Drosophila PTEN Regulates Cell Growth and Proliferation through PI3K-Dependent and -Independent Pathways

Targeted gene expression as a means of altering cell fates and generating dominant phenotypes

1993 • 9,476 citations

PTEN , a Putative Protein Tyrosine Phosphatase Gene Mutated in Human Brain, Breast, and Prostate Cancer

1997 • 4,753 citations

The Tumor Suppressor, PTEN/MMAC1, Dephosphorylates the Lipid Second Messenger, Phosphatidylinositol 3,4,5-Trisphosphate

1998 • 3,053 citations

Identification of a candidate tumour suppressor gene, MMAC1, at chromosome 10q23.3 that is mutated in multiple advanced cancers

1997 • 2,746 citations

Negative Regulation of PKB/Akt-Dependent Cell Survival by the Tumor Suppressor PTEN

1998 • 2,505 citations

Germline mutations of the PTEN gene in Cowden disease, an inherited breast and thyroid cancer syndrome

1997 • 2,063 citations

Analysis of genetic mosaics in developing and adult Drosophila tissues

1993 • 2,029 citations

New insights into tumor suppression: PTEN suppresses tumor formation by restraining the phosphoinositide 3-kinase/AKT pathway

1999 • 1,972 citations

Pten is essential for embryonic development and tumour suppression

1998 • 1,507 citations

Inhibition of Cell Migration, Spreading, and Focal Adhesions by Tumor Suppressor PTEN

1998 • 1,215 citations

The lipid phosphatase activity of PTEN is critical for its tumor supressor function

1998 • 1,180 citations

Expression of baculovirus P35 prevents cell death in Drosophila

1994 • 1,037 citations

Mutation ofPten/Mmac1in mice causes neoplasia in multiple organ systems

1999 • 941 citations

Autonomous Control of Cell and Organ Size by CHICO, a Drosophila Homolog of Vertebrate IRS1–4

1999 • 838 citations

High cancer susceptibility and embryonic lethality associated with mutation of the PTEN tumor suppressor gene in mice

1998 • 823 citations

The Berkeley Drosophila Genome Project Gene Disruption Project: Single P-Element Insertions Mutating 25% of Vital Drosophila Genes

1999 • 790 citations

PTEN modulates cell cycle progression and cell survival by regulating phosphatidylinositol 3,4,5,-trisphosphate and Akt/protein kinase B signaling pathway

1999 • 787 citations

P-TEN, the tumor suppressor from human chromosome 10q23, is a dual-specificity phosphatase

1997 • 778 citations

Coordination of Growth and Cell Division in the Drosophila Wing

1998 • 760 citations

Size Control in Animal Development

1999 • 742 citations

Drosophila S6 Kinase: A Regulator of Cell Size

1999 • 710 citations

Mutation spectrum and genotype-phenotype analyses in Cowden disease and Bannayan-Zonana syndrome, two hamartoma syndromes with germline PTEN mutation

1998 • 652 citations

Drosophila myc Regulates Cellular Growth during Development

1999 • 637 citations

PTEN: a tumour suppressor that functions as a phospholipid phosphatase

1999 • 592 citations

Kuzbanian Controls Proteolytic Processing of Notch and Mediates Lateral Inhibition during Drosophila and Vertebrate Neurogenesis

1997 • 516 citations

The Drosophila Caspase Inhibitor DIAP1 Is Essential for Cell Survival and Is Negatively Regulated by HID

1999 • 499 citations

PTEN/MMAC1/TEP1 suppresses the tumorigenicity and induces G ₁ cell cycle arrest in human glioblastoma cells

1998 • 480 citations

Germline mutations in the PTEN/MMAC1 gene in patients with Cowden disease

1997 • 465 citations

Targeted expression of the signaling molecule decapentaplegic induces pattern duplications and growth alterations in Drosophila wings.

1994 • 451 citations

The C. elegans PTEN Homolog, DAF-18, Acts in the Insulin Receptor-like Metabolic Signaling Pathway

1998 • 440 citations

The phosphoinositol phosphatase activity of PTEN mediates a serum-sensitive G1 growth arrest in glioma cells.

1998 • 393 citations

Cell-autonomous regulation of cell and organ growth in Drosophila by Akt/PKB

1999 • 368 citations

Uncoupling cadherin-based adhesion from wingless signalling in Drosophila

1996 • 365 citations

Drosophila tumor suppressor PTEN controls cell size and number by antagonizing the Chico/PI3-kinase signaling pathway

1999 • 349 citations

The Drosophila insulin receptor is required for normal growth.

1996 • 337 citations

The Drosophila insulin receptor homolog: a gene essential for embryonic development encodes two receptor isoforms with different signaling potential.

1995 • 335 citations

PTEN affects cell size, cell proliferation and apoptosis during Drosophila eye development

1999 • 316 citations

The PTEN/MMAC1 tumor suppressor induces cell death that is rescued by the AKT/protein kinase B oncogene.

1998 • 313 citations

Regulation of imaginal disc cell size, cell number and organ size by Drosophila class IA phosphoinositide 3-kinase and its adaptor

1999 • 299 citations

Ras1 Promotes Cellular Growth in the Drosophila Wing

2000 • 276 citations

Activation of Phosphatidylinositol 3-Kinase Is Sufficient for Cell Cycle Entry and Promotes Cellular Changes Characteristic of Oncogenic Transformation

1998 • 266 citations

Molecular mechanisms for the control of translation by insulin

1997 • 257 citations

cAMP-dependent protein kinase and hedgehog act antagonistically in regulating decapentaplegic transcription in drosophila imaginal discs

1995 • 236 citations

Cell cycle progression, growth and patterning in imaginal discs despite inhibition of cell division after inactivation of Drosophila Cdc2 kinase

1997 • 192 citations

The PTEN tumor suppressor homolog in Caenorhabditis elegans regulates longevity and dauer formation in an insulin receptor-like signaling pathway

1999 • 186 citations

Protein kinase A antagonizes Hedgehog signaling by regulating both the activator and repressor forms of Cubitus interruptus

1999 • 176 citations

Regulation of the insulin-like developmental pathway of Caenorhabditis elegans by a homolog of the PTEN tumor suppressor gene

1999 • 145 citations

Genetic analysis of protein kinase B (AKT) in Drosophila

1998 • 138 citations

Localization of proteins to the apico-lateral junctions ofDrosophila epithelia

1997 • 114 citations

Cell-autonomous and non-autonomous growth-defective mutants of Drosophila melanogaster

1999 • 79 citations

A family of oligo-adenylate-terminated transposable sequences in Drosophila melanogaster

1983 • 77 citations

Treatment of Ras-induced cancers by the F-actin cappers tensin and chaetoglobosin K, in combination with the caspase-1 inhibitor N1445.

1999 • 23 citations

Alternative splicing of the Drosophila PTEN gene

1999 • 14 citations