A role of the kinase mTOR in cellular transformation induced by the oncoproteins P3k and Akt

Akt Promotes Cell Survival by Phosphorylating and Inhibiting a Forkhead Transcription Factor

1999 • 6,443 citations

Akt Phosphorylation of BAD Couples Survival Signals to the Cell-Intrinsic Death Machinery

1997 • 5,665 citations

Inhibition of glycogen synthase kinase-3 by insulin mediated by protein kinase B

1995 • 5,143 citations

Cellular survival: a play in three Akts

1999 • 4,229 citations

Regulation of Cell Death Protease Caspase-9 by Phosphorylation

1998 • 3,129 citations

Interleukin-3-Induced Phosphorylation of BAD Through the Protein Kinase Akt

1997 • 2,245 citations

NF-κB activation by tumour necrosis factor requires the Akt serine–threonine kinase

1999 • 2,147 citations

Systematic variation in gene expression patterns in human cancer cell lines

2000 • 2,119 citations

eIF4 Initiation Factors: Effectors of mRNA Recruitment to Ribosomes and Regulators of Translation

1999 • 2,096 citations

New insights into tumor suppression: PTEN suppresses tumor formation by restraining the phosphoinositide 3-kinase/AKT pathway

1999 • 1,972 citations

A mammalian protein targeted by G1-arresting rapamycin–receptor complex

1994 • 1,954 citations

NF-κB is a target of AKT in anti-apoptotic PDGF signalling

1999 • 1,830 citations

RAFT1: A mammalian protein that binds to FKBP12 in a rapamycin-dependent fashion and is homologous to yeast TORs

1994 • 1,470 citations

PHOSPHOINOSITIDE KINASES

1998 • 1,321 citations

Mechanisms and consequences of activation of protein kinase B/Akt

1998 • 1,305 citations

Regulation of 4E-BP1 phosphorylation: a novel two-step mechanism

1999 • 1,255 citations

Insulin-dependent stimulation of protein synthesis by phosphorylation of a regulator of 5'-cap function

1994 • 1,222 citations

PIK3CA is implicated as an oncogene in ovarian cancer

1999 • 1,170 citations

Rapamycin-FKBP specifically blocks growth-dependent activation of and signaling by the 70 kd S6 protein kinases

1992 • 1,146 citations

RAFT1 phosphorylation of the translational regulators p70 S6 kinase and 4E-BP1

1998 • 1,136 citations

Protein kinase B/Akt-mediated phosphorylation promotes nuclear exclusion of the winged helix transcription factor FKHR1

1999 • 1,102 citations

Protein kinase B (c-Akt): a multifunctional mediator of phosphatidylinositol 3-kinase activation

1998 • 1,101 citations

Direct control of the Forkhead transcription factor AFX by protein kinase B

1999 • 1,080 citations

AKT/PKB and Other D3 Phosphoinositide-Regulated Kinases: Kinase Activation by Phosphoinositide-Dependent Phosphorylation

1999 • 997 citations

Phosphoinositide 3-kinase: the key switch mechanism in insulin signalling

1998 • 969 citations

Phosphorylation of the Translational Repressor PHAS-I by the Mammalian Target of Rapamycin

1997 • 953 citations

Malignant transformation by a eukaryotic initiation factor subunit that binds to mRNA 5' cap

1990 • 949 citations

Rapamycin suppresses 5'TOP mRNA translation through inhibition of p70s6k

1997 • 930 citations

A Retroviral Oncogene, akt , Encoding a Serine-Threonine Kinase Containing an SH2-Like Region

1991 • 900 citations

4E-BP1, a repressor of mRNA translation, is phosphorylated and inactivated by the Akt(PKB) signaling pathway

1998 • 872 citations

Isolation of a Protein Target of the FKBP12-Rapamycin Complex in Mammalian Cells

1995 • 859 citations

Induction of NF-κB by the Akt/PKB kinase

1999 • 847 citations

Molecular alterations of the AKT2 oncogene in ovarian and breast carcinomas

1995 • 831 citations

Amplification of AKT2 in human pancreatic cells and inhibition of AKT2 expression and tumorigenicity by antisense RNA.

1996 • 785 citations

Mechanism of activation and function of protein kinase B

1998 • 753 citations

AKT2, a putative oncogene encoding a member of a subfamily of protein-serine/threonine kinases, is amplified in human ovarian carcinomas.

1992 • 732 citations

A direct linkage between the phosphoinositide 3-kinase-AKT signaling pathway and the mammalian target of rapamycin in mitogen-stimulated and transformed cells.

2000 • 713 citations

Two distinct signal transmission pathways in T lymphocytes are inhibited by complexes formed between an immunophilin and either FK506 or rapamycin.

1990 • 699 citations

Ribosomal S6 Kinase Signaling and the Control of Translation

1999 • 679 citations

PHAS-I as a Link Between Mitogen-Activated Protein Kinase and Translation Initiation

1994 • 672 citations

Structure and function of phosphoinositide 3-kinases

1998 • 666 citations

Rapamycin-Induced Inhibition of the 70-Kilodalton S6 Protein Kinase

1992 • 666 citations

The mRNA 5′ cap-binding protein eIF4E and control of cell growth

1998 • 651 citations

Rapamycin selectively inhibits interleukin-2 activation of p70 S6 kinase

1992 • 601 citations

PTEN: a tumour suppressor that functions as a phospholipid phosphatase

1999 • 592 citations

Mutational Spectra of PTEN/MMAC1 Gene: a Tumor Suppressor With Lipid Phosphatase Activity

1999 • 539 citations

CONTROL OF TRANSLATION INITIATION IN ANIMALS

1998 • 507 citations

RAPT1, a mammalian homolog of yeast Tor, interacts with the FKBP12/rapamycin complex.

1994 • 475 citations

Up-regulation of Akt3 in Estrogen Receptor-deficient Breast Cancers and Androgen-independent Prostate Cancer Lines

1999 • 470 citations

Avian sarcoma virus 17 carries the jun oncogene.

1987 • 445 citations

The principal target of rapamycin-induced p70s6k inactivation is a novel phosphorylation site within a conserved hydrophobic domain.

1995 • 441 citations

Transformation of Chicken Cells by the Gene Encoding the Catalytic Subunit of PI 3-Kinase

1997 • 414 citations

Regulation of the p70 S6 Kinase by Phosphorylation in Vivo

1998 • 375 citations

The immunosuppressive macrolides FK-506 and rapamycin act as reciprocal antagonists in murine T cells.

1990 • 360 citations

A retroviral oncogene, akt, encoding a serine-threonine kinase containing an SH2-like region

1991 • 344 citations

eIF4E expression in tumors: its possible role in progression of malignancies

1999 • 327 citations

Amplification and overexpression of theAKT2 oncogene in a subset of human pancreatic ductal adenocarcinomas

1998 • 318 citations

The Akt kinase: Molecular determinants of oncogenicity

1998 • 294 citations

Avian sarcoma virus Y73 genome sequence and structural similarity of its transforming gene product to that of Rous sarcoma virus

1982 • 294 citations

Abrogation of translation initiation factor eIF-2 phosphorylation causes malignant transformation of NIH 3T3 cells.

1995 • 288 citations

eIF4E activity is regulated at multiple levels

1999 • 287 citations

Characteristics of two new avian tumor virus subgroups

1969 • 227 citations

cAMP- and rapamycin-sensitive regulation of the association of eukaryotic initiation factor 4E and the translational regulator PHAS-I in aortic smooth muscle cells.

1995 • 225 citations

The role of PI 3-kinase in insulin action

1998 • 224 citations

Translational control: the cancer connection

1999 • 222 citations

μ-Opioid Receptor Activates Signaling Pathways Implicated in Cell Survival and Translational Control

1998 • 188 citations

Efficient transformation of chicken embryo fibroblasts by c-Jun requires structural modification in coding and noncoding sequences.

1990 • 175 citations

Protein Kinase B Localization and Activation Differentially Affect S6 Kinase 1 Activity and Eukaryotic Translation Initiation Factor 4E-Binding Protein 1 Phosphorylation

1999 • 175 citations

Studies on the Mechanism of Resistance to Rapamycin in Human Cancer Cells

1998 • 173 citations

Rapamycin inhibits constitutive p70s6k phosphorylation, cell proliferation, and colony formation in small cell lung cancer cells.

1996 • 170 citations

Malignant transformation by overproduction of translation initiation factor eIF4G.

1997 • 163 citations

Structure-function analysis of the maf oncogene product, a member of the b-Zip protein family

1993 • 161 citations

v-Crk activates the phosphoinositide 3-kinase/AKT pathway in transformation

2000 • 134 citations

Translation factors as effectors of cell growth and tumorigenesis

1993 • 128 citations

Transformation by v-Src: Ras-MAPK and PI3K-mTOR Mediate Parallel Pathways

1999 • 127 citations

Isolation of DNA Sequences Amplified at Chromosome 19q13.1–q13.2 Including theAKT2Locus in Human Pancreatic Cancer

1996 • 122 citations

Heparin-binding epidermal growth factor-like growth factor, a v-Jun target gene, induces oncogenic transformation

1999 • 88 citations

The Catalytic Subunit of Phosphoinositide 3-Kinase: Requirements for Oncogenicity

2000 • 85 citations

Cell-free translation of avian erythroblastosis virus RNA yields two specific and distinct proteins with molecular weights of 75,000 and 40,000

1980 • 68 citations

Rapamycin inhibits the phosphorylation of p70 S6 kinase in IL-2 and mitogen-activated human T cells

1992 • 64 citations

Constitutive Activation of S6 Kinase by Deletion of Amino-Terminal Autoinhibitory and Rapamycin Sensitivity Domains

1996 • 63 citations

Chicken homolog of the mos proto-oncogene.

1988 • 62 citations

An avian transforming retrovirus isolated from a nephroblastoma that carries the fos gene as the oncogene

1987 • 48 citations

The zinc finger protein GLI induces cellular sensitivity to the mTOR inhibitor rapamycin.

1999 • 44 citations

A newly isolated avian sarcoma virus, ASV-1, carries the crk oncogene.

1989 • 40 citations

The putative transforming protein of S13 avian erythroblastosis virus is a transmembrane glycoprotein with an associated protein kinase activity.

1985 • 38 citations

Evidence for three classes of avian sarcoma viruses: comparison of the transformation-specific proteins of PRCII, Y73, and Fujinami viruses.

1981 • 29 citations

Rapamycin-resistant phosphorylation of the initiation factor-4E-binding protein (4E-BP1) in v-SRC-transformed hamster fibroblasts

1999 • 22 citations

Comparative analysis of the structure and function of the chicken c-myc and v-myc genes: v-myc is a more potent inducer of cell proliferation and apoptosis than c-myc.

1996 • 20 citations

Chicken Homolog of the mos Proto-Oncogene

1988 • 17 citations

Transformation of chicken embryo fibroblasts by direct DNA transfection of single oncogenes: comparative analyses of src, erbB, myc, and ras

1990 • 11 citations