 citations

Ageing of Clones of Mammalian Cells

1973 • 409 citations

Differentiation of normal and neoplastic hematopoietic cells

1978 • 394 citations

THE ROLE OF THE THYMUS IN DEVELOPMENT OF IMMUNOLOGIC CAPACITY IN RABBITS AND MICE

1962 • 391 citations

Thymus and Adrenals in the Response of the Organism to Injuries and Intoxications

1936 • 387 citations

Kinetics of cellular proliferation

1962 • 371 citations

The Immunologic Theory of Aging

1971 • 363 citations

Thymus-dependent membrane antigens in man: Inhibition of cell-mediated lympholysis by monoclonal antibodies to T _{H 2} antigen

1981 • 352 citations

Studies of a human T lymphocyte antigen recognized by a monoclonal antibody.

1981 • 349 citations

Thymic nurse cells. Lymphoepithelial cell complexes in murine thymuses: morphological and serological characterization

1980 • 343 citations

Nutrition and Longevity in the Rat

1960 • 319 citations

Development and Function of Subpopulations of Thymocytes and T Lymphocytes

2015 • 296 citations

Cell death in biology and pathology

1981 • 290 citations

ISOLATION, BIOCHEMICAL CHARACTERISTICS, AND BIOLOGICAL ACTIVITY OF A CIRCULATING THYMIC HORMONE IN THE MOUSE AND IN THE HUMAN

1975 • 288 citations

ROLE OF THE THYMUS IN IMMUNE REACTIONS IN RATS

1962 • 288 citations

Location of T cell and major histocompatibility complex antigens in the human thymus.

1980 • 286 citations

ROLE OF THE THYMUS IN IMMUNE REACTIONS IN RATS

1962 • 264 citations

Silver Impregnation of Reticulum in Paraffin Sections.

1937 • 244 citations

Is Cell Aging Caused by Respiration-Dependent Injury to the Mitochondrial Genome?

1982 • 242 citations

Distribution of Human Chromosome Counts in Relation to Age

1961 • 242 citations

Length of Life and Nutrition in the Rat

1961 • 236 citations

The Cell Biology of Human Aging

1976 • 235 citations

Lymphokines and aging: interleukin-2 production and activity in aged animals.

1981 • 234 citations

Immunological studies of aging. IV. The contribution of thymic involution to the immune deficiencies of aging mice and reversal with thymopoietin32-36.

1978 • 202 citations

STUDIES ON THE DIFFERENTIATION OF THYMUS-DERIVED LYMPHOCYTES

1970 • 198 citations

The Human Thymic Microenvironment: An Immunohistologic Study

1980 • 188 citations

The differentiation of T lymphocytes

1974 • 185 citations

Age-Related Changes in the Subsets and Functions of Human T Lymphocytes

1978 • 184 citations

Impaired Delayed Hypersensitivity in an Aging Population

1968 • 183 citations

Thymic Involution: Effect on T Cell Differentiation

1975 • 183 citations

THE WEIGHT OF THE THYMUS GLAND IN HEALTH AND IN DISEASE

1932 • 181 citations

Effect of Thymectomy in Adult Mice on Immunological Responsiveness

1965 • 179 citations

Subpopulations of human T lymphocytes

1977 • 178 citations

Immunologic deficiencies in senescence. I. Characterization of intrinsic deficiencies.

1972 • 177 citations

Tissues and organs: A text-atlas of scanning electron microscopy

1981 • 174 citations

Age, Thymic Involution, and Circulating Thymic Hormone Activity*

1978 • 162 citations

Cell-mediated immunity in aged mice: an underlying lesion in IL 2 synthesis.

1982 • 159 citations

THE FINE STRUCTURE OF MITOSIS IN RAT THYMIC LYMPHOCYTES

1965 • 157 citations

THE PATTERN OF LYMPHOPOIESIS IN THE MOUSE THYMUS AFTER CORTISONE ADMINISTRATION OR ADRENALECTOMY

1963 • 155 citations

Interdigitating reticulum cells in the human thymus

1974 • 152 citations

THE IMMUNOLOGIC THEORY OF AGING

1969 • 146 citations

THE FATE OF SERIALLY TRANSPLANTED BONE MARROW CELL POPULATIONS FROM YOUNG AND OLD DONORS

1976 • 145 citations

Immunological defect in aged population and its relationship to cancer

1965 • 145 citations

The human thymic microenvironment: an immunohistologic study.

1980 • 145 citations

Immune function in aged mice

1977 • 143 citations

Sensitivity of lymphocytes to prostaglandin E2 increases in subjects over age 70.

1979 • 139 citations

Human lymph node morphology as a function of age and site.

1980 • 134 citations

Distribution of H-2 microenvironments in the mouse thymus. Immunoelectron microscopic identification of I-A and H-2K bearing cells.

1980 • 127 citations

Loss of Genes coding for Ribosomal RNA in Ageing Brain Cells

1972 • 127 citations

Microenvironmental Aspects of Immunity

1973 • 126 citations

Immunologic Deficiencies in Senescence

1972 • 125 citations

AN IMMUNOLOGICAL APPROACH TO AGEING

1970 • 123 citations

Ageing and Immunological Function in Man

1972 • 118 citations

Terminal deoxynucleotidyl transferase is found in prothymocytes

1976 • 118 citations

Age-Related Decrease in Mouse T Cell Progenitors

1977 • 115 citations

Immunobiology of aging: Evaluation of current status

1976 • 115 citations

Effect of interleukin 1 on human thymocytes and purified human T cells.

1981 • 112 citations

The Human Thymus

2013 • 112 citations

Cytokinetic analysis of the impaired proliferative response of peripheral lymphocytes from aged humans to phytohemagglutinin.

1979 • 112 citations

T lymphocytes of young and aged rats. II. Functional defects and the role of interleukin-2.

1982 • 106 citations

Age involution in the normal human adult thymus.

1975 • 101 citations

An analysis of the data collected by the status lymphaticus investigation committee

1931 • 101 citations

Growth and senescence of antibody-forming cells

1966 • 94 citations

The Thymus Gland

1962 • 91 citations

Cytokine-dependent thymocyte responses: characterization of IL 1 and IL 2 target subpopulations and mechanism of action.

1982 • 88 citations

Lymphocyte subsets and integrated immune function in aging humans

1978 • 87 citations

Characterization of immunoregulatory T lymphocytes during ageing by monoclonal antibodies.

1982 • 87 citations

ELECTRON MICROSCOPIC OBSERVATIONS OF ACUTE THYMIC INVOLUTION PRODUCED BY HYDROCORTISONE.

1964 • 86 citations

Age-Related Changes in T Cell Function

1977 • 85 citations

Induction in vivo and in vitro of terminal deoxynucleotidyl transferase by thymosin in bone marrow cells from athymic mice.

1978 • 85 citations

The weight of the human thymus gland at necropsy.

1980 • 83 citations

Lymphocyte-Mediated Cytotoxicity: Effects of Ageing, Adult Thymectomy and Thymic Factor

1977 • 83 citations

Deficient Immunologic Functions of NZB Mice

1968 • 81 citations

Age-related changes in the thymus gland: CT-pathologic correlation

1983 • 81 citations

The thymus in myasthenia gravis

1943 • 80 citations

Ontogeny of mouse lymphocyte function. I. Paradoxical elevation of reactivity to allogeneic cells and phytohemagglutinin in BALB-c fetal thymocytes.

1974 • 80 citations

Age‐related changes in hematopoietic stem cell populations of a long‐lived hybrid mouse

1971 • 79 citations

Relationship between Aging and the Immune System

2015 • 78 citations

Restoration of impaired immune functions in aging animals

1976 • 75 citations

Involution patterns of the human thymus. I Size of the cortical area as a function of age.

1982 • 73 citations

Subpopulations of human T lymphocytes. X. Alterations in T, B, third population cells, and T cells with receptors for immunoglobulin M (Tmu) or G (Tgamma) in aging humans.

1979 • 72 citations

Immunology and Aging:Philip Levine Award

1980 • 71 citations

Increased Sensitivity of Lymphocytes from People Over 65 to Cell Cycle Arrest and Chromosomal Damage

1983 • 68 citations

Correlation of Lymphocyte Transformation and Morphology in the Human Fetal Thymus

1970 • 68 citations

Immune function in aged mice

1977 • 66 citations

Loss of tumor-specific and idiotype-specific immunity with age.

1981 • 63 citations

Age-related changes in the immune system of mice of eight medium and long-lived strains and hybrids. I. Organ, cellular, and activity changes

1979 • 62 citations

Natural killing and antibody-dependent cytotoxicity by lymphocyte subpopulations in young and aging humans

1981 • 61 citations

Alterations in cyclic nucleotides and cyclase-specific activities in T lymphocytes of aging normal humans and patients with Down's syndrome.

1980 • 60 citations

Frequencies of background immunoglobulin-secreting cells in mice as a function of organ, age, and immune status

1981 • 59 citations

Neoplastic Proliferation of the Epithelium of the Mammary Lobules: Adenosis, Lobular Neoplasia, and Small Cell Carcinoma

1972 • 58 citations

Age-Related Changes in Suppressor Functions of Human T Cells

1979 • 58 citations

Age-Dependent Tumor-Host Barrier and Effect of Carcinogen-Induced Immunodepression on Rejection of Isografted Methylcholanthrene-Induced Sarcoma Cells<xref ref-type="fn" rid="FN2">2</xref>

1966 • 58 citations

Unusual pattern of surface marker expression on peripheral lymphocytes from aged humans suggestive of a population of less differentiated cells.

1983 • 57 citations

Subpopulations of Human Thymus Cells Differing in Their Capacity to form Stable E-Rosettes and in Their Immunologic Reactivity

1975 • 55 citations

Tissues and Organs

1966 • 52 citations

Early biochemical events associated with lymphocyte activation in ageing. I. Evidence that Ca2+ dependent processes induced by PHA are impaired.

1981 • 51 citations

Ultrastructure of the age-involuted adult human thymus

1978 • 49 citations

Immunologic Deficiencies in Senescence

1972 • 49 citations

A Quantitative Histologic Comparison of the Thymus in 100 Healthy and Diseased Adults

1981 • 49 citations

Quantitative Cytological Studies on Thymic Lymphoid Cells in Normal, Preleukaemic and Leukaemic Mice

1961 • 47 citations

The Thymus and Aging

1977 • 46 citations

Age-dependency of lymphocyte ecto-5'-nucleotidase activity.

1980 • 45 citations

Adult thymectomy promotes the manifestation of autoreactive lymphocytes

1977 • 45 citations

Cellular Aging: Further Evidence for the Commitment Theory

1981 • 44 citations

The Immune System and the Aging Process in Man

1980 • 44 citations

Lymphoproliferative Diseases of the Skin

1982 • 42 citations

Reactivation of immunocompetence in spleen cells of aged mice

1974 • 41 citations

“Status Thymico-Lymphaticus” considered in the light of Recent Work on the Thymus

1927 • 40 citations

Thymosin and the immunopathology of aging.

1974 • 39 citations

EFFECT OF ACTH ON THYMIC MASSES

1952 • 39 citations

Cell death in biology and pathology

1982 • 38 citations

Fate of thymocytes: studies with 125I-iododeoxyuridine and 3H-thymidine in mice.

1977 • 36 citations

Generation of T-cell function in organ culture of foetal mouse thymus. I. Mitogen responsiveness

1976 • 36 citations

FACTORS INVOLVED IN MAINTAINING INVOLUTION OF THE THYMUS DURING SUCKLING

1946 • 35 citations

Assessment of interleukin 1 and interleukin 2 effects on cycling and noncycling murine thymocytes

1982 • 34 citations

The Immune Response During Aging

1979 • 34 citations

Morphologic findings in lymph nodes after occlusion of their efferent lymphatic vessels and veins.

1982 • 34 citations

Ontogeny of Mouse Lymphocyte Function

1974 • 34 citations

Subpopulations of Human T Lymphocytes

1979 • 33 citations

A specific biosynthetic marker for immature thymic lymphoblasts. Active synthesis of thymus-leukemia antigen restricted to proliferating cells

1982 • 33 citations

Role of interleukins 1 and 2 on human thymocyte mitogen activation

1981 • 32 citations

Age-dependent effects of zinc on the transformation response of human lymphocytes to mitogens

1979 • 32 citations

The fine structure of the thymocytes of young rats

1965 • 32 citations

Studies on Subpopulations of Theta-bearing Lymphoid Cells

1973 • 32 citations

Quantitative Histologic Effects on Mouse Thymus of Controlled Dietary Restriction

1980 • 32 citations

Status thymico-lymphaticus

1945 • 31 citations

The normal weight of the human thymus

1925 • 31 citations

ACTION OF CERTAIN HORMONES ON THE THYMUS OF THE DOMESTIC HEN

1959 • 31 citations

Immunology, aging, and cancer

1977 • 30 citations

The Thymus: Clock for Immunologic Aging?

1979 • 30 citations

CYTODYNAMICS IN THE THYMUS OF YOUNG ADULT MICE:

1976 • 30 citations

Normal anatomy of thymus and anterior mediastinum by pneumomediastinography

1980 • 29 citations

A multiple-parameter comparison of immunocompetence and tumor resistance in aged BALB/c mice

1977 • 28 citations

Suppressor cell function in man: Evidence for altered sensitivity of responder cells with age

1979 • 28 citations

The Immunoepidemiology of Aging

1977 • 28 citations

Age-dependent changes of B-cell reactivity and T cell-T cell interaction in the in vitro antibody response

1980 • 28 citations

Evidence That Thymocytes Require at Least Two Distinct Signals to Proliferate

1979 • 28 citations

T cell ontogeny. Organ location of maturing populations as defined by surface antigen markers is similar in neonates and adults.

1981 • 28 citations

Changes in human T lymphocytes after thymectomy and during senescence

1982 • 28 citations

Immunologicc activity of the aged.

1971 • 27 citations

Structural and Functional Alterations of the Aging Human Thymus

1982 • 26 citations

AGE DEPENDENT CHANGES IN SOME HUMAN LYMPHOCYTE SUB‐POPULATIONS

1981 • 26 citations

Immunology and Aging

2012 • 26 citations

Impaired Thymic Regeneration in Lethally Irradiated Mice Given Bone Marrow from Aged Donors

1976 • 26 citations

Cellular Immunosenescence

1980 • 25 citations

Strain-, Age-, and Tumor-Dependent Distribution of Terminal Deoxynucleotidyl Transferase in Thymocytes of Mice

1976 • 25 citations

T cell growth factor-enhanced PHA response of human thymus cells: requirement for T3+ cells.

1981 • 25 citations

Impaired Elkind Recovery in Hematopoietic Colony-Forming Cells of Aged Mice,

1974 • 23 citations

Cell-mediated cytotoxicity in humans: Age-related decline as measured by a xenogeneic assay

1979 • 23 citations

FURTHER PURIFICATION OF THE GROWTH HORMONE OF THE ANTERIOR PITUITARY¹

1940 • 23 citations

The Weight of the Thymus in Children of 0—2 Years of Age

1951 • 22 citations

Cytochemical study of human lymphocytes stimulated by PHA in function of donor age

1978 • 21 citations

Demonstration of a circulating thymic hormone in mouse and in man.

1973 • 21 citations

The Prenatal Growth of the Human Thymus.

1927 • 21 citations

Aging and immunity: decrease in interleukin-2 production and interleukin-2-dependent RNA-synthesis in lectin-stimulated and murine spleen cells.

1982 • 20 citations

A QUANTITATIVE HISTOLOGICAL ASSESSMENT OF CELLULAR DEATH, IN RELATION TO MITOSIS, IN RAT THYMUS DURING GROWTH AND AGE INVOLUTION

1977 • 20 citations

DECREASED LONGEVITY OF MICE FOLLOWING THYMECTOMY IN ADULT LIFE

1971 • 20 citations

Acid phosphatase activity and cell death in mouse thymus

1980 • 19 citations

Immuno‐electron microscopic tracing of lactoferrin, a regulator of myelopoiesis, into a subpopulation of human peripheral blood monocytes

1982 • 19 citations

Evidence of Aberration of T‐cell Subsets in Aged Individuals

1981 • 19 citations

Concanavalin A-induced suppressor cell activity for T-cell proliferative responses: Autologous and allogeneic suppression in aging humans

1980 • 19 citations

Serological Visualization of Interleukin 2

1983 • 19 citations

AGE‐RELATED CHANGES OF THYMUS – MORPHOLOGICAL and FUNCTIONAL ASPECTS –

1978 • 19 citations

Age-and maturation-dependent changes in the immune system of Fischer F344 rats.

1981 • 18 citations

Aging and Immunity: Decrease in Interleukin-2 Production and Interleukin-2-Dependent RNA-Synthesis in Lectin-Stimulated Murine Spleen Cells

1982 • 17 citations

Lymphocyte differentiation and its microenvironment in the human thymus during aging.

1984 • 16 citations

Thymus cell migration.

1974 • 15 citations

Decreased longevity of mice following thymectomy in adult life.

1971 • 15 citations

CELL KINETICS IN MOUSE THYMUS STUDIED BY SIMULTANEOUS USE OF ³H‐THYMIDINE AND COLCHICINE

1973 • 15 citations

Aldolase Activity and Cross-Reacting Material in Lymphocytes of Aged Individuals

1979 • 14 citations

Terminal deoxynucleotidyl transferase (TdT) enzyme in thymus and bone marrow

1981 • 14 citations

Thymic lymphocyte maturation in the thymic microenvironment

1982 • 14 citations

Role of the Immune System in Aging

1980 • 13 citations

Age‐Related Loss of Function of Alloactivated Interleukin 2‐Propagated Human Primed Lymphocyte Typing Clones

1983 • 13 citations

The thymus in the aging individual

1981 • 12 citations

The thymus in the aging individual

1981 • 11 citations

Effect of aging on acetate incorporation in nuclei of lymphocytes stimulated with phytohemagglutinin

1972 • 11 citations

A Colour Atlas of Thymus and Lymph Node Histopathology with Ultrastructure

1982 • 11 citations

Effect of thymosin on cellular immunity in old age

1981 • 11 citations

Human thymus cells: blastogenic response to mitogens, antigens and allogeneic cells.

1976 • 11 citations

Reduced lymphocyte colony formation with age.

1982 • 11 citations

Determining rôle of age and thymus in pathology of 7,12-dimethylbenz(a)anthracene-induced leukemia in mice.

1971 • 11 citations

Immunohistological Demonstration of Terminal Transferase (TdT) in the Age-involuted Human Thymus

1984 • 11 citations

T-cell growth factor (Interleukin 2) and terminal transferase activity in human leukemias and lymphoblastic cell lines

1981 • 10 citations

Ultrastructural demonstration of terminal deoxynucleotidyl transferase (TdT)

1981 • 10 citations

Studies of T, B, and ‘Null’ Blood Lymphocytes in Normal Persons of Different Age Groups

1981 • 9 citations

A colour atlas of thymus and lymph node histopathology : with ultrastructure

1981 • 9 citations

Growth and characterization of T cell colonies from human thymus.

1983 • 9 citations

PHA and ConA lymphocyte response in normal, hyperplastic and neoplastic human thymus: Morphologic and functional correlations

1980 • 8 citations

Modulation of T lymphocyte differentiation antigens: Influence of aging

1983 • 8 citations

Thymic medullary lymphocytes

1982 • 8 citations

129. Aging and immunocompetence skin testing

1978 • 7 citations

Aging and Involution of the Immunological Apparatus

1978 • 7 citations

Density-dependent cell division after cortisol treatment of rat thymus in relation to age involution

1977 • 6 citations

Thymocytes can be stimulated to give a strong vaccinia virus-immune cytotoxic T lymphocyte response

1981 • 6 citations

Qualitative changes in immunocompetent cells with age: Reduced sensitivity to cortisone acetate

1977 • 6 citations

Effect of gonadectomy on the peripheral lymphatic tissue of neonatally thymectomized mice.

1968 • 6 citations

Histogenesis of T Cells

1982 • 5 citations

[Current status of anti-poliomyelitis vaccination].

1962 • 5 citations

The Short-Lived Lymphocyte in the Thymus Cortex of the Rat

1981 • 5 citations

Age-Related Changes in the in vitro Glucocorticoid Responsiveness of Rat Spleen and Splenic Leukocytes

1982 • 3 citations

Distribution of transferred mature thymocytes of the rat.

1974 • 2 citations

Identification of interleukin-2 producer and responder T lymphocyte subpopulations by immunoperoxidase staining.

1985 • 2 citations

Regulation of macrophage phagocytosis of syngeneic erythrocytes by T-cell subsets from NZB mice: differential effects of T cells from young and old mice.

1982 • 2 citations

Darstellung der terminalen Deoxynukleotidyl-Transferase im histologischen Schnitt*

1983 • 1 citations

Age-Dependent Allospecific Change in Susceptibility to Local Lymph Node GVHR in Rats

1981 • 1 citations

Deleted Work

1955 • 0 citations