Lonely MHC molecules seeking immunogenic peptides for meaningful relationships

Three-dimensional structure of the human class II histocompatibility antigen HLA-DR1

1993 • 2,360 citations

The Biogenesis of Lysosomes

1989 • 1,583 citations

MHC-dependent antigen processing and peptide presentation: Providing ligands for T lymphocyte activation

1994 • 1,448 citations

Antigen-specific interaction between T and B cells

1985 • 1,396 citations

Binding of immunogenic peptides to Ia histocompatibility molecules

1985 • 1,209 citations

The Biochemistry and Cell Biology of Antigen Processing and Presentation

1993 • 1,022 citations

The receptor DEC-205 expressed by dendritic cells and thymic epithelial cells is involved in antigen processing

1995 • 959 citations

Signal-Dependent Membrane Protein Trafficking in the Endocytic Pathway

1993 • 808 citations

Sequences encoded in the class II region of the MHC related to the 'ABC' superfamily of transporters

1990 • 717 citations

HLA-DM induces clip dissociation from MHC class II αβ dimers and facilitates peptide loading

1995 • 684 citations

Cytotoxic T cells recognize fragments of the influenza nucleoprotein

1985 • 669 citations

Segregation of MHC class II molecules from MHC class I molecules in the Golgi complex for transport to lysosomal compartments

1991 • 663 citations

Peptides Presented to the Immune System by the Murine Class II Major Histocompatibility Complex Molecule I-A _d

1992 • 654 citations

MHC class II-associated invariant chain contains a sorting signal for endosomal compartments

1990 • 565 citations

Intracellular transport of class II MHC molecules directed by invariant chain

1990 • 548 citations

Cytoplasmic Domain Heterogeneity and Functions of IgG Fc Receptors in B Lymphocytes

1992 • 462 citations

The biosynthetic pathway of MHC class II but not class I molecules intersects the endocytic route

1990 • 445 citations

Transient accumulation of new class II MHC molecules in a novel endocytic compartment in B lymphocytes

1994 • 442 citations

Isolation and characterization of the intracellular MHC class II compartment

1994 • 426 citations

Antigen presentation by hapten-specific B lymphocytes. I. Role of surface immunoglobulin receptors.

1984 • 422 citations

MHC class II structure, occupancy and surface expression determined by post-endoplasmic reticulum antigen binding

1991 • 394 citations

An essential role for HLA–DM in antigen presentation by class II major histocompatibility molecules

1994 • 378 citations

Two distinct subpopulations of endosomes involved in membrane recycling and transport to lysosomes

1988 • 377 citations

Co-localization of molecules involved in antigen processing and presentation in an early endocytic compartment

1990 • 377 citations

Antigen processing and class II MHC peptide-loading compartments in human B-lymphoblastoid cells

1994 • 349 citations

Role for intracellular proteases in the processing and transport of class II HLA antigens.

1988 • 336 citations

Formation of a nine-subunit complex by HLA class II glycoproteins and the invariant chain

1991 • 326 citations

A role for peptide in determining MHC class II structure

1991 • 275 citations

Assembly and intracellular transport of HLA-DM and correction of the class II antigen-processing defect in T2 cells

1994 • 247 citations

HLA-DMA and DMB genes are both required for MHC class II/peptide complex formation in antigen-presenting cells

1994 • 247 citations

Accumulation of HLA-DM, a regulator of antigen presentation, in MHC class II compartments

1994 • 244 citations

Defective processing and presentation of exogenous antigens in mutants with normal HLA class II genes

1990 • 236 citations

Separation of subcellular compartments containing distinct functional forms of MHC class II.

1994 • 221 citations

Rapid analytical and preparative isolation of functional endosomes by free flow electrophoresis

1987 • 208 citations

Location of MHC-encoded transporters in the endoplasmic reticulum and cis-Golgi

1992 • 208 citations

The MHC class II-associated invariant chain contains two endosomal targeting signals within its cytoplasmic tail.

1993 • 206 citations

Extensive trafficking of MHC class II-invariant chain complexes in the endocytic pathway and appearance of peptide-loaded class II in multiple compartments

1995 • 198 citations

Invariant chain can function as a chaperone protein for class II major histocompatibility complex molecules.

1992 • 197 citations

The invariant chain is required for intracellular transport and function of major histocompatibility complex class II molecules.

1994 • 196 citations

Processed antigen binds to newly synthesized mhc class II molecules in antigen-specific B lymphocytes

1991 • 188 citations

Sorting signals in the MHC class II invariant chain cytoplasmic tail and transmembrane region determine trafficking to an endocytic processing compartment.

1994 • 188 citations

The CLIP region of invariant chain plays a critical role in regulating major histocompatibility complex class II folding, transport, and peptide occupancy.

1994 • 184 citations

Endosomal aspartic proteinases are required for invariant-chain processing.

1994 • 182 citations

How MHC class II molecules reach the endocytic pathway.

1995 • 173 citations

Peptide binding inhibits protein aggregation of invariant-chain free class II dimers and promotes surface expression of occupied molecules

1993 • 157 citations

Mutations of immunoglobulin transmembrane and cytoplasmic domains: Effects on intracellular signaling and antigen presentation

1990 • 154 citations

Invariant chain cleavage and peptide loading in major histocompatibility complex class II vesicles.

1995 • 150 citations

Immunogenic peptides bind to class II MHC molecules in an early lysosomal compartment.

1993 • 124 citations

Acidification and Ion Permeabilities of Highly Purified Rat Liver Endosomes

1989 • 123 citations

The segment of invariant chain that is critical for association with major histocompatibility complex class II molecules contains the sequence of a peptide eluted from class II polypeptides.

1993 • 123 citations

MHC class II compartments and the kinetics of antigen presentation in activated mouse spleen dendritic cells.

1995 • 122 citations

Association with BiP and aggregation of class II MHC molecules synthesized in the absence of invariant chain.

1994 • 104 citations

Antigen presentation by the B cell antigen receptor is driven by the αβ sheath and occurs independently of its cytoplasmic tyrosines

1993 • 101 citations

Major histocompatibility complex class II molecules induce the formation of endocytic MIIC-like structures.

1994 • 96 citations

Enhanced binding of peptide antigen to purified class II major histocompatibility glycoproteins at acidic pH.

1991 • 94 citations

A mutant human histocompatibility leukocyte antigen DR molecule associated with invariant chain peptides.

1994 • 91 citations

Intracellular targeting of antigens internalized by membrane immunoglobulin in B lymphocytes.

1995 • 91 citations

Endocytosis and recycling of specific antigen by human B cell lines.

1988 • 89 citations

Assembly of HLA DR1 molecules translated in vitro: binding of peptide in the endoplasmic reticulum precludes association with invariant chain.

1994 • 87 citations

Structure and Function of the B Cell Antigen Receptor

1993 • 86 citations

Endocytosis, intracellular trafficking, and processing of membrane IgG and monovalent antigen/membrane IgG complexes in B lymphocytes.

1990 • 85 citations

Antigen presentation abrogated in cells expressing truncated Ia molecules.

1989 • 81 citations

Transport and intracellular distribution of MHC class II molecules and associated invariant chain in normal and antigen-processing mutant cell lines.

1994 • 77 citations

Chemistry and functional role of the invariant chain

1992 • 76 citations

Antigen Presentation: Getting peptides into MHC class II molecules

1994 • 64 citations

Structural analysis of proteolytic products of MHC class II-invariant chain complexes generated in vivo.

1993 • 62 citations

B cell antigen receptors

1994 • 58 citations

Cytoplasmic tail deletion converts membrane immunoglobulin to a phosphatidylinositol-linked form lacking signaling and efficient antigen internalization functions

1991 • 57 citations

A segment of the MHC class II β chain plays a critical role in targeting class II molecules to the endocytic pathway

1994 • 50 citations

Molecular sorting in polarized and non-polarized cells: common problems, common solutions

1993 • 50 citations

A mutant antigen-presenting cell defective in antigen presentation expresses class II MHC molecules with an altered conformation.

1993 • 20 citations