THE ROLE OF THE MITOCHONDRION IN TRAUMA AND SHOCK

Tolerance, Danger, and the Extended Family

1994 • 4,654 citations

The Danger Model: A Renewed Sense of Self

2002 • 4,107 citations

Mitochondrial free radical generation, oxidative stress, and aging11This article is dedicated to the memory of our dear friend, colleague, and mentor Lars Ernster (1920–1998), in gratitude for all he gave to us.

2000 • 2,864 citations

The expanding role of mitochondria in apoptosis.

2001 • 2,377 citations

Mitochondrial reactive oxygen species trigger hypoxia-induced transcription

1998 • 1,864 citations

Intracellular Adenosine Triphosphate (ATP) Concentration: A Switch in the Decision Between Apoptosis and Necrosis

1997 • 1,851 citations

Molecular identification of a danger signal that alerts the immune system to dying cells

2003 • 1,649 citations

Mitochondrial Evolution

1999 • 1,603 citations

Association between mitochondrial dysfunction and severity and outcome of septic shock

2002 • 1,401 citations

Mitochondrial damage induced by conditions of oxidative stress

1999 • 829 citations

Necrosis: a specific form of programmed cell death?

2003 • 710 citations

The permeability transition pore complex: another view

2002 • 702 citations

Mitochondrial Genome Evolution and the Origin of Eukaryotes

1999 • 685 citations

Cytochrome c binds to inositol (1,4,5) trisphosphate receptors, amplifying calcium-dependent apoptosis

2003 • 624 citations

Role of Toll-Like Receptors in Pathogen Recognition

2003 • 545 citations

Involvement of Reactive Oxygen Species in Toll-Like Receptor 4-Dependent Activation of NF-κB

2004 • 527 citations

Mitochondrial dysfunction in a long-term rodent model of sepsis and organ failure

2004 • 448 citations

Origin and evolution of eukaryotic apoptosis: the bacterial connection

2002 • 411 citations

Heat shock proteins, cellular chaperones that modulate mitochondrial cell death pathways

2003 • 363 citations

An Innate Sense of Danger

2002 • 355 citations

Signaling Danger

2004 • 352 citations

Mitochondria as we don't know them

2002 • 348 citations

On the origin of mitochondria: a genomics perspective

2003 • 338 citations

Physiology and pathophysiology of poly(ADP‐ribosyl)ation *

2001 • 333 citations

Mitochondria and cell death

2000 • 314 citations

Mitochondrial N-formylmethionyl proteins as chemoattractants for neutrophils.

1982 • 309 citations

Intra-mitochondrial Poly(ADP-ribosylation) Contributes to NAD+ Depletion and Cell Death Induced by Oxidative Stress

2003 • 303 citations

Cytopathic Hypoxia

2001 • 300 citations

Methamphetamine induces neuronal apoptosis via cross‐talks between endoplasmic reticulum and mitochondria‐dependent death cascades

2004 • 269 citations

Apoptosis in sepsis: a new target for therapeutic exploration

2001 • 255 citations

NF-κB activation

2000 • 246 citations

Injury Primes the Innate Immune System for Enhanced Toll-Like Receptor Reactivity

2003 • 243 citations

Mitochondrial hyperpolarization: a checkpoint of T-cell life, death and autoimmunity

2004 • 224 citations

Oxidative Stress Caused by Inactivation of Glutathione Peroxidase and Adaptive Responses

2003 • 213 citations

Delayed neutrophil apoptosis in sepsis is associated with maintenance of mitochondrial transmembrane potential and reduced caspase-9 activity*

2004 • 208 citations

Cell Sorting Experiments Link Persistent Mitochondrial DNA Damage with Loss of Mitochondrial Membrane Potential and Apoptotic Cell Death

2003 • 205 citations

Reactive Oxygen Species (ROS), Troublemakers between Nuclear Factor-κB (NF-κB) and c-Jun NH2-terminal Kinase (JNK)

2004 • 171 citations

The role of mitochondrial nitric oxide synthase in inflammation and septic shock

2002 • 169 citations

Programmed Death Phenomena: From Organelle to Organism

2002 • 167 citations

Death Receptor Activation-Induced Hepatocyte Apoptosis and Liver Injury

2003 • 143 citations

Signal transduction via the NF‐κB pathway: a targeted treatment modality for infection, inflammation and repair

2004 • 141 citations

Injury, sepsis, and the regulation of Toll-like receptor responses

2003 • 136 citations

Cellular Responses to Fmlp Challenging: A Mini-Review

1999 • 135 citations

Evidence for Early Supply Independent Mitochondrial Dysfunction in Patients Developing Multiple Organ Failure after Trauma

1997 • 133 citations

Matrix detachment induces caspase-dependent cytochrome c release from mitochondria: inhibition by PKB/Akt but not Raf signalling

2000 • 130 citations

Mitochondrial biogenesis as a cellular signaling framework

2003 • 128 citations

Impaired mitochondrial function induced by serum from septic shock patients is attenuated by inhibition of nitric oxide synthase and poly(ADP-ribose) synthase*

2003 • 127 citations

Metabolic integration during the evolutionary origin of mitochondria

2003 • 124 citations

Altered Cytochrome c Display Precedes Apoptotic Cell Death in Drosophila

1999 • 123 citations

Recovery of hepatocellular ATP and “pericentral apoptosis” after hemorrhage and resuscitation

2003 • 97 citations

Cellular Apoptosis and Organ Injury in Sepsis: A Review

2002 • 91 citations

Hypoxia Diminishes Toll-Like Receptor 4 Expression Through Reactive Oxygen Species Generated by Mitochondria in Endothelial Cells

2002 • 84 citations

Antioxidants attenuate nuclear factor-kappa B activation and tumor necrosis factor-alpha production in alcoholic hepatitis patient monocytes and rat Kupffer cells, in vitro

1999 • 83 citations

A MEMBRANE-PERMEABLE RADICAL SCAVENGER REDUCES THE ORGAN INJURY IN HEMORRHAGIC SHOCK

1999 • 83 citations

Redox Regulation of Cytokine Expression in Kupffer Cells

2002 • 79 citations

Near-infrared spectroscopy

1997 • 78 citations

Deleterious poly(ADP-ribose)polymerase-1 pathway activation in traumatic brain injury in rat

2003 • 77 citations

Inhibition of Poly (ADP-ribose) Polymerase Attenuates Acute Lung Injury in an Ovine Model of Sepsis

2004 • 75 citations

Interspecific evolution: microbial symbiosis, endosymbiosis and gene transfer

2003 • 73 citations

Effect of adenosine triphosphate-magnesium chloride administration in shock.

1974 • 70 citations

O2 sensing in hypoxic pulmonary vasoconstriction: the mitochondrial door re-opens

2002 • 70 citations

The Death of Articular Chondrocytes after Intra-articular Fracture in Humans

2004 • 68 citations

Bench to Bedside: The Role of Mitochondrial Medicine in the Pathogenesis and Treatment of Cellular Injury

2003 • 60 citations

Endosymbiosis and the design of eukaryotic electron transport

2003 • 59 citations

PROTECTIVE EFFECT OF ALLOPURINOL ON HEPATIC ENERGY METABOLISM IN ISCHEMIC AND REPERFUSED RAT LIVER

2001 • 57 citations

Modulation of lipopolysaccharide-mediated activation in rat Kupffer cells by antioxidants

1998 • 56 citations

Induction of Apoptosis Following Blunt Chest Trauma

2003 • 54 citations

Cross Talk of Nitric Oxide, Oxygen Radicals, and Superoxide Dismutase Regulates the Energy Metabolism and Cell Death and Determines the Fates of Aerobic Life

2003 • 54 citations

Mitochondrial signaling in apoptosis: Mitochondrial daggers to the breaking heart

2003 • 50 citations

Redox proteins in mammalian cell death: an evolutionarily conserved function in mitochondria and prokaryotes

2003 • 43 citations

Use of ATP following Shock and Ischemia^a

1990 • 42 citations

The Use of Insulin and Glucose during Resuscitation from Hemorrhagic Shock Increases Hepatic ATP

2000 • 36 citations

Cross-talk between NO and oxyradicals, a supersystem that regulates energy metabolism and survival of animals

2000 • 35 citations

Peptides from the Amino-Terminus of Mouse Mitochondrially Encoded NADH Dehydrogenase Subunit 1 Are Potent Chemoattractants

1995 • 33 citations

The protective action of allopurinol in an experimental model of haemorrhagic shock and reperfusion

1986 • 32 citations

Tissue Energetics as Measured by Nuclear Magnetic Resonance Spectroscopy During Hemorrhagic Shock

2003 • 29 citations

Antigen Presentation by Murine Dendritic Cells is Nuclear Factor‐kappa B Dependent Both In Vitro and In Vivo

2003 • 28 citations

Adenosine Triphosphate—Magnesium Chloride Ameliorates Reperfusion Injury Following Ischemia as Determined by Phosphorus Nuclear Magnetic Resonance

1985 • 28 citations

The effect of prostaglandin E1 on liver adenine nucleotides and cytoplasmic enzymes in a porcine model of normothermic hepatic ischemia

1995 • 26 citations

Optimal choice between feedforward and feedback control in gene expression to cope with unpredictable danger

2003 • 24 citations

Scission, spores, and apoptosis: a proposal for the evolutionary origin of mitochondria in cell death induction

2003 • 23 citations

PEROXYNITRITE-MEDIATED DNA STRAND BREAKAGE ACTIVATES POLY(ADP-RIBOSE) SYNTHETASE AND CAUSES CELLULAR ENERGY DEPLETION IN A NONSEPTIC SHOCK MODEL INDUCED BY ZYMOSAN IN THE RAT

1998 • 23 citations

Salutary effects of ATP-MgCl2 on the depressed endothelium-dependent relaxation during hyperdynamic sepsis

1999 • 22 citations

ATP-MgCl2 produces sustained improvement in hepatic mitochondrial function and blood flow after hepatic ischemia

1984 • 21 citations

Glutamine administration during total parenteral nutrition protects liver adenosine nucleotides during and after subsequent hemorrhagic shock

2003 • 17 citations

Reduction of the drug-induced nephrotoxicity by ATP-MgCl2. 1. Effects on the cis-Diamminedichloroplatinum-treated isolated perfused kidneys

1985 • 16 citations

Administration of ATP-MgCl2after Trauma–;Hemorrhage and Resuscitation Restores the Depressed Cardiac Performance

1997 • 10 citations

The Cellular Energy Crisis: Mitochondria and Cell Death

2003 • 9 citations

Reduction of the drug-induced nephrotoxicity by ATP-MgCl2. II. Effects on gentamicin-treated isolated perfused kidneys

1985 • 8 citations

Administration of ATP–MgCl2 following hemorrhage and resuscitation increases hepatic phosphoenolpyruvate carboxykinase and decreases pyruvate kinase activities1Part of the work described in this article was performed when the authors were at the Shock and Trauma Research Institute at Michigan State University, East Lansing, MI, USA.1

1997 • 5 citations

Repair of metabolic processes

2003 • 5 citations

USE OF 3% HYPERTONIC SALINE VERSUS HETASTARCH FOR INITIAL VOLUME RESUSCITATION AFTER CARDIOPULMONARY BYPASS SURGERY

1999 • 3 citations

Deleted Work

1955 • 0 citations