PTEN: The down side of PI 3-kinase signalling

Mammalian MAP kinase signalling cascades

2001 • 5,041 citations

PTEN , a Putative Protein Tyrosine Phosphatase Gene Mutated in Human Brain, Breast, and Prostate Cancer

1997 • 4,753 citations

Cellular survival: a play in three Akts

1999 • 4,229 citations

The Tumor Suppressor, PTEN/MMAC1, Dephosphorylates the Lipid Second Messenger, Phosphatidylinositol 3,4,5-Trisphosphate

1998 • 3,053 citations

Identification of a candidate tumour suppressor gene, MMAC1, at chromosome 10q23.3 that is mutated in multiple advanced cancers

1997 • 2,746 citations

Negative Regulation of PKB/Akt-Dependent Cell Survival by the Tumor Suppressor PTEN

1998 • 2,505 citations

eIF4 Initiation Factors: Effectors of mRNA Recruitment to Ribosomes and Regulators of Translation

1999 • 2,096 citations

The PI3K–PDK1 connection: more than just a road to PKB

2000 • 1,563 citations

AFX-like Forkhead transcription factors mediate cell-cycle regulation by Ras and PKB through p27kip1

2000 • 1,431 citations

Modulation of hypoxia-inducible factor 1alpha expression by the epidermal growth factor/phosphatidylinositol 3-kinase/PTEN/AKT/FRAP pathway in human prostate cancer cells: implications for tumor angiogenesis and therapeutics.

2000 • 1,430 citations

Inhibition of Cell Migration, Spreading, and Focal Adhesions by Tumor Suppressor PTEN

1998 • 1,215 citations

The lipid phosphatase activity of PTEN is critical for its tumor supressor function

1998 • 1,180 citations

Structural Determinants of Phosphoinositide 3-Kinase Inhibition by Wortmannin, LY294002, Quercetin, Myricetin, and Staurosporine

2000 • 1,121 citations

Crystal Structure of the PTEN Tumor Suppressor

1999 • 1,011 citations

AKT/PKB and Other D3 Phosphoinositide-Regulated Kinases: Kinase Activation by Phosphoinositide-Dependent Phosphorylation

1999 • 997 citations

Phosphoinositide 3-kinases: A conserved family of signal transducers

1997 • 944 citations

Polarization of Chemoattractant Receptor Signaling During Neutrophil Chemotaxis

2000 • 892 citations

TEP1, encoded by a candidate tumor suppressor locus, is a novel protein tyrosine phosphatase regulated by transforming growth factor beta.

1997 • 883 citations

Signaling by Distinct Classes of Phosphoinositide 3-Kinases

1999 • 861 citations

C2-domains, Structure and Function of a Universal Ca2+-binding Domain

1998 • 835 citations

Loss of PTEN facilitates HIF-1-mediated gene expression

2000 • 824 citations

PTEN modulates cell cycle progression and cell survival by regulating phosphatidylinositol 3,4,5,-trisphosphate and Akt/protein kinase B signaling pathway

1999 • 787 citations

P-TEN, the tumor suppressor from human chromosome 10q23, is a dual-specificity phosphatase

1997 • 778 citations

Phosphorylation of the PTEN Tail Regulates Protein Stability and Function

2000 • 756 citations

Signal-dependent membrane targeting by pleckstrin homology (PH) domains

2000 • 692 citations

Signalling through phosphoinositide 3-kinases: the lipids take centre stage

1999 • 689 citations

Linkage of G Protein-Coupled Receptors to the MAPK Signaling Pathway Through PI 3-Kinase γ

1997 • 671 citations

PTEN: Life as a Tumor Suppressor

2001 • 670 citations

Structure and function of phosphoinositide 3-kinases

1998 • 666 citations

The PTEN/MMAC1 tumor suppressor phosphatase functions as a negative regulator of the phosphoinositide 3-kinase/Akt pathway

1998 • 654 citations

Inactivation of the tumor suppressor PTEN/MMAC1 in advanced human prostate cancer through loss of expression

1998 • 640 citations

Forkhead Transcription Factor FKHR-L1 Modulates Cytokine-Dependent Transcriptional Regulation of p27^KIP1

2000 • 609 citations

The Tumor Suppressor PTEN Is Phosphorylated by the Protein Kinase CK2 at Its C Terminus

2001 • 607 citations

Regulation of G₁progression by thePTENtumor suppressor protein is linked to inhibition of the phosphatidylinositol 3-kinase/Akt pathway

1999 • 572 citations

Forkhead Transcription Factors Are Critical Effectors of Cell Death and Cell Cycle Arrest Downstream of PTEN

2000 • 569 citations

Phospholipid signaling

1995 • 561 citations

Mutational Spectra of PTEN/MMAC1 Gene: a Tumor Suppressor With Lipid Phosphatase Activity

1999 • 539 citations

Phosphatidylinositol 3-kinase signaling mediates angiogenesis and expression of vascular endothelial growth factor in endothelial cells

2000 • 529 citations

PDZ domains in synapse assembly and signalling

2000 • 525 citations

Identification of pleckstrin-homology-domain-containing proteins with novel phosphoinositide-binding specificities

2000 • 515 citations

Combinatorial control of the specificity of protein tyrosine phosphatases

2001 • 500 citations

Pten and p27KIP1 cooperate in prostate cancer tumor suppression in the mouse

2001 • 495 citations

PTEN/MMAC1/TEP1 suppresses the tumorigenicity and induces G ₁ cell cycle arrest in human glioblastoma cells

1998 • 480 citations

Protein kinase B (PKB/Akt) activity is elevated in glioblastoma cells due to mutation of the tumor suppressor PTEN/MMAC

1998 • 479 citations

PDZ Proteins Organize Synaptic Signaling Pathways

1998 • 474 citations

PDZ domains: fundamental building blocks in the organization of protein complexes at the plasma membrane

1999 • 469 citations

Chemoattractant-mediated transient activation and membrane localization of Akt/PKB is required for efficient chemotaxis to cAMP in Dictyostelium

1999 • 444 citations

Phosphoinositide 3-kinase signalling pathways

2006 • 443 citations

The C. elegans PTEN Homolog, DAF-18, Acts in the Insulin Receptor-like Metabolic Signaling Pathway

1998 • 440 citations

Growth suppression of glioma cells by PTEN requires a functional phosphatase catalytic domain

1997 • 437 citations

Inhibition of integrin-linked kinase (ILK) suppresses activation of protein kinase B/Akt and induces cell cycle arrest and apoptosis of PTEN-mutant prostate cancer cells

2000 • 430 citations

Shc and Fak Differentially Regulate Cell Motility and Directionality Modulated by Pten

1999 • 418 citations

Cellular Signaling

2000 • 415 citations

Identification of pleckstrin-homology-domain-containing proteins with novel phosphoinositide-binding specificities

2000 • 398 citations

The phosphoinositol phosphatase activity of PTEN mediates a serum-sensitive G1 growth arrest in glioma cells.

1998 • 393 citations

Immunohistochemical Evidence of Loss of PTEN Expression in Primary Ductal Adenocarcinomas of the Breast

1999 • 381 citations

Evidence for regulation of the PTEN tumor suppressor by a membrane-localized multi-PDZ domain containing scaffold protein MAGI-2

2000 • 378 citations

The lipid phosphatase SHIP2 controls insulin sensitivity

2001 • 369 citations

Tumor suppressor and anti-inflammatory actions of PPARγ agonists are mediated via upregulation of PTEN

2001 • 358 citations

Drosophila tumor suppressor PTEN controls cell size and number by antagonizing the Chico/PI3-kinase signaling pathway

1999 • 349 citations

SHIP is a negative regulator of growth factor receptor-mediated PKB/Akt activation and myeloid cell survival

1999 • 344 citations

Mutations of the human PTEN gene

2000 • 323 citations

Differential Nuclear and Cytoplasmic Expression of PTEN in Normal Thyroid Tissue, and Benign and Malignant Epithelial Thyroid Tumors

2000 • 321 citations

PTEN affects cell size, cell proliferation and apoptosis during Drosophila eye development

1999 • 316 citations

The PTEN/MMAC1 tumor suppressor induces cell death that is rescued by the AKT/protein kinase B oncogene.

1998 • 313 citations

Protein Kinases as Mediators of Phosphoinositide 3-Kinase Signaling

2000 • 313 citations

The tumor-suppressor activity of PTEN is regulated by its carboxyl-terminal region

1999 • 312 citations

Structure, function, and biology of SHIP proteins

2000 • 298 citations

A role of the kinase mTOR in cellular transformation induced by the oncoproteins P3k and Akt

2000 • 296 citations

Genetic deletion of the Pten tumor suppressor gene promotes cell motility by activation of Rac1 and Cdc42 GTPases

2000 • 291 citations

Akt/PKB localisation and 3′ phosphoinositide generation at sites of epithelial cell–matrix and cell–cell interaction

1999 • 288 citations

PTEN is inversely correlated with the cell survival factor Akt/PKB and is inactivated via multiple mechanismsin haematological malignancies

1999 • 279 citations

Interaction of the Tumor Suppressor PTEN/MMAC with a PDZ Domain of MAGI3, a Novel Membrane-associated Guanylate Kinase

2000 • 267 citations

PTEN, a unique tumor suppressor gene.

2000 • 266 citations

Mutation and Expression Analyses Reveal Differential Subcellular Compartmentalization of PTEN in Endocrine Pancreatic Tumors Compared to Normal Islet Cells

2000 • 264 citations

PTEN coordinates G1 arrest by down-regulating cyclin D1 via its protein phosphatase activity and up-regulating p27 via its lipid phosphatase activity in a breast cancer model

2001 • 263 citations

Subcellular targeting by membrane lipids

2001 • 259 citations

Drosophila PTEN Regulates Cell Growth and Proliferation through PI3K-Dependent and -Independent Pathways

2000 • 255 citations

Adenovirus Endocytosis via α _v Integrins Requires Phosphoinositide-3-OH Kinase

1998 • 249 citations

PTEN controls tumor-induced angiogenesis

2001 • 243 citations

Genetic control of cell size

2000 • 243 citations

A Role for Nuclear PTEN in Neuronal Differentiation

2000 • 228 citations

The role of PI 3-kinase in insulin action

1998 • 224 citations

PTEN regulates the ubiquitin-dependent degradation of the CDK inhibitor p27KIP1 through the ubiquitin E3 ligase SCFSKP2

2001 • 223 citations

Constitutive Macropinocytosis in Oncogene-transformed Fibroblasts Depends on Sequential Permanent Activation of Phosphoinositide 3-Kinase and Phospholipase C

2000 • 222 citations

The Tumor Suppressor PTEN Negatively Regulates Insulin Signaling in 3T3-L1 Adipocytes

2000 • 190 citations

The PTEN tumor suppressor homolog in Caenorhabditis elegans regulates longevity and dauer formation in an insulin receptor-like signaling pathway

1999 • 186 citations

5′ Phospholipid Phosphatase SHIP-2 Causes Protein Kinase B Inactivation and Cell Cycle Arrest in Glioblastoma Cells

2000 • 178 citations

Stabilization and productive positioning roles of the C2 domain of PTEN tumor suppressor.

2000 • 177 citations

Receptor Tyrosine Kinases

2000 • 165 citations

Threonine phosphorylation of the MMAC1/PTEN PDZ binding domain both inhibits and stimulates PDZ binding.

2000 • 157 citations

Phospholipid signalling in the nucleus

1998 • 153 citations

Functional evaluation of PTEN missense mutations using in vitro phosphoinositide phosphatase assay.

2000 • 148 citations

Regulation of the insulin-like developmental pathway of Caenorhabditis elegans by a homolog of the PTEN tumor suppressor gene

1999 • 145 citations

Regulation of dauer larva development in Caenorhabditis elegans by daf-18, a homologue of the tumour suppressor PTEN

1999 • 142 citations

Phosphoinositide Binding Domains

1999 • 130 citations

Cytohesins and centaurins: mediators of PI 3-kinase-regulated Arf signaling

2000 • 129 citations

Polarized signaling: basolateral receptor localization in epithelial cells by PDZ-containing proteins

1997 • 119 citations

Phosphoinositide-Regulated Kinases and Phosphoinositide Phosphatases

2001 • 117 citations

PIPkins1We introduce here the abbreviation PIPkin (an abbreviation we have used in our lab for years) for cogent reasons. Previously, PtdIns4P 5-kinase was the favoured abbreviation, but in view of the extensive revision and uncertainty as to substrates and products that we discuss in this review, only PtdInsP kinase would now suffice. Moreover, we have recently recorded evidence that type II PIPkin is subject to multiple phosphorylations by protein kinases [1]. As we progress in our …

1998 • 110 citations

p27Kip1 is required for PTEN-induced G1 growth arrest.

2001 • 107 citations

Insulin-like Growth Factor I Stimulates Tyrosine Phosphorylation of p130Cas, Focal Adhesion Kinase, and Paxillin

1998 • 104 citations

Growth and gene expression profile analyses of endometrial cancer cells expressing exogenous PTEN.

2001 • 88 citations

Do growth and cell division rates determine cell size in multicellular organisms?

2000 • 83 citations

Novel vitamin D3 analog, 21-(3-methyl-3-hydroxy-butyl)-19-nor D3, that modulates cell growth, differentiation, apoptosis, cell cycle, and induction of PTEN in leukemic cells

2001 • 82 citations

Analysis of the cellular functions of PTEN using catalytic domain and C-terminal mutations: differential effects of C-terminal deletion on signalling pathways downstream of phosphoinositide 3-kinase

2000 • 76 citations

A testis-specific gene, TPTE , encodes a putative transmembrane tyrosine phosphatase and maps to the pericentromeric region of human chromosomes 21 and 13, and to chromosomes 15, 22, and Y

1999 • 72 citations

PTEN Expression Causes Feedback Upregulation of Insulin Receptor Substrate 2

2001 • 66 citations

Inhibition of H-Ras transformation by the PTEN/MMAC1/TEP1 tumor suppressor gene

2000 • 65 citations

Do membrane-bound enzymes access their substrates from the membrane or aqueous phase: interfacial versus non-interfacial enzymes

2000 • 58 citations

Targeting mutants of PTEN reveal distinct subsets of tumour suppressor functions

2001 • 53 citations

Targeting mutants of PTEN reveal distinct subsets of tumour suppressor functions

2001 • 48 citations