Cell-permeable ceramides preferentially inhibit coated vesicle formation and exocytosis in Chinese hamster ovary compared with Madin‒Darby canine kidney cells by preventing the membrane association of ADP-ribosylation factor

Functions of Ceramide in Coordinating Cellular Responses to Stress

1996 • 1,620 citations

The sphingomyelin pathway in tumor necrosis factor and interleukin-1 signaling

1994 • 934 citations

ADP-ribosylation factor, a small GTP-dependent regulatory protein, stimulates phospholipase D activity

1993 • 900 citations

Phospholipase D2, a distinct phospholipase D isoform with novel regulatory properties that provokes cytoskeletal reorganization

1997 • 698 citations

Reconstitution of the transport of protein between successive compartments of the golgi measured by the coupled incorporation of N-acetylglucosamine

1984 • 689 citations

Human ADP-ribosylation Factor-activated Phosphatidylcholine-specific Phospholipase D Defines a New and Highly Conserved Gene Family

1995 • 663 citations

Characterization of Two Alternately Spliced Forms of Phospholipase D1

1997 • 547 citations

Type I phosphatidylinositol 4-phosphate 5-kinase isoforms are specifically stimulated by phosphatidic acid

1994 • 410 citations

Evidence that phospholipase D mediates ADP ribosylation factor-dependent formation of Golgi coated vesicles.

1996 • 380 citations

New Developments in Phospholipase D

1997 • 313 citations

Mammalian phospholipase D structure and regulation

1999 • 311 citations

Structural and Functional Analysis of the ARF1–ARFGAP Complex Reveals a Role for Coatomer in GTP Hydrolysis

1999 • 301 citations

Phospholipase D Stimulates Release of Nascent Secretory Vesicles from the trans-Golgi Network

1997 • 251 citations

Regulation of Phospholipase D by Protein Kinase C Is Synergistic with ADP-ribosylation Factor and Independent of Protein Kinase Activity

1996 • 251 citations

Cloning and Initial Characterization of a Human Phospholipase D2 (hPLD2)

1998 • 234 citations

Cloning, Expression, and Characterization of a Novel Phospholipase D Complementary DNA from Rat Brain

1997 • 227 citations

Diacylglycerol and Phosphatidate Generated by Phospholipases C and D, Respectively, Have Distinct Fatty Acid Compositions and Functions

1997 • 200 citations

Coatomer, Arf1p, and nucleotide are required to bud coat protein complex I-coated vesicles from large synthetic liposomes

1998 • 200 citations

Phospholipase D1 localises to secretory granules and lysosomes and is plasma-membrane translocated on cellular stimulation

1998 • 200 citations

Phospholipase D is present on Golgi-enriched membranes and its activation by ADP ribosylation factor is sensitive to brefeldin A.

1995 • 193 citations

Cell-permeable ceramides inhibit the stimulation of DNA synthesis and phospholipase D activity by phosphatidate and lysophosphatidate in rat fibroblasts.

1994 • 188 citations

Phospholipase D and membrane traffic

1999 • 177 citations

Phosphatidic acid formation by phospholipase D is required for transport from the endoplasmic reticulum to the Golgi complex

1997 • 174 citations

Receptor and protein kinase C-mediated regulation of ARF binding to the Golgi complex

1993 • 158 citations

Interaction of Ceramides, Sphingosine, and Sphingosine 1-Phosphate in Regulating DNA Synthesis and Phospholipase D Activity

1995 • 153 citations

Detergent Influence on Rat‐Liver Galactosyltransferase Activities towards Different Acceptors

1977 • 150 citations

Evidence That Ceramide Selectively Inhibits Protein Kinase C-α Translocation and Modulates Bradykinin Activation of Phospholipase D

1995 • 139 citations

Secretory Vesicle Budding from the Trans-Golgi Network Is Mediated by Phosphatidic Acid Levels

1998 • 138 citations

Ceramide stimulates epidermal growth factor receptor phosphorylation in A431 human epidermoid carcinoma cells. Evidence that ceramide may mediate sphingosine action

1991 • 134 citations

Lipid regulators of membrane traffic through the Golgi complex

1999 • 127 citations

Ceramide As a Modulator of Endocytosis

1995 • 121 citations

Phospholipase D structure and regulation

1999 • 118 citations

Identification of a defect in the phospholipase D/diacylglycerol pathway in cellular senescence

1994 • 117 citations

Inhibition of Phosphatidic Acid Synthesis Alters the Structure of the Golgi Apparatus and Inhibits Secretion in Endocrine Cells

2000 • 115 citations

Phorbol myristate acetate-mediated stimulation of transcytosis and apical recycling in MDCK cells

1994 • 114 citations

Cell-permeable Ceramides Prevent the Activation of Phospholipase D by ADP-ribosylation Factor and RhoA

1997 • 106 citations

ADP-ribosylation Factor Translocation Correlates with Potentiation of GTPγS-stimulated Phospholipase D Activity in Membrane Fractions of HL-60 Cells

1995 • 95 citations

Inhibition of glycoprotein traffic through the secretory pathway by ceramide.

1993 • 94 citations

Regulation of phospholipase D by phosphorylation-dependent mechanisms

1999 • 86 citations

Human Phospholipase D1 Can Be Tyrosine-phosphorylated in HL-60 Granulocytes

1997 • 85 citations

ADP-ribosylation-factor-regulated phospholipase D activity localizes to secretory vesicles and mobilizes to the plasma membrane following N-formylmethionyl-leucyl-phenylalanine stimulation of human neutrophils

1997 • 84 citations

Assembly of Rubella Virus Structural Proteins into Virus-like Particles in Transfected Cells

1994 • 78 citations

Ceramide regulates oxidant release in adherent human neutrophils

1994 • 77 citations

A Novel Pathway for Tumor Necrosis Factor-α and Ceramide Signaling Involving Sequential Activation of Tyrosine Kinase, p21 , and Phosphatidylinositol 3-Kinase

1999 • 69 citations

Activation of exocytosis by cross-linking of the IgE receptor is dependent on ADP-ribosylation factor 1-regulated phospholipase D in RBL-2H3 mast cells: evidence that the mechanism of activation is via regulation of phosphatidylinositol 4,5-bisphosphate synthesis

2000 • 69 citations

Colocalization of phospholipase D1 and GTP‐binding‐defective mutant of ADP‐ribosylation factor 6 to endosomes and lysosomes

1999 • 67 citations

Tumor Necrosis Factor-α Induces Stress Fiber Formation through Ceramide Production: Role of Sphingosine Kinase

2001 • 64 citations

Ceramide inhibits IgE-mediated activation of phospholipase D, but not of phospholipase C, in rat basophilic leukemia (RBL-2H3) cells.

1996 • 64 citations

ADP ribosylation factor 1 mutants identify a phospholipase D effector region and reveal that phospholipase D participates in lysosomal secretion but is not sufficient for recruitment of coatomer I

1999 • 58 citations

Protein kinase C bound to the Golgi apparatus supports the formation of constitutive transport vesicles

1996 • 58 citations

The rubella virus E2 and E1 spike glycoproteins are targeted to the Golgi complex.

1993 • 55 citations

Membrane-Destabilizing Properties of C₂-Ceramide May Be Responsible for Its Ability To Inhibit Platelet Aggregation

1998 • 53 citations

Effects of Activated ADP-ribosylation Factors on Golgi Morphology Require neither Activation of Phospholipase D1 nor Recruitment of Coatomer

2000 • 42 citations

Role of Rubella Virus Glycoprotein Domains in Assembly of Virus-Like Particles

1999 • 38 citations

Ceramide Inhibition of Mammalian Phospholipase D1 and D2 Activities Is Antagonized by Phosphatidylinositol 4,5-Bisphosphate

2001 • 37 citations

Ceramide Accumulation Uncovers a Cycling Pathway for the cis-Golgi Network Marker, Infectious Bronchitis Virus M Protein

1997 • 34 citations

Activation of the sphingomyelin cycle by brefeldin A: effects of brefeldin A on differentiation and implications for a role for ceramide in regulation of protein trafficking.

1996 • 24 citations

Activation of exocytosis by cross-linking of the IgE receptor is dependent on ADP-ribosylation factor 1-regulated phospholipase D in RBL-2H3 mast cells: evidence that the mechanism of activation is via regulation of phosphatidylinositol 4,5-bisphosphate synthesis

2000 • 23 citations

ADP ribosylation factor 1 mutants identify a phospholipase D effector region and reveal that phospholipase D participates in lysosomal secretion but is not sufficient for recruitment of coatomer I

1999 • 14 citations