Involvement of Phospholipase D2 in Lysophosphatidate-induced Transactivation of Platelet-derived Growth Factor Receptor-β in Human Bronchial Epithelial Cells

Discovery of a Novel, Potent, and Src Family-selective Tyrosine Kinase Inhibitor

1996 • 1,946 citations

Role of transactivation of the EGF receptor in signalling by G-protein-coupled receptors

1996 • 1,473 citations

A role for Pyk2 and Src in linking G-protein-coupled receptors with MAP kinase activation

1996 • 971 citations

Signal characteristics of G protein-transactivated EGF receptor

1997 • 669 citations

The bioactive phospholipid lysophosphatidic acid is released from activated platelets

1993 • 653 citations

Identification of an intracellular receptor for lysophosphatidic acid (LPA): LPA is a transcellular PPARγ agonist

2002 • 545 citations

Phospholipase D: molecular and cell biology of a novel gene family

2000 • 495 citations

Lysophosphatidic Acid Receptors

2000 • 404 citations

Evidence that phospholipase D mediates ADP ribosylation factor-dependent formation of Golgi coated vesicles.

1996 • 380 citations

Sphingosine 1‐phosphate modulates human airway smooth muscle cell functions that promote inflammation and airway remodeling in asthma

2001 • 318 citations

Selective platelet-derived growth factor receptor kinase blockers reverse sis-transformation.

1994 • 272 citations

The G-protein G13 but Not G12 Mediates Signaling from Lysophosphatidic Acid Receptor via Epidermal Growth Factor Receptor to Rho

1998 • 265 citations

Src-mediated Tyrosine Phosphorylation of Dynamin Is Required for β2-Adrenergic Receptor Internalization and Mitogen-activated Protein Kinase Signaling

1999 • 259 citations

Pleiotropic Coupling of G Protein-coupled Receptors to the Mitogen-activated Protein Kinase Cascade

1999 • 259 citations

Transactivation of the EGF Receptor Mediates IGF-1-stimulated Shc Phosphorylation and ERK1/2 Activation in COS-7 Cells

2000 • 253 citations

Lysophosphatidic Acid Induction of Vascular Endothelial Growth Factor Expression in Human Ovarian Cancer Cells

2001 • 245 citations

Lysophosphatidic acid promotes matrix metalloproteinase (MMP) activation and MMP-dependent invasion in ovarian cancer cells.

2001 • 241 citations

Protein tyrosine phosphorylation induced by lysophosphatidic acid in Rat-1 fibroblasts. Evidence that phosphorylation of map kinase is mediated by the Gi-p21ras pathway.

1994 • 239 citations

Lysophosphatidic acid-induced squamous cell carcinoma cell proliferation and motility involves epidermal growth factor receptor signal transactivation.

2002 • 224 citations

Lysophosphatidic Acid and Sphingosine 1-Phosphate Protection of T Cells from Apoptosis in Association with Suppression of Bax

1999 • 219 citations

Role for Phospholipase D in Receptor-Mediated Endocytosis

2001 • 216 citations

Chemokine Receptors CXCR-1/2 Activate Mitogen-activated Protein Kinase via the Epidermal Growth Factor Receptor in Ovarian Cancer Cells

2000 • 207 citations

Phosphatidic acid: A lipid messenger involved in intracellular and extracellular signalling

1996 • 189 citations

Transactivation of Vascular Endothelial Growth Factor (VEGF) Receptor Flk-1/KDR Is Involved in Sphingosine 1-Phosphate-stimulated Phosphorylation of Akt and Endothelial Nitric-oxide Synthase (eNOS)

2002 • 188 citations

Transactivation: a Novel Signaling Pathway from Angiotensin II to Tyrosine Kinase Receptors

2001 • 171 citations

Phosphatidylinositol 3-Kinase Activity Is Required at a Postendocytic Step in Platelet-derived Growth Factor Receptor Trafficking

1995 • 165 citations

Tethering of the Platelet-derived Growth Factor β Receptor to G-protein-coupled Receptors

2001 • 153 citations

Modulation of platelet-derived growth factor receptor expression in microvascular endothelial cells during in vitro angiogenesis.

1994 • 152 citations

Tyrosine phosphorylation is involved in reorganization of the actin cytoskeleton in response to serum or LPA stimulation

1994 • 147 citations

β-Adrenergic Receptor-mediated DNA Synthesis in Cardiac Fibroblasts Is Dependent on Transactivation of the Epidermal Growth Factor Receptor and Subsequent Activation of Extracellular Signal-regulated Kinases

2002 • 139 citations

Phosphorylation Site-Specific Inhibition of Platelet-Derived Growth Factor β-Receptor Autophosphorylation by the Receptor Blocking Tyrphostin AG1296

1997 • 132 citations

Lysophosphatidic acid prevents apoptosis in fibroblasts via Gi-protein-mediated activation of mitogen-activated protein kinase

2000 • 121 citations

The LPA receptors

2001 • 121 citations

PLD2 Complexes with the EGF Receptor and Undergoes Tyrosine Phosphorylation at a Single Site upon Agonist Stimulation

1998 • 116 citations

Internalization of the epidermal growth factor receptor: role in signalling

2001 • 116 citations

Phospholipase D Activity Is Required for Actin Stress Fiber Formation in Fibroblasts

2001 • 102 citations

Differential effects of sphingosine 1-phosphate and lysophosphatidic acid on endothelial cells

2002 • 101 citations

Lysophosphatidic acid‐regulated mitogenic ERK signaling in androgen‐insensitive prostate cancer PC‐3 cells

2002 • 94 citations

Physiological responses to lysophosphatidic acid and related glycero-phospholipids

2001 • 93 citations

Oxidized low density lipoprotein-mediated activation of phospholipase D in smooth muscle cells: a possible role in cell proliferation and atherogenesis.

1995 • 89 citations

Lysophosphatidic Acid Induction of Transforming Growth Factors α and β: Modulation of Proliferation and Differentiation in Cultured Human Keratinocytes and Mouse Skin

1995 • 87 citations

Sphingosine 1-phosphate stimulation of the p42/p44 mitogen-activated protein kinase pathway in airway smooth muscle

1999 • 83 citations

An Epidermal Growth Factor Receptor/Gab1 Signaling Pathway Is Required for Activation of Phosphoinositide 3-Kinase by Lysophosphatidic Acid

1999 • 81 citations

Lipid metabolism and vesicle trafficking: More than just greasing the transport machinery

2001 • 78 citations

Lysophosphatidic acid prevents apoptosis in fibroblasts via Gi-protein-mediated activation of mitogen-activated protein kinase

2000 • 77 citations

A Function for Phosphoinositide 3-Kinase β Lipid Products in Coupling βγ to Ras Activation in Response to Lysophosphatidic Acid

2002 • 76 citations

Signal Transduction Pathways of G Protein-coupled Receptors and Their Cross-Talk with Receptor Tyrosine Kinases: Lessons from Bradykinin Signaling

2000 • 72 citations

The Platelet-Activating Factor Receptor Activates the Extracellular Signal-Regulated Kinase Mitogen-Activated Protein Kinase and Induces Proliferation of Epidermal Cells through an Epidermal Growth Factor-Receptor-Dependent Pathway

2002 • 64 citations

Lysophosphatidic acid stimulates phospholipase D activity and cell proliferation in PC-3 human prostate cancer cells

1998 • 63 citations

Involvement of phospholipases D1 and D2 in sphingosine 1-phosphate-induced ERK (extracellular-signal-regulated kinase) activation and interleukin-8 secretion in human bronchial epithelial cells

2002 • 63 citations

Sphingosine 1-phosphate stimulation of the p42/p44 mitogen-activated protein kinase pathway in airway smooth muscle

1999 • 56 citations

Signalling properties of lysophosphatidic acid in primary human skin fibroblasts: role of pertussis toxin-sensitive GTP-binding proteins

1996 • 56 citations

Lysophosphatidic acid in airway function and disease

2002 • 55 citations

Thrombin‐induced p38 mitogen‐activated protein kinase activation is mediated by epidermal growth factor receptor transactivation pathway

2001 • 53 citations

Sphingosine 1‐Phosphate Activates Erk‐1/‐2 by Transactivating Epidermal Growth Factor Receptor in Rat‐2 Cells

2000 • 46 citations

Trans-regulation of epidermal growth factor receptor by lysophosphatidic acid and G protein-coupled receptors

2002 • 40 citations

Ontogeny and regulation of platelet-derived growth factor gene expression in distal fetal rat lung epithelial cells.

1994 • 30 citations

Tyrosine kinases and calcium dependent activation of endothelial cell phospholipase D by diperoxovanadate.

1998 • 30 citations

Role of Src Kinase in Diperoxovanadate-Mediated Activation of Phospholipase D in Endothelial Cells

2001 • 29 citations

Differential Tyrosine Phosphorylation of Phospholipase D Isozymes by Hydrogen Peroxide and the Epidermal Growth Factor in A431 Epidermoid Carcinoma Cells

2001 • 24 citations

Potential Role of EDG Receptors and Lysophospholipids as their Endogenous Ligands in the Respiratory Tract

2000 • 21 citations

Characterization of epidermal growth factor receptor function in Lysophosphatidic acid signaling in PC12 cells

2000 • 17 citations

Lysophosphatidic acid sensitizes mechanical stress-induced Ca2+ response via activation of phospholipase C and tyrosine kinase in cultured smooth muscle cells

1997 • 15 citations

An endogenous redox molecule, thioredoxin, regulates transactivation of epidermal growth factor receptor and activation of NF‐κB by lysophosphatidic acid

2001 • 14 citations