The Cellular Energy Crisis: Mitochondria and Cell Death

Cleavage of BID by Caspase 8 Mediates the Mitochondrial Damage in the Fas Pathway of Apoptosis

1998 • 4,383 citations

Proapoptotic BAX and BAK: A Requisite Gateway to Mitochondrial Dysfunction and Death

2001 • 3,867 citations

Smac, a Mitochondrial Protein that Promotes Cytochrome c–Dependent Caspase Activation by Eliminating IAP Inhibition

2000 • 3,415 citations

Two CD95 (APO-1/Fas) signaling pathways

1998 • 3,045 citations

Identification of DIABLO, a Mammalian Protein that Promotes Apoptosis by Binding to and Antagonizing IAP Proteins

2000 • 2,344 citations

Bcl-2 family proteins regulate the release of apoptogenic cytochrome c by the mitochondrial channel VDAC

1999 • 2,157 citations

An APAF-1·Cytochrome c Multimeric Complex Is a Functional Apoptosome That Activates Procaspase-9

1999 • 2,088 citations

Ordering the Cytochrome c–initiated Caspase Cascade: Hierarchical Activation of Caspases-2, -3, -6, -7, -8, and -10 in a Caspase-9–dependent Manner

1999 • 1,927 citations

Intracellular Adenosine Triphosphate (ATP) Concentration: A Switch in the Decision Between Apoptosis and Necrosis

1997 • 1,851 citations

Sequential reduction of mitochondrial transmembrane potential and generation of reactive oxygen species in early programmed cell death.

1995 • 1,556 citations

Heat-shock protein 70 inhibits apoptosis by preventing recruitment of procaspase-9 to the Apaf-1 apoptosome

2000 • 1,484 citations

A receptor for phosphatidylserine-specific clearance of apoptotic cells

2000 • 1,480 citations

X-ray and NMR structure of human Bcl-xL, an inhibitor of programmed cell death

1996 • 1,456 citations

The Combined Functions of Proapoptotic Bcl-2 Family Members Bak and Bax Are Essential for Normal Development of Multiple Tissues

2000 • 1,427 citations

Bcl-xL Regulates the Membrane Potential and Volume Homeostasis of Mitochondria

1997 • 1,389 citations

tBID, a membrane-targeted death ligand, oligomerizes BAK to release cytochrome c

2000 • 1,245 citations

Mitochondrial cytochrome c release in apoptosis occurs upstream of DEVD-specific caspase activation and independently of mitochondrial transmembrane depolarization

1998 • 1,226 citations

Apaf1 Is Required for Mitochondrial Pathways of Apoptosis and Brain Development

1998 • 1,143 citations

Bcl-2 inhibits the mitochondrial release of an apoptogenic protease.

1996 • 1,143 citations

The coordinate release of cytochrome c during apoptosis is rapid, complete and kinetically invariant

2000 • 1,046 citations

Pro-apoptotic cascade activates BID, which oligomerizes BAK or BAX into pores that result in the release of cytochrome c

2000 • 994 citations

Mitochondrial permeability transition is a central coordinating event of apoptosis.

1996 • 857 citations

Changes in intramitochondrial and cytosolic pH: early events that modulate caspase activation during apoptosis

2000 • 728 citations

Bax-induced Caspase Activation and Apoptosis via Cytochromec Release from Mitochondria Is Inhibitable by Bcl-xL

1999 • 717 citations

The Permeability Transition Pore Complex: A Target for Apoptosis Regulation by Caspases and Bcl-2–related Proteins

1998 • 700 citations

HtrA2 Promotes Cell Death through Its Serine Protease Activity and Its Ability to Antagonize Inhibitor of Apoptosis Proteins

2002 • 550 citations

Bcl-xL Prevents Cell Death following Growth Factor Withdrawal by Facilitating Mitochondrial ATP/ADP Exchange

1999 • 496 citations

Comparison of the ion channel characteristics of proapoptotic BAX and antiapoptotic BCL-2

1997 • 489 citations

Bax and Bak Coalesce into Novel Mitochondria-Associated Clusters during Apoptosis

2001 • 466 citations

Cytochrome C Maintains Mitochondrial Transmembrane Potential and Atp Generation after Outer Mitochondrial Membrane Permeabilization during the Apoptotic Process

2001 • 431 citations

Dexamethasone-induced apoptosis involves cleavage of DNA to large fragments prior to internucleosomal fragmentation.

1993 • 419 citations

Phosphatidylserine Externalization during CD95-induced Apoptosis of Cells and Cytoplasts Requires ICE/CED-3 Protease Activity

1996 • 386 citations

Caspase inhibitors

1999 • 372 citations

Bcl-x Promotes the Open Configuration of the Voltage-dependent Anion Channel and Metabolite Passage through the Outer Mitochondrial Membrane

2001 • 356 citations

Electrophysiological Study of a Novel Large Pore Formed by Bax and the Voltage-dependent Anion Channel That Is Permeable to Cytochrome c

2000 • 335 citations

Bcl-2 family proteins as ion-channels

1998 • 299 citations

The Release of Cytochrome c from Mitochondria during Apoptosis of NGF-deprived Sympathetic Neurons Is a Reversible Event

1999 • 297 citations

Target Cell Lysis by CTL Granule Exocytosis Is Independent of ICE/Ced-3 Family Proteases

1997 • 237 citations

Adult Apaf-1-Deficient Mice Exhibit Male Infertility

2000 • 202 citations

Ion Channel Activity of the BH3 Only Bcl-2 Family Member, BID

1999 • 195 citations

Granzyme B-mediated Apoptosis Proceeds Predominantly through a Bcl-2-inhibitable Mitochondrial Pathway

2001 • 189 citations

Caspase Inhibition Extends the Commitment to Neuronal Death Beyond Cytochrome c Release to the Point of Mitochondrial Depolarization

2000 • 183 citations

Anti-apoptotic oncogenes prevent caspase-dependent and independent commitment for cell death

1998 • 179 citations

Mitochondrial Permeability Transition and Swelling Can Occur Reversibly without Inducing Cell Death in Intact Human Cells

1999 • 170 citations

Free radicals, exercise, apoptosis, and heat shock proteins.

2001 • 151 citations

Cleavage of CPP32 by Granzyme B Represents a Critical Role for Granzyme B in the Induction of Target Cell DNA Fragmentation

1996 • 148 citations

Granzyme B-induced loss of mitochondrial inner membrane potential (Delta Psi m) and cytochrome c release are caspase independent.

1999 • 133 citations

Sequential activation of three distinct ICE‐like activities in Fas‐ligated Jurkat cells

1996 • 120 citations

Electrical coupling and plasticity of the mitochondrial network

2000 • 118 citations

The protonophore CCCP induces mitochondrial permeability transition without cytochrome c release in human osteosarcoma cells

2001 • 108 citations

Cleavage of caspase family members by granzyme B: a comparative study in vitro

1997 • 54 citations

Dependence of granzyme B-mediated cell death on a pathway regulated by Bcl-2 or its viral homolog, BHRF1

2000 • 51 citations

Antioxidant administration inhibits exercise-induced thymocyte apoptosis in rats

1999 • 37 citations