Cytopathic Hypoxia

Multiple Organ Dysfunction Score

1995 • 2,453 citations

The mitochondrial permeability transition

1995 • 2,412 citations

Apoptotic cell death in patients with sepsis, shock, and multiple organ dysfunction

1999 • 1,307 citations

(ADP-ribose)n participates in DNA excision repair

1980 • 1,112 citations

Unifying theory of hypoxia tolerance: molecular/metabolic defense and rescue mechanisms for surviving oxygen lack.

1996 • 1,088 citations

Mitochondrial non-specific pores remain closed during cardiac ischaemia, but open upon reperfusion

1995 • 830 citations

The uncoupling protein homologues: UCP1, UCP2, UCP3, StUCP and AtUCP

2000 • 770 citations

Nitric Oxide Inhibits Electron Transfer and Increases Superoxide Radical Production in Rat Heart Mitochondria and Submitochondrial Particles

1996 • 726 citations

Differential Inhibitory Action of Nitric Oxide and Peroxynitrite on Mitochondrial Electron Transport

1996 • 719 citations

Inhibition of Mitochondrial Electron Transport by Peroxynitrite

1994 • 697 citations

Aconitase is readily inactivated by peroxynitrite, but not by its precursor, nitric oxide.

1994 • 596 citations

Nitric oxide synthase activity in mitochondria

1997 • 576 citations

Resistance to endotoxic shock as a consequence of defective NF-kappa B activation in poly (ADP-ribose) polymerase-1 deficient mice

1999 • 569 citations

Tetrahydrobiopterin synthesis. An absolute requirement for cytokine-induced nitric oxide generation by vascular smooth muscle.

1992 • 444 citations

The Mitochondrial Permeability Transition Is Required for Tumor Necrosis Factor Alpha-Mediated Apoptosis and Cytochrome c Release

1998 • 400 citations

Effect of exogenous and endogenous nitric oxide on mitochondrial respiration of rat hepatocytes

1991 • 395 citations

Contribution of the mitochondrial permeability transition to lethal injury after exposure of hepatocytes to t-butylhydroperoxide

1995 • 384 citations

Reevaluation of the Role of Cellular Hypoxia and Bioenergetic Failure in Sepsis

1992 • 383 citations

Endothelial dysfunction in a rat model of endotoxic shock. Importance of the activation of poly (ADP-ribose) synthetase by peroxynitrite.

1997 • 368 citations

Mitochondrial Nitric-oxide Synthase Stimulation Causes Cytochrome c Release from Isolated Mitochondria

1999 • 333 citations

Effect of sepsis on tissue adenine nucleotide levels.

1979 • 329 citations

Molecular and biochemical features of poly (ADP-ribose) metabolism

1993 • 300 citations

Inhibition of inducible nitric oxide synthase ameliorates endotoxin- induced gut mucosal barrier dysfunction in rats

1997 • 286 citations

Multiple Cytokines Are Required to Induce Hepatocyte Nitric Oxide Production and Inhibit Total Protein Synthesis

1990 • 273 citations

Defective oxidative metabolism of rat liver mitochondria in hemorrhagic and endotoxin shock

1971 • 268 citations

Endotoxemia causes ileal mucosal acidosis in the absence of mucosal hypoxia in a normodynamic porcine model of septic shock

1995 • 256 citations

Role of Poly-ADP Ribosyltransferase Activation in the Vascular Contractile and Energetic Failure Elicited by Exogenous and Endogenous Nitric Oxide and Peroxynitrite

1996 • 254 citations

Recruitment of mitochondrial cyclophilin to the mitochondrial inner membrane under conditions of oxidative stress that enhance the opening of a calcium-sensitive non-specific channel

1994 • 245 citations

Rapid reduction of nitric oxide by mitochondria, and reversible inhibition of mitochondrial respiration by nitric oxide

1996 • 243 citations

Skeletal muscle partial pressure of oxygen in patients with sepsis

1994 • 238 citations

Gut and muscle tissue PO2 in endotoxemic dogs during shock and resuscitation

1994 • 233 citations

The potential role of peroxynitrite in the vascular contractile and cellular energetic failure in endotoxic shock

1997 • 222 citations

The uncoupling protein homologues: UCP1, UCP2, UCP3, StUCP and AtUCP

2000 • 220 citations

Inhibition of cytochrome c oxidase in turnover by nitric oxide: mechanism and implications for control of respiration

1995 • 207 citations

Nitric oxide produced by activated astrocytes rapidly and reversibly inhibits cellular respiration

1995 • 204 citations

Endogenous peroxynitrite mediates mitochondrial dysfunction in rat diaphragm during endotoxemia

1999 • 186 citations

Cytopathic hypoxia in sepsis

1997 • 170 citations

Effect of sepsis on activity of pyruvate dehydrogenase complex in skeletal muscle and liver.

1989 • 169 citations

Dual Function for Poly(ADP-ribose) Synthesis in Response to DNA Strand Breakage

1994 • 168 citations

Oxidative Metabolism in Rat Hepatocytes and Mitochondria during Sepsis

1997 • 158 citations

Oxygen-Dependent Regulation of Mitochondrial Energy Metabolism by Nitric Oxide

1995 • 156 citations

Oxygen conformance of cellular respiration in hepatocytes

1993 • 151 citations

Hypoxia Downregulates Expression and Activity of Epithelial Sodium Channels in Rat Alveolar Epithelial Cells

1997 • 149 citations

On the Mechanism of Inhibition of Cytochrome c Oxidase by Nitric Oxide

1996 • 142 citations

SEPSIS-INDUCED ALTERATIONS IN PYRUVATE DEHYDROGENASE COMPLEX ACTIVITY IN RAT SKELETAL MUSCLE

1996 • 135 citations

Peripheral oxygen availability within skeletal muscle in sepsis and septic shock: Comparison to limited infection and cardiogenic shock

1991 • 135 citations

Peroxynitrite Inactivates Thiol-Containing Enzymes of Trypanosoma cruzi Energetic Metabolism and Inhibits Cell Respiration

1994 • 126 citations

Superoxide production by mitochondria in the presence of nitric oxide forms peroxynitrite

1996 • 116 citations

Oxygen tension in the bladder epithelium rises in both high and low cardiac output endotoxemic sepsis

1995 • 111 citations

Involvement of PARP and poly(ADP-ribosyl)ation in the early stages of apoptosis and DNA replication

1999 • 108 citations

Evaluation of the role of cellular hypoxia in sepsis by the hypoxic marker [18F]fluoromisonidazole

1991 • 104 citations

Sepsis does not impair tricarboxylic acid cycle in the heart

1991 • 97 citations

Early impairment of oxidative metabolism and energy production in severe sepsis.

1988 • 92 citations

Effect of Injury and Sepsis on High-energy Phosphates in Muscle and Red Cells

1980 • 87 citations

Anoxia-tolerant hepatocytes: model system for study of reversible metabolic suppression

1993 • 84 citations

Cellular energy utilization and supply during hypoxia in embryonic cardiac myocytes

1996 • 79 citations

Effect of sepsis on activity of pyruvate dehydrogenase complex in skeletal muscle and liver

1986 • 78 citations

Preliminary studies of energy-rich phosphagens in muscle from severely ill patients

1976 • 78 citations

Untitled

1999 • 78 citations

Mitochondrial proton leak and the uncoupling proteins.

1999 • 75 citations

Ileal mucosal oxygen consumption is decreased in endotoxemic rats but is restored toward normal by treatment with aminoguanidine

1999 • 72 citations

Altered mitochondrial redox responses in gram negative septic shock in primates.

1994 • 71 citations

Mitochondrial death in sepsis: A failed concept

1986 • 70 citations

PROTECTIVE EFFECTS OF NICOTINAMIDE AGAINST NITRIC OXIDE-MEDIATED DELAYED VASCULAR FAILURE IN ENDOTOXIC SHOCK

1996 • 60 citations

Alterations of mitochondrial metabolism and protein concentrations in subacute septicemia

1982 • 59 citations

Increased pyruvate dehydrogenase kinase activity in response to sepsis

1991 • 58 citations

Sepsis alters skeletal muscle energetics and membrane function.

1991 • 57 citations

Microcalorimetric measurement of reversible metabolic suppression induced by anoxia in isolated hepatocytes

1993 • 55 citations

The role of nitric oxide in sepsis and ARDS: Synopsis of a roundtable conference held in Brussels on 18–20 March 1995

1996 • 53 citations

Tissue oxygenation and perfusion in endotoxemia

1996 • 51 citations

Effects of short-term endotoxemia and dopamine on mucosal oxygenation in porcine jejunum

1996 • 51 citations

Hepatic cellular hypoxia in murine peritonitis.

1979 • 50 citations

Sepsis alters pyruvate dehydrogenase kinase activity in skeletal muscle.

1999 • 49 citations

A role for the POU-III transcription factor Brn-4 in the regulation of striatal neuron precursor differentiation

1999 • 48 citations

Prevention of Endotoxin-Induced Lethality, but Not of Liver Apoptosis in Poly(ADP-ribose) Polymerase-Deficient Mice

1999 • 47 citations

Regional blood flow and skeletal muscle energy status in endotoxemic rats

1987 • 45 citations

Poly (ADP-ribose) synthetase activation mediates pulmonary microvascular and intestinal mucosal dysfunction in endotoxin shock

1998 • 39 citations

Muscle adenosine 5′-triphosphate and creatine phosphate concentrations in relation to nutritional status and sepsis in man

1988 • 38 citations

Breakdown of adenine nucleotides, formation of oxygen free radicals, and early markers of cellular injury in endotoxic shock.

1995 • 37 citations

High-energy phosphates in heart, liver, kidney, and skeletal muscle of endotoxemic rats

1994 • 34 citations

Role of glutathione and nitric oxide in the energy metabolism of rat liver mitochondria

1997 • 34 citations

Cardiorespiratory and tissue oxygen dose response to rat endotoxemia

1996 • 32 citations

Concurrent quantification of tissue metabolism and blood flow via ²h/³¹P NMR in Viva iii. alterations of muscle blood flow and metabolism during sepsis

1992 • 29 citations

Effect of peritonitis on mitochondrial respiration

1971 • 26 citations

Tissue metabolite levels in different types of skeletal muscle during sepsis

1991 • 24 citations

Inhibition of PARS attenuates endotoxin-induced dysfunction of pulmonary vasorelaxation

1999 • 22 citations

The Duration of Infection Modifies Mitochondrial Oxidative Capacity in Rat Skeletal Muscle

1995 • 21 citations

Alterations in Renal Perfusion and Renal Energy Charge in Murine Peritonitis

1987 • 19 citations

Energy state, glycolytic intermediates and mitochondrial function in the liver during reversible and irreversible endotoxin shock.

1989 • 18 citations

In vivo 31P nuclear magnetic resonance spectroscopy of skeletal muscle energetics in endotoxemic rats

1994 • 18 citations

Hepatic Acute Phase Protein Synthesis is Indirectly Regulated by Tumor Necrosis Factor

1990 • 17 citations

Acidic conditions ameliorate both adenosine triphosphate depletion and the development of hyperpermeability in cultured Caco-2BBe enterocytic monolayers subjected to metabolic inhibition

1997 • 16 citations

In vivo [31P]NMR assessment of early hepatocellular dysfunction during endotoxemia

1992 • 16 citations

The effect of hypodynamic endotoxin shock on myocardial high energy phosphates in the rat

1989 • 14 citations

Protein and energy metabolism in liver tissue following intravenous infusion of live E. coli bacteria in rats.

1987 • 13 citations

Sequential Insult Enhances Liver Macrophage-Signaled Hepatocyte Dysfunction

1994 • 13 citations

Further characterization of a model of chronic endotoxemia in the rat: adenine nucleotide content in liver.

1988 • 11 citations

In vivo effects of lipopolysaccharide on hepatic free-NAD(P)+-linked redox states and cytosolic phosphorylation potential in 48-hour-fasted rats

1995 • 11 citations

Pathophysiology of acute renal failure following living Escherichia coli injection in rats: high-energy metabolism and renal functions.

1987 • 10 citations

Glucocorticoid Receptor Antagonism by Mifepristone Alters Phosphocreatine Breakdown During Sepsis

1996 • 9 citations