Matrix detachment induces caspase-dependent cytochrome c release from mitochondria: inhibition by PKB/Akt but not Raf signalling

Cytochrome c and dATP-Dependent Formation of Apaf-1/Caspase-9 Complex Initiates an Apoptotic Protease Cascade

1997 • 7,177 citations

Cleavage of BID by Caspase 8 Mediates the Mitochondrial Damage in the Fas Pathway of Apoptosis

1998 • 4,383 citations

Cellular survival: a play in three Akts

1999 • 4,229 citations

Bid, a Bcl2 Interacting Protein, Mediates Cytochrome c Release from Mitochondria in Response to Activation of Cell Surface Death Receptors

1998 • 3,603 citations

Disruption of epithelial cell-matrix interactions induces apoptosis

1994 • 3,167 citations

Regulation of Cell Death Protease Caspase-9 by Phosphorylation

1998 • 3,129 citations

Two CD95 (APO-1/Fas) signaling pathways

1998 • 3,045 citations

Phosphatidylinositol-3-OH kinase direct target of Ras

1994 • 1,923 citations

Movement of Bax from the Cytosol to Mitochondria during Apoptosis

1997 • 1,805 citations

The extracellular matrix as a cell survival factor.

1993 • 1,541 citations

Mechanisms and consequences of activation of protein kinase B/Akt

1998 • 1,305 citations

Bid-induced Conformational Change of Bax Is Responsible for Mitochondrial Cytochrome c Release during Apoptosis

1999 • 1,255 citations

Suppression of ICE and Apoptosis in Mammary Epithelial Cells by Extracellular Matrix

1995 • 1,184 citations

Cytosol-to-membrane redistribution of Bax and Bcl-X_Lduring apoptosis

1997 • 1,117 citations

Control of adhesion-dependent cell survival by focal adhesion kinase.

1996 • 1,113 citations

Role of Phosphoinositide 3-OH Kinase in Cell Transformation and Control of the Actin Cytoskeleton by Ras

1997 • 1,064 citations

Matrix adhesion and Ras transformation both activate a phosphoinositide 3-OH kinase and protein kinase B/Akt cellular survival pathway

1997 • 1,050 citations

Apoptosis signaling by death receptors

1998 • 976 citations

Multiple ras functions can contribute to mammalian cell transformation

1995 • 658 citations

Bax-induced Cytochrome C Release from Mitochondria Is Independent of the Permeability Transition Pore but Highly Dependent on Mg2+ Ions

1998 • 645 citations

Raf-Induced Proliferation or Cell Cycle Arrest Is Determined by the Level of Raf Activity with Arrest Mediated by p21^Cip1

1997 • 643 citations

Akt/Protein Kinase B Inhibits Cell Death by Preventing the Release of Cytochrome c from Mitochondria

1999 • 642 citations

Regulated Targeting of BAX to Mitochondria

1998 • 617 citations

PTEN: a tumour suppressor that functions as a phospholipid phosphatase

1999 • 592 citations

Presence of a pre-apoptotic complex of pro-caspase-3, Hsp60 and Hsp10 in the mitochondrial fraction of Jurkat cells

1999 • 518 citations

Ras effectors

1996 • 445 citations

B-Raf Inhibits Programmed Cell Death Downstream of Cytochrome c Release from Mitochondria by Activating the MEK/Erk Pathway

1999 • 311 citations

Integrins, adhesion and apoptosis

1997 • 274 citations

How BAD phosphorylation is good for survival

1999 • 242 citations

Involvement of FADD and caspase-8 signalling in detachment-induced apoptosis

1999 • 209 citations

Akt Phosphorylation Site Found in Human Caspase-9 Is Absent in Mouse Caspase-9

1999 • 181 citations

Evidence for a function of death-receptor-related, death-domain-containing proteins in anoikis

1999 • 172 citations