Protein Oxidation in Aging, Disease, and Oxidative Stress

Chemistry and biochemistry of 4-hydroxynonenal, malonaldehyde and related aldehydes

1991 • 6,550 citations

Role of Oxidative Stress in Development of Complications in Diabetes

1991 • 3,774 citations

Protein kinases and phosphatases: The Yin and Yang of protein phosphorylation and signaling

1995 • 2,907 citations

[37] Carbonyl assays for determination of oxidatively modified proteins

1994 • 2,605 citations

Excess brain protein oxidation and enzyme dysfunction in normal aging and in Alzheimer disease.

1991 • 1,290 citations

Age-related changes in oxidized proteins.

1987 • 1,229 citations

Metal ion-catalyzed oxidation of proteins: Biochemical mechanism and biological consequences

1990 • 1,143 citations

Methionine residues as endogenous antioxidants in proteins

1996 • 1,005 citations

Oxidative damage, mitochondrial oxidant generation and antioxidant defenses during aging and in response to food restriction in the mouse

1994 • 785 citations

Reversal of age-related increase in brain protein oxidation, decrease in enzyme activity, and loss in temporal and spatial memory by chronic administration of the spin-trapping compound N-tert-butyl-alpha-phenylnitrone.

1991 • 734 citations

Reaction mechanisms in the radiolysis of peptides, polypeptides, and proteins

1987 • 712 citations

Peroxynitrite Reaction with Carbon Dioxide/Bicarbonate: Kinetics and Influence on Peroxynitrite-Mediated Oxidations

1996 • 583 citations

Covalent attachment of 4-hydroxynonenal to glyceraldehyde-3-phosphate dehydrogenase. A possible involvement of intra- and intermolecular cross-linking reaction.

1993 • 512 citations

Rapid reaction between peroxonitrite ion and carbon dioxide: Implications for biological activity

1995 • 506 citations

Effects of peroxynitrite‐induced protein modifications on tyrosine phosphorylation and degradation

1996 • 450 citations

Proteolysis in Cultured Liver Epithelial Cells during Oxidative Stress

1995 • 412 citations

Protein oxidation and proteolysis during aging and oxidative stress

1989 • 396 citations

Protein oxidative damage is associated with life expectancy of houseflies.

1993 • 347 citations

Peroxynitrite disables the tyrosine phosphorylation regulatory mechanism: Lymphocyte-specific tyrosine kinase fails to phosphorylate nitrated cdc2(6-20)NH2 peptide.

1996 • 341 citations

One- and two-electron oxidations of methionine by peroxynitrite.

1994 • 318 citations

Mechanism of Carbon Dioxide-Catalyzed Oxidation of Tyrosine by Peroxynitrite

1996 • 297 citations

Acceleration of Peroxynitrite Oxidations by Carbon Dioxide

1996 • 277 citations

Protein oxidation associated with aging is reduced by dietary restriction of protein or calories.

1992 • 248 citations

Oxygen Effect in the Radiolysis of Proteins

1984 • 220 citations

An Emerging Hypothesis: Synergistic Induction of Aging by Free Radicals and Maillard Reactions

1992 • 220 citations

Radiation Chemistry of Organic Compounds

1961 • 211 citations

Susceptibility of Glucose-6-Phosphate Dehydrogenase Modified by 4-Hydroxy-2-nonenal and Metal-Catalyzed Oxidation to Proteolysis by the Multicatalytic Protease

1994 • 172 citations

Peroxynitrite-mediated nitration of tyrosine residues in Escherichia coli glutamine synthetase mimics adenylylation: relevance to signal transduction.

1996 • 171 citations

Oxidative stress and aging in the Mongolian gerbil (Meriones unguiculatus)

1995 • 170 citations

Mutations in the consensus helicase domains of the Werner syndrome gene. Werner's Syndrome Collaborative Group.

1997 • 146 citations

Radiation-Induced Oxidation of Protein in Aqueous Solution

1962 • 124 citations

A novel mechanism for oxidative cleavage of prolyl peptides induced by the hydroxyl radical

1990 • 121 citations

Recent developments in the age-related alteration of enzymes: A review

1977 • 120 citations

Biochemical Correlates of Longevity in Two Closely Related Rodent Species

1993 • 115 citations

Oxygen radicals in biology and medicine

1989 • 112 citations

Modification of hepatic proteins in rats exposed to high oxygen concentration

1987 • 108 citations

Regulation of Intracellular Protein Turnover: Covalent Modification as a Mechanism of Marking Proteins for Degradation

1986 • 104 citations

Posttranslational Modifications of Enzymes

1978 • 82 citations

Relationship between Aging and Susceptibility to Protein Oxidative Damage

1993 • 61 citations

Inactivation of glutamine synthetase by a purified rabbit liver microsomal cytochrome P-450 system

1985 • 49 citations

Inefficient Degradation of Oxidized Regions of Protein Molecules

1993 • 49 citations

Alteration of aminoacyl-tRNA synthetase with age: Heat-labilization of the enzyme by oxidative damage

1990 • 46 citations

Oxidative Stress and Aging

1995 • 43 citations

Fructated Protein Is More Resistant to ATP-Dependent Proteolysis than Glucated Protein Possibly as a Result of Higher Content of Maillard Fluorophores

1995 • 28 citations

Exposure of Rat Muscle Phosphoglycerate Kinase to a Nonenzymatic MFO System Generates the Old Form of the Enzyme

1991 • 23 citations

Chapter 6 Cyclic cascades in cellular regulation

1996 • 4 citations