Cloning and Characterization of Two Human Isozymes of Mg2+-independent Phosphatidic Acid Phosphatase

Cleavage of Structural Proteins during the Assembly of the Head of Bacteriophage T4

1970 • 253,849 citations

Intracellular Signaling by Hydrolysis of Phospholipids and Activation of Protein Kinase C

1992 • 4,480 citations

Signaling through phosphatidylcholine breakdown.

1990 • 1,362 citations

The sphingomyelin cycle and the second messenger function of ceramide.

1994 • 1,255 citations

The sphingomyelin pathway in tumor necrosis factor and interleukin-1 signaling

1994 • 934 citations

Calnexin: a membrane-bound chaperone of the endoplasmic reticulum

1994 • 533 citations

Signal transduction through lipid second messengers

1996 • 496 citations

THE ENZYMATIC DEPHOSPHORYLATION OF PHOSPHATIDIC ACIDS

1957 • 359 citations

Plasma membrane fractions from rat liver contain a phosphatidate phosphohydrolase distinct from that in the endoplasmic reticulum and cytosol.

1991 • 271 citations

Cell surface glycoconjugates as onco-differentiation markers in hematopoietic cells

1984 • 253 citations

Identification of a novel phosphatase sequence motif

1997 • 239 citations

Bromoenol Lactone Inhibits Magnesium-dependent Phosphatidate Phosphohydrolase and Blocks Triacylglycerol Biosynthesis in Mouse P388D1 Macrophages

1996 • 218 citations

The Drosophila protein Wunen repels migrating germ cells

1997 • 205 citations

Molecular Cloning of a Novel Diacylglycerol Kinase Isozyme with a Pleckstrin Homology Domain and a C-terminal Tail Similar to Those of the EPH Family of Protein-tyrosine Kinases

1996 • 163 citations

Interaction of Ceramides, Sphingosine, and Sphingosine 1-Phosphate in Regulating DNA Synthesis and Phospholipase D Activity

1995 • 153 citations

Purification of Streptomyces chromofuscus Phospholipase D by Hydrophobic Affinity Chromatography on Palmitoyl Cellulose

1979 • 149 citations

sn-1,2-Diacylglycerol kinase of Escherichia coli. Mixed micellar analysis of the phospholipid cofactor requirement and divalent cation dependence.

1986 • 148 citations

Identification of Diacylglycerol Pyrophosphate as a Novel Metabolic Product of Phosphatidic Acid during G-protein Activation in Plants

1996 • 144 citations

Phosphatidate Phosphohydrolase Catalyzes the Hydrolysis of Ceramide 1-Phosphate, Lysophosphatidate, and Sphingosine 1-Phosphate

1996 • 141 citations

An unexpected structural relationship between integral membrane phosphatases and soluble haloperoxidases

1997 • 134 citations

Molecular cloning of a diacylglycerol kinase isozyme predominantly expressed in human retina with a truncated and inactive enzyme expression in most other human cells

1994 • 113 citations

Identification and cDNA Cloning of 35-kDa Phosphatidic Acid Phosphatase (Type 2) Bound to Plasma Membranes

1996 • 109 citations

The Escherichia coli pgpB Gene Encodes for a Diacylglycerol Pyrophosphate Phosphatase Activity

1996 • 99 citations

Sphingosine inhibits phosphatidate phosphohydrolase in human neutrophils by a protein kinase C-independent mechanism

1991 • 97 citations

Inhibition of phosphatidic acid phosphohydrolase activity by sphingosine

1990 • 87 citations

Mammalian Mg2+-independent Phosphatidate Phosphatase (PAP2) Displays Diacylglycerol Pyrophosphate Phosphatase Activity

1997 • 85 citations

Purification and properties of phosphatidic acid phosphatase from porcine thymus membranes.

1992 • 82 citations

Lysophosphatidic acid: A bioactive phospholipid with growth factor-like properties

1992 • 75 citations

Decreased activities of phosphatidate phosphohydrolase and phospholipase D in ras and tyrosine kinase (fps) transformed fibroblasts.

1993 • 71 citations

The Dri 42 Gene, Whose Expression Is Up-regulated during Epithelial Differentiation, Encodes a Novel Endoplasmic Reticulum Resident Transmembrane Protein

1996 • 71 citations

Purification and Characterization of a Novel Plasma Membrane Phosphatidate Phosphohydrolase from Rat Liver

1995 • 70 citations

Effects of sphingosine, albumin and unsaturated fatty acids on the activation and translocation of phosphatidate phosphohydrolases in rat hepatocytes

1992 • 69 citations

Chaperone function of calnexin for the folding intermediate of gp80, the major secretory protein in MDCK cells. Regulation by redox state and ATP.

1994 • 65 citations

A novel ecto-phosphatidic acid phosphohydrolase activity mediates activation of neutrophil superoxide generation by exogenous phosphatidic acid.

1993 • 58 citations

Effects of okadaic acid on the activities of two distinct phosphatidate phosphohydrolases in rat hepatocytes

1992 • 54 citations

Phorbol ester-stimulated hydrolysis of phosphatidylcholine and phosphatidylethanolamine by phospholipase D in HeLa cells. Evidence that the basal turnover of phosphoglycerides does not involve phospholipase D.

1991 • 47 citations

Diacylglycerol kinase and phosphatidic acid phosphatase—enzymes metabolizing lipid second messengers

1993 • 47 citations

Purification and characterization of N-ethylmaleimide-insensitive phosphatidic acid phosphohydrolase (PAP2) from rat liver

1995 • 41 citations

Identification and Characterization of an Ecto-(lyso)phosphatidic Acid Phosphatase in PAM212 Keratinocytes

1994 • 32 citations

Bimodal distribution of phosphatidic acid phosphohydrolase in NG108–15 cells

1992 • 30 citations

Regulation of Phosphatidic Acid Phosphohydrolase by Epidermal Growth Factor

1996 • 29 citations

Identification of phosphatidate phosphohydrolase purified from rat liver membranes on SDS‐polyacrylamide gel electrophoresis

1996 • 26 citations

Regulation of phosphatidic acid phosphohydrolase activity during stimulation of human polymorphonuclear leukocytes

1992 • 22 citations

Isolation of a novel ras‐recision gene that is induced by hydrogen peroxide from a mouse osteoblastic cell line, MC3T3‐E1

1995 • 12 citations