Novel vitamin D3 analog, 21-(3-methyl-3-hydroxy-butyl)-19-nor D3, that modulates cell growth, differentiation, apoptosis, cell cycle, and induction of PTEN in leukemic cells

PTEN , a Putative Protein Tyrosine Phosphatase Gene Mutated in Human Brain, Breast, and Prostate Cancer

1997 • 4,753 citations

Cellular survival: a play in three Akts

1999 • 4,229 citations

Vitamin D

1979 • 3,814 citations

Identification of a candidate tumour suppressor gene, MMAC1, at chromosome 10q23.3 that is mutated in multiple advanced cancers

1997 • 2,746 citations

New insights into tumor suppression: PTEN suppresses tumor formation by restraining the phosphoinositide 3-kinase/AKT pathway

1999 • 1,972 citations

Pten is essential for embryonic development and tumour suppression

1998 • 1,507 citations

The Multiple Roles of PTEN in Tumor Suppression

2000 • 1,150 citations

TEP1, encoded by a candidate tumor suppressor locus, is a novel protein tyrosine phosphatase regulated by transforming growth factor beta.

1997 • 883 citations

1,25-Dihydroxyvitamin D3 increases the expression of the CaT1 epithelial calcium channel in the Caco-2 human intestinal cell line.

2001 • 849 citations

High cancer susceptibility and embryonic lethality associated with mutation of the PTEN tumor suppressor gene in mice

1998 • 823 citations

PTEN modulates cell cycle progression and cell survival by regulating phosphatidylinositol 3,4,5,-trisphosphate and Akt/protein kinase B signaling pathway

1999 • 787 citations

Regulation of G₁progression by thePTENtumor suppressor protein is linked to inhibition of the phosphatidylinositol 3-kinase/Akt pathway

1999 • 572 citations

Induction of differentiation in human promyelocytic HL-60 leukemia cells activates p21, WAF1/CIP1, expression in the absence of p53.

1994 • 514 citations

Impaired Fas Response and Autoimmunity in Pten ^+/− Mice

1999 • 512 citations

PTEN/MMAC1/TEP1 suppresses the tumorigenicity and induces G ₁ cell cycle arrest in human glioblastoma cells

1998 • 480 citations

MMAC1/PTEN mutations in primary tumor specimens and tumor cell lines.

1997 • 464 citations

Frequent PTEN/MMAC mutations in endometrioid but not serous or mucinous epithelial ovarian tumors.

1998 • 423 citations

The phosphoinositol phosphatase activity of PTEN mediates a serum-sensitive G1 growth arrest in glioma cells.

1998 • 393 citations

Frequent inactivation of PTEN in prostate cancer cell lines and xenografts.

1998 • 388 citations

The PTEN/MMAC1/TEP tumor suppressor gene decreases cell growth and induces apoptosis and anoikis in breast cancer cells

1999 • 317 citations

Cyclin-dependent kinase inhibitor p27 as a mediator of the G1-S phase block induced by 1,25-dihydroxyvitamin D3 in HL60 cells.

1996 • 300 citations

PTEN is inversely correlated with the cell survival factor Akt/PKB and is inactivated via multiple mechanismsin haematological malignancies

1999 • 279 citations

1,25-Dihydroxyvitamin D3: in vivo and in vitro effects on human preleukemic and leukemic cells.

1985 • 275 citations

Regulation of Akt/PKB activity, cellular growth, and apoptosis in prostate carcinoma cells by MMAC/PTEN.

1999 • 275 citations

PTEN suppresses breast cancer cell growth by phosphatase activity-dependent G1 arrest followed by cell death.

1999 • 253 citations

Induction of macrophage differentiation of human normal and leukemic myeloid stem cells by 1,25-dihydroxyvitamin D3 and its fluorinated analogues.

1984 • 236 citations

Apoptosis induced by vitamin D compounds in breast cancer cells is inhibited by Bcl-2 but does not involve known caspases or p53.

1999 • 213 citations

Inhibition of proliferation of prostate cancer cells by a 19-nor-hexafluoride vitamin D3 analogue involves the induction of p21waf1, p27kip1 and E-cadherin

1997 • 189 citations

20-epi-vitamin D3 analogues: a novel class of potent inhibitors of proliferation and inducers of differentiation of human breast cancer cell lines.

1995 • 188 citations

PTEN Gene Alterations in Lymphoid Neoplasms

1998 • 180 citations

A Novel Vitamin D₃Analog, 22-Oxa-1, 25- Dihydroxyvitamin D₃, Inhibits the Growth of Human Breast Cancerin Vitroandin Vivowithout Causing Hypercalcemia*

1991 • 175 citations

Phorbol ester effect on differentiation of human myeloid leukemia cell lines blocked at different stages of maturation.

1981 • 163 citations

1 alpha,25-Dihydroxy-16-ene-23-yne-26,27-hexafluorocholecalciferol (Ro24-5531), a new deltanoid (vitamin D analogue) for prevention of breast cancer in the rat.

1994 • 140 citations

Posttranscriptional stabilization underlies p53-independent induction of p21WAF1/CIP1/SDI1 in differentiating human leukemic cells.

1995 • 123 citations

Adenovirus-mediated gene transfer of MMAC1/PTEN to glioblastoma cells inhibits S phase entry by the recruitment of p27Kip1 into cyclin E/CDK2 complexes.

1999 • 121 citations

Combination of a potent 20-epi-vitamin D3 analogue (KH 1060) with 9-cis-retinoic acid irreversibly inhibits clonal growth, decreases bcl-2 expression, and induces apoptosis in HL-60 leukemic cells.

1996 • 118 citations

PTEN gene transfer in human malignant glioma: sensitization to irradiation and CD95L-induced apoptosis

1999 • 112 citations

Development of a novel 1,25(OH)2-vitamin D3 analog with potent ability to induce HL-60 cell differentiation without modulating calcium metabolism

1991 • 92 citations

Vitamin D3 analogs and their 24-Oxo metabolites equally inhibit clonal proliferation of a variety of cancer cells but have differing molecular effects

1997 • 89 citations

5,6-trans-16-ene-vitamin D3: a new class of potent inhibitors of proliferation of prostate, breast, and myeloid leukemic cells.

1999 • 87 citations

Characterization of a Novel Analogue of 1α,25(OH)₂-Vitamin D₃ with Two Side Chains: Interaction with Its Nuclear Receptor and Cellular Actions

2000 • 81 citations

A new series of vitamin D analogs is highly active for clonal inhibition, differentiation, and induction of WAF1 in myeloid leukemia

1996 • 81 citations

Mutation analysis of PTEN/MMAC1 in acute myeloid leukemia

2000 • 78 citations

Vitamin D3 analogs: Effect on leukemic clonal growth and differentiation, and on serum calcium levels

1995 • 72 citations

Synergistic decrease of clonal proliferation, induction of differentiation, and apoptosis of acute promyelocytic leukemia cells after combined treatment with novel 20-epi vitamin D3 analogs and 9-cis retinoic acid.

1997 • 63 citations

1,25(OH)2-16ENE-vitamin D3 is a potent antileukemic agent with low potential to cause hypercalcemia

1994 • 61 citations

Restoration of Wild-type PTEN Expression Leads to Apoptosis, Induces Differentiation, and Reduces Telomerase Activity in Human Glioma Cells

1999 • 59 citations

PTEN transcriptionally modulates c-myc gene expression in human breast carcinoma cells and is involved in cell growth regulation

1999 • 56 citations

19-nor Vitamin-D Analogs: A New Class of Potent Inhibitors of Proliferation and Inducers of Differentiation of Human Myeloid Leukemia Cell Lines

1998 • 52 citations

A dual block to cell cycle progression in HL60 cells exposed to analogues of vitamin D,

1994 • 52 citations

19-nor-26,27-bishomo-vitamin D3 analogs: a unique class of potent inhibitors of proliferation of prostate, breast, and hematopoietic cancer cells.

1998 • 50 citations

Growth suppression of human ovarian cancer cells by adenovirus-mediated transfer of the PTEN gene.

1999 • 50 citations

Adenovirus-mediated delivery of the PTEN gene inhibits cell growth by induction of apoptosis in endometrial cancer.

1999 • 46 citations

19-nor-hexafluoride analogue of vitamin D3: a novel class of potent inhibitors of proliferation of human breast cell lines.

1997 • 43 citations

Cell cycle arrest and astrocytic differentiation resulting from PTEN expression in glioma cells

1999 • 41 citations

The specific N-ras mutation in rat 7,12-dimethylbenz[a]anthracene (DMBA)-induced leukemia.

1997 • 26 citations

Alterations of differentiation, clonal proliferation, cell cycle progression and bcl-2 expression in RARα-altered sublines of HL-60

1997 • 20 citations

1,25-dihydroxyvitamin D3-induced retardation of the G2/M traverse is associated with decreased levels of p34cdc2 in HL60 cells

1999 • 19 citations